Clinical trials: Lobectomy, open to volunteers
NSCLC, Stage I
Comparison of Sublobar and Lobectomy in Small (2 Cm or Less 0.5<CTR<1) Non-small Cell Lung Cancer: a Prospective, Multicenter Randomized Controlled Study
The early NSCLC（Non-small cell lung cancer） patients with partial solid nodules mainly composed of solid components, whose maximum tumor diameter was ≤ 2.0cm and 0.5<CTR（Consolidation tumor ratio）<1, as indicated by preoperative…
- Trial name
- NCT06028412
- Testing
- Sublobar, Lobectomy
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Xiaolong Yan, Dr.
Lung, Lung Adenocarcinoma
Reinforced and Non-Reinforced Staple Lines in Fissureless Lobectomy
Prolonged Air Leak (PAL) is a common and serious problem after lung surgery. It can lead to worse patient outcomes, longer hospital stays, and higher costs.
- Conditions
- Lung, Lung Adenocarcinoma, Lung Adenosquamous Carcinoma, Lung Cancer, Non-Small Cell
- Trial name
- NCT06602661
- Testing
- Fissureless Lobectomy with Reinforced Staple Lines, Fissureless Lobectomy with Non-Reinforced Staple Lines
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Surrey Thoracic Surgery Group
Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch, Local Incision, Postoperative Pain
- Trial name
- NCT07591220
- Testing
- Loxoprofen Sodium Patch on the incision site, Loxoprofen Sodium Patch on the contralateral side
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Carcinoma, Non-Small-Cell Lung
ELobectomy for NSCLC by VATS Versus Thoracotomy (ECTOP-1007)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1007). The goal of this study is to determine video-assisted thoracoscopic surgery is non-inferior to thoracotomy in terms of disease-free survival for…
- Trial name
- NCT03786003
- Testing
- VATS, Thoracotomy
- Where
- China
- Volunteers
- 1,086 people, healthy volunteers welcome
- Sponsor
- Fudan University
Non Small Cell Lung Cancer
Clinical Outcomes and Quality Of Life After Minimally Invasive Segmentectomy Versus Lobectomy for Lung Cancer
The goal is to compare patient reported outcomes, such as dyspnea, physical functioning and quality of life, between minimally invasive segmentectomy and lobectomy for stage I NSCLC during the first year after surgery.
- Trial name
- NCT07477158
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Lung Neoplasms, Surgery
Comparison of Segmentectomy Versus Lobectomy for Non-small Cell Lung Cancer ≤ 2 cm in the Middle Third of the Lung Field
This study aims to investigate whether segmentectomy had non-inferiority long-term oncological effects (disease-free survival and overall survival) compared with lobectomy in the treatment of patients with early-stage non-small…
- Trial name
- NCT04944563
- Testing
- Segmentectomy, Lobectomy
- Where
- China
- Volunteers
- 1,120 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Newly-diagnosed Glioblastoma, Temporal Lobe
Anterior Temporal Lobectomy in Temporal Glioblastoma
The ATLAS/NOA-29 trial is a prospective, multicenter, phase III randomized controlled study evaluating whether anterior temporal lobectomy (ATL), a standardized resection technique adapted from epilepsy surgery, improves clinical…
- Trial name
- ATLAS/NOA-29 (NCT07021339)
- Testing
- Anterior temporal lobectomy (ATL), Gross Total Resection (GTR)
- Where
- Germany
- Volunteers
- 178 people
- Sponsor
- University Hospital, Bonn
Lung Cancer (NSCLC)
Postoperative Pulmonary Function Assessment Based on Deep Learning Study
Improvements in low-dose CT screening have led to an increase in early-stage NSCLC diagnoses, with surgical resection-usually lobectomy or segmentectomy-remaining the primary curative option.
- Trial name
- NCT07256457
- Testing
- Segmentectomy, Lobectomy, Bronchoscopic Ablation
- Where
- Hong Kong
- Volunteers
- 192 people
- Sponsor
- Chinese University of Hong Kong
Thoracic Paravertebral Block, Postoperative Analgesia
Liposomal and Standard Bupivacaine in Thoracic Paravertebral Block for Post-Thoracoscopic Pain
I. Research purpose 1.1 Main Objective: To investigate the efficacy and safety of bupivacaine liposome thoracic paravertebral nerve block for postoperative analgesia after thoracoscopic lobectomy 1.2 Exploratory Objective: To…
- Conditions
- Thoracic Paravertebral Block, Postoperative Analgesia, Thoracoscopic Lobectomy
- Trial name
- NCT06165991
- Testing
- GroupB:Liposomal bupivacaine and bupivacaine hydrochloride;, Group A: bupivacaine hydrochloride;
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Yongtao Sun
Lung Cancer, Non-Small Cell
Sleeve Lobectomy for Lung Cancer in Minimally Invasive Surgical Techniques
The goal of this multicenter observational study is to evaluate the long-term survival and perioperative outcomes of sleeve lobectomy in robotic-assisted thoracic surgery (RATS) for patients with central lung cancer when compared…
- Trial name
- NCT06687408
- Testing
- RATS Group, VATS group
- Where
- 3 sites in China
- Volunteers
- 450 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lung Surgery, Enhanced Recovery After Surgery, ERAS
Evaluation of the Effectiveness of Enhanced Recovery After Surgery (ERAS) Program in Pediatric Lung Surgery
This study aims to evaluate the clinical effectiveness of the Enhanced Recovery After Surgery (ERAS) program for pediatric lung surgery at our institution.
- Conditions
- Lung Surgery, Enhanced Recovery After Surgery, ERAS, Pediatric
- Trial name
- NCT07241286
- Testing
- Enhanced Recovery After Surgery, ERAS
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Pneumothorax, Pleural Effusion
16F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or Segmentectomy
The aim of the study is to evaluate postoperative pain in patients receiving a small-bore (16F) chest drain compared to those receiving the standard large-bore (24F) chest drain after minimally invasive pulmonary lobectomy and/or…
- Trial name
- ChestDrain (NCT06958848)
- Testing
- 16 F chest tube, 24 F chest tube, Early removal
- Where
- Switzerland
- Volunteers
- 124 people
- Sponsor
- University Hospital, Basel, Switzerland
Lobectomy
Tegileridine Combined With Intercostal Nerve Block After Thoracoscopic Lung Resection
Combining tegileridine PCIA with ICNB targeting peripheral nerves, may constitute an ideal analgesic model with complementary advantages.
- Trial name
- NCT07386626
- Testing
- Tegileridine, Intercostal Nerve Block, Sufentanil
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Tongji Hospital
Atelectasis, Postoperative Pulmonary Complications
Effect of Inspired Oxygen Concentration on Postoperative Atelectasis After VATS Lobectomy
This study aims to investigate whether using 50% FiO₂ during one-lung ventilation, compared with 100% FiO₂, reduces postoperative atelectasis in the non-dependent (healthy) lung of patients undergoing VATS pulmonary lobectomy…
- Trial name
- NCT07721558
- Testing
- Low inspired oxygen concentration (FiO₂=50%) during one-lung ventilation, High inspired oxygen concentration (FiO₂=100%) during one-lung ventilaion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Frailty, Thoracic
Auricular Acupressure in Prehabilitation
Complementary medicine is recognized for its ability to enhance appetite, increase energy, reduce anxiety, decrease pain, and improve sleep, among many other benefits.
- Conditions
- Frailty, Thoracic, Prehabilitation, Lung Surgery
- Trial name
- NCT06516198
- Testing
- Auricular Acupressure
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Non-small Cell Lung Cancer, Lung Cancer
3D Virtual Resection for Predicting Lung Function in VATS
This study aims to validate a novel preoperative assessment strategy using three-dimensional (3-D) computed tomography (CT) reconstruction and virtual resection simulation.
- Conditions
- Non-small Cell Lung Cancer, Lung Cancer, Lung Neoplasms
- Trial name
- NCT07436598
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Lung Adenocarcinoma
Segmentectomy vs Lobectomy for 2 - 3cm IASLC Grade 1-2 Lung Adenocarcinoma: A Multi-center RCT
This study is a prospective, multicenter randomized controlled trial (RCT) designed to compare the efficacy of segmentectomy and lobectomy for invasive lung adenocarcinoma with a diameter of 2-3 cm and intraoperative frozen…
- Trial name
- STAR012 (NCT07169903)
- Testing
- Pulmonary segmentectomy
- Where
- China
- Volunteers
- 587 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Lung Cancer (Diagnosis)
Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1
The goal of this clinical trial is to assess how the location of local anesthetic medication affects pain control capabilities in adult patients undergoing thoracic(chest)-only minimally invasive surgery.
- Trial name
- CALMS-1 (NCT07254650)
- Testing
- Arm 1 "LipoB-I": Liposomal Bupivacaine via Multi-Level Intercostal Nerve Block, Arm 2 "LipoB-S": Liposomal Bupivacaine via Serratus Anterior Plane Block, Arm 3 "LipoB-C": Liposomal Bupivacaine Administered via Combination Block
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Esophagectomy, Pneumonectomy
Stellate Ganglion Block
The purpose of this study is to determine if the addition of an ultrasound guided left sided stellate ganglion block with bupivacaine in patients undergoing esophagectomy, pneumonectomy, or lobectomy will result in lower rates of…
- Conditions
- Esophagectomy, Pneumonectomy, Lobectomy
- Trial name
- NCT06271707
- Testing
- 0.5% bupivacaine, Saline
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Minnesota
Thoracotomy, Toracosurgery
Preoperative Nutritional Status and Postoperative Outcomes in Geriatric Lung Resection
Malnutrition is a common comorbidity in patients undergoing thoracic surgery. Furthermore, chronic diseases, polypharmacy, low nutrient intake, reduced appetite, and psychological factors-all frequently observed in geriatric…
- Conditions
- Thoracotomy, Toracosurgery, Thoracic Anesthesia, Older Adults (65 Years and Older)
- Trial name
- NCT07889336
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital