Clinical trials: Life Limiting Conditions
COPD, Heart Failure
Personalized Experiences to Inform Improved Communication for Minorities With Life Limiting Illness
The purpose of this research is to develop patient-centered palliative care interventions to improve patient-provider communication and Quality of Life (QoL) of ethnic and racial minority patients living with life-limiting…
- Conditions
- COPD, Heart Failure, Cancer
- Trial name
- NCT03391115
- Testing
- Storytelling Intervention for Patient Participants, Storytelling Intervention for Nurse Participants
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Disease, Life-limiting Illness
Quality of Life Assessment and Practice Support System in Home Care Services for Older Adults
Older adults living with incurable and advancing life-limiting illness frequently desire to spend as much time as possible comfortably at home, rather than in hospital.
- Conditions
- Chronic Disease, Life-limiting Illness, Palliative Care
- Trial name
- QPSS (NCT02940951)
- Testing
- QPSS, Usual care
- Where
- 2 sites in Canada
- Volunteers
- 565 people
- Sponsor
- Trinity Western University
Pediatric Palliative Care, Life Limiting Conditions
Experiential and Relaxation Virtual Reality as a Tool for Easing Anxiety in Seriously Ill Children
The goal of this clinical trial is to assess the use of experiential and relaxation virtual reality (VR) interventions in easing anxiety and other distress symptoms in children with life-limiting and/or life-threatening…
- Conditions
- Pediatric Palliative Care, Life Limiting Conditions, Life Threatening Diseases
- Trial name
- NCT06915883
- Testing
- Relaxation virtual reality (VR), Experiential virtual reality (VR)
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- National Institute of Mental Health, Czech Republic
Cancer, Cardiac Disease
A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders
Rural patients with life-limiting illness are at very high risk of not receiving appropriate care due to a lack of health professionals, long distances to treatment centers, and limited palliative care (PC) clinical expertise.
- Conditions
- Cancer, Cardiac Disease, Pulmonary Disease, Neuro-Degenerative Disease
- Trial name
- NCT03767517
- Testing
- Active Intervention, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 209 people
- Sponsor
- University of Alabama at Birmingham
Severe Life-limiting COPD, Severe Life-limiting Heart Failure
Communication During Hospitalization About Resuscitation Trial
This multicenter RCT of 200 hospitalized patients and their family members evaluates an "informed assent" approach to discussing cardiopulmonary resuscitation, compared to usual care, in older seriously ill hospitalized patients…
- Conditions
- Severe Life-limiting COPD, Severe Life-limiting Heart Failure, Severe Life-limiting Cirrhosis, Severe Life-limiting Malignancy
- Trial name
- CHART (NCT02984124)
- Testing
- Informed Assent Discussion, Usual Care with Attention Control
- Where
- 4 sites in United States
- Volunteers
- 182 people
- Sponsor
- University of Vermont
Anorexia, Cachexia
Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer
RATIONALE: Megestrol helps improve appetite. It is not yet known if megestrol is effective in limiting weight loss caused by cancer.
- Conditions
- Anorexia, Cachexia, Head and Neck Cancer, Quality of Life
- Trial name
- NCT00006799
- Testing
- megestrol acetate, quality-of-life assessment
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Bradycardia
LIFE Study - Limiting Chronotropic Incompetence for Pacemaker Recipients
This study will compare how two different sensors inside the pacemaker may affect patients' quality of life.
- Trial name
- NCT00146861
- Testing
- sensor programming
- Volunteers
- 1,500 people
- Sponsor
- Boston Scientific Corporation
Neuroendocrine Tumors, Carcinoid Tumor of GI System
Evaluating an Amino Acid Based Medical Food w/ Diarrhea in Carcinoid Syndrome & Other NETs
Primary Objective: To assess how an amino acid based medical food (Enterade®) helps maintain the intestine's ability to absorb and retain fluids, leading to a reduction in diarrhea due to Neuroendocrine Tumors (NET) and/or…
- Conditions
- Neuroendocrine Tumors, Carcinoid Tumor of GI System, Diarrhea, Carcinoid Syndrome
- Trial name
- NCT03722511
- Testing
- Amino Acid Based Medical Food/Drink
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lowell Anthony, MD
Quality of Life, Chronic Disease
Comprehensive Care of Children With Medical Complexity
Under the auspice of 'Specially for Children and with funding from the Seton Healthcare Family, Children's Comprehensive Care (CCC) in Austin, Texas, has developed a coordinated and integrated model of care for children with…
- Conditions
- Quality of Life, Chronic Disease, Chronic Illness
- Trial name
- NCT01834456
- Testing
- Med Complex Children Intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Seton Healthcare Family
Neurological Impairment
Music Therapy for Pain Modification in Pediatric Palliative Care
The purpose of this within-subjects randomized controlled trial is to determine whether two music therapy interventions are efficacious in reducing pain symptoms, in order to improve the quality of care for children in pediatric…
- Trial name
- NCT01456884
- Testing
- Live guitar and vocal music therapy, Vibroacoustic Music Therapy
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of British Columbia
Xerostomia, Dry Mouth
Xerostomia in Patients With a Life-limiting Condition or Frailty
Xerostomia, the subjective feeling of dry mouth, is a common symptom during the last year of life in patients with a life-limiting condition or frailty.
- Trial name
- NCT05506137
- Testing
- Pilocarpine
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Xerostomia, End of Life
A Mouth Education Program for Dry Mouth
The goal of this cluster based intervention trial is to evaluate the effect of a nurse-led patient education program on dry mouth in patients with a life-limiting condition or frailty.
- Conditions
- Xerostomia, End of Life, Frailty, Dry Mouth
- Trial name
- MEP (NCT05964959)
- Testing
- Mouth Educational Program, Care as Usual
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Leiden University Medical Center
Sickle Cell Disease
Patient and Public Involvement and Engagement in Research With Children and Young People With Sickle Cell Disorder and Their Families
Aim: To co-produce resources for inclusive and equitable Patient and Public Involvement and Engagement in research on life-limiting conditions, with children and young people with sickle cell disorder and their families.
- Trial name
- NCT06293222
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College London
Anorexia, Cachexia
Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer
RATIONALE: Megestrol helps improve appetite. It is not yet known if megestrol is effective in limiting weight loss in patients who are undergoing radiation therapy.
- Conditions
- Anorexia, Cachexia, Lung Cancer
- Trial name
- NCT00031785
- Testing
- megestrol acetate, radiation therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Pressure Injury, Limitation, Mobility
Effect of Structured Pressure Injury Patient Education
This study was planned as a prospective quasi-experimental study with the control group to determine the effect of structured pressure injury patient education (program on the knowledge, participation, wound healing progress, and…
- Trial name
- SPIPE (NCT04944186)
- Testing
- Structured Pressure Injury Patient Education (mySPIPE), Standard Patient Education
- Where
- Malaysia
- Volunteers
- 116 people
- Sponsor
- University of Malaya
Decision Making About Life-sustaining Treatment in Patients With Serious Cardiac, Respiratory and Oncological Conditions Likely to Limit Life Expectancy
Intuition vs. Deliberation in Medical Decision Making
The purpose of this study is to determine whether there are systematic differences between the decisions patients make intuitively versus deliberatively about life-sustaining medical therapies.
- Trial name
- NCT02487810
- Testing
- Cognitive load, Deliberative instructions
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
Critically Ill
Health and Quality of Life One Year After Discharge From the Intensive Care Unit (ICU)
The goal is to capture the Quality of life and survival of patients one year after the stay at ICU. Data will be collected during the stay in the ICU and evaluated.
- Trial name
- QoL_ICU (NCT02671916)
- Testing
- questionnaire
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- Prof. Dr. med. Cristoph Haberthür
Obesity, Frailty
Weight Loss and Exercise in Physically Limited Obese Elderly Subjects
The overall purpose of this research is to determine the effect of weight loss and physical training on quality of life, physical function, metabolism, bone strength, body fat and muscle mass.
- Conditions
- Obesity, Frailty, Elderly
- Trial name
- NCT00146133
- Testing
- diet, exercise
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Washington University School of Medicine
Complex Care, Medical Complexity
Complexity in Health, Education, and Social Support for Children and Young People With Life-limiting Conditions.
Children and young people (CYP) with life-limiting conditions represent a growing population with complex care needs that span health, education, and social care systems.
- Conditions
- Complex Care, Medical Complexity, Pediatrics, Life-limiting Illness
- Trial name
- CHESS (NCT07102433)
- Testing
- Children and young people with life-limiting conditions, their parents/carers, and professionals across healthcare, education, and social care sectors.
- Where
- 5 sites in United Kingdom
- Volunteers
- 170 people
- Sponsor
- King's College London
Critical Illness
Cost Effectiveness Analysis of Critical Care in Resource Limited Setting
The purpose of this study was to examine the cost effectiveness of critical care in a middle income country with limited resources. The main study hypothesis was that critical care is cost effective in low resources setting.
- Trial name
- CEACCLR (NCT02556476)
- Testing
- mechanical ventilation, neuromuscular blockade, renal replacement therapy
- Volunteers
- 148 people
- Sponsor
- University of Sarajevo