Clinical trials: Local Cryoablation
Recurrent Hepatocellular Carcinoma, Lenvatinib
The Comparison of TACE-Lenvatinib With TACE-Lenvatinib-ablation for Intermediate Recurrent Hepatocellular Carcinoma
Studies have shown that combination therapy of TACE with Lenvatinib could achieve better survival outcomes than TACE alone for hepatocellular carcinoma (HCC) at BCLC B stage.
- Conditions
- Recurrent Hepatocellular Carcinoma, Lenvatinib, Local Therapy, Ablation
- Trial name
- NCT06609850
- Testing
- TACE, Ablation, Lenvatinb
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-sen University
Liver Cancer (Primary and Metastatic), Lung Cancer (Diagnosis)
Registry of Minimally Invasive Cancer Treatment Using Spectral Angio-CT Image Guidance
This study collects data from patients undergoing minimally invasive, image-guided cancer treatments at participating hospitals in the Netherlands and France.
- Conditions
- Liver Cancer (Primary and Metastatic), Lung Cancer (Diagnosis), Bone Cancer Metastatic, Bone Cancer Tumor
- Trial name
- PreciseOnco (NCT07636148)
- Where
- 3 sites in France, Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Mark C Burgmans, MD PhD
Breast Cancer, Breast Neoplasms
FreezIng bReaST Cancer in Brazil: a Before-after Study
Image-guided tumor ablation is a non-surgical, minimally invasive therapy available for local therapy of some carcinomas as an alternative to surgical treatment.
- Trial name
- FIRST (NCT05398497)
- Testing
- Cryoablation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital do Coracao
Cancer
Analysis of Percutaneous Ablations for Cancer Treatment
This is a study involving patients with cancer who are referred by their treating physician for percutaneous locoregional therapies.
- Trial name
- NCT01563679
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University
Triple Negative Breast Cancer
Grouping Immune-modulation With Cryoablation (LOGIC) for Breast Cancers
Summary Points: 1. High Risk Breast Cancers: Triple negative cancer is considered high risk due to high rate of local and systemic failure.
- Trial name
- LOGIC (NCT05806385)
- Testing
- Cryoablation, Cryoablation combined with PD1 Inhibitor
- Volunteers
- 36 people
- Sponsor
- Texas Tech University Health Sciences Center
Unresectable Solid Tumors
SEED-CRYO: Sequential 125I Seed Implantation Followed by Cryoablation vs Single-Modality Local Therapy in Unresectable Solid Tumors
This open-label, randomized Phase II trial evaluates whether sequential iodine-125 seed implantation followed by cryoablation improves local tumor control versus single-modality local therapy (125I seeds alone or cryoablation…
- Trial name
- NCT07450352
- Testing
- Iodine-125 (125I) Seed Implantation, cryoablation, Sequential 125I Seed Implantation Followed by Cryoablation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Li Min
Prostate Cancer
Prostate Conformal Cryotherapy
The goal of this clinical research study is to learn if using cryotherapy to treat only the part of the prostate that contains cancer is an effective treatment for prostate cancer.
- Trial name
- NCT00877682
- Testing
- Cryoablation
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- M.D. Anderson Cancer Center
Postamputation Pain, Lower Limb Amputation
Acute Post-Amputation Pain Management After Combat-Related Lower Limb Injury
Acute post-amputation pain remains a significant clinical challenge in patients with combat-related lower limb injuries and may negatively affect early rehabilitation, mobility, and opioid consumption.
- Conditions
- Postamputation Pain, Lower Limb Amputation, Combat Trauma
- Trial name
- APAPMACRLLI (NCT07863921)
- Testing
- Continuous Peripheral Nerve Blocks, Peripheral Nerve Cryoablation, Standard multimodal analgesia
- Where
- Ukraine
- Volunteers
- 36 people
- Sponsor
- Kharkiv National Medical University
Breast Cancer, Breast Neoplasm
CRYoablation for Small Tumors As Local Treatment - SIX Trial
To demonstrate the non-inferiority of cryoablation compared to breast surgery for the local treatment of early-stage breast cancer and to conduct a cost-minimization analysis comparing direct costs between treatments.
- Trial name
- CRYSTAL - SIX (NCT06839001)
- Testing
- cryoablation, Breast Surgery (Lumpectomy or Mastectomy)
- Where
- 2 sites in Brazil
- Volunteers
- 750 people
- Sponsor
- Hospital do Coracao
Metastatic Breast Cancer
CRYO-TOUCH: Cryoablation of the Primary Breast Tumor in Metastatic Breast Cancer
Metastatic breast cancer remains an incurable disease for most patients. While surgical treatment of the primary breast tumor is commonly performed in localized breast cancer, its role in metastatic breast cancer remains…
- Trial name
- CRYO-TOUCH (NCT07676344)
- Testing
- Cryoablation, Patient-Reported Outcome Assessment
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Lung Adenocarcinoma, Local Cryoablation
Local and Peripheral Immune Responsive Landscape Induced by Local Cryoablation in Patients With Lung Adenocarcinoma
The goal of this observational study is to learn about local and peripheral immune and metabolic changes in patients with lung adenocarcinoma undergoing cryoablation.
- Trial name
- NCT06104709
- Volunteers
- 10 people
- Sponsor
- China-Japan Friendship Hospital
Pain, Postoperative, Rib Fracture Multiple
Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures
To determine if patients with intraoperative cryoablation have better analgesia results compared to the control group of Surgical Stabilization of Rib Fractures (SSRF) without cryoablation
- Trial name
- NCT05415384
- Testing
- Cryoablation of Intercostal Nerves, Standard surgical treatment of patients with multiple rib fractures
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer
Cryoablation of Low Risk Small Breast Cancer- ICE3 Trial
To evaluate the efficacy of cryoablation without lumpectomy and its impact on local and distant recurrence of early stage breast cancer .
- Trial name
- NCT02200705
- Testing
- Ice-Sense3TM/ ProSenseTM
- Where
- 19 sites in United States
- Volunteers
- 206 people
- Sponsor
- IceCure Medical Ltd.
Lung Cancer (Non-Small Cell), Lung Metastases From Any Primary
Evaluation of Efficacy of Minimally Invasive Local Therapy for Lung Tumors and Its Impact on Breathing Function
This clinical study is evaluating different treatment options for patients with malignant lung tumors, including both primary lung cancer and tumors that have spread to the lungs from other parts of the body.
- Trial name
- NCT07272356
- Testing
- Surgery, Ablation, SBRT
- Where
- Lithuania
- Volunteers
- 68 people
- Sponsor
- Aurimas Macionis
Mesothelioma
Cryoablation for the Promotion of Local Tumor Infiltration in Patients With Mesothelioma
This trial evaluates if cryoablation will stimulate a local immune response by cluster of differentiation 8 positive (CD8+) cells which are not present in ablation naive regions of the tumors in patients with mesothelioma.
- Trial name
- NCT04429204
- Testing
- Biospecimen Collection, Cryosurgery
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
High-Burden Metastatic Solid Tumors
Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease
This open-label, randomized Phase II trial evaluates whether a strategy-based, multimodal local treatment approach improves local control compared with single-modality local therapy in patients with high-burden metastatic disease…
- Trial name
- NCT07437625
- Testing
- Iodine-125 (125I) Seed Implantation (Low-Dose-Rate Brachytherapy), cryoablation, Lesion Allocation and Tumor Zoning Strategy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Li Min
Breast Cancer Stage I, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
CRYO-1: Cryoablation in Elderly Patients With Early-Stage Breast Cancer.
This study looks at a new way to treat early-stage breast cancer in older adults using a freezing technique called cryoablation.
- Trial name
- CRYO-1 (NCT07398118)
- Testing
- Cryoablation / Cryotherapy
- Where
- 3 sites in Netherlands
- Volunteers
- 61 people
- Sponsor
- St. Antonius Hospital