Clinical trials: Lung Lesions
Vaccination; Infection, COVID-19
Establishing Immunogenicity and Safety of Needle-free Intradermal Delivery of mRNA COVID-19 Vaccine
COVID-19 vaccines are limited in supply, especially in low- and middle-income countries, leading to substantial morbidity and mortality.
- Trial name
- MILESTONE (NCT05315362)
- Testing
- solid microneedle skin patch, mRNA-1273, standard needle
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Peripheral Pulmonary Lesions
Optical Biopsy for Peripheral Pulmonary Lesions
The purpose of the study is to describe confocal laser endomicroscopy (CLE) interpretation criteria for different types of peripheral pulmonary lesions (PPLs), with histopathological correlation, and to perform the validation of…
- Trial name
- NCT06457087
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Chest Hospital
Lung Nodule, Lung Mass
Cone Beam CT Guided Electromagnetic Navigational Bronchoscopy
Electromagnetic navigation bronchoscopy (ENB) is used to access peripheral and central parenchymal lung lesions via endobronchial and transbronchial approach.
- Conditions
- Lung Nodule, Lung Mass, Lesion of the Lung
- Trial name
- CBCTENB (NCT04194333)
- Testing
- Cone Beam CT with Embo Guide to creat 3D Overlay and CT Augmented Fluoroscopy to guide Electromagnetic Navigational Bronchoscopy instead of Standard Fluroscopic guidance using the C-Arm
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Columbus Regional Health
Lung Cancer
UTB-VBN-EBUS With or Without Fluoroscopy for the Diagnosis of PPLs
The purpose of this study is to evaluate the feasibility,efficacy and safety of ultrathin bronchoscopy(UTB) combined with virtual bronchoscopic navigation(VBN) and endobronchial ultrasound(EBUS) for the diagnosis of peripheral…
- Trial name
- NCT02664259
- Testing
- VBN, EBUS, X-ray
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial
A postoperative autologous blood patch (ABP) intervention trial for patients who underwent lung resection for cancer to examine its effectiveness in preventing a prolonged air leak.
- Trial name
- NCT04954625
- Testing
- Autologous Blood Patch, Standard of Care (per Physician)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rush University Medical Center
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Pulmonary Lesion, Lung Cancer
Study on the Effectiveness and Safety of CLE Combined With Cryobiopsy for Diagnosis of Pulmonary Lesions
Forty subjects meeting the inclusion and exclusion criteria were recruited at a single center and signed informed consent forms.
- Trial name
- NCT07352176
- Testing
- Confocal laser endomicroscopy combined cryobiopsy, Conventional cryobiopsy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Guangzhou Medical University
Cancer of the Lung, Lung Cancer
NEUWAVE Flexible Probe Study #2
Patients with medically inoperable and operable secondary soft tissue lesion(s) of the lung will have transbronchial microwave ablation performed using cone beam CT for probe guidance and confirmation.
- Conditions
- Cancer of the Lung, Lung Cancer, Neoplasms, Lung, Carcinoma, Non-Small Cell Lung
- Trial name
- NCT03713099
- Testing
- Microwave ablation
- Where
- 5 sites in United States
- Sponsor
- Ethicon, Inc.
Lung Cancer
Navigation Endobronchial Ultrasound
Lung cancer is the primary cause of cancer related deaths in Denmark. In order to improve the prognosis diagnosis in earlier stages are needed. This will however require improved sampling techniques from very small lung lesions.
- Trial name
- NEBULA (NCT04553809)
- Testing
- ENB, ENB in combination with rEBUS
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Amanda Dandanell Juul
Stage IV Non-Small Cell Lung Cancer
Pembrolizumab Alone or Sequentially Following Single Fraction Non-ablative Radiation to One of the Target Lesions, in Previously Treated Patients With Stage IV NSCLC
The goal of this clinical trial is to determine if low single palliative dose radiation to the lung cancer will improve your immune response against the tumor and if sequential treatment with pembrolizumab (the study drug) would…
- Trial name
- NCT02658097
- Testing
- Pembrolizumab, Single Fraction Radiation Therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Peripheral Pulmonary Lesions (PPLs)
CLE vs. ROSE for Ex Vivo Lung Biopsy Assessment
The goal of this observational study is to evaluate the diagnostic efficacy of Confocal Laser Endomicroscopy (CLE) compared to Rapid On-Site Evaluation (ROSE) for ex vivo lung biopsy specimens obtained via bronchoscopy.
- Trial name
- NCT07725510
- Testing
- Ex Vivo Confocal Laser Endomicroscopy (CLE) Imaging and Interpretation, Rapid On-Site Evaluation (ROSE) Imaging and Interpretation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Lung Diseases
Safety and Effectiveness Study for a Needle Guidance System in Lung Biopsies
This study is designed to provide clinical data regarding safety and clinical effectiveness of the ActiSight Needle Guidance System in assisting radiologically guided percutaneous needle biopsy or aspiration of pulmonary lesions…
- Trial name
- NCT01183182
- Testing
- ActiSight Needle Guidance System
- Where
- 3 sites in Canada
- Volunteers
- 48 people
- Sponsor
- ActiViews Ltd.
Peripheral Pulmonary Lesion
Diagnostic Value of Confocal Laser Endomicroscopy (CelTouch) for Peripheral Lung Lesions
This study uses CelTouch to explore patients with lung lesions scheduled for lung biopsy. By comparing with preclinical CLE images and pathological images, CLE diagnostic criteria for benign and malignant lung lesions under the…
- Trial name
- NCT07004946
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Guangzhou Medical University
Lung Cancer
Cost-effectiveness Evaluation of Robotic Surgery in the Removal of Lung Lesions in the ATS of Milan
The goal of this observational study is to compare cost-effectiveness of robotic surgery with open surgery and video-assisted thoracoscopy surgery (VATS) in adult patients, resident in the ATS of Milan area, operated for lung…
- Trial name
- NCT05674227
- Testing
- Robotic surgery, Video-assisted thoracoscopy, Open surgery
- Volunteers
- 5,400 people
- Sponsor
- Agenzia di Tutela della Salute della Città Metropolitana di Milano
Lung Neoplasms, Pulmonary Neoplasms
Feasibility of Fluorescence Imaging With Bevacizumab-800CW During Bronchoscopy
In this feasibility study, bronchoscopy will be combined with fluorescence molecular imaging using the near-infrared fluorescence (NIRF) tracer bevacizumab-800CW for assessment of pulmonary lesions and/or lymph nodes considered…
- Conditions
- Lung Neoplasms, Pulmonary Neoplasms, Lymph Node Involvement, Pulmonary Nodule
- Trial name
- DEFLECT I (NCT06809946)
- Testing
- injection with 15 mg bevacizumab-800CW before bronchoscopy, injection with 25 mg bevacizumab-800CW before bronchoscopy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Lung Cancer
superDimension™ Navigation System Version 7.2 With Fluoroscopic Navigation Technology
The purpose of this investigation is to confirm the clinical accuracy of the superDimension™ Navigation System Version 7.2 with Fluoroscopic Navigation Technology.
- Trial name
- NCT03585959
- Testing
- superDimension™ Navigation System Version 7.2
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic - MITG
Lung Cancer
InvestigatioN of a Smart Probe for Lung lEsion Characterization Using Impedance Technology
The objective of the study is to evaluate the feasibility of the BioSpy System sensor to differentiate tissues that are encountered during bronchoscopic biopsy of endobronchial tumors and peripheral lung nodules and masses.
- Trial name
- INSPECT (NCT06380361)
- Testing
- BioSpy System
- Where
- 2 sites in Australia, France
- Volunteers
- 30 people
- Sponsor
- Sensome
Asthma (Diagnosis)
Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma
Acute asthma exacerbation is caused by dysregulated pulmonary inflammatory pathways such that standard treatment includes prompt administration of exogenous systemic corticosteroids (SCs), but there remains an ongoing dialogue…
- Trial name
- PATCH (NCT07455396)
- Testing
- Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Johns Hopkins All Children's Hospital
Thoracic Cancers, Malignant Pleural Mesotheliomas NOS
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
Background: Chromatin is is the structural building block of a chromosome. It is found inside the nucleus of the cell and consists of a complex of DNA and protein.
- Conditions
- Thoracic Cancers, Malignant Pleural Mesotheliomas NOS, Lung Cancer NOS, Esophageal Cancers NOS
- Trial name
- NCT00242723
- Where
- United States
- Volunteers
- 1,559 people
- Sponsor
- National Cancer Institute (NCI)
Brain Metastases, Adult, Brain Tumor - Metastatic
Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction
The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation…
- Conditions
- Brain Metastases, Adult, Brain Tumor - Metastatic, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Extra-cranial Solid Tumors
- Trial name
- NCT07132190
- Testing
- Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ayal A. Aizer, MD