Clinical trials: Lung Lesions
Lung Nodules, Peripheral Lung Lesions
Shape-Sensing Robotic-Assisted Bronchoscopy for Diagnosis of Peripheral Pulmonary Nodules in Korea
What is this study about? This study tests a new robotic technology to take tissue samples from lung nodules (small spots in the lungs). Some lung nodules are cancer, but doctors need a tissue sample to know for sure.
- Conditions
- Lung Nodules, Peripheral Lung Lesions, Pulmonary Nodules, Lung Cancers
- Trial name
- ULSAN-ION (NCT07057648)
- Testing
- Shape-sensing Robotic-assisted Bronchoscopy (ssRAB)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Ulsan University Hospital
Tracheal Intubation, Postoperative Complications (Cardiopulmonary)
Tracheal Cuff Pressure and Postoperative Complications
This prospective observational study aims to identify risk factors for tracheal mucosal injuries caused by orotracheal tube use during the intraoperative period in patients undergoing elective surgeries at the Hospital de…
- Trial name
- TCP-POC (NCT07264179)
- Where
- Brazil
- Volunteers
- 362 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Prolonged Air Leak, Persistent Air Leak
Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for Postoperative Air Leak After Lung Resections
Prolonged or persistent air leak (PAL) is one of the most common complications in patients after surgery on the lung parenchyma.
- Trial name
- GLUC-PAL (NCT06936969)
- Testing
- Autologous blood patch pleurodesis, 40% glucose solution pleurodesis
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii
Sentinel Lymph Node
Bronchial NIR Image-guided Resection
This is a clinical trial to evaluate the use of peritumoral injection of near-infrared dye indocyanine green to identify lung lesions and sentinel lymph nodes.
- Trial name
- NCT03097575
- Testing
- ICG Intervention, Near Infrared Imaging
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Non Small Cell Lung Cancer, Lung Metastases
SBRT Dose Escalation for Reirradiation of Inoperable Lung Lesions
Prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation. Dose limiting toxicity will be pneumonitis ≥ G3.
- Trial name
- STRILL (NCT04455438)
- Testing
- SBRT dose escalation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Clinico Humanitas
Locally Advanced Non Small Cell Lung Cancer, Metastatic Non Small Cell Lung Cancer
Local Ablative Stereotactic Radiotherapy for Residual Hypermetabolic Lesion in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Long-term Responders to Immunotherapy
At present, it is recommended to continue immunotherapy until progression or unacceptable toxicity. However, only a minority of patients benefits from a durable response and most see the disease progress despite several months of…
- Trial name
- TRAILOCLORI01 (NCT05111197)
- Testing
- SRT, Immunotherapy
- Where
- 5 sites in France
- Volunteers
- 112 people
- Sponsor
- Institut Cancerologie de l'Ouest
Lung Cancer, Heart Disease
Does Moderate Intensity Exercise Help Prevent Smoking Relapse Among Women?
This study compares the effects of a standard smoking cessation treatment, including one-time brief counseling and provision of nicotine patch plus an 8-week moderate intensity exercise program versus the same standard smoking…
- Conditions
- Lung Cancer, Heart Disease, COPD
- Trial name
- NCT00420160
- Testing
- Smoking cessation treatment plus moderate intensity exercise, Smoking cessation treatment plus health education
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Lung Cancer
Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial
A postoperative autologous blood patch (ABP) intervention trial for patients who underwent lung resection for cancer to examine its effectiveness in preventing a prolonged air leak.
- Trial name
- NCT04954625
- Testing
- Autologous Blood Patch, Standard of Care (per Physician)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rush University Medical Center
Non-Small Cell Lung Cancer
Docetaxel + Plinabulin Compared to Docetaxel + Placebo in Patients With Advanced NSCLC
To compare the overall survival of NSCLC patients receiving 2nd- or 3rd-line systemic therapy with docetaxel + plinabulin (DP Arm) to patients treated with docetaxel + placebo (D5W) (D Arm) for advanced or metastatic disease.
- Trial name
- DUBLIN-3 (NCT02504489)
- Testing
- Docetaxel + Plinabulin (DP), Docetaxel (D)
- Where
- 57 sites in United States, Australia and 1 more
- Volunteers
- 559 people
- Sponsor
- BeyondSpring Pharmaceuticals Inc.
Lung Ultrasound, Lung Cancer (Diagnosis)
3D-US Construct on Volumetric Assessment of Lung Disease & Clinical Application
The goal of this observational study is to establish the three-dimensional construct of lung lesion via ultrasound in patients with peripheral lung lesions or any superficial lesion in thoracic fields.
- Conditions
- Lung Ultrasound, Lung Cancer (Diagnosis), Peripheral Lung Lesions, Ultrasound Assessment
- Trial name
- NCT07574255
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
PET/CT, COVID-19
Study for Quantitative Analysis of the Recovered COVID-19 Patients by 18F-FDG-PET/CT
In this study, clinically cured patients with severe COVID-19 were used to evaluate the therapeutic effect of COVID-19 and the recovery and health status of patients over time with highly sensitive PET/CT imaging technology.
- Conditions
- PET/CT, COVID-19, Respiratory Function, Inflammatory Lesions
- Trial name
- NCT04519255
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Lung Lesions, Mediastinal and Hilar Lymph Node Enlargement
A Study of Contrast-enhanced EBUS in Lung Lesions and Intrathoracic Lymph Nodes
Exploring the Clinical Application Value of Contrast Enhancement Features in CE-EBUS Images for the Diagnosis of Pulmonary Lesions and Intrapulmonary Lymph Nodes
- Trial name
- NCT07060378
- Testing
- Contrast-enhanced endobronchial ultrasound
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Skin and Connective Tissue Diseases
Safety and Tolerability of Topically Applied Bovine Lung Surfactant on Intact Skin
Bovine Lung Surfactant is used as standard therapy for reducing alveolar surface tension in preterm infants. Here the drug is administered via airways.
- Trial name
- SATOSU (NCT02985437)
- Testing
- Surfactants, Saline Solution
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Dr. Ursula Mirastschijski
Lung Neoplasms
A Study of Robot-Assisted Bronchoscopy in Chinese Participants With Lung Lesions
Robot-assisted bronchoscopy biopsy procedure will be conducted for all eligible subjects under general anesthesia status by trained investigators in hospital.
- Trial name
- NCT05426213
- Testing
- Robot-assisted Bronchoscopy (Monarch Platform)
- Sponsor
- Auris Health, Inc.
Lung Cancer, Lung Metastases
Oxford Pleural Embolisation Trial
Thermal ablation is an established treatment for lung cancer. It involves insertion of a applicator under image guidance into a lung tumour and destroying it with radiofrequency, microwave or cryotherapy.
- Trial name
- OxPET (NCT06651658)
- Testing
- Pleural embolisation
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- Oxford University Hospitals NHS Trust
Pneumothorax
Predictive Score of PneumOThorax Secondary to CT-guided Transthoracic Lung Biopsy Made From a Large Retrospective Cohort and Validated on a Prospective Cohort
Transthoracic lung biopsy (TLB) provides a histological diagnosis of nodule or lung mass. Pneumothorax is the main complication of TLB with an average of 20%.
- Trial name
- SPOT (NCT03488043)
- Testing
- Needle lung biopsy
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Carcinoma, Non-Small-Cell Lung, Neoadjuvant Immunotherapy
Comparison of the Effect of Surgical Resection Based on Lesion Extent Before and After Neoadjuvant Therapy in Patients With Stage II-IIIB Non-Small Cell Lung Cancer: A Single-Center, Real-World, Open-Label Study
This study intends to conduct a prospective, non-interventional study to compare the survival benefits of different surgical resection patterns for patients with non-small cell lung cancer who have achieved partial response (PR)…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Neoadjuvant Immunotherapy, Surgery
- Trial name
- NCT07373899
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Pulmonary Nodule
Feasibility and Safety of Remote Robotic Bronchoscopy System in Diagnosis of Peripheral Pulmonary Lesions: a Multicenter, Randomized Controlled, proof-of Concept Trial
Robotic bronchoscopy represents the latest localization technology for peripheral pulmonary nodules, enabling precise and stable manipulation and potentially improving the diagnostic yield of peripheral lung pathologies.
- Trial name
- NCT06613412
- Testing
- Remote Robotic Bronchoscopy system
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou Medical University
ARDS, Human
Decrease of Lesions Induced by Mechanical Ventilation During ARDS
Modification of mechanically ventilated lesions by an ultra-protective multimodal strategy compared to a protective strategy in patients with veno-venous ECMO for severe ARDS.
- Trial name
- ECMO-VILI (NCT03918603)
- Testing
- ventral décubitus
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Lung Lesion(s) Requiring Evaluation
NAVIGATE: Clinical Evaluation of superDimension™ Navigation System for Electromagnetic Navigation Bronchoscopy™
The purpose of this study is to evaluate outcomes following electromagnetic navigation bronchoscopy™ (ENB™) procedures using the superDimension™ navigation system.
- Trial name
- NCT02410837
- Testing
- Electromagnetic Navigation Bronchoscopy
- Where
- 37 sites in United States, Austria and 5 more
- Volunteers
- 1,388 people
- Sponsor
- Medtronic - MITG