Clinical trials: Longstanding Persistent Atrial Fibrillation
Atrial Fibrillation, Persistent or Longstanding Persistent Atrial Fibrillation
Pivotal Study Of A Dual Epicardial & Endocardial Procedure (DEEP) Approach
The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presenting with Persistent Atrial Fibrillation or Longstanding Persistent Atrial…
- Trial name
- DEEP (NCT02393885)
- Testing
- AtriCure Bipolar System and AtriClip® PRO LAA Exclusion System, Endocardial Ablation
- Where
- 17 sites in United States, Belgium and 1 more
- Volunteers
- 90 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation
Safety and Efficacy Study of The Combined Ablation Procedure To Treat Longstanding Persistent Atrial Fibrillation
This is a multi-center, prospective open label, feasibility study evaluating the safety and efficacy of the combined ablation procedure for the treatment of longstanding persistent atrial fibrillation.
- Trial name
- CAPstopsLSPAF (NCT01103661)
- Testing
- Numeris®-AF Guided Coagulation System with VisiTrax®
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- nContact Surgical Inc.
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Comparison of Treatment Outcomes Between Convergent Procedure and Catheter Ablation for Persistent and Longstanding Persistent Atrial Fibrillation
In the last 20 years, atrial fibrillation has become one of the leading healthcare burden in Europe and other developed countries.
- Trial name
- NCT04509180
- Testing
- Catheter ablation, Convergent procedure
- Where
- Slovenia
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation
aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation
This study is a prospective, multicenter, randomized (2:1) controlled study to evaluate the safety and effectiveness of the LARIAT System to percutaneously isolate and ligate the Left Atrial Appendage from the left atrium as an…
- Trial name
- aMAZE (NCT02513797)
- Testing
- LARIAT + PVI, Pulmonary Vein Isolation
- Where
- 53 sites in United States
- Volunteers
- 600 people
- Sponsor
- AtriCure, Inc.
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
ABLATE Post Approval Study - Synergy Ablation Lesions for Non-Paroxysmal Atrial Fibrillation
The primary objective of this post-approval study is to evaluate the clinical outcomes in a cohort of patients with non-paroxysmal forms of atrial fibrillation (persistent or long-standing persistent) treated during commercial…
- Trial name
- ABLATE-PAS (NCT01694563)
- Testing
- Synergy Ablation System
- Where
- 49 sites in United States
- Volunteers
- 365 people
- Sponsor
- AtriCure, Inc.
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Medtronic Terminate AF Study
The purpose of this study is to demonstrate the safety and effectiveness of the Cardioblate iRF and CryoFlex hand held devices for the treatment of non-paroxysmal atrial fibrillation (AF).
- Trial name
- NCT03546374
- Testing
- Surgical Ablation, Cardioblate and Cryoflex hand held devices
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Medtronic Cardiac Surgery
Longstanding Persistent Atrial Fibrillation
Evaluation of the Cardioblate CryoFlex Surgical Ablation System in Longstanding Persistent Atrial Fibrillation
Studies have shown that taking drugs to stay out of AF has limited success. This research is designed to study heart rhythm after surgical therapy, namely by measuring if there are benefits to having surgery to treat Atrial…
- Trial name
- CRYO-AF (NCT01558635)
- Testing
- Cardioblate CryoFlex Surgical Ablation, Mitral Valve surgery, Medtronic Reveal XT Insertable Cardiac Monitor
- Where
- 4 sites in Germany, Israel and 2 more
- Volunteers
- 17 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation, Persistent
Subxyphoid Hybrid MAZE Registry for Patients With Persistent Atrial Fibrillation
Minimally invasive surgical procedures have been advocated as an alternative to catheter ablation for the treatment of persistent atrial fibrillation.
- Trial name
- SubXMAZE (NCT04148625)
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Atrial Fibrillation
Clinical Benefits of Additional Complex Fractionated Atrial Electrogram Targeted Catheter Ablation for Longstanding Persistent Atrial Fibrillation
1. Purpose of the study 1) To compare clinical outcome, procedure time, complication rate of persistent atrial fibrillation patients between conventional additional linear ablation and additional complex fractionated atrial…
- Trial name
- NCT02175043
- Testing
- atrial electrogram and liner ablation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Persistent Atrial Fibrillation, Persistent Atrial Fibrillation Longstanding
Catheter Ablation of Advanced Forms of Atrial Fibrillation
The purpose of this study is to evaluate feasibility, safety, and efficacy of pulmonary vein isolation combined with posterior left atrial isolation and multiple linear lesions in both atria in patients with persistent and…
- Trial name
- ENDO MAZE (NCT07446244)
- Testing
- Endovascular ablation set mimicking cox maze 4 procedure.
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation
Dual Epicardial Endocardial Persistent Atrial Fibrillation(AF) Study (Staged DEEP)
The purpose of this study is to assess the safety and technical feasibility of treating subjects with Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation in a minimally invasive thoracoscopic ablation…
- Trial name
- Staged DEEP (NCT01661205)
- Testing
- Ablation procedure staged catheter ablation
- Where
- 6 sites in United States, Belgium and 1 more
- Volunteers
- 30 people
- Sponsor
- AtriCure, Inc.
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Electrographic Flow Mapping Validation in Patients With Persistent Atrial Fibrillation (EVAL AF)
This is a prospective, observational, single center pilot trial to find out if a new computerized technology for analysis of the electrical activity recorded during atrial fibrillation can identify the electrical source of this…
- Trial name
- NCT05093868
- Testing
- Electrographic Flow Mapping
- Where
- United States
- Sponsor
- Corewell Health East
Persistent Atrial Fibrillation
Ganglionated Plexi Ablation Combined With Pulmonary Vein Isolation
The investigators have conducted a prospective, double-blind, randomized study to assess the comparative safety and efficacy of two different ablation strategies, PVI plus linear lesions (LL) versus PVI plus GP ablation, in…
- Trial name
- NCT01703247
- Testing
- Pulmonary vein isolation, Ganglionated plexi ablation, Linear Lesion Ablation
- Where
- Russia
- Volunteers
- 264 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation
Hybrid Versus Catheter Ablation in Persistent AF
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a lifetime risk of developing AF of 1 in 4 people aged over 40.
- Trial name
- HARTCAP-AF (NCT02441738)
- Testing
- Hybrid Ablation, Catheter Ablation
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Univu-guided Vein of Marshall Ethanol Infusion (Marshall-Merge)
The study is a prospective, randomized, single-blind clinical trial aiming to compare two method in guidance of Vein of Marshall ethanol infusion (VOMEI), i.e., the conventional fluoroscopy-guided VOMEI and UNIVU-guided VOMEI.
- Trial name
- NCT05652517
- Testing
- Vein of Marshall ethanol infusion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation
Cryoballoon Ablation in Patients With Longstanding Persistent Atrial Fibrillation
Prospective and explorative clinical study. The objective is to assess the clinical efficacy of pulmonary vein isolation using the Arctic Front Advance cryoballoon in patients with longstanding persistent atrial fibrillation (AF)…
- Trial name
- CRYO-LPAF (NCT02294929)
- Testing
- Atrial fibrillation ablation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University Hospital
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Dual Epicardial Endocardial Persistent Atrial Fibrillation (AF) Study
The purpose of this clinical investigation is to evaluate how safe a less invasive cardiac surgery is using the AtriCure Bipolar System combined with a catheter ablation procedure in treating AF, and how effective this combined…
- Trial name
- DEEP (NCT01246466)
- Testing
- Hybrid: AtriCure Bipolar System & EP ablation procedure
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation
European Carto® XP REgistry for Validating Specialized CFAE SOftware
The purpose of this prospective observational study (registry) is to determine the acute success rate of a complex fractionated atrial electrogram (CFAE) guided ablation procedure using a dedicated software and to determine the…
- Trial name
- EXPRESSO (NCT00812916)
- Testing
- RF ablation, using specialized CFAE software
- Where
- 13 sites in France, Germany and 1 more
- Volunteers
- 206 people
- Sponsor
- Biosense Webster EMEA
Atrial Fibrillation
Catheter Ablation of Longstanding Persistent Atrial Fibrillation
This randomized prospective study compared three ablation strategies in patients with longstanding persistent atrial fibrillation (LPeAF).
- Trial name
- NCT02929836
- Testing
- PVI, LA linear ablation, CFAE ablation
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation Longstanding
Multitarget Pulse Field Ablation Guided by Endocardial and Non-invasive Atrial Driver Mapping (PFA+ADM) Pilot Study. Development of an Ablation Strategy to Improve the Efficacy of Long Standing Atrial Fibrillation Ablation in Patients With High Comorbidity Burden or Heart Failure
To assess the efficacy and safety of a percutaneous ablation strategy that targets multiple extrapulmonary structures as the Cox-Maze IV.
- Trial name
- PFA+ADM (NCT07118488)
- Testing
- Multitarget PFA Ablation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Innovacion en Biomedicina (FIBMED)