Clinical trials: Low Anterior Resection
Low Anterior Resection Syndrome
Paula Method of Exercises in Patients With LARS Syndrome
Sphincter sparing rectal resection surgery, either total mesorectal excision (TME) with a temporary loop ileostomy or partial mesorectal excision (PME), is the mainstay of rectal cancer treatment , however, these treatments are…
- Trial name
- NCT05016583
- Testing
- Paula Method
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Low Anterior Resection Syndrome, Malignant Anal Neoplasm
Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study
This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to…
- Conditions
- Low Anterior Resection Syndrome, Malignant Anal Neoplasm, Malignant Bladder Neoplasm, Malignant Cervical Neoplasm
- Trial name
- NCT04066894
- Testing
- Explantation, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Rectal Cancer
The Longitudinal Study of Low Anterior Resection Syndrome in Patients with Newly Diagnosed Rectal Cancer.
The aims are to identify the trajectory of LAR Syndrome and explore the adaptation process and coping strategies of LAR Syndrome in patients newly diagnosed with rectal cancer.
- Trial name
- NCT05445245
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- Chang Gung Memorial Hospital
Low Anterior Resection Syndrome
Transanal Irrigation to Prevent Major Low Anterior Resection Syndrome
Bowel dysfunction after rectal cancer resection comprises a vast array of bowel symptoms and associated quality-of-life impairment, collectively termed as low anterior resection syndrome (LARS).
- Trial name
- TAILARS (NCT04758195)
- Testing
- Transanal irrigation, Best supportive therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Rectum Cancer, Quality of Life
Determining Early Development of Faecal Incontinence and Anorectal Muscle Function After Surgery for Rectal Cancer.
Background: Patients treated for rectal cancer are in high risk of developing poor quality of life and faecal incontinence. Faecal incontinence has a negative impact on quality of life.
- Conditions
- Rectum Cancer, Quality of Life, Faecal Incontinence, Low Anterior Resection Syndrome
- Trial name
- EDFI-Cohort (NCT03257332)
- Testing
- Low Anterior Resection for Rectum Cancer
- Where
- 2 sites in Denmark
- Sponsor
- Slagelse Hospital
Low Anterior Resection Syndrome, Cancer
Contributing Factors to Anterior Resection Syndrome and Its Impact on Quality of Life: A Retrospective Cohort Study
This study adds to the understanding of the contributing factors leading to LARS, the long term effects of this syndrome post-operatively and its impact on quality of life.
- Conditions
- Low Anterior Resection Syndrome, Cancer, Quality of Life
- Trial name
- NCT04114591
- Testing
- anterior resection
- Where
- Malta
- Volunteers
- 179 people
- Sponsor
- University of Malta
Low Anterior Resection Syndrome, Rectal Carcinoma
A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients
This clinical trial studies if a bowel management program with a retrograde rectal enema (RRE) for the treatment of low anterior resection syndrome (LARS) in rectal cancer patients is better than medical management alone.
- Trial name
- NCT06424522
- Testing
- Dietary Fiber, Enema Administration, Loperamide Hydrochloride
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Low Anterior Resection Syndrome
International Low Anterior Resection Score Evaluation
Aim: The aim of this study is to perform a prospective, international 4 months cohort study evaluating bowel function before curative rectal cancer surgery and one year after the surgery using the LARS score.
- Trial name
- PrePostLARS (NCT04040842)
- Testing
- Patients undergoing low anterior resection
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Rectal Cancer, Low Anterior Resection Syndrome
Rectal Cancer Survivorship: Impact of Low Anterior Resection Syndrome (LARS) on the Quality of Life
Quality of life and risk factors for developing major LARS are explored. Therapeutic options were explored in the cohort experiencing major LARS
- Trial name
- NCT06059170
- Testing
- LARS score/ EORTC QLQ C30
- Where
- Belgium
- Volunteers
- 187 people
- Sponsor
- University Hospital, Ghent
LARS - Low Anterior Resection Syndrome
5-HT3 Receptor Antagonist (Ramosetron) vs Loperamide for the Treatment of Low Anterior Resection Syndrome(RALARS)
Safety \& Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) versus Loperamide for the Treatment of Low Anterior Resection Syndrome (RALLARS): Multicenter Randomized Controlled Trial
- Trial name
- RaLARS (NCT05577845)
- Testing
- Ramosetron
- Where
- South Korea
- Volunteers
- 212 people
- Sponsor
- Seoul National University Hospital
Colorectal Surgery, Rectal Cancer
Early and Late Removal of the Urinary Catheter After Rectum Resection
It was aimed to investigate the need for urinary retention and recatheterization in the postoperative period by removing the urinary catheter in patients undergoing low anterior resection, in the early or late period.
- Conditions
- Colorectal Surgery, Rectal Cancer, Urinary Retention Postoperative
- Trial name
- NCT05020613
- Testing
- Procedure: Early removal group, Procedure: Late removal group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Marmara University
Rectal Cancer
Efficacy of Ondansetron in LARS Treatment
Patients will be randomized (1:1 ratio) to receive either 4 weeks of Ondansetron followed by 4 weeks of placebo (O-P sequence) or 4 weeks of placebo followed by 4 weeks of Ondansetron (P-O sequence).
- Trial name
- Hodolar (NCT03182179)
- Testing
- Ondansetron 4 MG
- Where
- 2 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Colorectal Cancer
Radial Reload Laparoscopic LAR Case Series
To evaluate the Radial Reload Stapler during laparoscopic low anterior resection (LAR) or anterior proctosigmoidectomy for rectal cancer by assessing the primary and secondary endpoints.
- Trial name
- NCT01706822
- Testing
- Covidien Radial Reload Stapler with Tri-Staple Technology
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medtronic - MITG
Extended Ileal Resection Under Laparotomy, Total Proctocolectomy Under Laparotomy
Postoperative Analgesia in Abdominal Surgery: a Medico-economic Study
Background : Epidural anaesthesia is associated in abdominal surgery with reduced pain and postoperative respiratory complications together with quicker recovery of bowel function.
- Conditions
- Extended Ileal Resection Under Laparotomy, Total Proctocolectomy Under Laparotomy, Colectomy Left/Right/Total Under Laparotomy, Rectosigmoidal Resection Under Laparotomy
- Trial name
- PERIDIGE (NCT01470846)
- Testing
- epidural analgesia, PCA
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Limoges
Low Anterior Resection Syndrome (LARS)
Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer Surgery
This study aims to evaluate the optimal timing of trans-anal irrigation (TAI) for participants with low anterior resection syndrome (LARS) who have undergone surgery for rectal cancer.
- Trial name
- EARLY-TAI (NCT07696689)
- Testing
- Water-based transanal irrigation system
- Volunteers
- 250 people
- Sponsor
- Simona Ascanelli
Rectal Cancer, Surgery
Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled Trial
After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS).
- Conditions
- Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection
- Trial name
- NCT03828318
- Testing
- Patient Activation Booklet and nursing support for patients with LARS
- Where
- 6 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Jewish General Hospital
Rectal Cancer
Comparing of Different Biomarkers From Vena Rectalis Superior and Vena Cubiti in Patients Undergoing Low Anterior Resection for Rectum Cancer
The primary aim of the present study is to investigate different biomarkers like VEGF, EVGF and others ability to predict time to recidive and progressions free survival.
- Trial name
- NCT01706809
- Testing
- blood sampels from vena rectalis superior and vena cubiti
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital
Rectal Cancer
Rectal Surgery Evaluation Trial (RESET)
Total mesorectal excision (TME) is the standard of care for rectal cancer, which can be combined with low anterior resection (LAR) in patients with mid-to-low rectal cancer.
- Trial name
- RESET (NCT03574493)
- Testing
- TME with LAR
- Where
- France
- Volunteers
- 1,098 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Rectal Cancer, Surgical Anastomosis
The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal Anal-preserving Surgery
The goal of this clinical trial is to explore the difference in 3-year stoma-free survival between the Turnbull-Cutait delayed coloanal anastomosis (TCA) surgery and the low anterior resection combined with protective stoma (LAR)…
- Conditions
- Rectal Cancer, Surgical Anastomosis, Survival , Tumor, Anal Function
- Trial name
- FIAS (NCT07369531)
- Testing
- Turnbull-Cutait anastomosis, LAR
- Where
- 2 sites in China
- Volunteers
- 520 people
- Sponsor
- The First Hospital of Jilin University
Colorectal Cancer
Incidence and Risk Factors of Low Anterior Resection Syndrome
Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome.
- Trial name
- NCT06359730
- Testing
- LARS score questionnaire
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University