Clinical trials: MCI, active
Hearing Loss, Cognitive Impairment, Mild
ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life
Although previous studies indicated that tackling hearing loss may have a secondary benefit in improving cognitive function and delaying the onset of dementia, a more integrated care approach to optimize both hearing and…
- Trial name
- NCT06955494
- Testing
- Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment, Healthy Aging
A Novel Computer-Based Functional Skills Assessment and Training Program
People with cognitive impairments such as Mild Cognitive Impairment (MCI), often experience difficulty performing everyday routine activities.
- Trial name
- NCT04679441
- Testing
- The Computerized Functional Skills Assessment and Training Program, Brain HQ Double Decision
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- i-Function, Inc.
Mild Cognitive Impairment
Voice Technology-Based Self-Management Intervention
This study aims to test a new technology-based program designed to help improve the ability to manage chronic conditions. This program includes daily smart speaker use for managing different tasks and technology learning.
- Trial name
- NCT06982261
- Testing
- Voice-activated smart speakers
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Alzheimer Disease, Dementia, Mild
Paper-Based and Smartphone-Based Memory Supports
Alzheimer's disease and related dementias lead to marked declines in daily functioning, independence, and quality of life. One of the earliest cognitive changes in these conditions is impairment in prospective memory, or the…
- Conditions
- Alzheimer Disease, Dementia, Mild, Mild Cognitive Impairment
- Trial name
- NCT06444841
- Testing
- Digital - Google Calendar, Paper-based - Memory Support System
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Baylor University
Mild Cognitive Impairment, Mild Dementia
Sensory Enrichment Using Aromatherapy for Neurobehavioral and Psychological Symptoms in Early Dementia
To determine if diffusion aromatherapy exposure to an essential oil blend can potentially improve mild cognitive impairment/mild dementia symptoms and relieve caregiver stress.
- Trial name
- SENSE (NCT07234357)
- Testing
- No Intervention, Aromatherapy
- Where
- 2 sites in Singapore
- Volunteers
- 200 people
- Sponsor
- National Cancer Centre, Singapore
MCI
Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment
This research study investigates the feasibility and efficacy of a personalized, closed-loop electroencephalogram-transcranial electrical stimulation (EEG-tES) intervention for individuals with mild cognitive impairment (MCI)…
- Trial name
- NCT07512193
- Testing
- Active tES, Cognitive Interventions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer s Disease, MCI Conversion to Dementia
Development of a Home Test for Measuring Blood P-tau217 in Alzheimer's Disease Using the Tasso Lancet Device
This study compares p-tau217 concentrations in blood collected via the Tasso device versus standard venipuncture in subjects with and without Alzheimer's disease, including a subset with confirmed amyloid pathology.
- Conditions
- Alzheimer s Disease, MCI Conversion to Dementia, pTau217, Biomarkers
- Trial name
- NCT07701161
- Where
- 5 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Neurogen Biomarking LLC
Mild Cognitive Impairment
Spatial Memory Training and Cognitive Function
Mild cognitive impairment (MCI) is often considered a transitional stage between normal aging and dementia, particularly Alzheimer's disease (AD).
- Trial name
- NCT07002996
- Testing
- SMIP, No intervention
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Douglas Mental Health University Institute
Cognitive Decline
TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics.
The study is based on the hypothesis that the integration of biological, psychological, and social factors, according to the biopsychosocial paradigm, allows for more accurate identification of the different stages of the…
- Trial name
- TRIAD (NCT07399418)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Mild Neurocognitive Disorder, Healthy Aging
tFUS for Memory in mNCD and Healthy Adults
Dementia is an ongoing and growing public health crisis in the US and worldwide. The purpose of this study is to examine a form of noninvasive brain stimulation called transcranial focused ultrasound (tFUS) to the hippocampus…
- Trial name
- NCT06718140
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Mild Cognitive Impairment, Accidental Falls
A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment
To determine the efficacy of a dual-task tai ji quan training therapy in reducing the incidence of falls in older adults with mild cognitive impairment.
- Conditions
- Mild Cognitive Impairment, Accidental Falls, Aging
- Trial name
- NCT05725668
- Testing
- dual-task tai ji quan, standard tai ji quan, stretching
- Where
- United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Alzheimer Disease, Mild Cognitive Impairment
Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants
Phase 1b study to assess the pharmacodynamics, safety, tolerability, and pharmacokinetics of NIO752 in patients with early Alzheimer's disease (AD)
- Trial name
- NCT05469360
- Testing
- NIO752
- Where
- 10 sites in Finland, France and 2 more
- Volunteers
- 38 people
- Sponsor
- Novartis Pharmaceuticals
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer Disease, Aging
Vanderbilt Memory and Aging Project
This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults.
- Conditions
- Alzheimer Disease, Aging, Aged, 80 and Over, Biomarkers
- Trial name
- VMAP (NCT05372159)
- Testing
- none, observational study
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease, Alzheimer Disease
Autoimmune Features of Neurodegenerative Disorders
This study is being conducted to better understand the role of inflammation in Parkinson's disease (PD) and Alzheimer's disease (AD).
- Conditions
- Parkinson Disease, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT04239079
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Columbia University
Mild Cognitive Impairment
Resistance Exercise Training in Individuals Aged 60 and Older With Mild Cognitive Impairment
The aging population in Chile and worldwide is increasing, with older people expected to represent 32.1% of the population by 2050.
- Trial name
- RET-MCI (NCT06470568)
- Testing
- Progressive Resistance exercise training
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Universidad de La Frontera
Mild Cognitive Impairment, Dementia
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
As our population ages, more older adults face motor-cognitive declines, increasing their risk of falls and fear of falling. Exercise is an effective way to maintain cognitive function, as supported by recent studies.
- Conditions
- Mild Cognitive Impairment, Dementia, Cognitive Impairment, Memory Loss
- Trial name
- NCT05235113
- Testing
- Tele-Exergame Platform, No Tele-Exergame Platform
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment (MCI), Healthy Aging
cMIND AI Web Tool Usability Study (Hong Kong)
This study is testing a new web-based tool that uses artificial intelligence (AI) to help older adults in Hong Kong check how healthy their Cantonese-style meals are for brain health.
- Conditions
- Mild Cognitive Impairment (MCI), Healthy Aging, Nutrition
- Trial name
- NCT07735013
- Testing
- Web-Based AI Dietary Assessment System
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Mild Cognitive Impairment
Improving Neurological Health With Acetylcholine Via Neuroplasticity-based Computerized Exercise in Mild Cognitive Impairment
This study is a validation study to evaluate efficacy of two neuroplasticity-based, computerized cognitive training programs to improve neurological and neuropsychological health in older adults with mild cognitive impairment…
- Trial name
- INHANCE-MCI (NCT07243600)
- Testing
- Computerized speed-based cognitive training, Computerized executive function cognitive training
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Posit Science Corporation
Cognitive Intervention, Mild Cognitive Impairment
Cognitive Intervention for Cognitive Impairment
Mild cognitive impairment is characterized by cognitive dysfunction without impairment in instrumental activities of daily living, with aging being the primary risk factor.
- Conditions
- Cognitive Intervention, Mild Cognitive Impairment, Elderly Adults, Diabetes Mellitus
- Trial name
- NCT07747675
- Testing
- cognitive intervention
- Volunteers
- 102 people
- Sponsor
- Instituto Mexicano del Seguro Social