Clinical trials: Lung Cancer Screening
Colorectal Neoplasms Malignant
Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread…
- Trial name
- COVID-CRC (NCT04712292)
- Testing
- Surgical procedure for confirmed or suspected colorectal cancer
- Where
- 45 sites in Italy
- Volunteers
- 15,000 people
- Sponsor
- University of Bologna
Lung Cancer, COPD
DEPRECAP: Lung Cancer Screening Programme by LDCT for Patients With COPD or Emphysema.
The DEPRECAP (Early detection of lung cancer) study is an ongoing, prospective, longitudinal, multicenter lung cancer screening program that recruited individuals with COPD or emphysema from the pulmonary clinics of Fundación…
- Conditions
- Lung Cancer, COPD, Emphysema
- Trial name
- DEPRECAP (NCT06690385)
- Where
- 2 sites in Spain
- Volunteers
- 1,998 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Any Stage of Lung Cancer (Any Histotype), Any Stage of Malignant Pleural Mesothelioma
SPECTAlung: Screening Patients With Thoracic Tumors for Efficient Clinical Trial Access
SPECTAlung is a program aiming at screening patients with thoracic tumors to identify the molecular characteristics of their disease.
- Conditions
- Any Stage of Lung Cancer (Any Histotype), Any Stage of Malignant Pleural Mesothelioma, Any Stage of Any Thymic Malignancy
- Trial name
- SPECTAlung (NCT02214134)
- Testing
- Tumour markers testing
- Where
- 18 sites in Belgium, France and 7 more
- Volunteers
- 539 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Lung Neoplasms
Sputum Cytometry Analysis in Lung Cancer Screening After Professional Asbestos Exposure
Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of…
- Trial name
- AMORCE-CBP (NCT01687647)
- Testing
- low-dose CT-scan AND induced sputum sample AND blood test
- Where
- 3 sites in France
- Volunteers
- 463 people
- Sponsor
- University Hospital, Caen
Lung Cancer, Blood Biomarkers
AI for Lung Cancer Risk Definition in Computed Tomography Screening Programs
Low-dose computed tomography (LDCT) lung cancer (LC) screening can reduce mortality among heavy smokers, but there is a critical need to better identify people at higher risk and to reduce harms related to management of benign…
- Trial name
- NCT06320184
- Testing
- Artificial Intelligence risk model
- Where
- Italy
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Thoracic Cancers, Malignant Pleural Mesotheliomas NOS
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
Background: Chromatin is is the structural building block of a chromosome. It is found inside the nucleus of the cell and consists of a complex of DNA and protein.
- Conditions
- Thoracic Cancers, Malignant Pleural Mesotheliomas NOS, Lung Cancer NOS, Esophageal Cancers NOS
- Trial name
- NCT00242723
- Where
- United States
- Volunteers
- 1,559 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer Screening
LDCT-SC-FI Low-dose CT Screening for Lung Cancer
This is a randomized phase II trial investigating different smoking cessation methods in study subjects undergoing lung cancer screening with low-dose CT (LDCT).
- Trial name
- NCT05630950
- Testing
- Smoking cessation mobile application, Written material for smoking cessation
- Where
- 2 sites in Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Lung Cancer
Manchester Lung Health Study
The Manchester Lung Health Study (qUEST) will assess the uptake of a community-based lung cancer screening service and its impact across a deprived area of North and East Manchester, which has high rates of lung cancer.
- Trial name
- qUEST (NCT04409444)
- Testing
- Lung Cancer Screening, Biomarkers
- Where
- United Kingdom
- Volunteers
- 9,730 people
- Sponsor
- Manchester University NHS Foundation Trust
Lung Cancer
Diagnostic Performance of Small RNA Blood Test in Patients Undergoing Follow-up Imaging After Positive Low Dose CT Screening for Cancer of the Lung
2,000 individuals, aged 50-80 who have received a lung-RADS category 3 or 4 result on a LDCT screening study and who are scheduled for follow-up diagnostic imaging study, biopsy, clinical consultation or surgical appointment at…
- Trial name
- NCT05987189
- Testing
- Small RNA-based lung cancer assay
- Where
- 11 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Hummingbird Diagnostics
Smoking, Tobacco, Tobacco-Related Carcinoma
The Lung Screening, Tobacco and Health Project
The purpose of this study is to compare intensive telephone counseling (ITC) plus the nicotine patch vs. standard telephone counseling plus the nicotine patch (Usual Care; UC) among current smokers undergoing lung cancer…
- Conditions
- Smoking, Tobacco, Tobacco-Related Carcinoma, Tobacco Use, Lung Cancer Screening
- Trial name
- NCT03200236
- Testing
- Intensive Telephone Counseling (8 sessions) with nicotine replacement, Usual Care: Telephone counseling (3 sessions) with nicotine replacement
- Where
- 7 sites in United States
- Volunteers
- 1,114 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Lung Cancer
Patient Navigation for Lung Screening at MGH Community Health Centers
To develop and implement a patient navigator (PN) program for lung screening and smoking cessation in community health center primary care practices.
- Trial name
- NCT02705365
- Testing
- Patient Navigation, Usual Care
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Addition of microRNA Blood Test to Lung Cancer Screening Low Dose CT
To demonstrate that the specificity of the Hummingbird microRNA profile for the diagnosis of lung cancer in a cohort of patients who meet current eligibility criteria for lung cancer screening in the U.S.
- Trial name
- NCT03452514
- Where
- 4 sites in United States
- Volunteers
- 479 people
- Sponsor
- Hummingbird Diagnostics
Lung Cancer, Shared Decision Making
Inpatient Smokers and LDCT Screening RCT
Current smokers who undergo annual low dose CT (LDCT) lung cancer screening and successfully quit smoking derive the greatest reduction in lung cancer mortality.
- Trial name
- NCT03276806
- Testing
- tobacco dependence/smoking cessation counseling, SDM, Decision Aid
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Boston University
Lung Cancers, Liver Cancer
AI-Assisted Non-Contrast CT for Multi-Cancer Screening
Cancer poses a major public health challenge in China. Early detection can improve treatment outcomes and survival rates. In this study, we will conduct a large-scale, prospective, multi-center cohort study to evaluate the…
- Conditions
- Lung Cancers, Liver Cancer, Gastric Cancers, Colorectal, Cancer
- Trial name
- NCT06632886
- Testing
- AI-Assisted Non-Contrast CT for Multi-Cancer Screening
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Guo ShiWei
Ovarian Carcinoma, Ovarian Germ Cell Tumor
Screening for Ovarian Cancer in Older Patients (PLCO Screening Trial)
This clinical trial studies whether screening methods used to diagnose cancer of the prostate, lung, colon, rectum, or ovaries can reduce deaths from these cancers.
- Trial name
- NCT01696994
- Testing
- Laboratory Biomarker Analysis, Screening Questionnaire Administration, Ultrasound Imaging
- Where
- United States
- Volunteers
- 78,216 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer
Tribally Engaged Approaches to Lung Screening (TEALS)
Lung cancer is the leading cause of cancer mortality among American Indians and Alaska Natives (AI/AN), and AI/AN have worse lung cancer incidence rates, survival, and death compared to the general population.
- Trial name
- TEALS (NCT04948060)
- Testing
- Enhanced lung cancer screening services
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Lung Cancer
The DANTE Trial. A Randomized Study on Lung Cancer Screening With Low-Dose Spiral Computed Tomography
High survival rates have been reported for screen-detected Stage I lung cancer patients, but there are concerns about the potential biases of uncontrolled studies.
- Trial name
- NCT00420862
- Testing
- Spiral Computed Tomography
- Where
- Italy
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Non-Small Cell Lung Carcinoma, Compliance Behavior
Patient Navigation for Lung Cancer Screening in an Urban Safety-Net System
The study proposes to evaluate a patient navigation intervention among a sample of 446 individuals referred for CT-based lung cancer screening in an urban safety-net setting.
- Conditions
- Non-Small Cell Lung Carcinoma, Compliance Behavior, Prevention Harmful Effects
- Trial name
- NCT02758054
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Lung Cancer, Precancerous Condition
Screening for Lung Cancer in Current or Past Smokers With Chronic Obstructive Pulmonary Disease
RATIONALE: Screening tests or exams may help doctors find lung cancer sooner, when it may be easier to treat. PURPOSE: This randomized clinical trial is studying screening tests or exams to see how well they work compared to…
- Trial name
- NCT00512746
- Testing
- cytology and cytometry specimen collection procedure, Chest x ray, Autofluorescence bronchoscopy
- Where
- 10 sites in United Kingdom
- Volunteers
- 1,569 people
- Sponsor
- University College, London
Covid-19, Cancer
Screening of Cancer Patients to Assess Impact of COVID-19
The purpose of this study is to investigate the impact of COVID -19 in the cancer patient population. This will be done by looking at the rate of asymptomatic COVID-19 infection in cancer patients receiving cancer therapy, as…
- Trial name
- NCT04373005
- Testing
- Nasopharyngeal (NP) swab
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- University Health Network, Toronto