Clinical trials: Liver Regeneration
Liver Regeneration
To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery
Posthepatectomy liver failure (PHLF) remains a significant life-threatening problem after major hepatectomies. Pentoxifylline is shown to have potent vasodilating properties for peripheral blood vessels, along with the hepatic…
- Trial name
- NCT07085806
- Testing
- Pentoxifylline (also known as oxpentifylline), Plasmalyte
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Dysfunction, Morbidity
Von Willebrand Factor to Predict Postoperative Outcome
vWF is stored in weibel-palade-bodies of endothelial cells as well as alpha-granula of platelets and is released upon their activation.
- Conditions
- Liver Dysfunction, Morbidity, Mortality, Hospitalisation
- Trial name
- NCT02118545
- Where
- 4 sites in Austria, Switzerland
- Volunteers
- 133 people
- Sponsor
- Medical University of Vienna
Liver Regeneration, Liver Cancer
ARAPS Study on Accelerated Liver Regeneration
Liver resection is the golden standard in the treatment of hepatic malignancies. The size and function of the remnant liver is a major concern.
- Conditions
- Liver Regeneration, Liver Cancer, Liver Metastases, Liver Failure
- Trial name
- ARAPS (NCT04107324)
- Testing
- ARAPS, PVE
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Rotator Cuff Tear
Polydeoxyribonucleotide (PDRN) for Cuff Regeneration
This study is to evaluate the effect of polydeoxyribonucleotide (PDRN) for healing and fatty degeneration of rotator cuff. The investigators will enroll 130 patients with rotator cuff tear who will undergo arthroscopic rotator…
- Trial name
- NCT03916198
- Testing
- Polydeoxyribonucleotides, Normal saline
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver
HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization
This phase IIb trial tests the effect of HRX215 in treating patients with colorectal cancer that has spread from where it first started to the liver (liver metastasis) after undergoing a portal vein embolization (PVE).
- Conditions
- Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Resectable Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- NCT07612007
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Liver Metastasis Colon Cancer
Simultaneous Portal and Hepatic Vein Versus Portal Vein Embolizations for Hypertrophy of the Future Liver Remnant
The hypothesis is that liver venous deprivation (LVD) could strongly improve hypertrophy of the future remnant liver (FRL) at 3 weeks, as compared to portal vein embolization (PVE) in patient with liver metastases from…
- Trial name
- HYPER-LIV01 (NCT03841305)
- Testing
- Liver preparation before major hepatectomy
- Where
- 12 sites in France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Montpellier
Complication, Postoperative, Regeneration Liver
Randomized Controlled Trial to Study the Outcome of Intravenous Phosphate Supplementation in Live Donors Undergoing Hepatectomy for Living Donor Liver Transplantation (LDLT)
In this study, we aim to analyse the effect of phosphate supplementation on donors undergoing partial hepatectomy for LDLT. In Group A, we are going to supplement phosphate in donors postoperatively from day 1 to day 5.
- Trial name
- NCT04026438
- Testing
- Potassium Phosphate Injection
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Regeneration
Effect of Novel Donor Lifestyle Optimisation Protocol on Liver Regeneration in Live Liver Donors
Steatosis in case of live liver donors is on the rise and around 20- 40 % of prospective liver donors are estimated to have hepatic steatosis.
- Trial name
- NCT04565535
- Testing
- Novel donor lifestyle optimisation protocol
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Neoplasms, Liver Regeneration
Registry of Major Liver Resections Including ALPPS and Other Liver Resections in Two Stages
Recently a new method of induce similar hypertrophy in the liver as is observed after hepatectomy has been described and was given the eponym "ALLPS".
- Trial name
- ALPPSREG (NCT01924741)
- Testing
- ALPPS
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Liver Cirrhosis
Safety and Feasibility of Human Umbilical Cord Mesenchymal Stem Cell-Derived Secretome in the Treatment of Liver Cirrhosis: a Comprehensive Evaluation of Fibrosis Reduction, Immunomodulation, and Hepatic Regeneration: a Single Center, Randomized, Phase I Clinical Trial
The goal of this clinical trial is to learn if Human Umbilical Cord Mesenchymal Stem Cell (HUCMSC) derived secretome injection is safe and effective in patient with liver cirrhosis. The main questions it ams to answer are: 1.
- Trial name
- NCT06629909
- Testing
- Secretome
- Where
- Indonesia
- Volunteers
- 54 people
- Sponsor
- Baermed
Liver Diseases, Hepatectomy
Liver Regeneration After Liver Resection
The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy.
- Trial name
- NCT01220986
- Testing
- Liver biopsy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury
Renal Histopathology and Transcriptomic Analysis in Hepatorenal Syndrome During Liver Transplantation
Hepatorenal Syndrome (HRS) is a serious complication that can occur in patients with liver cirrhosis, characterised by kidney dysfunction, or acute kidney failure (AKI).
- Conditions
- Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury, Liver Transplant
- Trial name
- NCT07300709
- Testing
- renal biopsy
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- The University of Hong Kong
Hepato Cellular Carcinoma (HCC), Hepatobiliary Cancers
Effect and Mechanism of ALPPS Operation on Liver Regeneration
Hepatobiliary malignancies-principally hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA)-are highly aggressive and often diagnosed at advanced stages.
- Conditions
- Hepato Cellular Carcinoma (HCC), Hepatobiliary Cancers, Liver Cancer, Liver Regeneration
- Trial name
- NCT07142213
- Testing
- ALPPS
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Haitao Zhao, MD
Liver Transplant Rejection
Cell Infusion Intraportal Autologous Bone Marrow Mononuclear as Enhancer of Liver Regeneration
This is a randomized controlled trial in which the safety and feasibility of cell therapy medicinal product shall be measured by comparing the variables of the response after treatment compared to baseline prior to…
- Trial name
- NCT01745731
- Testing
- Cell infusion intraportal mononuclear bone marrow autologous and portal embolization of the affected segments.
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Liver Regeneration, Liver Metastases
Impact of Chemotherapy and Regenerative Markers of Liver Regeneration After Liver Resection for Liver Metastases
Liver is special organ, which can regenerate. On that ability there are many treatment modalities, where liver resection is performed, especially in cancer patients with liver metastases.
- Trial name
- VULSK-Hep (NCT04178759)
- Testing
- Liver resection
- Where
- Lithuania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Procedure-Related Complication, Degree of Liver Regeneration
Ipsilateral Hepatic Vein Embolization After Portal Vein Embolization
Portal vein embolization (PVE) induces shrinkage of the embolized lobe and compensatory enlargement of the non-embolized lobe, but it does not always induce sufficient liver regeneration.
- Trial name
- NCT00698880
- Testing
- Right hepatic vein embolization
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Asan Medical Center
Malignant Liver Disease, Major Liver Resection
Administration of Rifaximin to Improve Liver Regeneration and Outcome Following Major Liver Resection
Surgery is in almost all cases the only potentially curative treatment option for patients with primary or secondary malignancies of the liver.
- Trial name
- ARROW (NCT02555293)
- Testing
- XIFAXAN® (Rifaximin)
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- RWTH Aachen University
Liver Regeneration
Safety Study of Liver Regeneration Therapy Using Cultured Autologous BMSCs
Patients eligible for this study include those with decompensated liver cirrhosis with a Child-Pugh score ≥7 (Child-Pugh B) in whom further improvement with current medical treatment is not expected.
- Trial name
- NCT02327832
- Testing
- Autologous BMSCs, bone marrow-derived mesenchymal stem cells
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Yamaguchi University Hospital
Chronic Liver Disease
Effect of Ursodeoxycholic Acid Supplementation on Liver Regeneration in Adult Living Donor Liver Transplant (LDLT) Recipients.
This placebo controlled randomized control study aims to analyze the effect of UDCA supplementation on liver regeneration in Living Donor Liver Transplant (LDLT) recipients.
- Trial name
- NCT07664020
- Testing
- Ursodeoxycholic acid, Standard Medical Treatment
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Insufficiency
Metabolomics of Liver Regeneration Following Partial Hepatectomy in Healthy Living Liver Donors
The PI will study metabolism during liver regeneration in living liver donors
- Trial name
- NCT01922323
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute