Clinical trials: Left Bundle-Branch Block
AV Block, Bundle-Branch Block
Outcomes and Safety of Various Conduction System Pacing Methods
The aim of this study is to evaluate safety and clinical outcomes after different pacing approaches of conduction system pacing in a prospective registry.
- Conditions
- AV Block, Bundle-Branch Block, Atrial Fibrillation Rapid
- Trial name
- NCT04749836
- Testing
- His bundle pacing implantation, Left bundle branch area pacing implantation, Bachmann bundle pacing
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Left Bundle-Branch Block, Right Bundle-Branch Block
Non-invasive Mapping Using Ultra-high Frequency Electrocardiography
Cardiac electrical mapping is an important tool that allows doctors to study the electrical activity of the heart in detail. Electrical mapping systems used in clinical practice are time consuming, invasive and very costly.
- Conditions
- Left Bundle-Branch Block, Right Bundle-Branch Block, Non-Specific Intraventricular Conduction Defect
- Trial name
- NCT04537455
- Testing
- Ultra-high frequency electrocardiography
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Left Bundle-Branch Block, Aortic Valve Stenosis
Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI
The primary hypothesis of the proposed study is that an electrophysiology-based algorithmic approach is superior to standard clinical follow-up with 30-day monitoring in reducing the combined endpoint of syncope, hospitalization…
- Trial name
- COME-TAVI (NCT03303612)
- Testing
- Pacemaker implant, Transcutaneous cardiac monitor
- Where
- 10 sites in Canada, France
- Volunteers
- 250 people
- Sponsor
- Montreal Heart Institute
Block Complete Heart, Atrial Fibrillation (AF)
Closed-Loop Stimulation in Left Bundle Branch Area Pacing
This prospective, single-center, crossover study evaluated the effects of closed-loop stimulation (CLS) compared with conventional accelerometer-based rate-adaptive pacing (VVIR) in patients with permanent atrial fibrillation…
- Conditions
- Block Complete Heart, Atrial Fibrillation (AF), Chronotropic Incompetence
- Trial name
- NCT07812935
- Testing
- Closed-Loop Stimulation, Accelerometer-Based VVIR Pacing
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Bartlomiej Wrobel
Left Bundle Branch Block (LBBB) on ECG
Clinical Observational Registry of Patients With Left Bundle Branch Block
The electromechanical dyssynchrony induced by the presence of LBBB is in some patients, but not all, the cause of progressive left ventricular systolic dysfunction and heart failure. Aims 1.
- Trial name
- RECOrd-LBBB (NCT05283603)
- Testing
- ECG, Echocardiogram, Magnetic resonance
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Azienda Ospedaliero Universitaria di Sassari
Heart Failure, Left Bundle Branch Block
Clinical Efficacy and Safety of Left Bundle Branch Area Pacing Using Quantitative Guidance of Multimodal Data in the Treatment of Heart Failure
Heart failure is a common chronic cardiovascular disease that seriously impairs patients' quality of life and long-term prognosis.
- Conditions
- Heart Failure, Left Bundle Branch Block, Non-ischemic Cardiomyopathy
- Trial name
- NCT07814612
- Testing
- Apply multimodal data fusion for quantitative guidance of left bundle branch region pacing, Conventional Biventricular Pacing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Heart Failure, Cardiac Resynchronization Therapy
Left Ventricular Septal Pacing: Potential Application for Cardiac Resynchronization Therapy
In cardiac resynchronization therapy (CRT), biventricular pacing is performed by pacing the right ventricle (RV) and epicardium of the left ventricular (LV) postero-lateral wall.
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Bundle-Branch Block
- Trial name
- NCT03415945
- Testing
- Cardiac resynchronization therapy (CRT)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Maastricht University Medical Center
Left Bundle-Branch Block, Heart Failure
The Left Bundle Cardiac Resynchronization Therapy Trial
Cardiac resynchronization therapy (CRT) via biventricular (BiV) pacing significantly reduces morbidity and mortality in patients with left bundle branch block (LBBB), impaired LV function and heart failure in spite of optimal…
- Conditions
- Left Bundle-Branch Block, Heart Failure, Impaired Left Ventricular Function
- Trial name
- NCT05434962
- Testing
- Cardiac resynchronization therapy
- Where
- 10 sites in Spain
- Volunteers
- 176 people
- Sponsor
- Óscar Cano Pérez
Heart Failure, Left Bundle-Branch Block
Optimised MultiSite Pacing Vector Study
The objective of this clinical investigation is to evaluate the clinical benefits of an MultiSite pacing (MSP) with patient specific left ventricular vector optimization in patients receiving cardiac resynchronization therapy…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Systolic Dysfunction
- Trial name
- NCT03938090
- Testing
- Optimised MultiSite Pacing, Standard biventricular pacing
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Left Bundle-Branch Block
Prediction of Outcome by Echocardiography in Left Bundle Branch Block
Patients with left bundle branch block have an increased risk for the development of heart-failure and death. However, risk factors for unfavorable outcomes are still poorly defined.
- Trial name
- EchoLBBB (NCT04293471)
- Where
- Norway
- Volunteers
- 2,000 people
- Sponsor
- University Hospital of North Norway
Bradyarrhythmia, Atrioventricular Block
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period.
- Conditions
- Bradyarrhythmia, Atrioventricular Block, Left Bundle Branch Area Pacing
- Trial name
- NCT05585411
- Testing
- Left bundle branch area pacing, Right ventricular pacing
- Where
- 8 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- Yonsei University
Pacemaker DDD, Heart Block
Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing
High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF).
- Trial name
- NCT05015660
- Testing
- Left bundle branch pacing lead, Right ventricular active fixation lead
- Where
- Canada
- Volunteers
- 1,300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Heart Failure, Left Bundle Branch Block
High Septal Pacing for Cardiac Resynchronization Therapy
The purpose of this acute study is to perform a preliminary investigation of high septal right ventricular pacing in the vicinity of the His bundle region as an alternate or adjunctive means for cardiac resynchronization in…
- Conditions
- Heart Failure, Left Bundle Branch Block, Heart Disease
- Trial name
- HISTORY (NCT01325480)
- Testing
- Cardiac Pacing
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Left Bundle-Branch Block, Aortic Stenosis
Study on Heart Block Risks Using Outcome-Based Modeling
This study developed a prediction model for high-grade atrioventricular block (AVB) and complete left bundle branch block (CLBBB) following transcatheter aortic valve replacement (TAVR) in Chinese patients with aortic stenosis…
- Trial name
- SAVIOR (NCT07065123)
- Testing
- The population undergoing TAVR for aortic valve stenosis with outcomes of permanent pacemaker implantation and complete left bundle branch block after surgery
- Volunteers
- 112 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Left Bundle-Branch Block, Electrocardiographic Pattens
Clinical, Structural and Mechanical Features in Patients With Left Bundle Branch Block.
Clinical, structural and mechanical features in patients with left bundle branch block.
- Conditions
- Left Bundle-Branch Block, Electrocardiographic Pattens, Clinical Features
- Trial name
- NCT04328649
- Volunteers
- 250 people
- Sponsor
- Policlinico Casilino ASL RMB
Atrioventricular Block, Pacemaker
Trial Evaluating the Benefit of Left Bundle Branch Area Stimulation Compared With Conventional Pacing in Post-TAVI Atrioventricular Atrioventricular Block
Transcatheter aortic valve implantation (TAVI) has rapidly expanded over the past decade as a treatment for severe aortic valve stenosis, with over 14,000 procedures performed in France in 2021.
- Trial name
- LBAP-TAVI (NCT07236489)
- Testing
- Pacemaker implantation using left bundle branch area stimulation, Right ventricular pacemaker implantation
- Where
- 7 sites in France
- Volunteers
- 266 people
- Sponsor
- Nantes University Hospital
Heart Failure, Heart Failure With Reduced Ejection Fraction
Left vs Left Randomized Clinical Trial
The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality)…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB
- Trial name
- NCT05650658
- Testing
- His/LBBP, BiVP
- Where
- 71 sites in United States, Canada
- Volunteers
- 2,136 people
- Sponsor
- Baylor College of Medicine
Heart Failure, Left Bundle-Branch Block
Tailor-CRT: Better Application of Cardiac Resynchronization Therapy
Approximately one third of patients treated with cardiac resynchronization therapy (CRT) do not derive any clinical benefit. CRT response can be improved by tailoring LV lead placement and programming of atrio-ventricular (AV)…
- Trial name
- NCT02326493
- Testing
- Cardiac Resynchronization Therapy
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Maastricht University Medical Center
Heart Failure, Reduced Left Ventricular Ejection Fraction
EP-Catheter Guided CS-Lead Implantation
In patients undergoing CRT device implantation a lead positioning in the coronary sinus is required. Even this part of the surgical procedure is challenging.
- Conditions
- Heart Failure, Reduced Left Ventricular Ejection Fraction, Left Bundle Branch Block
- Trial name
- NCT01922544
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Cologne
Heart Failure, Left Bundle-Branch Block
Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients
Heart failure (HF) is the most common nosology encountered in clinical practice. Its incidence and prevalence increase exponentially with increasing age and it is associated with increased mortality, more frequent hospitalization…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Ischemic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy
- Trial name
- RECOVER-HF (NCT05769036)
- Testing
- Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Biventricular Pacing, Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Left Bundle Branch Pacing
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences