Clinical trials: Lung Aspiration
Aspiration Pneumonia
The Effect of Continuous Versus Enteral Pump Feeding in Aspiration in Tube Fed Patients
Background: Tube feeding had been found to be a cause of aspiration pneumonia. Continuous pump feeding at slower rates as compared to bolus feeding may be less associated with aspiration pneumonia.
- Trial name
- NCT00164957
- Testing
- continuous pump feeding, intermittent bolus feeding
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Chinese University of Hong Kong
Hemorrhagic Shock, Pediatric Trauma
Effect of Resuscitation on Gastric Emptying Using POCUS in Pediatric Trauma Patients
Pediatric trauma often leads to hemorrhagic shock, which reduces blood flow to the digestive tract and delays gastric emptying. This delay can cause fluid and food to remain in the stomach, increasing the risk of pulmonary…
- Conditions
- Hemorrhagic Shock, Pediatric Trauma, Delayed Gastric Emptying, Gastric Dysmotility
- Trial name
- NCT07810907
- Volunteers
- 50 people
- Sponsor
- Assiut University
Orthostatic Hypotension
Breathing Device for Orthostatic Hypotension (OH)
The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease blood pressure drops on standing in patients with orthostatic hypotension.
- Trial name
- NCT00962884
- Testing
- Inspiratory Threshold Device (Res-Q-Gard ITD)
- Where
- United States
- Sponsor
- Alfredo Gamboa
Asthma
AZD1419 Ph2a Study
Ph2a study planned to be run at approximately 16-18 sites in 4 EU countries (Denmark, Hungary, Poland and Sweden) enrolling approximately 170 patients to ensure 70 randomized patients with eosinophilic, moderate to severe asthma.
- Trial name
- INCONTRO (NCT02898662)
- Testing
- AZD1419
- Where
- 15 sites in Denmark, Hungary and 2 more
- Volunteers
- 81 people
- Sponsor
- AstraZeneca
Pancreatic Cancer
Endoscopic Ultrasound (EUS) Guided Fine Needle Aspiration (FNA) EUS-FNA of Solid Pancreatic Mass Lesions Using a Novel Corkscrew Technique: a Pilot Study
This research is being done to investigate if a new technique to biopsy the pancreas will lead to a larger amount tissue material that can be analyzed.
- Trial name
- NCT02116322
- Testing
- EUS-FNA with Corkscrew technique, Expect 19 G Flex needle
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Healthy Volunteers
AZD5423 Single Ascending Dose Study
The aim of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD5423 following single ascending dose administrations in healthy male subjects.
- Trial name
- NCT00963183
- Testing
- AZD5423
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diabete Type 2, Regurgitation
Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors
Treatment with semaglutide slows down gastric emptying , food remains in the stomach for a longer period of time. This slowing has important implications for anesthesia management.
- Conditions
- Diabete Type 2, Regurgitation, Pulmonary Aspiration During Anaesthetic Induction
- Trial name
- SAGUSE (NCT07506356)
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University Hospital, Geneva
Nosocomial Pneumonia, Healthcare-Associated Pneumonia
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
Oropharyngeal bacteria play an important role in the pathogenesis of nosocomial pneumonia in critically ill patients. Oral cleansing with chlorhexidine has been shown to decrease incidence of pneumonia in patients undergoing open…
- Conditions
- Nosocomial Pneumonia, Healthcare-Associated Pneumonia, Aspiration Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- NCT00610324
- Testing
- Chlorhexidine gluconate, Potassium permanganate
- Where
- India
- Volunteers
- 512 people
- Sponsor
- King Edward Memorial Hospital
Artificial Respiration, Consciousness Disorders
Evaluation of a New Mechanical Ventilation Weaning Strategy for Patients With Altered Level of Consciousness
The purpose of this study is to determine if a weaning strategy from artificial ventilation governs by respiratory behaviour status assessed by our method is safe enough.
- Conditions
- Artificial Respiration, Consciousness Disorders, Wearing Off Effect
- Trial name
- ORGAR (NCT00700869)
- Testing
- mechanical ventilation
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Emphysema, Chronic Obstructive Pulmonary Disease(COPD)
A Continuation Study of the AeriSeal® System Administered at 3 to 4 Sites During a Single Treatment Session for Lung Volume Reduction in Patients With Advanced Emphysema
The purpose of this study is to assess the long term safety and efficacy of AeriSeal System treatment administered at up to 4 subsegments during a single treatment session for lung volume reduction in patients with advanced…
- Conditions
- Pulmonary Emphysema, Chronic Obstructive Pulmonary Disease(COPD), Lung Diseases
- Trial name
- NCT01320566
- Testing
- AeriSeal System
- Where
- 2 sites in Israel
- Volunteers
- 18 people
- Sponsor
- Aeris Therapeutics
Pain Uterus
Intranasal Fentanyl for Pain Control During First-Trimester Uterine Aspiration
Intranasal fentanyl has been found to be safe and effective in the reduction of pain among pediatric and adult populations. The investigators hypothesize that patients who receive 100 mcg of intranasal fentanyl for pain control…
- Trial name
- NCT03057041
- Testing
- Fentanyl
- Where
- 2 sites in United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Aspiration, Gastroesophageal Reflux
Pepsin As A Biomarker For Aspiration
Evaluation of tracheal pepsin as a biomarker for aspiration
- Trial name
- NCT00865995
- Testing
- Tracheal Lavage
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Oropharyngeal Dysphagia, Pneumonia
Health Education to Caregivers to Reduce Aspiration Pneumonia
Randomized clinical study with a control group for assessing the decrease in the incidence of pneumonia, in a 12-month follow-up, in older people with cognitive impairment, risk of bronchial aspiration, risk of malnutrition and…
- Conditions
- Oropharyngeal Dysphagia, Pneumonia, Malnutrition
- Trial name
- HECGPN (NCT05405829)
- Testing
- Health education
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Universitat Internacional de Catalunya
Meconium Aspiration Syndrome
Role of Endotracheal Suction on the Occurrence of Meconium Aspiration Syndrome in Non-vigorous Meconium Stained Babies
The purpose of this study is to evaluate the role of endotracheal suction on the occurrence of meconium aspiration syndrome in depressed meconium stained babies.
- Trial name
- ETMAS (NCT01758822)
- Testing
- No endotracheal suction
- Where
- India
- Volunteers
- 175 people
- Sponsor
- Lady Hardinge Medical College
Parotid Gland Neoplasms
Diagnostic Accuracy of Fine Needle Aspiration in Parotid Tumors
Liberal use of fine needle aspiration biopsy of parotid gland masses is controversial. All information regarding this procedure has been retrospective.
- Trial name
- NCT00534612
- Testing
- aspiration biopsy
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- National Institute of Cancerología
Ventilation, Lung Function
Respiratory Effects of Flow-Controlled Ventilation and Jet Ventilation in Patients Undergoing Laryngotracheal Surgery
Laryngotracheal surgery often requires a small diameter endotracheal tube to oxygenate patients under general anesthesia. Oxygenation is often only possible with high-frequency jet ventilators due to the use of small diameter and…
- Conditions
- Ventilation, Lung Function, Anesthesia, General
- Trial name
- Flowjet (NCT06063798)
- Testing
- General anesthesia for laryngotracheal surgery, Mechanical ventilation by FCV, Mechanical ventilation by HFJV
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Geneva
Vagus Nerve Stimulation, Autonomic Nervous System
Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters
This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz/sham, 10 Hz, 25 Hz, 50 Hz, 100 Hz)…
- Conditions
- Vagus Nerve Stimulation, Autonomic Nervous System, Heart Rate, Blood Pressure
- Trial name
- AVNS-DRC (NCT07274332)
- Testing
- Pulsetto FIT™ - tcVNS 10 Hz, Pulsetto FIT™ - tcVNS 25 Hz, Pulsetto FIT™ - tcVNS 50 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Community-Acquired Pneumonia
Efficacy and Safety Trial to Assess Moxifloxacin in Treating Community-Acquired Pneumonia (CAP) With Aspiration Factors
The purpose of this study is to determine whether moxifloxacin in comparison to levofloxacin plus metronidazole are effective and safe in the treatment of community-acquired pneumonia with aspiration factors.
- Trial name
- NCT00752947
- Testing
- moxifloxacin, levofloxacin, metronidazole
- Where
- 2 sites in China
- Volunteers
- 186 people
- Sponsor
- Beijing Hospital
Smokers
Effects of Mental Practice and Therapeutic Exercise in Mild Smokers
The goal of this clinical trial is to learn about the effects who would add mental practice based on action observation to a therapeutic exercise program in young mild smokers.
- Trial name
- NCT06123598
- Testing
- Therapeutic exercise program plus action observation training
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Respiration, Artificial
Effects of Sternal Wall Pressure in Children
This protocol is a prospective, pilot, observational study in the Pediatric Intensive Care Unit (PICU), Progressive Care Unit (PCU) and the Operating Room (OR) settings at the Children's Hospital of Philadelphia (CHOP).
- Trial name
- SWP (NCT00628407)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
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