Clinical trials: Left Atrial Appendage Occlusion
Dialysis, Chronic Kidney Disease (Stages 3b-5)
Left Atrial Appendage Occlusion in Dialysis Patients With Atrial Fibrillation: A Multicentre Pilot Study
Objectives: This pilot study aims to evaluate the safety and efficacy of left atrial appendage occlusion (LAAO) in dialysis patients and atrial fibrillation (AF) to establish a novel stroke prevention strategy and determine an…
- Conditions
- Dialysis, Chronic Kidney Disease (Stages 3b-5), Atrial Fibrillation, End Stage Kidney Failure
- Trial name
- LAAO-DAF (NCT07257614)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Percutaneous Left Atrial Appendage Occlusion (LAAO), Device-related Thrombus (DRT)
Recurrent or Persistent Device Related Thrombus After Left Atrial Appendage Occlusion: The RE-DRT Study
This study is a prospective, multicenter international trial aimed at assessing the actual incidence, identifying associated factors, and evaluating the clinical consequences of both persistent and recurrent device-related…
- Conditions
- Percutaneous Left Atrial Appendage Occlusion (LAAO), Device-related Thrombus (DRT), Thromboembolic Event, Major Cardioembolic Events
- Trial name
- RE-DRT (NCT06177704)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Atrial Fibrillation, Left Atrial Appendage Occlusion
Pulsed Field Ablation for Non-valvular Atrial Fibrillation After Left Atrial Appendage Occlusion
This is a single-center, prospective, single-arm clinical trial designed to evaluate the safety and efficacy of pulsed field ablation (PFA) after left atrial appendage occlusion (LAAO) in patients with non-valvular atrial…
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Occlusion, Pulsed Field Ablation
- Trial name
- PFA after LAAO (NCT07313228)
- Testing
- Pulsed Field Ablation
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Atrial Fibrillation, Left Atrial Appendage Occlusion
RCT of Minimalist vs Standard Procedure for LAAC in NVAF Patients
Percutaneous left atrial appendage closure (LAAC) is an effective strategy for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Occlusion, General Anesthesia, Local Anesthesia
- Trial name
- NCT06969118
- Testing
- Minimalism Transcatheter LAAC Group, Standard Transcatheter LAAC Group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Zhongshan Hospital
Left Atrial Appendage Occlusion
Study of Intra-Cardiac Echocardiography in Guiding Left Atrial Appendage Occlusion With the Watchman Device
The purpose of this research is to to assess the feasibility and safety of left atrial appendage (LAA) occlusion with the WATCHMAN FLX™ device using a standardized intra-procedural intracardiac echocardiography (ICE) protocol…
- Trial name
- NCT05136417
- Testing
- intra-procedural intracardiac echocardiography (ICE) probe
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Leadless Pacemaker, Left Atrial Appendage Occlusion
Combined Leadless Pacemaker and Left Atrial Appendage Occlusion Registry
Leadless pacemakers (LP) are safe and effective alternatives to transvenous pacemakers in selected patients. Implantation is performed with a large caliber delivery catheter.
- Trial name
- NCT06702865
- Where
- Hong Kong
- Volunteers
- 47 people
- Sponsor
- Chinese University of Hong Kong
Atrial Fibrillation, Left Atrial Appendage Ligation
Transatrial Pericardial Separation to Enhance Safety of Subxiphoid Pericardial Access for Left Atrial Appendage Ligation
We use a tiny catheter through the heart to separate the pericardium with gas. We expect this to improve the safety of the Lariat procedure.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Ligation, Pericardium, Epicardial Mapping
- Trial name
- NCT06584370
- Testing
- Pericardial insufflation with carbon dioxide through a transatrial microcatheter
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Henry Ford Health System
Left Atrial Appendage Occlusion
LAmbre Versus AMPLATZER Amulet Left AtrIal Appendage Occluder for StRoke ProphylaxIs
The objective of this trial is to compare two different commercially available left atrial appendage occlusion (LAAO) devices in patients with non-valvular Atrial fibrillation/ atrial flutter (AF) at increased risk for stroke…
- Trial name
- AMPIRI (NCT06060912)
- Testing
- Left Atrial Appendage Occlusion
- Where
- Germany
- Volunteers
- 226 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Left Atrial Appendage Occlusion
Use of Intracardiac Echocardiography or Left Atrial Appendage Radiography to Guide Implantation of a Left Atrial Appendage Occlusion Device
A total of 40 patients with atrial fibrillation were scheduled to receive left atrial appendage occlusion, which were divided into two groups.
- Trial name
- NCT04524741
- Testing
- intracardiac echocardiography
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Second Hospital of Hebei Medical University
Atrial Fibrillation, Left Atrial Appendage Occlusion
Efficacy of Different Anti-Thrombotic Strategies on the Incidence of Silent Cerebral Embolism After Percutaneous Left Atrial Appendage Occlusion
The primary objective of this investigation is to compare the efficacy of two different antithrombotic strategies after percutaneous LAA occlusion with a Watchman device on the prevention of silent cerebral embolism.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Occlusion, Silent Cerebral Embolism
- Trial name
- NCT05671276
- Testing
- aspirin and clopidogrel, Rivaroxaban
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Left Atrial Appendage Occlusion
Apixaban vs Dual Antiplatet Therapy Study After Left Atrial Appendage Occlosure (ADALA)
Objective: To demonstrate superiority of a strategy of anticoagulation with apixaban 5mg/2.5mg bid as compared with the current standard of care (dual antiplatelet therapy) after occlusion of the left atrial appendage (LAAC) in…
- Trial name
- ADALA (NCT05632445)
- Testing
- Apixaban vs. DAPT
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- DR. XAVIER FREIXA
Heart Failure, Left Atrial Appendage Occlusion
Left Atrial Appendage Occlusion Study III Extended Follow Up
LAAOS III Extension is a longer term follow-up of an international cohort study of patients who were enrolled in the Left Atrial Appendage Occlusion Study (LAAOS III) trial.
- Trial name
- LAAOSIIIX (NCT05399342)
- Testing
- No Intervention
- Sponsor
- Population Health Research Institute
Left Atrial Appendage Occlusion, Antiplatelet Therapy
Head-to-head Comparison of Single Versus Dual Antiplatelet Treatment Strategy After Percutaneous Left Atrial Appendage Closure: a Multicenter, Randomized Study
The study will perform a randomized, head-to-head comparison between SAPT (aspirin) and DAPT (aspirin plus clopidogrel) after percutaneous LAA closure with implantation of the Amulet device (AbbottTM, Abbott Park, Illinois, US)…
- Trial name
- ARMYDA-AMULET (NCT05554822)
- Testing
- Aspirin 100mg, Aspirin 100 mg OD plus clopidogrel 75 mg OD
- Where
- 19 sites in Italy
- Volunteers
- 574 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Left Atrial Appendage Occlusion
Use of Intracardiac Echocardiography or Left Atrial Appendage Radiography to Guide Implantation of a Left Atrial Appendage Occlusion Device.
A total of 60 patients with atrial fibrillation were scheduled to receive left atrial appendage occlusion, which were divided into two groups.
- Trial name
- NCT04524780
- Testing
- intracardiac echocardiography
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Hebei Medical University
Atrial Fibrillation, Left Atrial Appendage
Left Atrial Appendage Electrical Isolation in Persistent Atrial Fibrillation
This project intends to enroll patients with persistent atrial fibrillation who are planning to undergo catheter ablation of atrial fibrillation.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage, Left Atrial Appendage Occlusion, Catheter Ablation
- Trial name
- NCT04897204
- Testing
- Catheter ablation and left atrial appendage occlusion, Additional left atrial appendage electrical isolation combined with catheter ablation and left atrial appendage occlusion
- Volunteers
- 120 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Device-Related Thrombosis, Atrial Fibrillation
Efficacy of Different Anti-Thrombotic Strategies on Device-Related Thrombosis Prevention After Percutaneous Left Atrial Appendage Occlusion
Comparison among three different antithrombotic strategies after percutaneous LAA occlusion with a Watchman FLX LAAC device.
- Conditions
- Device-Related Thrombosis, Atrial Fibrillation, Left Atrial Appendage Occlusion
- Trial name
- FADE-DRT (NCT04502017)
- Testing
- ASA plus Clopidogrel, Genetic-Tailored AntiThrombotic Strategy, Half-Dose of novel OAC
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation, Left Atrial Appendage Occlusion
Left Atrial Appendage Occlusion in Patients With Non-valvular Atrial Fibrillation From Shanghai
The prognostic implication of left atrial appendage occlusion (LAAO) procedure in non-valvular atrial fibrillation (NVAF) patients from China is still unclear.
- Trial name
- LAAO-SH (NCT03987945)
- Testing
- left atrial appendage occlusion devices
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai 10th People's Hospital
Left Atrial Appendage Occlusion
Evaluation of the Cardioblate Closure Device in Facilitating Occlusion of the Left Atrial Appendage
The purpose of this study is to evaluate the performance of the Cardioblate Closure Device to occlude the LAA
- Trial name
- NCT00841529
- Testing
- Medtronic LAA Occlusion Device
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Medtronic Cardiovascular