Clinical trials: Longevity
Chronic Kidney Disease, Hemodialysis
Red Blood Cell Lifespan
Background: A low amount of red blood cells in the blood of patients with limited kidney function is a well known problem. Besides the lack of substances in the blood like iron or erythropoietin the shortened survival of red…
- Trial name
- RBC (NCT01462071)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Renal Research Institute
Clinical Trial
BONDING TO ENAMEL USING A UNIVERSAL ADHESIVE
Objective: This double-blind randomized clinical trial evaluates strategies for improving the bonding of universal adhesive to enamel in non-carious cervical lesions (NCCL) of a new universal multi-mode adhesive (Ambar Universal…
- Trial name
- RCT (NCT03254693)
- Testing
- 1-step self-etch approach (SE), selective enamel etching (SEE), 1-step self-etch for double time (SE2X)
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ponta Grossa
Healthy
The Healthy Elderly Longevity Cohort
With the completion of the human genome project, investigators can now explore new questions in human biology. Previously human genetics focused on highly penetrant, Mendelian traits; however, now rare and common variants can be…
- Trial name
- Wellderly (NCT01004133)
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Clinical Trial
Effect of Increased Improve Time on Adhesive System
Objective: This double-blind randomized clinical trial evaluates the influence of increased application time of a new etch-and-rinse two-step adhesive Single Link; (Angelus Dental Products Industry) applied in non-carious…
- Trial name
- RCT (NCT03254706)
- Testing
- Peak etch-and-rinse (P1), Peak applied for double time(P2X), Single Link etch-and-rinse (SL1)
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ponta Grossa
Dental Caries
Sealing Manifest Occlusal Caries Lesions in the Permanent Dentition
The research project "SEAL-DK" is focusing on advantages and disadvantages of two treatment strategies: non-invasive fissure sealing and invasive restorative treatment of manifest occlusal caries lesions in permanent teeth in…
- Trial name
- SEAL-DK (NCT02573090)
- Testing
- Non-invasive resin based fissure sealing, Invasive resin based restoration
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Aged
Clinical Power Testing Across Human Lifetime
We will determine when to transition from the common vertical jump to chair stand depending on age and physical activity levels.
- Trial name
- NCT03160963
- Testing
- Power Testing
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Spina Bifida, Neurogenic Bowel
Bowel Continence Across the Lifespan in People With Spina Bifida
The goal of this observational study is to learn how different enema programs affect bowel control in children and adults with spina bifida.
- Conditions
- Spina Bifida, Neurogenic Bowel, Bowel Incontinence
- Trial name
- BCALS (NCT07390318)
- Testing
- Retrograde Enema, Antegrade Enema
- Where
- 24 sites in United States
- Volunteers
- 943 people
- Sponsor
- David Chu
Aging, Healthy Aging
Study of Microbiota in Longevity County, Yongfu
This study is an observational study designed to adopt a cross-sectional study design. In the context of China's longevity town (East Asian population), Yongfu, Guangxi, the background of non-medical care and antibiotic use was…
- Trial name
- SoMiLY (NCT04210934)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beijing Hospital
Longevity, Familial Longevity
Longevity Families of the Netherlands
The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind.
- Conditions
- Longevity, Familial Longevity, Extreme Longevity, Aging
- Trial name
- LOF-NL (NCT06374069)
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Dental Restoration Failure
Increasing Composite Restorations Sealants
A cohort of 20 patients aged 18 to 80 years (mean 28.35 years) of both genres females (65%) and males (35%) with 80 composite restorations were recruited at the Operative Dentistry Clinic at the Dental School of the University of…
- Trial name
- SEALCOMP (NCT02119195)
- Testing
- Sealant
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chile
Posttraumatic Stress Disorder
Lifespan Integration for Posttraumatic Stress Disorder From an Auto Accident
The purpose of this study is to evaluate if lifespan integration (LI) therapy reduces posttraumatic stress symptoms following a motor vehicle accident (MVA) trauma
- Trial name
- NCT01263067
- Testing
- Lifespan Integration Therapy, Lifespan Integration- Control
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Argosy University
Health Knowledge, Attitudes, Practice, Vaccine-Preventable Diseases
Culturally Tailored HPV Psychoeducational Multimedia Intervention
Community members ages 18 - 45 years old from the El Paso, Texas, U.S.-Mexico Border Region will be recruited to compare psychoeducational multimedia interventions focused on the human papillomavirus (HPV).
- Conditions
- Health Knowledge, Attitudes, Practice, Vaccine-Preventable Diseases, Intention, Adherence, Patient
- Trial name
- NCT06098690
- Testing
- Culturally Tailored Multimedia Psychoeducational HPV Intervention, General HPV Multimedia Psychoeducational Control Group
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Polycystic Ovary Syndrome, Menopause
Health Risks and Barriers to Management Across the PCOS Lifespan
The overall objective of the proposed pilot project is to explore health literacy and barriers to management of PCOS across the lifespan and determine whether the cardiometabolic risks of PCOS extend beyond menopause.
- Trial name
- HERBS (NCT05769426)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Healthy Aging
ELITE: Deep Profiling and Algorithmic Polytherapy to Map Individual Response in Healthy Aging
ELITE, Evidence-Based Longevity Interventions and Targeted Engagement, was a randomized, open-label, two-active-arm Phase IIa pilot conducted at Sheba Medical Center in Ramat Gan, Israel.
- Trial name
- ELITE (NCT07871799)
- Testing
- AgeBiotics AB-01, AgeBiotics AB-02, Metformin
- Where
- Israel
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Obesity, Aging
Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals
Mechanisms that drive addiction to sugar rich foods are a major driving factor in the pathogenesis of obesity, which has become one of the most significant health care burdens.
- Trial name
- NCT05083546
- Testing
- Gly-low
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sarcoma
Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan
This study evaluates the impact that a sarcoma diagnosis and treatment have had on patients over time.
- Trial name
- CAUSAL (NCT06482957)
- Testing
- Surveys, Blood Collection, Saliva Collection
- Where
- United States
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Intrusive Memories of Traumatic Event(s)
The Lóa Study: A Brief Digital Intervention for Women With Intrusive Memories in the SAGA Cohort
Intrusive memories are sensory memories of a traumatic event(s) that spring to mind involuntarily, and can evoke strong emotions and disrupt functioning in daily life.
- Trial name
- NCT05849337
- Testing
- Brief imagery-competing task, Brief psychoeducation and signposting task, Treatment as usual (TAU)
- Where
- Iceland
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Aging
Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study
This is a randomized, placebo-controlled trial into the safety and efficacy in reducing clinical measures of aging in an older adult population.
- Trial name
- PEARL (NCT04488601)
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- AgelessRx
Longevity, Quality of Life
Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures
The goal of this clinical study has two objectives. The Primary Objective is to evaluate the effectiveness of microdosed GLP-1 receptor agonists in improving measures of health, quality of life, and longevity.
- Conditions
- Longevity, Quality of Life, Mood, Inflammation
- Trial name
- NCT07092605
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- AgelessRx