Clinical trials: Lentigo
Lentigo, Melasma
Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion
Hypothesis - The developments of solar lentigine and melasma are due to mutations in keratinocytes that drive the production and transfer of pigment from melanocytes to keratinocytes.
- Trial name
- NCT01136629
- Where
- Singapore
- Volunteers
- 160 people
- Sponsor
- National University Hospital, Singapore
Solar Lentigo, Senile Lentigo
Tolerance and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots.
CS5_3 aims to evaluate the tolerance and to adjust the mode of administration of 4 different conditions of cryotherapy treatments applied on the brown spots of the face and hands with 3 prototypes.
- Conditions
- Solar Lentigo, Senile Lentigo, Post-inflammatory Hyperpigmentation
- Trial name
- NCT05625815
- Testing
- Prototypes (816-v1 001) to (816-v1 050), Prototype (816-v1 051) to (816-v1 100), Prototypes (816-v1 101) to (816-v1 150)
- Where
- South Africa
- Volunteers
- 32 people
- Sponsor
- Cryonove Pharma
Lentigo Solar
Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots PROOF OF CONCEPT
CRYO (N° 21D588A0001) study aims to evaluate the tolerance and adjust the mode of administration of a cyto-selective difluoroethane-based cryotherapy in the treatment of brown spots.
- Trial name
- CRYO-EC4 (NCT05014321)
- Testing
- EC16 medical device (CE marked), device prototype (810A-v1), device prototype (810B-v1)
- Where
- Ukraine
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cryonove Pharma
Skin Cancer, Melanoma
In Vivo Confocal Microscopy for Pigmented Lesion Diagnosis
The purpose of this study is to image pigmented skin lesions suspicious for melanoma with an imaging technology called in vivo reflectance confocal microscopy.
- Conditions
- Skin Cancer, Melanoma, Lentigo Maligna
- Trial name
- NCT00785369
- Testing
- Reflectance confocal microscopy
- Where
- 6 sites in United States
- Volunteers
- 441 people
- Sponsor
- Lucid, Inc.
Noonan Syndrome, LEOPARD Syndrome
Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes
Noonan and LEOPARD syndromes share, with variable severity, different clinical traits, notably craniofacial manifestations, cardiopathies, short stature, and juvenile cancers.
- Trial name
- NOLEO (NCT02486731)
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Photoaging, Lentigo
TCA 15% Chemical Peel for Improvement in Hand Lentigines
This study will evaluate the efficacy of the a 15% trichloroacetic acid + 3% glycolic acid peel combination for treatment of lentigines on the hands. This peel combination is sold over the counter.
- Trial name
- NCT05471947
- Testing
- 15% Trichloroacetic acid + 3% glycolic acid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Main Line Center for Laser Surgery
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06268496
- Testing
- serum formula 2039125 03
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06320314
- Testing
- tested product (2039125 03)
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Pancreatic Neoplasm, Peutz-Jeghers Syndrome
Cancer of the Pancreas Screening Study (CAPS 3)
The purpose of this study is to find the best and most sensitive screening modality (CT, MRI, EUS)for very small pre-cancerous pancreatic lesions and to treat these small lesions before they turn into cancer.
- Trial name
- CAPS 3 (NCT00438906)
- Testing
- Biopsy, Fine Needle Aspiration (FNA), Secretin (human synthetic) - ChiRhoClin
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Melanoma (Skin), Basal Cell Carcinoma
Use of Electrical Impedance Spectroscopy (EIS) for Early Diagnosis of Skin Damage
The purpose of this clinical study is to evaluate if the DermaSense prototype EIS scanner can provide medical decision support which can complement dermoscopy-based identification of the disease at time of biopsy decision.
- Conditions
- Melanoma (Skin), Basal Cell Carcinoma, Squamous Cell Carcinoma, Dysplastic Nevus Syndrome
- Trial name
- DermaSense (NCT04688749)
- Testing
- Electrical Impedence Spectroscopy DermaSense
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Li Fraumeni Syndrome, Lynch Syndrome
Inherited Cancer Early Diagnosis (ICED) Study
ICED is a prospective sample collection research study, aiming to develop or validate a blood/urine biomarker which could potentially detect cancers early in individuals at high risk of developing cancers, due to certain germline…
- Conditions
- Li Fraumeni Syndrome, Lynch Syndrome, Hereditary Diffuse Gastric Cancer, Cowden Syndrome
- Trial name
- ICED (NCT06163365)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Solar Lentigo
Tolerance of Cyto-selective Difluoroethane-based Cryotherapy
Cryotherapy is more and more used to improve skin appearance. Devices using difluoroethane, manufactured by CRYONOVE PHARMA, are already available on the local and international markets, e.g.
- Trial name
- AGILE3 (NCT05322668)
- Testing
- Prototypes (812A-v1), (812C-v1), (812D-v1) and (812F-v1)
- Where
- Ukraine
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Cryonove Pharma
Solar Lentigo
Evaluation of Broadband Light Treatment for Solar Lentigines
Broadband light treatment for Solar Lentigines
- Trial name
- NCT06363240
- Testing
- Broadband Light
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Sciton
Solar Lentigo
Clinical Evaluation of the Performance of a Difluoroethane-based Cyto-selective Cryotherapy to Treat Dark Spots on the Hand in 30 Volunteers.
This study evaluates the performance of "CRYOBEAUTY MAINS", a Cyto-selective Cryotherapy based on Difluoroethane as a treatment of Solar Lentigines in 30 volunteers.
- Trial name
- CBT (NCT03157427)
- Testing
- CRYOBEAUTY MAINS
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Cryobeauty
Familial Pancreatic Cancer, BRCA1 Mutation
Registry of Subjects at Risk of Pancreatic Cancer
IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.
- Conditions
- Familial Pancreatic Cancer, BRCA1 Mutation, BRCA2 Mutation, Lynch Syndrome
- Trial name
- IRFARPC (NCT04095195)
- Testing
- MRCP, Endoultrasonography
- Where
- 4 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Associazione Italiana per lo Studio del Pancreas
Basal Cell Carcinoma, Lentigo Maligna
Comparison of 3 in Vivo Microscopic Imaging Techniques for the Diagnosis of Pigmented Tumors
Reflectance confocal microscopy (RCM) is the reference in vivo imaging technique for identifying malignant melanocytic tumors prior to surgical excision.
- Conditions
- Basal Cell Carcinoma, Lentigo Maligna, Melanoma, Nevus
- Trial name
- Micro3 (NCT06046144)
- Testing
- Fluorescence-Advanced videodermatoscopy, Reflectance confocal microscopy, Super-high magnification dermoscopy
- Where
- France
- Volunteers
- 161 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Lentigo Maligna
Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream
This study investigates the efficacy of photodynamic therapy (PDT) in the treatment of lentigo maligna (LM). Hyperspectral imaging system (HIS) will be used to determine the margins of LM and to rule out possible invasion.
- Trial name
- LM PDT (NCT02685592)
- Testing
- 5-aminolevulinic acid nanoemulsion
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Facial Solar Lentigines
Study for the RevLite Laser System for Facial Solar Lentigines
The purpose of this study is to evaluate the effects of the Revlite Laser System for treatment of facial solar lentigines
- Trial name
- NCT02110108
- Testing
- Revlite Laser System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cynosure, Inc.
Lentigo Maligna, Melanoma In Situ
Mohs and Immunofluorescence for Malignant Melanoma In Situ
The purpose of this study is to determine if immunofluorescence (IF) can effectively identify features of malignant melanoma in situ, on sun-damaged skin, in the setting of Mohs Micrographic Surgery.
- Trial name
- NCT02306512
- Testing
- H&E, IHC MART-1, IF MART-1
- Where
- 2 sites in United States
- Sponsor
- University of Miami
Pancreas Cancer, Peutz-Jeghers Syndrome (PJS)
The Cancer of the Pancreas Screening-5 CAPS5)Study
Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.
- Conditions
- Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier
- Trial name
- CAPS5 (NCT02000089)
- Testing
- Secretin, MRI, Tumor marker gene test with CA19-9
- Where
- 9 sites in United States
- Volunteers
- 9,000 people
- Sponsor
- Johns Hopkins University