Clinical trials: Lymph Node Excision
Breast Cancer Surgery, Neoadjuvant Therapy
Application of Targeted Axillary Lymph Node Resection in Axillary Surgery After Neoadjuvant Chemotherapy for Breast Cancer: an Open-label, Multicenter Study
In this study, following the full informed consent of patients regarding the safety and potential benefits of the new intervention regimen, pathologically confirmed lymph nodes were pre-labeled with carbon nanoparticles prior to…
- Conditions
- Breast Cancer Surgery, Neoadjuvant Therapy, Sentinel Lymph Node Biopsy (SLNB)
- Trial name
- NCT07032220
- Testing
- carbon suspension
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Fujian Medical University Union Hospital
Rectal Cancer
Preservation Vs. Dissection of No. 253 Lymph Nodes of Robotic Resection for Mid/Low Rectal Cancer
In this study, patients with middle or low rectal cancer will receive robotic radical resection, and will be randomly assigned to receive inferior mesenteric artery lymph nodes dissection or preservation.
- Trial name
- REAL2 (NCT06956976)
- Testing
- Dissection of Inferior Mesenteric Artery Root Lymph Node, Preservation of Inferior Mesenteric Artery Root Lymph Node
- Where
- China
- Volunteers
- 1,596 people
- Sponsor
- Fudan University
Non-Small Cell Lung Cancer
ArticuGrasp Trial: New Flexible Tool vs Standard Grasper for Lung Cancer Node Removal in Keyhole Chest Surgery
This study is testing whether a new, flexible surgical tool-the SurgeoFlex Grasp-makes keyhole chest operations for early-stage lung cancer easier, faster, and safer than the standard rigid tool used today.
- Trial name
- NCT07201077
- Testing
- Articulating lymph-node grasper (SurgeoFlex Grasp), Arm 2 Intervention Name Traditional rigid endograsper
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jianxing He
Testis Cancer, Germ Cell Tumor
Role of Axumin PET Scan in Germ Cell Tumor
Investigators will use Axumin PET/CT to help with the imaging modalities to determine the presence of occult retroperitoneal disease.
- Conditions
- Testis Cancer, Germ Cell Tumor, Testicular Cancer, Germ Cell Tumor of Testis
- Trial name
- TESTPET (NCT03426865)
- Testing
- Axumin PET scan
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
NSCLC, Non Small Cell Lung Cancer
Radical Resection With Contralateral Lymph Node Dissection for Clinical N3 NSCLC
*Study Overview This study is investigating a surgical approach for patients with a serious type of lung cancer known as non-small cell lung cancer (NSCLC), particularly those in an advanced stage where cancer has spread to both…
- Trial name
- NCT07003490
- Testing
- Radical Resection with Bilateral Lymph Node Dissection
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Carcinoma, Pancreatic Ductal
Standard Versus Extended Lymphadenectomy in Pancreatoduodenectomy for Patients With Pancreatic Head Adenocarcinoma
The aim of this study is to determine whether the performance of extended lymphadenectomy in association with pancreatoduodenectomy improves the long-term survival in patients with pancreatic head ductal adenocarcinoma.Half of…
- Trial name
- NCT02928081
- Testing
- Extended lymphadenectomy, Standard lymphadenectomy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- West China Hospital
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery
This randomized phase III trial studies radiation therapy with chemotherapy to see how well they work compared to radiation therapy alone in treating patients with stage I-IIA cervical cancer who previously underwent surgery.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Stage I Cervical Cancer AJCC v6 and v7
- Trial name
- NCT01101451
- Testing
- Cisplatin, External Beam Radiation Therapy, Intensity-Modulated Radiation Therapy
- Where
- 719 sites in United States, Japan and 1 more
- Volunteers
- 340 people
- Sponsor
- GOG Foundation
Stage I Vulvar Cancer, Stage II Vulvar Cancer
Observation in Patients With Early-Stage Vulvar Cancer Undergoing Sentinel Lymph Node Dissection
This research trial studies patients with early-stage vulvar cancer undergoing sentinel lymph node dissection. Sentinel lymph node dissection may have fewer side effects than removing all lymph nodes.
- Conditions
- Stage I Vulvar Cancer, Stage II Vulvar Cancer, Stage III Vulvar Cancer, Vulvar Squamous Cell Carcinoma
- Trial name
- GROINSS-V (NCT01500512)
- Testing
- Clinical Observation
- Where
- 37 sites in United States, Canada
- Volunteers
- 148 people
- Sponsor
- Gynecologic Oncology Group
Lymphedema of Limb, Sentinel Lymph Node
Early Detection of Lower Extremity Lymphedema After Lymphadenectomy in Gynecological Cancer
This study aims to detect and treat early lower limb lymphedema secondary to lymphadenectomy with the aim of increasing the quality of life of patients with this chronic condition.
- Trial name
- NCT03917771
- Testing
- Early lymphedema detection, Usual follow-up
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Donostia
Lung Cancer
Feasibility of Radioisotope-guided Excision of Mediastinal Lymph Nodes in Patients With Non-small Cells Lung Carcinoma
Non-small cells lung carcinoma (NSCLC) represents one of the most common and lethal neoplasms. NSCLC is characterized by an early asymptomatic phase, which hinders the disease identification in its earliest stages.
- Trial name
- SLN_NSCLC (NCT05072561)
- Testing
- Sentinel lymph node scintigraphy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Clinico Humanitas
Non-small Cell Lung Cancer
Comparison of Diagnostic and Therapeutic Efficacy of EBUS-TBNA/EUS-FNA and TEMLA in Operable NSCLC.
The aim of the study is prospective comparison of diagnostical and therapeutical efficiency between different methods of mediastinal lymph node preoperative staging in Non-Small-Cell Lung Cancer (NSCLC).
- Trial name
- NCT03188562
- Testing
- PET/CT, EBUS-TBNA, EUS-NA, TEMLA
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Pulmonary Hospital Zakopane
Penile Cancer, Penile Neoplasms Malignant
DEfeating PEnile CAncer-2
Open inguinal lymphadenectomy (O-ILAD) is the current standard of care for invasive staging and simultaneously the curative approach for patients with PeCa and elevated risk for or clinically detectable lymphatic disease in the…
- Trial name
- DEPECA-2 (NCT07378670)
- Testing
- open inguinal lymphadenectomy, robot-assisted inguinal lymphadenectomy
- Where
- 9 sites in Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Tuebingen
Cancer, Malignant Melanoma
Effect of rIL-21 on Metastases in Lymph Nodes in Melanoma Skin Cancer
The trial is conducted in Europe. This trial aims for a comparison of the pathology in lymph nodes before and after the effect of recombinant interleukin-21 in patients with stage III melanoma
- Trial name
- NCT00601861
- Testing
- recombinant interleukin-21
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Novo Nordisk A/S
Breast Cancer, Invasive Breast Cancer
Sentinel Node Biopsy Following NeoAdjuvant Chemotherapy in Biopsy Proven Node Positive Breast Cancer
Title of Study: Sentinel node biopsy following neoadjuvant chemotherapy in biopsy proven node positive breast cancer. Objectives of the study: Primary objective 1.
- Trial name
- SN-FNAC (NCT00909441)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Canada
- Volunteers
- 153 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Cancer, Sigmoid Cancer
Complete Mesocolon Excision vs Locoregional Lymphadenectomy in Sigmoid Colon Cancer (CMELL)
A randomized, controlled clinical trial comparing lymphadenectomy with extended inferior mesenteric artery ligation (complete mesocolon excision: which includes lymphoma tissue from the origin of the inferior mesenteric vein)…
- Trial name
- CMELL (NCT03083951)
- Testing
- Complete mesocolon excision, Conventional locoregional lymphadenectomy
- Where
- Spain
- Volunteers
- 93 people
- Sponsor
- Pere Planellas Giné
Breast Cancer
Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00881361
- Testing
- systemic chemotherapy, axillary lymph node dissection, neoadjuvant therapy
- Where
- 324 sites in United States
- Volunteers
- 756 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer
Clinical Trial Comparing Outcomes of Breast Conserving Operations With Classic v High-frequency Electrocoagulation
The aim of this study is to assess the outcomes of breast conserving therapy operation depending on the type of surgical tool used: classic electrocoagulation with higher operative temperatures and high frequency…
- Trial name
- NCT01216254
- Testing
- classic v high-frequency electrocoagulation
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Gdansk
Progression
A Multiple-center Study on the Effect of Different Ways of Lymph Node Dissection on the Prognosis of Ground Glass Nodules Smaller Than 3cm and With More Than 50% Solid Components
A multiple-center study on the effect of different ways of lymph node dissection on the prognosis of less than 3cm ground glass nodules with more than solid components
- Trial name
- NCT04581122
- Testing
- Lymphadenectomy
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Shanghai Zhongshan Hospital
Prostate Cancer
SPECT-CT Guided Lymphatic Mapping and Sentinel Lymphadenectomy (LM/SL) in Prostate Cancer
Nodal staging is a key-step in pre-treatment assessment of prostate cancer. In patients with a low probability of nodal metastasis, bilateral pelvic lymphadenectomy is controversial.
- Trial name
- NCT00773318
- Testing
- SPECT/CT guided LM/SL
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Endometrial Cancer
Sentinel Lymph Node Dissection (SLND) in Patients With Apparent Early Stage Endometrial Cancer
The investigators hypothesize that SLND (unlike lymphadenectomy) decreases complications such as hemorrhage, lower extremity lymphedema and lymphocyst formation while enhancing quality of life in EC patients with low risk for…
- Trial name
- NCT02834988
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Miami