Clinical trials: Liver Resection
Hepatectomy, Cancer, Metastatic
Efficacy and Tolerability of Hemopatch After Hepatic Resection
Previous in vitro and in vivo studies detected the Hemopatch Sealing Hemostat® to be a new versatile, self-adhering hemostatic sealing pad consisting of a polyethylene glycol-coated collagen.
- Conditions
- Hepatectomy, Cancer, Metastatic, Hemostasis
- Trial name
- NCT03323359
- Testing
- Hemopatch, Common Surgical Techniques
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Resection, Upper Abdominal Surgeries
Comparative Effects of ESP Block and EOIP Block on Postoperative Respiratory Recovery Following Liver Resection
This study evaluates respiratory recovery as a multidimensional construct using clinically relevant and measurable parameters, including LUS, diaphragmatic excursion, oxygen requirement, and PPCs.
- Trial name
- NCT07740382
- Testing
- Ultrasound-guided bilateral external oblique intercostal plane (EOIP) block, Ultrasound-guided bilateral erector spinae plane (ESP) block
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Menoufia University
Elective Hepatic Resection
Non-invasive Measurement of Hemoglobin Concentration With Pulse Co-oximetry
The purpose of this study is to evaluate the accuracy of continuous SpHb measurement ( Rainbow DCI, Masimo, Irvine Ca, USA) compared to the current method of monitoring (blood sampling), both during phases of hemoconcentration…
- Trial name
- NCT01060683
- Testing
- Hemoglobin determination + NaCl 0.9% bolus, hemoglobin determination + Venofundin bolus
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Colorectal Neoplasms
Anti-OX40 Antibody (MEDI6469) in Patients With Metastatic Colorectal Cancer
This study will test the ability of an immune modulator, anti-OX40 (MEDI6469) to alter the immune cell environment within colorectal cancer metastases. The drug will be administered to patients before surgical treatment.
- Trial name
- NCT02559024
- Testing
- MEDI6469
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Providence Health & Services
Hemangioma Liver
Surgical Approach in Liver Hemangiomas
Operations performed for liver hemangioma between January 2017 and December 2018 will be retrospectively analyzed.
- Trial name
- NCT04669314
- Testing
- Liver resection or enucleation for liver hemangioma
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Ankara University
Hepatic Surgery
Inflammation and Organ Impact During Hepatic Surgery
Monitoring of inflammatory substances (such as interleukins, CRP, albumine), and markers of organ dysfunction (such as creatinine, proenkephaline, amylase, troponine, IFABP and lactate) during elective liver resection.
- Trial name
- NCT03878615
- Testing
- elective surgery, according to deprtement routine
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Sahlgrenska University Hospital
Laparoscopic Hepatectomy, Hepatocellular Carcinoma
Surgical Specification and Efficacy Evaluation of Total Laparoscopic Left Liver Resection
Recent clinical experience showed that laparoscopic hepatectomy has advantages of minimally invasive compared to open liver resection, however, laparoscopic liver resection is still difficult and risky.
- Trial name
- NCT02131441
- Testing
- laparoscopic hepatectomy, open liver resection
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hepatocellular Carcinoma
SHR-1210 Plus Apatinib in Patients With Hepatocellular Carcinoma After Surgery
SHR-1210 is a humanized anti-PD1 Immunoglobulin G4 (IgG4) monoclonal antibody. This is an open- label，single center ，non-randomized ，Single Arm Exploratory Study .
- Trial name
- NCT03722875
- Testing
- SHR-1210, apatinib
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Zhongshan Hospital
Bile Leakage
Diagnostic Role of the "White Test" With Lipidic Solution in the Early Intraoperative Identification of Open Bile Ducts for the Prevention of Bile Leakage After Liver Resection (BiLe -Trial)
Bile leakage (BL) is the most frequent complication after liver resection. This study is to investigate the role of intraoperative administration of SMOFlipid 20% (fat emulsion which allows intraoperative identification of open…
- Trial name
- BiLe (NCT04523701)
- Testing
- "white" test" (= the administration of SMOFlipid retrograde through the cystic duct)
- Where
- 5 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Giulia Manzini
Liver Transplant Surgery, Colorectal Cancer Metastatic
Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM).
- Conditions
- Liver Transplant Surgery, Colorectal Cancer Metastatic, Colon Cancer Liver Metastases
- Trial name
- CLEAR (NCT06698146)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Liver Metastases, Recurrent Colon Cancer
Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer
This phase II trial studies how well giving combination chemotherapy and bevacizumab before surgery and radiolabeled monoclonal antibody therapy works in treating liver metastases in patients with metastatic colorectal cancer.
- Conditions
- Liver Metastases, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IVA Colon Cancer
- Trial name
- NCT01320683
- Testing
- oxaliplatin, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- City of Hope Medical Center
Hepatocellular Carcinoma (HCC), Downstaging
Radiomics Subtyping to Guide Surgery vs. Maintenance Therapy After HCC Downstaging
The goal of this observational study is to learn about the long-term treatment outcomes for patients with initially unresectable hepatocellular carcinoma (HCC) who achieve successful downstaging with the combination therapy of…
- Conditions
- Hepatocellular Carcinoma (HCC), Downstaging, Liver Resection, Lenvatinib
- Trial name
- NCT07581769
- Testing
- Liver resection, TACE plus Lenvatinib and PD1 inhibiter
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hepatocellular Carcinoma, Tumor Recurrence
Effect of Babaodan on Tumor Recurrence After Curative Resection of Hepatocellular Carcinoma
The aim of this study is to evaluate the effect of traditional Chinese medicine Babaodan on tumor recurrence of hepatocellular carcinoma after curative resection, as well as the safety of this treatment
- Trial name
- NCT03515369
- Testing
- Babaodan oral capsule
- Volunteers
- 459 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Indocyanine Green, Postoperative Complications
One Way to Diagnose Hepatic Insufficiency the First Postoperative Day After Resection: Prospective Cohort Study
Introduction: Hepatic insufficiency is a complication that puts the life of the patient undergoing resective surgery at risk. Thus, the diagnosis should be made early.
- Conditions
- Indocyanine Green, Postoperative Complications, Acute Liver Failure
- Trial name
- IGHI (NCT04570800)
- Volunteers
- 44 people
- Sponsor
- Castilla-La Mancha Health Service
Liver Diseases, Surgery
A Study to Evaluate Safety and Feasibility of Robotic Liver Resection
The robotic surgery system, the most advanced technology in minimally invasive surgery, overcame some shortcomings of laparoscopic surgery and improved the flexibility and precision of liver resection.
- Trial name
- NCT06353672
- Testing
- Robotic liver resection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhejiang University
Liver Cancer, Liver Failure
Quantitative MRI and Outcomes of Liver Resection
The present observational study aims to assess the benefit of this quantitative multiparametric magnetic resonance imaging (MRI) in clinical practice, to quantify future liver remnant performance, and to accurately predict the…
- Conditions
- Liver Cancer, Liver Failure, Bile Leak, Liver Metastases
- Trial name
- NCT06181318
- Testing
- Multiparametric MRI scan of the liver
- Volunteers
- 33 people
- Sponsor
- University Hospital Heidelberg
Hepatic Cancer
Direct Peritoneal Resuscitation Plus Conventional Resuscitation
The purpose of this study is to find out if direct peritoneal resuscitation (DPR) (putting a sugar solution into the abdominal cavity) helps blood flow through vital organs in the body that may suffer from low blood flow due to…
- Trial name
- NCT01882218
- Testing
- Galactose, Standard Treatment
- Where
- 2 sites in United States
- Sponsor
- University of Louisville
Rupture, Spontaneous, Rupture Liver
Management of Spontaneous Ruptured Hepatocellular Carcinoma
To investigate the best treatment for hepatocellular carcinoma rupture
- Conditions
- Rupture, Spontaneous, Rupture Liver, Hepatocellular Carcinoma
- Trial name
- NCT03516890
- Testing
- Partial hepatectomy
- Volunteers
- 216 people
- Sponsor
- Huazhong University of Science and Technology
Predictive Value of ICG Clearance Measurement During Selective Hepatic Vascular Trial Clamping on Remnant Liver Function After Anatomic Liver Resection
Predictive Value of Intraoperative Indocyanine Green Clearance Test After Partially Blood Flow Blocking in Postoperative Liver Reserve
Predictive value of intraoperative indocyanine green clearance measurement during selective hepatic vascular trial clamping on remnant liver function after anatomic liver resection.
- Trial name
- NCT03654183
- Testing
- Indocynine green clearance test
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Fudan University
Recurrent Hepatocellular Carcinoma
Efficacy Analysis of Complete Laparoscopic Resection of Recurrent Hepatocellular Carcinoma
This study is aiming to evaluate the clinical efficacy of complete laparoscopic resection of recurrent hepatocellular carcinoma (HCC).
- Trial name
- NCT02613156
- Testing
- laparoscopic resection
- Volunteers
- 25 people
- Sponsor
- Sun Yat-sen University