Clinical trials: Lichen Planus, Oral
Lichen Planus
Adjunctive Oral Systemic Vitamin E Therapy on Salivary Nitric Oxide Level in Patients With Erosive Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory disease affecting the skin, mucous membranes,s and rarely scalp and nails. It is a T-cell-mediated autoimmune disease.
- Trial name
- NCT05787925
- Testing
- Topical corticosteroid and Vitamin E, Topical corticosteroid
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Hams Hamed Abdelrahman
Oral Lichen Planus
Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study
Due to the change of life style, the incidence of oral cavity mucous membrane disease increased.In this study，been done a large number of pre-clinical practice and some experimental studies， based on the application of…
- Trial name
- OLP (NCT02332486)
- Testing
- Qingxuan Decoction
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Heilongjiang University of Chinese Medicine
Lichen Planus, Oral
The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus
evaluate clinically and biochemically the efficacy of topically applied selenium as complementary or alternative to triamcinolone acetonide 0.1% and tacrolimus 0.1% in patients with oral lichen planus.
- Trial name
- RCT (NCT06362005)
- Testing
- Triamcinolone Acetonide 0.1% Oint, Tacrollimus Topical, Selenium
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Oral Lichen Planus
Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases
On the basis of previous studies, a validation cohort will be established to explore the relationship between oral lichen planus and autoimmune thyroid diseases, and a disease efficacy prediction strategy can be formed.
- Trial name
- NCT05403216
- Testing
- no intervention
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Oral Lichen Planus
Free Soft Tissue Graft in Treatment of Oral Lichen Planus
Oral lichen planus is a common chronic mucocutaneous disease with various clinical forms. Erosive-ulcerative forms usually cause symptoms of pain and discomfort.
- Trial name
- TOLP (NCT00737854)
- Testing
- Surgical resection
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Qazvin University Of Medical Sciences
Oral Lichen Planus
The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus
Oral Lichen Planus (OLP) is an inflammatory disease of mucosal and skin with unknown etiology. The prevalence rate in England is reported to be between 1-2.4%.
- Trial name
- CABRIO (NCT03052179)
- Testing
- Poly-biotic
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Oral Lichen Planus, Oral Cancer
Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions
investigating the level of malondialdehyde (MDA) \& nitric oxide (NO) in saliva in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant and potentially malignant lesions.
- Conditions
- Oral Lichen Planus, Oral Cancer, Leukoplakia, Oral Keratoses
- Trial name
- NCT04267419
- Testing
- salivary biomarker
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Oral Lichen Planus, Oral Squamous Cell Carcinoma
Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity
The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa.
- Trial name
- NCT03026361
- Testing
- global proteomic profiling
- Where
- Croatia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Lichen Planus, Oral
Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory and relapsing. The average prevalence is 1 to 4%. The clinics forms are many and symptoms are varied.
- Trial name
- LICHENVIR (NCT02276573)
- Testing
- buccal cavity sample
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lichen Planopilaris, Frontal Fibrosing Alopecia
Oral Low-Dose Naltrexone for Lichen Planopilaris and Frontal Fibrosing Alopecia
Oral naltrexone was initially FDA approved to treat opioid use disorder and alcohol dependence at doses from 50-100mg/day. At lower doses of 1-5mg/day, naltrexone has been used off-label with success in treatment of several…
- Trial name
- NCT04409041
- Testing
- Low-Dose Naltrexone
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model
This study aims to improve how oral mucosal disorders-such as oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, herpes viral infection and oral candidiasis-are treated in dental settings.
- Conditions
- Oral Lichen Planus, Recurrent Aphthous Stomatitis, Burning Mouth Syndrome, Oral Candidiasis
- Trial name
- NCT07721090
- Testing
- Pharmacist-Led Prescribing Optimization and Patient Counselling
- Volunteers
- 336 people
- Sponsor
- University of Fujairah
Oral Lichen Planus
Effect of Adjunctive Systemic Vitamin E on Clinical Parameters and Salivary Total Antioxidant Capacity in Symptomatic Oral Lichen Planus Patients: Randomized-controlled Clinical Trial
Treatment of oral lichen planus is challenging. Diverse therapeutic modalities have been suggested, but a permanent cure is not yet available.
- Trial name
- NCT04126720
- Testing
- topical corticosteroids and vitamin E suplements
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Evaluation of Efficacy and Safety of add-on Tofacitinib in Patients With Oral Lichen Planus
Many of the patients with oral lichen planus (OLP) either fail to achieve complete remission or experience frequent relapses with conventional topical corticosteroid therapy, which is currently the mainstay of treatment.
- Trial name
- NCT07131813
- Testing
- Tofacitinib 5 mg BID and Triamcinolone ointment
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Oral Lichen Planus, Oral Lichen Planus Related Stress
Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus
The goal of this clinical trial is to learn if a mucoadhesive patch containing clobetasol alone or in combination with resveratrol can reduce symptoms and improve quality of life in adults with Oral Lichen Planus (OLP).
- Conditions
- Oral Lichen Planus, Oral Lichen Planus Related Stress, Oral Mucosal Disease, Oral Pain
- Trial name
- EMPATIA (NCT07100613)
- Testing
- Clobetasol Patch, Clobetasol + Resveratrol Patch, Clobetasol in Orabase
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Palermo
Gingival Diseases, Gingivitis
Acquired Chronic Erosive Gingivitis: Clinical Relevance of Papillary Gingival Biopsy
Chronic erosive gingivitis is a syndrome (CEGS) that combines severe gingival inflammation and gingival erosion. The term "desquamative gingivitis" is often used in the literature to define chronic erosive gingivitis.
- Conditions
- Gingival Diseases, Gingivitis, Autoimmune Diseases, Oral Lichen Planus
- Trial name
- NCT04293718
- Testing
- papillary gum biopsies
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oral Lichen Planus
Evaluation of Efficacy of Neem (Azadirachta Indica) Versus Triamcinolone Acetonide in the Treatment of Oral Lichen Planus.
The goal of this clinical trial is to learn if Neem works to treat Oral Lichen Planus in adults. It will also learn about the safety of Neem in oral lesions.
- Trial name
- NCT07141446
- Testing
- Neem gel, Triamcinolone Acetonide
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Goa Dental College
Oral Lichen Planus, Erosive Lichen Planus
Photobiomodulation, Photodynamic Therapy, and Clobetasol in the Treatment of Oral Lichen Planus.
This study aims to compare three treatment approaches for the erosive form of oral lichen planus, a chronic inflammatory condition that often causes pain, impaired oral function, and frequent relapses.
- Conditions
- Oral Lichen Planus, Erosive Lichen Planus, Mucosal Lesions
- Trial name
- NCT07278999
- Testing
- Photobiomodulation using 635 nm diode laser, Photodynamic therapy - laser mucosal treatment, Clobetasol propionate 0.05 percent topical application
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Silesia
Lichen Planopilaris
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with lichen planopilaris
- Trial name
- ALPINE (NCT07532603)
- Testing
- Oral Brepocitinib
- Where
- 61 sites in United States, Australia and 2 more
- Volunteers
- 342 people
- Sponsor
- Priovant Therapeutics, Inc.
Oral Lichen Planus
Effectiveness of a Sodium Hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash for the Treatment of Symptomatic Oral Lichen Planus
Annex 1. Patient Information and Informed Consent for the Study Study Title: Effectiveness of a sodium hyaluronate 0.01% and Sh-Oligopeptide-85 SP mouthwash for the treatment of symptomatic oral lichen planus: a randomized…
- Trial name
- NCT07280442
- Testing
- Sodium hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Complutense de Madrid
Oral Lichen Planus
Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus
Lichen planus is an inflammatory disorder of unknown aetiology affecting the stratified squamous epithelia, with an estimated global prevalence of 0.22 to 0.5 %.
- Trial name
- NCT06260904
- Testing
- Prednisolone, Apremilast, Methotrexate
- Where
- India
- Volunteers
- 64 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar