Clinical trials: Left Bundle-Branch Pacing
Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction
Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response
This study aims to investigate whether the investigators can improve heart function in patients with heart failure who have undergone cardiac resynchronization therapy, but have not had an improvement in their heart function at…
- Conditions
- Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction, CRT Non-Response, Left Bundle Branch Area Pacing
- Trial name
- NCT05884411
- Testing
- Left bundle branch area pacing, Cardiac MRI
- Where
- United States
- Sponsor
- VA Office of Research and Development
Left Bundle Branch Block, Left Bundle Branch Area Pacing
UHF ECG in LBBB and Response to CRT Prediction
The main objective of the project is to demonstrate that in patients with heart failure and QRS complex of nonRBBB morphology lasting over 130 ms, UHF-ECG can differentiate patients with trueLBBB from IVCD better than existing…
- Conditions
- Left Bundle Branch Block, Left Bundle Branch Area Pacing, Biventricular Pacing, Intraventricular Conduction Delay
- Trial name
- UHF BLOCK (NCT07057544)
- Testing
- LBBAP CRT device implantation, BVP-CRT
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Heart Failure, Left Bundle-Branch Block
Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure
The purpose of this study is to evaluate the efficacy and safety of conduction system pacing versus biventricular pacing in patients with chronic heart failure with reduced ejection fraction and left bundle branch block.
- Conditions
- Heart Failure, Left Bundle-Branch Block, Cardiac Resynchronization, Conduction System Pacing
- Trial name
- PhysioSync-HF (NCT05572736)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- 14 sites in Brazil
- Volunteers
- 179 people
- Sponsor
- Hospital Moinhos de Vento
Pacemaker DDD, His Bundle Pacing
Pacing to Maintain Physiologic Ventricular Activation
Right ventricular pacing causes ventricular dyssynchrony and may be associated with impaired outcome. In the last decade, several approaches for more physiological pacing became available and were implemented in the latest…
- Conditions
- Pacemaker DDD, His Bundle Pacing, LBB Area Pacing, Pacing-Induced Cardiomyopathy
- Trial name
- Pace-Conduct (NCT04416958)
- Testing
- cardiac implantable electronic device (CIED) implantation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Klinikum-Fuerth
Heart Failure With Reduced Ejection Fraction, Left Bundle Branch Area Pacing
Left Bundle Branch Area Pacing in Patients With Heart Failure
The relevance of Left Bundle Branch Pacing (LBBP) lies in its potential as a promising treatment option for patients with heart failure and left bundle branch block.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Left Bundle Branch Area Pacing, Heart Failure, Cardiac Resynchronization Therapy
- Trial name
- LBBAPHF (NCT06488989)
- Testing
- left bundle branch area pacing
- Where
- Kazakhstan
- Volunteers
- 50 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Left Bundle Branch Pacing, Heart Failure
Left Bundle Branch Area Pacing 3D Guidance System
The investigator's project proposes the development of a 3D hybrid guidance system which has the aim of avoidance of scar and septal perforation through targeted lead deployment via a personalised septal real time image overlay…
- Conditions
- Left Bundle Branch Pacing, Heart Failure, Bradycardia
- Trial name
- NCT06461715
- Testing
- Machine learning with artificial intelligence software program
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Left Bundle Branch Area Pacing, Biventricular Pacing
Clinical Efficacy of Left Bundle Branch Area Pacing for Patients With Permanent Atrial Fibrillation and Heart Failure
This is a multicenter, randomized controlled study. This study aims to compare the clinical efficacy of LBBAP with traditional biventricular pacing in patients with permanent atrial fibrillation and heart Failure
- Conditions
- Left Bundle Branch Area Pacing, Biventricular Pacing, Heart Failure, Permanent Atrial Fibrillation
- Trial name
- LBBAP-AFHF (NCT05549544)
- Testing
- Left bundle branch area pacing, Biventricular pacing
- Where
- 5 sites in China
- Volunteers
- 60 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Left Bundle-Branch Pacing
STylet-driven vs. LumenlEss Lead in Left-Bundle-Branch Pacing
The STYLE-LBBP study aims to compare the efficacy and safety of left-bundle branch pacing between the two types of available pacing leads: lumenless vs stylet-driven.
- Trial name
- STYLE-LBBP (NCT06049992)
- Testing
- Pacemaker implantation with conduction system pacing using Lumenless leads, Pacemaker implantation with conduction system pacing using Stylet-driven leads
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Puerta de Hierro University Hospital
Permanent His Bundle Pacing, Permanent Left Bundle Branch Pacing
Safety and Efficacy of His Bundle Pacing Validated by Extracardiac Vagal Nerve Stimulation
Different studies for extracardiac vagal nerve stimulation (ECANS) have been published and confirmed the influence of the vagus nerve on automaticity and conduction properties of the sinus node, atria, atrioventricular node, as…
- Trial name
- HIS-STORY (NCT04816864)
- Testing
- extracardiac vagal nerve stimulation (ECANS) + EPS
- Where
- 3 sites in Poland
- Volunteers
- 60 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Atrioventricular Block, Left Bundle Branch Pacing
Long-term Efficacy and Safety Research of Left Bundle Branch Pacing
Patients with successful left bundle branch pacing in our center were included in this study from April 2018 to December 2019. Baseline data was collected, and pacing parameters, ECG and echocardiographic results were analyzed…
- Trial name
- NCT05600699
- Testing
- Cardiac pacemaker and Select Secure lead
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Linyi People's Hospital
Left Bundle Branch Pacing
Feasibility of Simplified Permanent Left Bundle Branch Pacing Without Electrophysiological Recording System
This is a prospective, single-center study of patients with an indication for ventricular pacing who attempted LBBP without electrophysiology recording system (EP system).
- Trial name
- NCT05553431
- Testing
- Left bundle branch pacing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Atrioventricular Block, Second and Third Degree, Heart Failure
Safety and Effectiveness of Left Bundle Branch Pacing in Patients With Cardiac Dysfunction and AV Block
This study is a multicenter, prospective, randomized study to assess if cardiac dysfunction patients with LVEF <50% and the estimated ventricular pacing percentage >40% with LBBP have the non-inferior safety and efficacy than CRT…
- Conditions
- Atrioventricular Block, Second and Third Degree, Heart Failure, Left Bundle Branch Pacing
- Trial name
- NCT05553626
- Testing
- Left bundle branch pacing, Bi-ventricular pacing
- Where
- China
- Volunteers
- 160 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Slow Arrhythmia; Left Bundle Branch Pacing; Cardiac Function
Comparison of Cardiac Function Between Left Bundle Branch Pacing and Right Ventricular Outflow Tract Septal Pacing in Pacemaker-dependent Patients
Permanent pacemaker implantation is a common method for bradycardia and cardiac conduction dysfunction. With the development of physiological pacing, the optimal location of ventricular pacing site is still improving.
- Trial name
- NCT04386473
- Testing
- pacemaker
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruiqin xie
Left Bundle Branch Area Pacing
Cardiac ResynchronizatiOn and arrhythmiaS Sensing Via the LEFT Bundle.
Evaluation of ventricular arrhythmias sensing via a left bundle branch area pacing lead.
- Trial name
- CROSS LEFT (NCT05102227)
- Testing
- Left bundle branch area pacing
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Tours
Atrioventricular Block, Left Bundle Branch Area Pacing
Left Bundle Branch Area Pacing in AVB Patients
Right ventricular pacing (RVP) causes left ventricular mechanical dyssynchrony by inducing electrical interventricular and intraventricular dyssynchrony.
- Trial name
- NCT03851315
- Testing
- permanent left bundle branch area pacing
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fu Wai Hospital, Beijing, China