Clinical trials: Long Covid19, active
Pulmonary Fibrosis, COVID-19 Pneumonia
Assessing the Efficacy of Sirolimus in Patients With COVID-19 Pneumonia for Prevention of Post-COVID Fibrosis
The primary purpose of this study is to determine whether the drug sirolimus reduces the likelihood of developing of pulmonary fibrosis in patients who are hospitalized with COVID-19 pneumonia.
- Conditions
- Pulmonary Fibrosis, COVID-19 Pneumonia, Long COVID
- Trial name
- NCT04948203
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
Long COVID-19, Post-COVID-19 Syndrome
Effects of a Home-Based Exercise Intervention in Subjects with Long COVID
The current Coronavirus Disease 2019 (COVID-19) pandemic is the most severe health crisis of the 21st century. This is not only due to the deaths caused by the disease.
- Trial name
- NCT06073002
- Testing
- home-based concurrent exercise
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- University of Vienna
Long Covid19, Neuropsychiatric Symptom
Acupuncture for Post COVID-19 Condition (Long COVID) Neuropsychiatric Symptoms
In this study, a 12-week pragmatic, randomized, double-blinded clinical trial will be conducted to evaluate the efficacy of acupuncture for the treatment of long Covid neuropsychiatric symptoms and provide reference for clinical…
- Conditions
- Long Covid19, Neuropsychiatric Symptom, Acupuncture
- Trial name
- NCT06633666
- Testing
- Acupuncture
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Hong Kong Baptist University
Long COVID, Long COVID Syndrome
Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19
At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue.
- Trial name
- NCT06864156
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Rehabilitacion
Long COVID, Postural Orthostatic Tachycardia Syndrome
The Long COVID-19 Wearable Device Study
To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can…
- Conditions
- Long COVID, Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Myalgic Encephalomyelitis
- Trial name
- NCT05741112
- Testing
- Wearable device
- Where
- United States
- Volunteers
- 100,500 people
- Sponsor
- Scripps Translational Science Institute
COVID-19, SARS CoV 2 Infection
NIH RECOVER Tissue Pathology: Understanding the Long-Term Impact of COVID-19
The Post-Acute Sequelae of SARS-CoV-2 (PASC) Autopsy Study is a cross-sectional study designed to define and characterize the epidemiology, natural history, clinical spectrum, and underlying mechanisms of post-acute effects of…
- Trial name
- NCT05292274
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- NYU Langone Health
Post-COVID / Long-COVID
SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID)
This placebo-controlled, randomized, blinded, two-arm phase II study will test the safety and potential efficacy of the targeted mAb, Sipavibart (formerly AZD3152) in patients with Long COVID.
- Trial name
- Monoclonal (NCT07021794)
- Testing
- Sipavibart
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nancy Klimas
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Long COVID
Long-term Symptomatic Follow-up of Patients with Long COVID Syndrome
The goal of this observational study is to learn about the long-term evolution of long COVID. The main question it aims to answer is: Does the main symptoms of the patients diagnosed with long COVID aproximate to those of…
- Trial name
- NCT06879535
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital del Rio Hortega
COVID-19, Brain Fog
Transcranial Ultrasound Stimulation for Cognitive Function Modulation in Patients With Post COVID-19 Brain Fog
This study aims to investigate whether a specific brain region mediates the cognitive deficit in long COVID brain fog, and whether targeted modulation of this region can improve cognition.
- Conditions
- COVID-19, Brain Fog, Long COVID, Transcranial Ultrasound Stimulation
- Trial name
- NCT07154199
- Testing
- real transcranial ultrasound stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
SARS-CoV-2 Infection
Understanding the Long-term Impact of COVID on Children and Families
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals age 0-25 years who will enter the cohort with and without SARS-CoV-2 infection at varying stages before and after infection.
- Trial name
- NCT05172011
- Where
- 65 sites in United States
- Volunteers
- 15,028 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Long COVID Syndrome
Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?
Millions have developed Long COVID (LC), and recent findings show an association between taurine deficiency (an amino acid) and symptoms in LC.
- Trial name
- NCT07312409
- Testing
- Taurine supplementation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- York University
COVID Long-Haul
Covid-19 Long Immunité IMagerie (CLIIM)
Covid-long pathology affects a large number of patients, and represents a major medical, economic and societal challenge. To date, we have no objective criterion for a definitive diagnosis, nor any predictive tool for monitoring…
- Trial name
- CLIIM (NCT06528171)
- Testing
- Brain MRI, Specific blood samples
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Post-acute Sequelae of COVID-19, Long COVID
SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
The purpose of this research study is to test if the combination of three drugs, valacyclovir, celecoxib, and Paxlovid will decrease the symptoms of Long COVID in adults compared to a placebo (this does not contain the…
- Trial name
- SHIELD (NCT07597902)
- Testing
- Valacyclovir, Celecoxib, Paxlovid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post-Acute COVID-19 Syndrome
Exercise Training Using an App on Physical Cardiovascular Function Individuals With Post-covid-19 Syndrome
The aim of this study is to assess the effect of a physical exercise program via a mobile application on functional parameters in individuals with post-COVID-19 syndrome.
- Trial name
- Recovery (NCT06168006)
- Testing
- Exercise, Control
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
Long COVID, Major Depressive Disorder
Presynaptic Imaging in Major Depressive Episodes After COVID-19
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP).
- Conditions
- Long COVID, Major Depressive Disorder, Major Depressive Episode
- Trial name
- PCOV (NCT06086366)
- Testing
- [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Long COVID, Long Covid19
Understanding the Long-term Impact of COVID-19 in Adults
Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences.
- Trial name
- NCT07498504
- Where
- United States
- Volunteers
- 5,205 people
- Sponsor
- NYU Langone Health
Post-Acute COVID-19 Syndrome
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from an acute COVID-19 infection may continue to have symptoms that persist for months or years.
- Trial name
- NCT07388550
- Testing
- Keytruda
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Post COVID-19 Condition, Post-COVID-19 Syndrome
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments
Over 500 million people have been infected with COVID-19, and to date, more than 6 million people have died. Many individuals who have recovered from COVID-19 continue to experience symptoms even after they have been "cured" of…
- Conditions
- Post COVID-19 Condition, Post-COVID-19 Syndrome, Post-COVID Syndrome, COVID-19
- Trial name
- PCS-HBOT (NCT06082518)
- Testing
- Monoplace Hyperbaric Chamber (Class III medical device).
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre