Clinical trials: Living Donors
Renal Transplantation
Effect of Probiotics on Immunosuppressive-drug-associated Diarrhea Among Renal Transplant Recipients
The goal of this pilot project is to 1) examine whether oral administration of probiotics are helpful in reducing immunosuppressive drugs-associated diarrhea and adhering to the required dose of immunosuppressive drugs and 2)…
- Trial name
- NCT06150287
- Testing
- Florajen Digestion
- Volunteers
- 70 people
- Sponsor
- State University of New York - Upstate Medical University
Chronic Kidney Diseases, Apolipoprotein L1
APOL1 Genetic Testing Program for Living Donors
Living donor (LD) kidney transplantation is the optimal treatment for patients with end-stage kidney disease (ESKD). However, LDs take on a higher risk of future ESKD themselves.
- Conditions
- Chronic Kidney Diseases, Apolipoprotein L1, Kidney Transplantation
- Trial name
- NCT04910867
- Testing
- Components of Genetic Counseling, APOL1 genetic testing, EHR integration
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- Northwestern University
Liver Transplant; Complications
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation
the aim of the study is to approve the hypothesis that dexmedetomidine can protect against glycocalyx degradation induced by hepatic ischemia-reperfusion injury and hence can reduce the subsequent complications as early allograft…
- Trial name
- NCT05031026
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Kidney Transplantation
Eculizumab for Prevention of Antibody-Mediated Rejection in ABO-Incompatible Living Donor Kidney Transplantation
The aim of this study is to determine whether a single dose of eculizumab can effectively prevent antibody-mediated rejection in recipients undergoing living donor kidney transplantation with a different ABO blood group type than…
- Trial name
- NCT06453135
- Testing
- Eculizumab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tao Lin
Liver Transplant; Complications, Renal Injury
Association of Intraoperative Renal Regional Oxygen Saturation and Acute Kidney Injury
This study is a prospective observational study of a single cohort of the patients who will undergo a scheduled living donor liver transplantation.
- Trial name
- NCT03877133
- Testing
- Near-infrared spectroscopy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Opioid Use, Kidney Diseases
Enhanced Recovery After Surgery in Kidney Transplant Donors
Enhanced recovery after surgery (ERAS) pathways are designed to optimize perioperative management, improving patient outcomes and satisfaction through multimodal techniques.
- Conditions
- Opioid Use, Kidney Diseases, Pain, Postoperative, Postoperative Complications
- Trial name
- NCT04110080
- Testing
- multimodal pain management, goal directed fluid management, preoperative carbohydrate loading
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Acute Pain
Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy
Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in…
- Trial name
- NCT02645903
- Testing
- Transversus Abdominis Plane Block, standard general anesthesia
- Volunteers
- 50 people
- Sponsor
- Inonu University
Kidney Disease
Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants
Diabetes and end-stage kidney, liver and heart disease are prominent health issues among veteran patients. Successful solid organ transplantation in the absence of chronic immunosuppressive therapy (specific acquired…
- Trial name
- NCT00018785
- Testing
- donor bone marrow infusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Quadratus Lumborum Block, Surgical Wound Infiltration
Surgeon Infiltration QL Block Comparison
The purpose of this study is to learn if using a Quadratus Lumborum (QL) plane injection technique (also called a "nerve block") that numbs the nerves going to the abdominal area improve pain control after surgery compared to…
- Trial name
- NCT03496610
- Testing
- Liposomal Bupivicaine, QL Block
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
Renal Transplant, DGF
Does Early Postoperative Fluid Management Affect Functional Delayed Graft Function After Living Donor Kidney Transplantation?
Fluid management in renal transplantation is of critical importance for optimizing graft function and minimizing complications such as delayed graft function (DGF) and acute kidney injury (AKI).
- Trial name
- NCT07392996
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Ankara University
Skin Closure of Surgical Incisions by Tissue Glue vs Suture
Tissue Glue (Cyanoacrylate) Versus Conventional Suture in Kidney Donors
By means of a prospective, randomised trial the investigators want to examine skin closure in living donors - subjected to laparoscopic, hand-assisted nephrectomy - by tissue glue (Cyanoacrylate (Liquiband)) versus conventional…
- Trial name
- TG-CYANO (NCT01521871)
- Testing
- Skin wound closure by tissue glue, Skin wound closure by conventional suture + dressing
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Oslo University Hospital
No Disease or Condition is Being Studied
ANI-Guided Fentanyl Infusion During Living Donor Liver Resections
Thу goal of this study was to learn whether intraoperative analgesia nociception monitoring (ANI) could be beneficial during intraoperative monitoring for patients undergoing living donor liver resections.
- Trial name
- NCT06619977
- Testing
- Analgesia nociception monitoring (ANI)
- Where
- Ukraine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University
Hematologic Malignancy, Acute Leukemia
Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic Malignancies
Prospective, multi-center open label study of HLA-partially to fully matched allogeneic cryopreserved deceased donor bone marrow transplantation and living donor transplantation for patients with hematologic malignancies.
- Conditions
- Hematologic Malignancy, Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- NCT07710781
- Testing
- Ossium HPC, Marrow, Standard of care living donor - Haplo Related, Standard of care living donor - Mismatched Unrelated
- Volunteers
- 300 people
- Sponsor
- Ossium Health, Inc.
Transplantation, Kidney, Living Donors
Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients
The aim of this study is to determine a comprehensive immune profile of transplant donors and recipients through assessment of immune cell compositions in bone marrow, and lymph nodes.
- Conditions
- Transplantation, Kidney, Living Donors, Kidney Transplant Recipients
- Trial name
- NCT01150487
- Testing
- bone marrow aspirations, lymph node collection
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Mayo Clinic
Pain, Postoperative, Donor Site Complication
Pain Management in Laparoscopic Living-donor Nephrectomy: The Impact of Erector Spinae Plane Block (ESPB) on Perioperative Period
Laparoscopic living donor nephrectomy (LLDN) is a safe procedure and rapid wound healing, affecting the quality of life. The physiology of postoperative pain after LLDN has been attributed to reasons such as tissue damage…
- Trial name
- NCT04867070
- Testing
- NAS score
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Liver Transplant
Cardiac Functions in Living Donor Liver Transplant Recipients. An Echocardiographic Study.
The stress of orthotopic living donor liver transplantation in patients with cirrhosis could induce worsening of an already recorded myocardial dysfunction or may be associated with a new myocardial dysfunction in patients…
- Trial name
- NCT01840514
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Disorder Related to Renal Transplantation, Chronic Kidney Disease
Contribution of Renal Function to Endothelial Dysfunction in Living Kidney Donors and Transplant Recipients
Endothelial dysfunction one-year after transplantation mainly depends on transplant-associated factors and only marginally on reduced renal function.
- Conditions
- Disorder Related to Renal Transplantation, Chronic Kidney Disease, Endothelial Dysfunction
- Trial name
- CONFUCIUS (NCT02515643)
- Testing
- Endothelial dysfunction
- Where
- 4 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Function of Renal Transplant
RituxiMab INDuction in Renal Transplantation
Hypothesis: That B cell depletion, rather than reducing acute rejection, will allow minimisation of immunosuppression, which may lead to better graft survival.
- Trial name
- ReMIND (NCT01095172)
- Testing
- Rituximab, Tacrolimus, Mycophenylate mofetil
- Where
- 6 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Kidney Injury, Liver Diseases
Impact of Dexmedetomidine on Acute Kidney Injury Following Living Donor Liver Transplantation
Acute kidney injury (AKI) following liver transplantation (LT) is associated with increased costs, morbidity, and mortality. Dexmedetomidine has known to have anti-inflammatory effect and has been shown to ameliorate IRI in…
- Trial name
- NCT03522688
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Asan Medical Center
End-Stage Renal Disease
Pediatric Kidney Transplant Without Calcineurin Inhibitors
The purpose of this study is to see the effect of using drugs other than calcineurin inhibitors to improve the rate of kidney transplant failure. Kidney transplantation can help children with end-stage kidney disease.
- Trial name
- NCT00023231
- Testing
- Daclizumab, Methylprednisolone/prednisone, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)