Clinical trials: Lyme Disease
Relapsing Fever, Tick-Borne
Postexposure Prophylaxis With Single Dose Doxycycline for the Prevention of Tick-borne Relapsing Fever
The goal of this clinical trial is to compare standard treatment (5 days of doxycycline) vs single dose doxycycline for the prevention of tick-borne relapsing fever in soldiers who found bite marks on their bodies after an…
- Trial name
- NCT06045481
- Testing
- administration of single dose of doxycycline
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Post-Treatment Lyme Disease
Transcranial Direct Current Stimulation for Post Treatment Lyme Disease
The primary purpose of this pilot study is to investigate a novel approach to the treatment of cognitive symptoms that persist despite prior antibiotic treatment for Lyme disease (Post treatment Lyme Disease or PTLD).
- Trial name
- NCT06915324
- Testing
- Transcranial Direct Current Stimulation (tDCS), Cognitive training
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Columbia University
Long Covid, Post-treatment Lyme Disease Syndrome
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: Long Covid (LC) Post-treatment Lyme disease syndrome (PTLDS) Myalgic…
- Conditions
- Long Covid, Post-treatment Lyme Disease Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
- Trial name
- NCT06511050
- Testing
- Lumbrokinase
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lyme Borreliosis
Borrelia Species in Cutaneous Lyme Borreliosis
The aim of this study is to identify the species of Borrelia involved in the dermatologic manifestations of Lyme borreliosis in France.
- Trial name
- NCT00576082
- Testing
- Cutaneous biopsy
- Where
- 2 sites in France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Strasbourg, France
Lyme Disease
Safety Study of a Vaccine to Help Protect Against Lyme Disease in Healthy Children
This study is to understand if the study vaccine (called VLA15) is safe in healthy children. We are looking for children who: are healthy are age 5 through 17 have not been diagnosed with any form of Lyme disease in the past have…
- Trial name
- NCT05634811
- Testing
- VLA15, Normal Saline
- Where
- 65 sites in United States
- Volunteers
- 3,547 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Borreliosis
Place of Intrathecal CXCL-13 in the Diagnosis of Lyme Neuroborreliosis
Neuroborreliosis (NBL) is diagnosed in 10-15% of patients with Lyme borreliosis. In Europe in adults, the main clinical manifestation is called "Bannwarth syndrome".
- Trial name
- CXCL13-LYME (NCT05625100)
- Where
- France
- Volunteers
- 141 people
- Sponsor
- University Hospital, Strasbourg, France
Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease
Natural History of Trisomy 8-Associated Autoinflammatory Disease (TRIAD) and Related Disorders
Background: Trisomy 8 mosaicism is a genetic disorder that can increase inflammation in the body. Symptoms include fevers; sores or ulcers in the mouth, digestive tract, or genital area; skin rashes; problems in organs or…
- Conditions
- Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease, Mucosal Ulcerations
- Trial name
- NCT07683104
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Atrophic Acrodermatitis
Laboratory Characteristics in Chronic Atrophic Acrodermatitis
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with chronic atrophic dermatitis to gain better insight into pathogenesis of chronic…
- Trial name
- NCT02147262
- Testing
- doxycycline orally, 100 mg, bid, 14 days, doxycycline orally, 100 mg, bid, 28 days
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Post-Lyme Disease Syndrome (PLDS)
A Novel Nutraceutical to Combat Post-Lyme Disease Syndrome
This study will determine the effectiveness of a nutraceutical in treating the lingering effects of Lyme Disease after antibiotic treatment.
- Trial name
- PLDS (NCT04141969)
- Testing
- RLP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Optimal Health Research
Lyme Disease, Post Treatment Lyme Disease
Navigating Pregnancy and Parenthood With Lyme Disease
This is a mixed methods study exploring the experiences of pregnancy and parenting among participants with Lyme disease. Eligible participants will have been diagnosed with Lyme disease (LD), post-treatment Lyme disease syndrome…
- Conditions
- Lyme Disease, Post Treatment Lyme Disease, Chronic Lyme Disease, Tick-Borne Infections
- Trial name
- NCT06397794
- Testing
- Quantitative surveys and qualitative interview
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's National Research Institute
Acute Bacterial Infections, Acute Viral Infections
300 Antibody Diagnostic Test Kit
For the development of a Point of Care IVD test kit for acute phase disease detection against a variety of bacterial and viral infections.
- Trial name
- Antibody 300 (NCT01646411)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Plasma Source
Post-Lyme Disease Syndrome (PLDS)
Treating Post-Lyme Disease Syndrome With Acetogenins
To access the effectiveness of Acetogenins in treating Post-Lyme Disease Syndrome (PLDS).
- Trial name
- NCT04078841
- Testing
- ReaLife+ (RLP), Inert Brown powder
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Optimal Health Research
Lyme Disease
Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes
Hypothesis: Does treatment of lower extremity clothing with permethrin prevent Lyme disease? This is a double-blind, randomized clinical trial using permethrin treatment of clothing to prevent Lyme disease.
- Trial name
- NCT00958139
- Testing
- Permethrin
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Lyme Disease
Xenodiagnosis After Antibiotic Treatment for Lyme Disease
Background: The most common tick-borne illness in the United States, Lyme disease is caused by Borrelia burgdorferi bacteria that are transmitted to people by Ixodes scapularis ticks.
- Trial name
- NCT02446626
- Testing
- Skin biopsy, Blood draw, Xenodiagnosis
- Where
- 5 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fatigue, Quality of Life
Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease
Approximately 10-20% of patients experience ongoing symptoms despite having received standard antibiotic therapy for Lyme disease.
- Trial name
- NCT03891667
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Lyme Disease
An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease Vaccine (VLA15)
The main purpose of this clinical study is to evaluate a 6-valent OspA-based Lyme disease vaccine (VLA15) for prevention of Lyme disease within North America and Europe.
- Trial name
- VALOR (NCT05477524)
- Testing
- VLA15, Saline
- Where
- 129 sites in United States, Canada and 5 more
- Volunteers
- 12,546 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Disease
Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel
The T2Lyme assay will be compared to Borrelia culture from erythema migrans (EM) biopsy and/or detection of the C6 antigen in serum collected prospectively from patients suspected of early Lyme disease.
- Trial name
- NCT03581279
- Testing
- T2Lyme Panel testing
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- T2 Biosystems
Lyme Borreliosis
Risk of Exposure and Prevention of Ticks and Tick-borne Diseases Among Foresters in Alsace
Ticks are blood-sucking arthropods that feed on vertebrate hosts. Although wild and domestic animals are the primary source of tick blood meals, humans can be an accidental host.
- Trial name
- PREFORTIC (NCT06492668)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Lyme Disease
Searching for Persistence of Infection in Lyme Disease
Background: Lyme disease is an infection caused by Borrelia burgdorferi, a bacteria that is transmitted to humans by ticks. It can cause many different symptoms including rash, fever, headache, meningitis (infection of the…
- Trial name
- NCT01143558
- Testing
- Lyme Disease Xenodiagnosis
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Suspected Early Lyme Neuroborreliosis
Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis
The investigators will compare doxycycline and ceftriaxone in treatment of patients with suspected early Lyme neuroborreliosis and normal CSF cell count.
- Trial name
- NCT00942006
- Testing
- doxycycline, ceftriaxone
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana