Clinical trials: Low Anterior Resection Syndrome
Low Anterior Resection Syndrome, Rectal Cancer
Bowel Dysfunction 3 Years After Anterior Resection a in a Swedish National Cohort
The primary objectives are to evaluate the prevalence of LARS and Quality of Life in rectal cancer patients 3 years after anterior resection, to investigate if anastomotic technique is a risk factor for major LARS and to study…
- Trial name
- NCT04591821
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane
Rectal Cancer Patients
Validation of the Moroccan Arabic Version of the Low Anterior Resection Syndrome (LARS) and Wexner Score of Continence Among Rectal Cancer Patients
In the past decade, colorectal cancer management improved considerably with total mesorectal excision as well as the multidisciplinary management relying on neoadjuvant radiochemotherapy.
- Trial name
- MA_LARSWEX (NCT04128657)
- Testing
- MA_LARS
- Where
- 2 sites in Morocco
- Volunteers
- 143 people
- Sponsor
- Moroccan Society of Surgery
Incidence and Risk Factors of Low Anterior Resection Syndrome
LARS for Chinese Patients
Low anterior resection syndrome (LARS) frequently occurs in patients undergoing low anterior resection (LAR). However, the incidence, exact mechanism and risk factors of major LARS largely variate in different studies.
- Trial name
- NCT05373602
- Testing
- LARS questionnaire
- Where
- China
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Rectal Cancer, Low Anterior Resection Syndrome
Rectal Cancer Shared Care
The investigators propose a multifaceted rectal cancer survivorship care program involving oncology specialists, nursing support and primary care physicians.
- Trial name
- NCT04966819
- Testing
- Survivorship Care Initiative
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Jewish General Hospital
Anterior Resection Syndrome
Low Anterior Resection Syndrome and Rectal Irrigation Study
Prospective study assessing treatment acceptability and the impact of rectal irrigation on patients with low anterior resection syndrome (LARS) in terms of quality of life and bowel function.
- Trial name
- LARRIS (NCT04246775)
- Testing
- Peristeen
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Cardiff and Vale University Health Board
Sphincter Ani Incontinence, Rectal Cancer
Patient Reported Outcomes Following Cancer of the Rectum
The surgical management of rectal cancer includes a Total Mesorectal Excison (TME); depending on the height of the tumor, the problem of preservation of the anal sphincter arises, being able to perform a low anterior resection…
- Trial name
- PROCaRe (NCT04936581)
- Testing
- Open Total Mesorectal Excision, Laparoscopic Total Mesorectal Excision, Robotic Total Mesorectal Excision
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- University Hospital Gregorio Marañón
Rectal Cancer, Rectum Neoplasm
Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Trial
Study Purpose: This study aims to understand how pelvic floor rehabilitation (PFR) after low anterior resection (LAR) surgery for rectal cancer affects bowel control and quality of life compared to usual care.
- Conditions
- Rectal Cancer, Rectum Neoplasm, Rectal Neoplasms, Rectal Adenocarcinoma
- Trial name
- PERECARE (NCT06524362)
- Testing
- Pelvic Floor Physiotherapy (PFR), Conventional group
- Where
- India
- Volunteers
- 77 people
- Sponsor
- GEM Hospital & Research Center
Low Anterior Resection Syndrome, Rectal Cancer
Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.
The goal of this clinical trial is to learn if antegrade intestinal fluid reinfusion works to prevent low anterior resection syndrome (LARS) in patients with prophylactic ileal stoma. The main questions it aims to answer are: 1.
- Trial name
- NCT07537998
- Testing
- intestinal fluid infusion, potable water
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Pei-Rong Ding
Bowel; Functional Syndrome
Long - Term Low Anterior Resection Syndrome
Data assessing the long-term bowel dysfunction following low anterior resection is still lacking. The aim of this study is to evaluate late functional results of patients who underwent rectal resection for rectal cancer.
- Trial name
- LongLARS (NCT03920202)
- Where
- Lithuania
- Volunteers
- 67 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Rectal Cancer, Ulcerative Colitis
Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
The primary purpose of this prospective, randomized multicenter center study is to evaluate and compare the outcomes of colorectal, coloanal and ileoanal anastomoses reinforced with a bioabsorbable staple line reinforcement…
- Conditions
- Rectal Cancer, Ulcerative Colitis, Familial Adenomatous Polyposis, Diverticulitis
- Trial name
- NCT00663819
- Testing
- GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement, Staple line without reinforcement
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- W.L.Gore & Associates
Low Anterior Resection Syndrome
Retrograde and Antegrade Enema for Prevention of LARS After LAR: a Randomized Controlled Trial
The goal of this clinical trial is to learn if enema works to prevent low anterior resection syndrome (LARS) in adults. The main questions it aims to answer are: 1.
- Trial name
- NCT06717854
- Testing
- transanal irrigation, antegrade enema
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Low Anterior Resection Syndrome
The Effects of Colorectal Prehabilitation Via Reinfusion or Retention Enema of Ileal Contents Filtrate on the Defecation Functions for the LAR Patients With Ileostomy Before Stoma Closure
This study was a single-center RCT study to compare the effect of preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon with that of traditional…
- Trial name
- NCT06569966
- Testing
- preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon
- Where
- China
- Volunteers
- 154 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Colorectal Cancer, Low Anterior Resection Syndrome
Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS)
Transanal irrigation (TAI) has shown to improve fecal incontinence and increase quality of life in patients with low anterior resection syndrome (LARS).
- Trial name
- NCT07219745
- Testing
- Peristeen Plus Irrigation kit, LARS mobile application
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Case Comprehensive Cancer Center
Rectal Cancer, Low Anterior Resection Syndrome
Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal Cancer
This prospective, single-center, single-arm, open-label clinical study aims to evaluate whether autologous fecal microbiota transplantation can improve bowel and anal function after ileostomy reversal in patients with rectal…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, Fecal Incontinence, Diversion Colitis
- Trial name
- NCT07711509
- Testing
- Autologous Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study
Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study.
- Trial name
- NCT07267767
- Testing
- nCRT, BMI, Distance from AV
- Volunteers
- 3,500 people
- Sponsor
- Northern Jiangsu People's Hospital
Rectal Cancer
Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome.
This study aims to develop and test the effect of online interactive videos in improving LARS.
- Trial name
- NCT06628674
- Testing
- core muscle exercise, pelvic muscle exercise
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Chang Gung Memorial Hospital