Clinical trials: Lower Leg Edema
Heart Failure
Lancashire Objective Volume Evaluation of Leg Oedema in Heart Failure Second Pilot
Patients with heart failure (HF) who recently received treatment with IV diuretics for worsening congestion or outpatients with HF and peripheral oedema treated with at least 80 mg furosemide (or equivalent)/day will be recruited…
- Trial name
- LOVE-HF-2 (NCT04787393)
- Testing
- Heartfelt device, Connected weighing scales
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Heartfelt Technologies
Total Knee Arthroplasty, Edema
The Effects of Manual Lymphatic Drainage and Kinesiotaping on Lower Extremity Edema
Significant trauma and muscular tightness often result during Total Knee Arthroplasty (TKA) surgery and thus act to restrict tissue fluid movement resulting with lower extremity edema.
- Conditions
- Total Knee Arthroplasty, Edema, Exercise
- Trial name
- NCT04164927
- Testing
- Manual Lymphatic Drainage, Kinesio Taping, Control
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Post Thrombotic Syndrome
Treatment Trial for Post-Thrombotic Syndrome
The purpose of this study is to determine if complex lymphedema therapy is effective in decreasing disease severity and improving quality of life in patients with post thrombotic syndrome.
- Trial name
- NCT00633971
- Testing
- complex lymphedema therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Vermont
Compression; Vein, Venous Insufficiency
Digital Supported Compression Bandaging in Patients With Chronic Edema in the Lower Limbs
Patients with chronic edema of the lower limb referred to compression bandaging in a hospital setting will be invited to participate in the validation study of a novel sensor (CIMON), which have been developed for assessing the…
- Conditions
- Compression; Vein, Venous Insufficiency, Lymphedema of Leg, Digital Technology
- Trial name
- CIMON (NCT06438133)
- Testing
- CIMON, Sens Motion
- Where
- 5 sites in Denmark
- Volunteers
- 52 people
- Sponsor
- Carsten Bogh Juhl
Edema Leg, Pain
Does Edema Affect the Adjustment of TENS Amplitude
The goal of this pre-post clinical trial is to compare the amplitude settings of three different frequency TENS modes (Conventional TENS, LF TENS, HF TENS) in patients who had undergone total knee arthroplasty, both with the…
- Trial name
- NCT06153277
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Karamanoğlu Mehmetbey University
Heart Failure，Congestive, Leg Edema
The ROle of Compression StocKings in Heart Failure Patients
Congestive heart failure (CHF) occurs when the heart is weak and not able to effectively pump blood to the body. One of the common manifestations of CHF is fluid overload and swelling of the legs.
- Conditions
- Heart Failure，Congestive, Leg Edema, Venous Insufficiency, Venous Ulcers
- Trial name
- ROCK-HF (NCT06350695)
- Testing
- low grade compression stockings (10-15 mmHg), high grade compression stockings (20-30 mmHg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Nocturia, Venous Insufficiency of Leg
Discovering the Effect of Venous Insufficiency on Nocturia
With this prospective controlled trial, we hope to obtain more information about the coexistence between venous insufficiency and nocturia.
- Conditions
- Nocturia, Venous Insufficiency of Leg, Fluid Overload
- Trial name
- DEVINe (NCT04266496)
- Testing
- Questionnaires, Frequency Volume Chart, Collect urine during 1 day
- Where
- Belgium
- Volunteers
- 84 people
- Sponsor
- University Hospital, Ghent
Lymphedema
Lymphedema Study for Arm or Leg Lymphedema
This study compares the effectiveness of a study drug versus placebo in the treatment of lymphedema.
- Trial name
- NCT02257970
- Testing
- Ketoprofen
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Stanford University
Varicose Veins, Pregnancy Related
Graduated Elastic compRession for vAricose Veins in PrEgnancy
This study will be evaluate the clinical efficacy of using graduated compression hosiery for venospecific symptoms, leg edema, and quality of life (QoL) in pregnant women with varicose veins (VV's).
- Conditions
- Varicose Veins, Pregnancy Related, Quality of Life
- Trial name
- GRAPE (NCT05122195)
- Testing
- Compression therapy
- Where
- 2 sites in Belarus
- Volunteers
- 80 people
- Sponsor
- Belarusian State Medical University
Edema Secondary, Edema Leg
A Dose-finding Study of JMKX003142 in Treatment of Renal Edema
To evaluate the safety,efficacy, and pharmacokinetic characteristics of JMKX003142 administered randomly, double-blind, placebo-controlled study in Chinese renal edema patients with inadequate response to conventional diuretic…
- Trial name
- NCT06670534
- Testing
- JMKX003142 tablets
- Where
- 2 sites in China
- Volunteers
- 133 people
- Sponsor
- Jemincare
Pregnancy Related
Effects of Foot Exercises and Hydrotherapy on Pedal Edema & Lower Extremity Function
To determine the Effects of foot exercises with and without hydrotherapy on pedal Edema \& lower extremity function in antenatal women.
- Trial name
- NCT05777538
- Testing
- hydrotherapy, foot exercises
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Surgical Wound, Bilateral Total Knee Arthroplasty
Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA
This study will compare the effects of closed incision negative pressure dressing vs. standard of care silver dressing on lower limb swelling after bilateral primary total knee arthroplasty.
- Conditions
- Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases
- Trial name
- ENABLE (NCT04712019)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Solventum US LLC
Edema Leg
Breaking of Sitting Time Prevents Lower Leg Swelling
Sitting or standing during a prolonged and uninterrupted period of time is related to negative health outcomes, such as lower extremity swelling.
- Trial name
- Break_sitting (NCT05173558)
- Testing
- Uninterrupted motionless standing, Uninterrupted motionless sitting, Sit-to-stand transitions
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Varicose Veins of Lower Limb, Varicose Veins and Edema of Leg
Effects of Kinesio Taping Method on Functional Capacity and Quality of Life in Patients With Chronic Venous Disease
The purpose of this randomised and controlled study is to investigate the effects of Kinesio Taping method and compression stockings, combined with exercise therapy, on pain, edema, functional capacity and quality of life in…
- Conditions
- Varicose Veins of Lower Limb, Varicose Veins and Edema of Leg, Chronic Venous Hypertension Peripheral, Spider Veins
- Trial name
- NCT04148950
- Testing
- Kinesio Tape, Compression Stockings, Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Istanbul University
Kidney Transplant, Kidney Pancreas Transplant
The Effect of Neuromuscular Stimulation on Post-Transplant Leg Edema
This will be a randomized, controlled trial involving kidney and kidney pancreas transplant patients. There will be 2 groups and patients that will be randomized to one of the two groups.
- Conditions
- Kidney Transplant, Kidney Pancreas Transplant, Edema
- Trial name
- NCT01860820
- Testing
- Geko device
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Oedema
Does NMES Help Relieve Lower Limb Oedema and Improve Joint Mobility and Skin Tissue Oxygenation Levels?
Neuromuscular Electrical Stimulation (NMES) will be facilitated through the use of a stimulator, with the patient in a semi recumbent position, using UltraStim electrodes.
- Trial name
- NCT01936155
- Testing
- Custom-built, two-channel stimulator
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Ireland, Galway, Ireland
Lymphatic Edema, Cellulitis of Leg
Efficacy of Complex Decongestive Therapy (CDT) in Patients With Venous Insufficiency: a Experimental Study
The study investigates the effectiveness of Complex Decongestive Therapy (CDT) in improving venous flow and reducing symptoms in venous insufficiency patients.
- Conditions
- Lymphatic Edema, Cellulitis of Leg, Vein Disease
- Trial name
- CDT (NCT06231940)
- Testing
- Complex Decongestive Therapy (CDT) in venous insufficiency,
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- University of Salamanca
Lipedema
Effects of Exercise in Patients with Lipedema
Lipedema is a chronic progressive disease characterized by symmetrical, disproportionate swelling of subcutaneous adipose tissue, which is common in women and mostly seen in the lower extremities and to a lesser extent in the…
- Trial name
- NCT06811961
- Testing
- Exercise, Physical activity
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ilke Keser
Gestational Edema
Efficacy of Acupressure Versus Traditional Treatment on Reducing Ankle Edema During Pregnancy
Incidence of ankle edema is high during pregnancy, If left untreated, it may lead to difficulty walking; stiffness; stretched skin which can become itchy and uncomfortable.
- Trial name
- NCT06026007
- Testing
- advices, Traditional physical therapy, Acupressure
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Badr University
Lower Extremity Edema, Congestive Heart Failure(CHF)
Pedal Pump Clinical Trial on Edema V1
Previous research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal…
- Conditions
- Lower Extremity Edema, Congestive Heart Failure(CHF), Chronic Venous Insufficiency (CVI), Kidney Disease
- Trial name
- NCT07760363
- Testing
- Pedal Pump
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David McVay