Clinical trials: Left Main Coronary Artery Disease
Cardiovascular Diseases
Time-trend Analysis of Clinical Characteristic and Outcomes in Patients With Unprotected Left Main Coronary Artery Disease Treated With PCI Over a 10-year Period
Surgical coronary bypass surgery (CABG) has been demonstrated to confer significant survival benefit over medical therapies patients with LMCA in earlier clinical trials1,2,3 and therefore was the revascularization modality of…
- Trial name
- NCT05548023
- Testing
- The AngioliteTM Durable Fluoroacrylate Polymer-based Sirolimus-Eluting Stent
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Disease (non-left Main), Coronary Bifurcation Lesion
The European Bifurcation Club Randomized Trial of Stepwise Provisional Stenting Versus Drug Coated Balloon Therapy for Non-left Main True Coronary Bifurcations
Clinical outcomes are worse in patients with coronary artery bifurcation lesions, even if commonly encountered in clinical practice.
- Trial name
- EBC DCB (NCT06822322)
- Testing
- Percutaneous Coronary Angioplasty, Stepwise Provisional Stent Strategy, Drug Coated Balloon Strategy
- Volunteers
- 750 people
- Sponsor
- Ceric Sàrl
Coronary Artery Disease Left Main, Coronary Artery Disease
Fractional Flow Reserve Versus Angiography for Treatment-Decision and Evaluation of Significant Left MAIN Coronary Artery Disease
The primary purpose of the study was to determine whether the 2-year probability of major adverse cardiac events (primary composite outcome) differed significantly between patients who underwent angiography-guided Percutaneous…
- Trial name
- FATE-MAIN (NCT05829889)
- Testing
- FFR-Guided PCI, Angiography-Guided PCI
- Where
- 49 sites in Hong Kong, India and 3 more
- Volunteers
- 960 people
- Sponsor
- Seung-Jung Park
Coronary Stenosis, Stent Stenosis
Culotte Versus DK-CRUSH Technique in Non-left Main Coronary Bifurcation Lesions
Randomised comparison of Culotte technique versus "Double Kissing" - Crush technique (DK-Crush) for the percutaneous treatment of de novo non-left main coronary bifurcation lesions with modern everolimus-eluting stents (DES) …
- Trial name
- BBK-3 (NCT04192760)
- Testing
- Stenting
- Where
- 13 sites in Germany
- Volunteers
- 400 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Stable Angina, Non-ST-elevation Acute Coronary Syndrome
Japanese Coronary Intervention Using Drug Eluting and Perfusion Therapy for Left Main Disease (JDEPTH-LM Registry)
JDEPTH-LM Registry is a prospective, observational, multi-center study designed for the efficacy and safety of Double-effect kissing balloon technique (W-KBT) in left main (LM) bifurcation percutaneous coronary intervention (PCI)…
- Conditions
- Stable Angina, Non-ST-elevation Acute Coronary Syndrome, Unstable Angina
- Trial name
- NCT06436092
- Where
- 32 sites in Japan
- Volunteers
- 280 people
- Sponsor
- TCROSS Co., Ltd.
Coronary Artery Disease
Clinical and Procedural Outcomes of Ostial Left Anterior Descending Artery Intervention With or Without Crossover to Left-main
Prospective interventional study evaluating clinical and procedural outcomes of patients with ostial left anterior descending artery lesion PCI alone or crossover with left main artery
- Trial name
- NCT05933473
- Testing
- Percutaneous coronary intervention
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease, Coronary Artery Bypass Grafting
Total Arterial vs. Mixed Grafting in Left Coronary CABG
This is a prospective, randomized, double-blind controlled trial comparing the clinical efficacy of total arterial grafting (internal thoracic artery and radial artery) versus conventional mixed grafting (internal thoracic artery…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Arterial Graft, Graft Patency
- Trial name
- NCT07057713
- Testing
- Total Arterial Grafting, Conventional Mixed Grafting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Hospital of Jilin University
ST Elevation (STEMI) Myocardial Infarction
PICSO in Patients With STEMI Treated by Primary Percutaneous Coronary Intervention
A prospective multi-center study in which patients with an acute heart attack (in the left anterior descending artery) with ECG changes (ST segment elevation) receive angioplasty followed by stent placement and 90 minutes of…
- Trial name
- pRAMSES (NCT01493037)
- Testing
- PICSO (Pressure-controlled Intermittent Coronary Occlusion
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Miracor Medical SA
Coronary Stenosis
POLish Bifurcation Optimal Treatment Strategy Study for Left Main Bifurcation Percutaneous Coronary Intervention (PCI)
The primary objective of this study is to study the safety and efficacy of the BiOSS LIM C with respect to Patient oriented Composite Endpoint (PoCE) at 12 months in a "real world" left-main bifurcation population and as compared…
- Trial name
- POLBOS-LM (NCT03508219)
- Testing
- BiOSS LIM C
- Where
- 15 sites in France, Italy and 1 more
- Volunteers
- 130 people
- Sponsor
- ECRI bv
ST Elevation Myocardial Infarction, Remodeling, Left Ventricle
Predictors of Adverse Left Ventricular Remodeling and Final Infarct Size After Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: A Strain Analysis Study Using Echocardiography and Feature Tracking Cardiac Magnetic Resonance
ST-segment elevation myocardial infarction (STEMI) is one of the most important causes of death and disability around the world.
- Trial name
- NCT04773652
- Testing
- speckle tracking echo
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Coronary Artery Disease
Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease
The primary objective of the PRE-COMBAT trial is: To establish the safety and effectiveness of coronary stenting with the sirolimus-eluting balloon expandable stent (Cordis Johnson \& Johnson, Warren, New Jersey) compared with…
- Trial name
- PRECOMBAT (NCT00422968)
- Testing
- Percutaneous coronary intervention, coronary artery bypass graft
- Where
- 13 sites in South Korea
- Volunteers
- 1,454 people
- Sponsor
- Seung-Jung Park
Left Main Coronary Artery
LMCA Treatment Outcome
Left main coronary artery (LMCA) is a major branch of coronary artery and supplies a large bulk of myocardium. Revascularization by either surgical coronary bypass grafting (CABG) or percutaneous coronary intervention (PCI) is…
- Trial name
- NCT06431516
- Where
- Hong Kong
- Volunteers
- 4,600 people
- Sponsor
- Chinese University of Hong Kong
Multivessel Coronary Artery Disease
Insights From the FAST-TRACK CABG Trial: a Clinical Outcome Study in Patient With Previous Surgical Revascularization for Complex Three-vessel or Left Main Coronary Artery Disease Based on Coronary Computed Tomography Angiogram, and Fractional Flow Reserve Derived by Computed Tomography
Coronary computed tomography angiography (CCTA) is a non-invasive imaging tool that characterizes coronary artery anatomy and provides detailed assessments of plaque morphology, composition , inflammation, and hemodynamics, which…
- Trial name
- FAST-CABG (NCT07628270)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Centro Cardiologico Monzino
Coronary Stenosis
Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT
Significant left main (LM) stenosis is associated with a poor prognosis, therefore, adequate judgement of the prognostic significance of LM stenosis is essential to improve patients' prognosis.
- Trial name
- OPTICO-LM (NCT03820492)
- Testing
- OCT, FFR, CTA and FFRCT
- Where
- 13 sites in France, Germany and 2 more
- Volunteers
- 104 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
Observational Study for Left Main Disease Treatment
The purpose of this study is to observe clinical courses for long-term in patients with unprotected LMCA disease and to evaluate comparative results of medical treatment, coronary stenting with drug-eluting stents, and CABG for…
- Trial name
- IRIS-MAIN (NCT01341327)
- Where
- 42 sites in China, Malaysia and 3 more
- Volunteers
- 10,000 people
- Sponsor
- Seung-Jung Park
Myocardial Infarction, Left Ventricular Remodeling
Circulating miR-126 as a Novel Biomarker for Post Myocardial Infarction Remodeling
Purpose: The purpose of this study is to evaluate the impact of circulating miR-126 on left ventricular remodeling and clinical outcomes in patients undergoing primary percutaneous coronary intervention for ST-segment elevation…
- Conditions
- Myocardial Infarction, Left Ventricular Remodeling, miR-126
- Trial name
- PMIR-miR-126 (NCT01875484)
- Where
- 17 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Qilu Hospital of Shandong University
Myocardial Infarct, Remodeling, Left Ventricle
Heart Attack Blood Oxygen Therapy Trial
'Heart attack', known as acute ST-segment elevation myocardial infarction, is a leading cause of heart failure and death. A lack of blood and oxygen damages the heart muscle potentially causing heart failure and premature death.
- Trial name
- SSO2 Radial MI (NCT06662890)
- Testing
- Supersaturated oxygen
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- NHS National Waiting Times Centre Board
Coronary Artery Disease
Outcomes of Surgically Ineligible Patients With Multivessel CAD
The OPTIMUM registry is a minimal risk observational study that uses a prospective cohort design to follow patients who have multivessel or left main coronary artery disease ("surgical anatomy" according to ACC/AHA…
- Trial name
- OPTIMUM (NCT02996877)
- Where
- 21 sites in United States
- Volunteers
- 750 people
- Sponsor
- Saint Luke's Health System
Coronary Artery Stenosis, Myocardial Revascularization
Study of Unprotected Left Main Stenting Versus Bypass Surgery (LE MANS Study)
Unprotected left main coronary artery (ULMCA) stenting, offering restoration of a native flow to left coronary artery, is the subject of intense investigations as a potential alternative to bypass surgery.
- Conditions
- Coronary Artery Stenosis, Myocardial Revascularization, Myocardial Ischemia
- Trial name
- NCT00375063
- Testing
- Percutaneous Coronary Intervention, Coronary Artery Bypass Grafting
- Where
- 5 sites in United States, Poland
- Volunteers
- 130 people
- Sponsor
- Ministry of Science and Higher Education, Poland
Cardiovascular Disease, Coronary Artery Disease
Italian Registry on Unprotected Left Main
The RITMO (Registro Italiano sul trattamento del Tronco coMune non protettO) observational study will appraise the prevalence, management strategy, and prognosis of unprotected left main coronary artery disease in Italy.
- Trial name
- RITMO (NCT00612053)
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- University of Turin, Italy