Clinical trials: Lung Cancer Screening, open to volunteers
Lung Cancer Screening
A Study of Lung Cancer Screening in People With Unexplained Weight Loss
The researchers are doing this study to see if people with unexplained weight loss who have lung cancer screening are more likely to have or develop lung cancer than people without unexplained weight loss.
- Trial name
- NCT06717334
- Testing
- Low Dose CT imaging, blood draws, screening questionnaire
- Where
- 8 sites in United States
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lung Cancer Screening, Military Service-related Environmental and Occupational Exposures
Personalizing Veterans' Lung Cancer Screening and Diagnosis
Lung cancer screening with low-dose chest computed tomography (CT) is currently recommended for high-risk individuals who are 50 to 80 years old, have smoked cigarettes for at least 20 pack-years, and currently smoke or quit…
- Conditions
- Lung Cancer Screening, Military Service-related Environmental and Occupational Exposures, Cancer Survivor, Family History of Lung Cancer
- Trial name
- MAS-EXPAND (NCT07838519)
- Testing
- Low-dose computed tomography
- Where
- 7 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- VA Office of Research and Development
Lung Cancer Screening, Lung Neoplasms
Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)
Lung cancer screening (LCS) with low-dose computed tomography (LDCT) can reduce the risk of dying from lung cancer, but many people who are eligible for screening do not receive it.
- Conditions
- Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer
- Trial name
- Empower LCS+ (NCT07711691)
- Testing
- Empower LCS, Call+ Telephone Navigation, Usual Care
- Where
- 57 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Irvine
Cancer Screening, Lung Cancer
Precision Navigation to Improve Community Cancer Screening Participation
This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening.
- Conditions
- Cancer Screening, Lung Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT07676383
- Testing
- Precision Navigation Intervention, Usual Health Education
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hunan Cancer Hospital
Lung Cancer Screening
C-Raven LDCT: Lung Cancer Screening Intervention
This study is a three-arm, randomized controlled pilot of a lung cancer screening intervention. The investigators will recruit participants ages 50-80 who are likely to meet lung cancer screening guidelines.
- Trial name
- C-Raven LDCT (NCT07819318)
- Testing
- Video/Brochure, Video/Brochure/Follow-up Call
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization
This study evaluates whether multiparametric chest magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), performed without any contrast material, can distinguish malignant from benign lung lesions that were…
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
- Trial name
- NCT07768046
- Testing
- Multiparametric chest MRI with diffusion-weighted imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Smoking Cessation, Smoking Cessation Counseling Ability and Practice
Evaluating the Impact of CONNECT in a Multilingual Population
This study aims to broaden the reach of the lung cancer screening (LCS) CONNECT program (NCT04149249, NCT06213532), by developing a version of the program to be available to multilingual communities.
- Conditions
- Smoking Cessation, Smoking Cessation Counseling Ability and Practice, Smoking Cessation Counselling, Lung Cancer Screening
- Trial name
- CONNECT-ML (NCT07111936)
- Testing
- CONNECT Intervention for multilingual populations, Saliva Sample, Interview
- Where
- United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lung Cancer Screening
Facilitation of Information eXchange for Shared Decision Making for Lung Cancer Screening
The goal of this pilot clinical trial is to learn whether the patient and provider support program, called FIX-SDM, helps patients and providers engage in shared decision-making for lung cancer screening during primary care…
- Trial name
- FIX-SDM LCS (NCT07517692)
- Testing
- FIX-SDM, Usual Care
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Massachusetts, Worcester
Lung Cancer Screening
LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)
This research study aims to investigate methods for enhancing lung cancer screening. The study will investigate whether an artificial intelligence (AI) tool, known as Sybil, can aid in predicting the risk of lung cancer.
- Trial name
- NCT07408531
- Testing
- Sybil Artificial Intelligence (AI) screening
- Where
- 2 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Lung Cancer, Lung Cancer Screening
Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Lung Cancer
The purpose of this research study is to test a new process for diagnosing lung cancer by examining changes to your DNA that can be detected from a blood test.
- Conditions
- Lung Cancer, Lung Cancer Screening, Healthy Volunteers (HV), Unhealthy Volunteers
- Trial name
- NCT07008664
- Testing
- Epigenetic Signature Assay
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Lung Cancer Screening
Pilot Testing a Web-based Prototype of a Lung Cancer Screening Digital Health Tool
The purpose of this study is to evaluate the acceptability, usability, and preliminary efficacy of a web-based prototype of a digital health tool for lung cancer screening (LCS).
- Trial name
- NCT07716527
- Testing
- Digital health tool prototype, Control Arm - standard of care
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Rutgers, The State University of New Jersey
Lung Cancer Screening
Statewide Optimization of Lung Cancer Screening Utilizing the QUILS™ System in Nevada and Mississippi: State-Based Initiative Component
This clinical trial studies whether a Quality Implementation of Lung Cancer Screening (QUILS™) System state-based initiative (SBI) intervention works to improve the statewide capacity for implementing and sustaining lung cancer…
- Trial name
- NCT07682597
- Testing
- QUILS SBI Intervention
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- Timothy Mullett
Lung Cancer Screening
Kentucky - Quality Improvement Implementation Lung Cancer Screening (QUILS™) Health Services Research Intervention
This clinical trial studies statewide optimization of lung cancer screening (LCS) in Kentucky using the Quality Implementation of Lung Screening (QUILS™) System.
- Trial name
- NCT07682610
- Testing
- Quality Implementation of Lung Cancer Screening (QUILS) System
- Where
- 17 sites in United States
- Volunteers
- 35,500 people, healthy volunteers welcome
- Sponsor
- Timothy Mullett
Lung Cancer Screening
Kentucky - Quality Improvement Implementation Lung Cancer Screening (QUILS™) Implementation
This is an optimization pathway for lung cancer screening programs. Enrolled programs will undergo an audit for elements associated with improved quality and retention of patients in the screening process.
- Trial name
- NCT07639255
- Testing
- QUILS System
- Where
- 17 sites in United States
- Volunteers
- 330 people
- Sponsor
- Timothy Mullett
Lung Cancer, Lung Cancer Screening
Prediction Augmented Screening Initiative
Lung cancer is responsible for more deaths in the United States than breast, prostate and colon cancer combined and is the number one cancer killer of Veterans.
- Trial name
- PASI (NCT06538636)
- Testing
- PCP-Facing Tools, LCS team population management tools
- Where
- 4 sites in United States
- Volunteers
- 23,520 people
- Sponsor
- VA Office of Research and Development
Lung Nodules, Lung Cancer Screening
ctDNA Mutations and Methylation Status for Early Detection of Lung Cancer in Patients With Suspicious Lung Nodules
Lung Cancer is common in Asia and is different from lung cancer from Western countries in terms of lung cancer epidemiology and management.
- Conditions
- Lung Nodules, Lung Cancer Screening, Suspected Lung Cancer
- Trial name
- NCT07615556
- Testing
- ctDNA mutations and methylation with SPOTMAS Lung assays, Non-contrast LDCT Thorax scans
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Epigenetics, DNA Methylation
Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening
The MET-SELS study aims to revolutionize how we identify individuals for lung cancer screening by moving beyond the limitations of self-reported smoking history.
- Conditions
- Epigenetics, DNA Methylation, Lung Cancer Screening, Risk Stratification With Biomarker
- Trial name
- MET-SELS (NCT07631624)
- Testing
- DNA-methylation in saliva
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Tobacco Dependence Treatment, Lung Cancer Screening
ICARE-LCS QUERI Partnered Evaluation Initiative: Integrating Comprehensive Tobacco Treatment to Enhance Lung Cancer Screening
Lung cancer is the leading cause of cancer-related death among Veterans with 90% of cases attributable to smoking. Lung cancer screening (LCS) combined with smoking cessation saves the most lives.
- Trial name
- ICARE-LCS (NCT06745258)
- Testing
- External Facilitation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
Lung Cancer, Health Screening
Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT
The goal of this clinical trial is to evaluate whether an AI tool that alerts providers to patients at high 6-year risk of lung cancer based on their chest x-ray images will improve lung cancer screening CT participation.
- Conditions
- Lung Cancer, Health Screening, Early Cancer Detection, Deep Learning
- Trial name
- NCT06910956
- Testing
- CXR-LC
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer Screening, Tobacco Use Disorder
Multilevel Intervention for LDCT Lung Cancer Screening and Smoking Cessation Among African Americans
This study aims to reduce disparities and the burden of lung cancer among African American smokers by supporting a Multiple-level intervention integrating lung cancer screening and smoking cessation (MILS), followed the NIH DEIA…
- Conditions
- Lung Cancer Screening, Tobacco Use Disorder, Smoking Cessation
- Trial name
- NCT07576595
- Testing
- Smoking cessation multilevel Intervention
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans