Clinical trials: Low Bone Mineral Density
Osteopenia, Osteoporosis
A Study of Changes in Bone Mineral Density as a Function of Consuming Two Different Forms of Calcium Carbonate
The purpose of this study is to determine whether consuming calcium carbonate that has been micronized is more effective than the traditional form of calcium carbonate in maintaining or increasing bone mineral density in people…
- Trial name
- NCT01857154
- Testing
- Micronized Calcium Carbonate, Non-Micronized Calcium Carbonate, Vitamin D3
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Integrative Health Technologies, Inc.
Periimplant Crestal Bone Level Changes
Influence of Platform-switching on Bone Level Alterations: a 3 Year Randomized Clinical Trial (RCT).
The concept of platform-switching has been introduced to implant dentistry based on clinical observations of reduced periimplant crestal bone loss.
- Trial name
- NCT01917305
- Testing
- platform-shifted implant
- Volunteers
- 25 people
- Sponsor
- Søren Jepsen
Bone Loss, Alveolar
Outcomes of Ridge Splitting Versus Sausage Technique
The current study aims to increase the width of the alveolar bone in defective mandibular ridge with simultaneous implant placement and enhance the implant stability
- Trial name
- NCT07664605
- Testing
- Ridge split
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Bone Density, Bone Loss, Alveolar
Evaluation of Immediately Placed Dental Implants With Local Application of Injectable PRF in Periodontally Compromised Sites
The present study is a human, prospective, parallel, randomised controlled clinical trial conducted to explore the efficacy of injectable PRF around dental implants.
- Trial name
- PRF (NCT04029779)
- Testing
- I-PRF
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Health, Subjective, Nutrition Disorders
Relative Energy Deficiency in Sport Multicenter Study
Relative Energy Deficiency in Sport (RED-S) characterizes a range of negative health and performance outcomes that result from chronically low energy availability.
- Conditions
- Health, Subjective, Nutrition Disorders, Athletic Injuries, Hormone Disturbance
- Trial name
- NCT04766203
- Testing
- Treatment of REDS using a holistic treatment arm
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Trent Stellingwerff
Osteoporosis
HIV UPBEAT: Understanding the Pathology of Bone Disease in HIV-infected Patients.
Despite the prevalence of osteopenia and osteoporosis in the HIV positive population, relatively little is known about the underlying pathology.
- Trial name
- UPBEAT (NCT01778361)
- Where
- Ireland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Postmenopausal Osteoporosis
Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation
In contrast with bisphosphonates,discontinuation of denosumab results in gradual loss of bone mineral density gains. The investigators aim to evaluate whether in patients treated with denosumab, a single zoledronic acid infusion…
- Trial name
- AfterDmab (NCT02499237)
- Testing
- Denosumab, Zoledronic acid
- Where
- 2 sites in Greece
- Volunteers
- 57 people
- Sponsor
- 424 General Military Hospital
Edentulous Jaw, Bone Loss, Alveolar
Effects of Different Centrifuged Platelet Concentrates on Bone Remodelling Around Dental Implants
Platelet concentrates obtained from blood have been used as regenerative biomaterials in periodontal surgery. Along with the migration and proliferation of osteogenic cells, platelets accelerate bone regeneration by increasing…
- Conditions
- Edentulous Jaw, Bone Loss, Alveolar, Resorption, Bone
- Trial name
- NCT04851002
- Testing
- Application of concentrated growth factor with dental implants, Application of advanced platelet rich fibrin with dental implants, Control side of concentrated growth factor study group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Muhammet Atilgan
Dehiscence, Tooth Extraction
Effect of Collagen Membrane on Ridge Preservation
This study will evaluate whether adding a resorbable collagen membrane to an anorganic bone-collagen composite (ABCC) graft improves ridge preservation after tooth extraction.
- Conditions
- Dehiscence, Tooth Extraction, Alveolar Bone Loss
- Trial name
- NCT07580495
- Testing
- Minimally Invasive tooth extraction, Alveolar ridge preservation with ABCC, Resorbable collagen membrane (InterCollagen® Guide)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Debora Dias
HIV Infection, Osteopenia
Effect of HIV Infection and Highly Active Antiretroviral Treatment (HAART) on Bone Homeostasis
Advances in HAART have been a huge success story in the management of HIV infection. However, serious metabolic complications including osteoporosis and bone fractures are increasingly been seen with HAART, and the responsible…
- Conditions
- HIV Infection, Osteopenia, Osteoporosis
- Trial name
- OPG-2 (NCT01020045)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Bone Loss
Can Risedronate Prevent Periprosthetic Bone Loss After Total Hip Arthroplasty
Can risedronate given once weekly for 6 months prevent periprosthetic bone loss after uncemented total hip arthroplasty?
- Trial name
- PREVENT (NCT00772395)
- Testing
- Risedronate
- Where
- Sweden
- Volunteers
- 78 people
- Sponsor
- Danderyd Hospital
Osteoporosis, Osteopenia
The Effect of 16 Weeks of Hip Adduction and Abduction Resistance Exercise
Performing adduction and abduction resistance exercise will increase hip bone density and strength to a greater extent than doing squat and deadlift exercise.
- Conditions
- Osteoporosis, Osteopenia, Sarcopenia
- Trial name
- Ad/Ab (NCT01228877)
- Testing
- exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ridge Preservation, Alveolar Bone Loss
Evaluation of Autogenous Demineralized Dentin Graft for Ridge Preservation With and Without Injectable Platelet Rich Fibrin
Ridge preservation should be considered whenever possible after tooth extraction. Whether implant placement would be performed or for aesthetic consideration at pontic sites when conventional bridge is planned.
- Conditions
- Ridge Preservation, Alveolar Bone Loss, Dentin Graft
- Trial name
- NCT05437172
- Testing
- injectable platelet rich fibrin with demineralized dentin graft, demineralized dentin graft
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Prostate Cancer
Efficacy Study of Risedronate to Prevent Cancer Treatment-Induced Bone Loss in Prostate Cancer
Prostate cancer patients treated with LHRH agonists (e.g., leuprolide) lose bone mineral density. This is similar to post-menopausal osteoporosis. Risedronate is approved to prevent osteoporosis.
- Trial name
- NCT00426777
- Testing
- risedronate, Control
- Where
- 21 sites in Canada
- Volunteers
- 160 people
- Sponsor
- CMX Research
Osteoporosis
Comparison of Raloxifene and Lasofoxifene - A Randomized, Blinded Study of These Drugs and Placebo on Bone Loss
To compare the effects of 2 years of lasofoxifene treatment with 2 years of raloxifene 60 mg/day use and 2 years of placebo use on bone mineral density (BMD) of the lumbar spine.
- Trial name
- CORAL (NCT00163137)
- Testing
- lasofoxifene, raloxifene
- Where
- 72 sites in United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Ligand Pharmaceuticals
Maxillofacial Bone Defects, Alveolar Bone Atrophy
Gene-activated Matrix for Bone Tissue Repair in Maxillofacial Surgery
The purpose of this study is to evaluate safety and efficacy of gene-activated matrix ("Nucleostim") for regeneration of bone tissue in maxillofacial area.
- Conditions
- Maxillofacial Bone Defects, Alveolar Bone Atrophy, Jaw Fractures, Maxillofacial Bone Deformities
- Trial name
- NCT02293031
- Testing
- Gene-activated matrix "Nucleostim"
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- NextGen Company Limited
Chronic Kidney Diseases, Bone Loss
Bone in CKD Alkali Response (BICARb Pilot Trial)
The goal of this clinical trial is to test whether potassium citrate improves skeletal health in adults and children with chronic kidney disease.
- Trial name
- BICARb (NCT05918029)
- Testing
- Potassium Citrate Extended Release Oral Tablet, Potassium Citrate and Citric Acid Oral Solution
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Albert Einstein College of Medicine
Osteopenia, Spine Fusion
Denosumab Effect on Bone Quality and Function After Lumbar Fusion Surgery
Degenerative lumbar spinal diseases have become a common health problem and the most frequent indication for spinal surgery in elderly individuals.
- Conditions
- Osteopenia, Spine Fusion, Denosumab Allergy
- Trial name
- NCT05415657
- Testing
- Denosumab
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Shenzhen People's Hospital
Osteopenia, Osteoporosis
Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis
Osteoporosis, a condition in which bones are fragile and break easily, is a major health problem for postmenopausal women. Research studies have shown that both estrogen/progestin replacement therapy (hormone replacement therapy…
- Trial name
- NCT00000430
- Testing
- Alendronate, Estrogen/progestin therapy
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Alveolar Bone Loss
Localized Alveolar Ridge Augmentation With Dental Implant
The purpose of this research study is to shorten the treatment time course for patients who are scheduled for surgery to have a dental implant(s) placed into the upper front part of their mouths and need to have more bone in…
- Trial name
- RidgeDI (NCT00991965)
- Testing
- INFUSE® Bone Graft
- Where
- 6 sites in United States
- Volunteers
- 8 people
- Sponsor
- Medtronic Spinal and Biologics
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