Clinical trials: Liver Surgery, open to volunteers
Liver Diseases, Surgery
A Study to Evaluate Safety and Feasibility of Robotic Liver Resection
The robotic surgery system, the most advanced technology in minimally invasive surgery, overcame some shortcomings of laparoscopic surgery and improved the flexibility and precision of liver resection.
- Trial name
- NCT06353672
- Testing
- Robotic liver resection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhejiang University
Hepatic Tumors
Prediction of Complications in Hepatic Tumors
Liver failure is one of the most severe complications in patients undergoing liver surgery for hepatic malignancies. However, it can be predicted through preoperative assessment of liver function.
- Trial name
- NCT07358975
- Testing
- [99mTc] Tc-GSA SPECT/CT
- Where
- Denmark
- Volunteers
- 192 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Transplantation
Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation
Liver transplantation carries a substantial risk of bleeding, making precise haemostasis control essential, although assessing coagulation remains challenging.
- Trial name
- QUALIVERT (NCT06749405)
- Testing
- Transfusion algorithm based on Quantra®, Conventional transfusion algorithm
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Toulouse
Obesity, Weight Loss
Bariatric Embolization of Arteries for the Treatment of Nonalcoholic Steatohepatitis
Obesity is an epidemic in the US. With progression of obesity, Nonalcoholic steatohepatitis (NASH) has been a growing public health issue.
- Conditions
- Obesity, Weight Loss, Body Weight, Nonalcoholic Steatohepatitis
- Trial name
- NCT02933554
- Testing
- Embospheres Microspheres
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Keith Pereira, MD:
Hepatocellular Carcinoma, Circulating Tumor Cell
Value of Dynamic Monitoring of Early Recurrence of Hepatocellular Carcinoma After Radical Resection Based on CTCS
On the basis of previous retrospective studies, the Task Force will further optimize the CTCs longitudinal surveillance model and initially validate the subclonal origin (CTC-DNA) of recurrent/metastatic foci derived from CTCs at…
- Conditions
- Hepatocellular Carcinoma, Circulating Tumor Cell, Recurrence, Surgery
- Trial name
- NCT06317896
- Testing
- circulating tumor cells
- Where
- 3 sites in China
- Volunteers
- 82 people
- Sponsor
- Zhujiang Hospital
Laparoscopy, Discharge Planning
Post-discharge Monitoring Initiative on Outcomes of Post-surgical Patients
The investigators are conducting a prospective study to evaluate the SKH@Home programme, a post-discharge monitoring initiative for surgical patients.
- Trial name
- SKH@home (NCT06980402)
- Testing
- Early post-surgical discharge with post-surgical home based monitoring, Standard inpatient care until deemed suitable for discharge
- Volunteers
- 1,000 people
- Sponsor
- Sengkang General Hospital
Echinococcosis, Hepatic, Biliary Fistula
Biliary Fistulas in Surgery of Liver Echinococcosis
The objective of the study is to improving the results of surgical treatment of liver echinococcosis complicated by biliary fistula by optimizing diagnostic approaches to early verification of this complication and improving the…
- Trial name
- BFISOLE (NCT06612229)
- Testing
- Conservative surgical treatment of liver echinococcosis, verification of occult biliary fistulas and their elimination by weaving and using medical cyanoacrylate glue
- Where
- Uzbekistan
- Volunteers
- 200 people
- Sponsor
- Republican Specialized Scientific and Practical Medical Center of Surgery Named After V. Vakhidov
Liver Neoplasms, Hepatobiliary Diseases
Outcomes After Liver and Biliary Resection at a High-Volume Center
The goal of this observational study is to evaluate clinical and oncologic outcomes in adult patients undergoing liver and/or biliary resection for benign and malignant diseases.
- Conditions
- Liver Neoplasms, Hepatobiliary Diseases, Cholangiocarcinoma, Hepatocellular Carcinoma
- Trial name
- BILIVER (NCT07556835)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Azienda USL Toscana Centro
Morbid Obesity, Type2diabetes
Comorbidities Resolution After MGB Surgery and Change in Body Composition
This observational study aims to learn about the correlation between the improving comorbidities associated with obesity after MGB (Mini-Gastric Bypass) surgery and changes in body composition in morbidly obese patients.
- Conditions
- Morbid Obesity, Type2diabetes, Sleep Apnea, Hypothyroidism
- Trial name
- MOGAMBO (NCT06015620)
- Testing
- Mini gastric bypass surgery
- Where
- India
- Volunteers
- 35 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Liver Metastases From Colorectal Cancer
Liver-First, Bowel-First, or Simultaneous Resection for Synchronous Colorectal Liver Metastases: Outcomes, Quality of Life, and Cost-Effectiveness
The goal of this observational study is to learn about treatment outcomes, quality of life, and healthcare costs in patients with colorectal cancer who have liver metastases detected at the same time as their primary tumor…
- Trial name
- OPTIMAL (NCT07564284)
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
HCC - Hepatocellular Carcinoma
The DoHAICs Study Expansion Phase
We explored the efficacy and safety of the first-line treatment of unresectable hepatocellular carcinoma with donafenib combined with hepatic artery infusion chemotherapy (HAIC) and sintilimab .
- Trial name
- NCT07584018
- Testing
- Donafenib, sintilimab, HAIC
- Volunteers
- 90 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Liver Transplant, Organ Perfusion
NRP vs DHOPE vs COR-NMP in ECD-DCD Donation
There is still a discrepancy between the number of liver transplant candidates and the availability of liver grafts, resulting in waiting list mortality.
- Conditions
- Liver Transplant, Organ Perfusion, Complication of Surgical Procedure
- Trial name
- NCT05327478
- Testing
- NRP, DHOPE, COR-NMP
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Anesthesia, Surgery
Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection
During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss.
- Trial name
- SHIELD-pilot (NCT07440121)
- Testing
- restrictive fluid infusion, preload, nitro
- Volunteers
- 90 people
- Sponsor
- Zhihong LU
Liver Resection, Liver Tumours
Evaluation Of Liver Resection Using Harmonic Scalpel Versus Cavitron Ultrasonic Surgical Aspirator (CUSA).
Evaluation Of Liver Resection Using Harmonic Scalpel Versus Cavitron Ultrasonic Surgical Aspirator (CUSA) Introduction The mode of parenchymal transection in hepatic resection has been a topic of great debate for decades.
- Conditions
- Liver Resection, Liver Tumours, Liver Transplant Disorder, Trauma Abdomen
- Trial name
- NCT07142876
- Testing
- Liver resection Cavitron Ultrasonic Surgical Aspirator (CUSA), Liver resection with the harmonic scalpel
- Volunteers
- 50 people
- Sponsor
- Sohag University
Colo-rectal Cancer, Liver Metastasis
The Role and Safety of Radiofrequency Ablation in Recurrent Liver Metastasis of Colorectal Cancer
The goal of this clinical trial is to learn if radiofrequency ablation works to treat recurrent colorectal cancer liver metastases after surgery in adults. It will also learn about the safety of radiofrequency ablation.
- Trial name
- NCT06609434
- Testing
- Radiofrequency ablation
- Volunteers
- 111 people
- Sponsor
- Peking University Cancer Hospital & Institute
Hepatocellular Carcinoma
ITGA6 Targeting NIR-II Fluorescence Image Guided Surgery
In this study, the investigators will detect hepatocellular carcinoma lesions using fluoescence imaging with ITGA6 targeting probes during tumor resection surgery.
- Trial name
- NCT06204835
- Testing
- RD-Cy7 fluorophore
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- Institute of Automation, Chinese Academy of Sciences
Hepatocellular Carcinoma (HCC), Metastases
Local Consolidation After Sintilimab Plus Lenvatinib for Metastatic Liver Cancer
This study evaluates whether comprehensive local consolidative therapy added to continued sintilimab plus lenvatinib improves survival compared with continued sintilimab plus lenvatinib alone in patients with oligo-extrahepatic…
- Trial name
- NCT07537946
- Testing
- Sintilimab, Lenvatinib, Comprehensive Local Consolidative Therapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tongji Hospital
Hepatocellular Carcinoma, Organoids
Organoid Models of Hepatocellular Carcinoma
A promising tool to elucidate the molecular characteristics of HCC are patient-derived organoids (PDOs), three-dimensional cultures of cells that self-organise according to tissue-specific patterns and can be used to test the…
- Conditions
- Hepatocellular Carcinoma, Organoids, Gut Microbiota, Tumor Microenvironment
- Trial name
- NCT06929845
- Testing
- organoids models
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity, Morbid, Metabolic Syndrome
Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach
Variable outcomes after weight loss surgery are likely attributable to complex, poorly understood mechanisms. Due to the significant impact that morbid obesity has on a patient's health, successful management of obesity and its…
- Conditions
- Obesity, Morbid, Metabolic Syndrome, NASH - Nonalcoholic Steatohepatitis
- Trial name
- NCT04841057
- Testing
- 50 cm BP limb length, 100 cm BP limb length, 150 cm BP limb length
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Liver Resection, Upper Abdominal Surgeries
Comparative Effects of ESP Block and EOIP Block on Postoperative Respiratory Recovery Following Liver Resection
This study evaluates respiratory recovery as a multidimensional construct using clinically relevant and measurable parameters, including LUS, diaphragmatic excursion, oxygen requirement, and PPCs.
- Trial name
- NCT07740382
- Testing
- Ultrasound-guided bilateral external oblique intercostal plane (EOIP) block, Ultrasound-guided bilateral erector spinae plane (ESP) block
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Menoufia University