Clinical trials: Lower Extremity Blood Flow
Peripheral Vascular Disease
Evaluation of the Effect of the Flowaid Device in Increasing Local Circulation in the Leg
This is an open label pilot study to evaluate the efficacy and the safety of the Flowaid device in increasing local circulation in the legs.
- Trial name
- NCT00538226
- Testing
- External Electric Muscle Stimulation
- Where
- United States
- Sponsor
- Rosenblum, Jonathan I., DPM
Peripheral Artery Disease, Intermittent Claudication
Intermittent Negative Pressure to Improve Blood Flow in Patients With Peripheral Artery Disease: Optimal Pulse Pressure Regime
Recent studies have shown that applying intermittent negative pressure (INP) with short negative pressure (-40 mmHg) pulses to the lower extremities increase arterial blood flow velocity and skin blood flow.
- Conditions
- Peripheral Artery Disease, Intermittent Claudication, Lower Extremity Claudication
- Trial name
- NCT03547817
- Testing
- Intermittent negative pressure device
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- Oslo University Hospital
Peripheral Arterial Disease
Supervised Treadmill Exercise and Ranolazine for Intermittent Claudication of Lower Extremities
The goal of this study is to evaluate whether supervised treadmill exercise combined with ranolazine 1000 mg twice daily provides an incremental benefit in absolute walking distance over supervised exercise alone in patients with…
- Trial name
- STERILE (NCT00914316)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Corewell Health East
Vascular Disease, Critical Lower Limb Ischemia
Pilot Study of Hemospan® in Patients With Chronic Critical Limb Ischemia
The purpose of this study is to evaluate the effects of Hemospan infusion on vascular reactivity, regional perfusion and oxygenation of ischemic tissue in patients with chronic critical lower limb ischemia.
- Trial name
- NCT00633659
- Testing
- Hemospan (MP4OX), Voluven (HES 130/0.4)
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Sangart
Pain, Persistent Pain
Is Low-load Resistance Training With Blood Flow Restriction Feasible During Rehabilitation of Military Personnel With Lower Limb Injuries? Phase One RCT.
Pain can be one of the primary limiting factors to progress following musculoskeletal injury and may be caused by trauma or degenerative changes.
- Conditions
- Pain, Persistent Pain, Musculoskeletal Pain
- Trial name
- LIMITLESS (NCT06621914)
- Testing
- BFR 80, BFR40
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Defence Medical Rehabilitation Centre, UK
ACL, ACL - Anterior Cruciate Ligament Rupture
Conservative Treatment With Blood Flow Restriction in Patients With Total ACL Rupture. "Randomized Clinical Trial"
The goal of this randomised clinical trial is to evaluate the effects of exercise with blood flow restriction (BFR) in patients with a complete anterior cruciate ligament (ACL) rupture.
- Trial name
- NCT06727344
- Testing
- Blood Flow Restriction, Brace
- Where
- 2 sites in Cyprus
- Volunteers
- 20 people
- Sponsor
- European University Cyprus
Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree
The Effect of Low-Intensity Blood Flow Restriction Therapy on the Management of Acute Ankle Sprains
The primary objective of this study is to evaluate the feasibility of implementing BFR in the rehabilitation treatment of isolated ankle sprains as well as to evaluate the clinical benefits of BFR when compared to standard…
- Conditions
- Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree, Musculoskeletal Injury
- Trial name
- NCT05596162
- Testing
- Blood Flow Restriction Therapy, Standard Physical Therapy
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Postoperative Circulatory Changes, Peripheral Vascular Diseases
Effects of Different Compression Pressure Levels on Peripheral Circulation After Surgery
After surgery, elastic compression is commonly used on the legs to support blood circulation and reduce the risk of complications such as swelling and venous thromboembolism.
- Conditions
- Postoperative Circulatory Changes, Peripheral Vascular Diseases, Venous Insufficiency of Leg
- Trial name
- COMP-PILOT (NCT07394829)
- Testing
- Pressure-Controlled Compression Device
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Agri Ibrahim Cecen University
Neuromuscular Function, Athletic Performance Enhancement
Effects of Blood Flow Restriction Training on Neuromuscular Function and Performance in Artistic Jump Rope Athletes
The goal of this randomized controlled trial is to investigate whether blood flow restriction training can improve physical function and sports performance in artistic jump rope athletes.
- Trial name
- NCT07750977
- Testing
- Blood Flow Restriction Training, Conventional Artistic Jump Rope Training
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Sport
Obesity
Evaluation of Endothelial and Vascular Functions in Obese Patients (FUENVASOB)
The primary objective of the present study will be to evaluate, in obese patients, the blood flow response in the femoral artery in response to passive limb movements, taken as a biomarker of a possible limitation of the…
- Trial name
- FUENVASOB (NCT05778513)
- Testing
- Passive knee flexion-extension + Cycle ergometer exercise + 3-week body weight reduction program, Passive knee flexion-extension + Cycle ergometer exercise
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Istituto Auxologico Italiano
Knee Injuries
The Effect of Blood Flow Restriction Training on Muscle Atrophy Following Knee Surgery
The investigators will compare differences in quadriceps strength, leg girth, and functional outcome scores between two groups of patients after weeks 6 and 12 as well as 6 months following meniscus or articular cartilage…
- Trial name
- NCT03035266
- Testing
- Blood Flow Restriction, Standard rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Keller Army Community Hospital
ACL Injury
Low-Intensity Blood Flow Restriction Training as a Pre-Operative Rehabilitative Modality to Improve Post-Operative Outcomes for ACL Reconstruction
Researchers are trying to find out whether the use of low-intensity strength exercises during the 2 weeks before surgery, and while the blood flow to the leg is reduced, will improve the outcomes after surgery to repair an…
- Trial name
- NCT04302558
- Testing
- Exercise Blood Flow Restriction training
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Anterior Cruciate Ligament Injury
Effects of Low-intensity Strength Training With Concomitant Blood Flow Restriction on Pain Perception in Patients With Anterior Cruciate Ligament Surgery
After surgical treatment of a tear of the anterior cruciate ligament, physiotherapeutic exercises are done as standard therapy. This is to achieve a rapid improvement in pain and knee function.
- Trial name
- BFR (NCT06699264)
- Testing
- Blood Flow Restriction Training, Training without BFR
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Praxisklinik Rennbahn AG
Peripheral Arterial Disease, Peripheral Artery Disease
Impacts of Mitochondrial-targeted Antioxidant on Peripheral Artery Disease Patients
Peripheral artery disease (PAD) is a common cardiovascular disease, in which narrowed arteries reduce blood flow to the limbs, causing pain, immobility and in some cases amputation or death.
- Trial name
- NCT03506633
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Nebraska
Tibial Fracture
Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures
This study will assess the feasibility and effectiveness of blood flow restriction therapy in patients with tibia fractures (or lower leg bone).
- Trial name
- BOOST (NCT07103252)
- Testing
- Blood Flow Restriction Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Anterior Cruciate Ligament Injuries, Knee Injuries
Effects of Early Rehabilitation Using Blood Flow Restriction and/or Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled Trial
Many patients experience quadriceps inhibition after anterior cruciate ligament (ACL) reconstruction, delaying strength recovery, hindering return to sport, and potentially increasing the risk of re-injury.
- Conditions
- Anterior Cruciate Ligament Injuries, Knee Injuries, Muscle Weakness
- Trial name
- NCT07145606
- Testing
- Standard Rehabilitation, Blood Flow Restriction (BFR) Training, sEMG Biofeedback
- Where
- 4 sites in France, Switzerland
- Volunteers
- 200 people
- Sponsor
- Haute Ecole ARC Sante
Pain, Low Back Pain
Changes in Cerebral Blood Flow in Patients Treated With Spinal Cord Stimulation for Low Back and Leg Pain
The primary objective of this study is to identify the brain regions in which activity is affected by SCS. Baseline cerebral blood flow scans with the device turned off will be generated compared to scans produced with the device…
- Conditions
- Pain, Low Back Pain, Leg Pain
- Trial name
- NCT00418301
- Testing
- Precision Spinal Cord Stimulation and PET Scan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Peripheral Vascular Disease
Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
In this investigation, the investigators will attempt to demonstrate that patients who have received nerve blocks (regional anesthesia) prior to open surgical vascular bypass of the lower extremities (infrainguinal bypass…
- Trial name
- NCT01803165
- Testing
- Single shot femoral and sciatic nerve block
- Sponsor
- University of Nebraska
Healthy
Resistance Training With Blood Flow Restriction
Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy.
- Trial name
- NCT05863039
- Testing
- Blood flow restriction, Regular training type 1, Regular training type 2
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Circulatory Failure
the Impact of Manual or Mechanical Ways to Perform PLR on the Accuracy of Evaluation of Fluid Responsiveness
Our goal was to study the impact of different ways to perform passive leg raising (PLR) on the accuracy of evaluation of fluid responsiveness.
- Trial name
- PLR (NCT06285331)
- Testing
- Automatic Bed, Manual
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southeast University, China