Clinical trials: Large Core Infarct
Acute Ischemic Stroke
Methylprednisolone With Endovascular Thrombectomy for Large Ischemic Stroke
It is uncertain whether intravenous methylprednisolone improves outcomes for acute anterior circulation large vascular occlusion (LVO) patients with a large infarct core.
- Trial name
- MATCH (NCT06870448)
- Testing
- Methyprednisolone sodium succinate
- Where
- China
- Volunteers
- 1,614 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Ischemic Stroke
Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core
Endovascular therapy (EVT) was recommended as the primary treatment for patients with acute large vascular occlusion (LVO) in anterior circulation.
- Trial name
- ANGEL-ASPECT (NCT04551664)
- Testing
- Best medical management, Endovascular therapy
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Beijing Tiantan Hospital
Mechanical Thrombectomy, Large Ischemic Core
Randomized Controlled Trial of Endovascular Therapy for Acute Large Vessel Occlusion With Large Ischemic Core
RESCUE-Japan LIMIT(Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism Japan Large IscheMIc core Trial) is a prospective, open label, blinded endpoint (PROBE), Japanese, two-arm, randomized, controlled, post-market…
- Trial name
- NCT03702413
- Testing
- Endovascular treatment
- Where
- Japan
- Volunteers
- 203 people
- Sponsor
- Hyogo Medical University
Acute Ischemic Stroke, Large Infarct Core
Methylprednisolone Adjunctive to Endovascular Thrombectomy for Stroke
The efficacy and safety of methylprednisolone in acute ischemic stroke patients with large infarct cores (ASPECTS score < 6 or infarct volume ≥50 mL) due to anterior circulation large vessel occlusion have not been clearly…
- Trial name
- MIRACLE (NCT06360458)
- Testing
- Methylprednisolone sodium succinate
- Where
- 99 sites in China
- Volunteers
- 928 people
- Sponsor
- Wan-Jin Chen
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE3 (NCT07046299)
- Testing
- Endovascular Therapy Plus Best Medical Treatment, Best Medical Treatment Alone
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Capital Medical University
Stroke, Acute Ischemic
Endovascular Treatment for eXtra-Large Ischemic Stroke
The role of endovascular thrombectomy in patients with extra-large ischemic burden is still unclear. The XL STROKE-2 randomized trial is aiming to investigate the efficacy and safety of mechanical thrombectomy in acute…
- Trial name
- XL STROKE-2 (NCT06388148)
- Testing
- Medical management, Endovascular thrombectomy
- Where
- 2 sites in China
- Volunteers
- 286 people
- Sponsor
- Zhongming Qiu
Large Infarct Core, Post-stroke Lymphocytopenia
Methylprednisolone for Stroke With Large Infarct Core and Post-stroke Lymphocytopenia
The efficacy and safety of early adjunctive methylprednisolone therapy in acute ischemic stroke patients with large infarct cores (ASPECTS score < 6) and post-stroke lymphocytopenia remain unclear.
- Trial name
- MIRACLE-2 (NCT07202143)
- Testing
- Methylprednisolone sodium succinate, Normal Saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- YiLin
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct
This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE-LC (NCT07345702)
- Testing
- Endovascular Therapy
- Where
- China
- Volunteers
- 518 people
- Sponsor
- Xuanwu Hospital, Beijing
Basilar Artery Occlusion, Large Ischemic Core
EVT in Acute Basilar Artery Occlusion With Large Infarction Core
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial designed to evaluate the efficacy and safety of best medical management (BMM) combined with endovascular treatment (EVT) versus BMM alone in…
- Conditions
- Basilar Artery Occlusion, Large Ischemic Core, Large Core Infarct, Endovascular Treatments
- Trial name
- BOLT (NCT07090941)
- Testing
- Endovascular Treatment
- Where
- 2 sites in China
- Volunteers
- 372 people
- Sponsor
- The First Affiliated Hospital of Hainan Medical University
Stroke
Intravenous Thrombolysis With Tenecteplase Plus Thrombectomy Versus Thrombectomy Alone In Patients With A Large Ischemic Stroke: A Multicenter Randomized Controlled Trial (IVT-ALL-IN)
Stroke is a frequent and severe disease worldwide, representing the second leading cause of death and the leading cause of acquired disability.
- Trial name
- IVT-ALL-IN (NCT07603440)
- Testing
- Intravenous administration, MT alone
- Where
- 36 sites in France
- Volunteers
- 486 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Basilar Artery Occlusion, Endovascular Therapy
The Efficacy and Safety of Endovascular Therapy for Acute Ischemic Stroke Due to Large Core Infarction
This study assesses the efficacy and safety of endovascular therapy in patients with acute basilar artery occlusion with large core infarction within a multicenter, prospective, open-label, blinded endpoint, randomized controlled…
- Conditions
- Acute Basilar Artery Occlusion, Endovascular Therapy, Large Core Infarction
- Trial name
- NCT07333950
- Testing
- Endovascular Recanalization Strategy, Best Medical Management
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Imaging Guided Patient Selection for Interventional Revascularization Therapy
The primary objective of this clinical evaluation is to determine the safety and effectiveness of the Penumbra System in a stroke cohort who presents within 8 hours from symptom and with a known core infarct volume at admission.
- Trial name
- START (NCT00963989)
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Penumbra Inc.
Acute Ischemic Stroke
PROMISE: PRedictors Of Good outcoMes in Thrombectomy for Large Infarct Core Stroke Evaluation
Identify the factors associated with a favorable clinical outcome in participants with acute ischemic stroke and large core infarcts within 24 hours of onset who are treated with endovascular intervention.
- Trial name
- NCT06016348
- Testing
- Endovascular treatment
- Where
- 4 sites in Vietnam
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- 115 People's Hospital
Stroke, Large Ischemic Core
Assessing Local Hypothermia and Endovascular Recanalization for Acute Stroke With a Large Core Infarction
A multicenter, prospective, open-label, blinded-endpoint, randomized controlled trial to assess the effectiveness and safety of catheter-based focal intracranial hypothermia combined with endovascular reperfusion therapy for…
- Trial name
- RESCUE-LCI (NCT07232082)
- Testing
- intra-arterial local therapeutic hypothermia, Control (Normal saline)
- Volunteers
- 322 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Coronary Atherosclerosis, Myocardial Infarction
CANARY: Coronary Assessment by Near-infrared of Atherosclerotic Rupture-prone Yellow
The CANARY (Coronary Assessment by Near-infrared of Atherosclerotic Rupture-prone Yellow) Study is a pivotal trial to evaluate criteria for defining a Lipid Core Plaque (LCP) that is at high risk of rupturing during standard of…
- Conditions
- Coronary Atherosclerosis, Myocardial Infarction, Coronary Plaque Embolization
- Trial name
- CANARY (NCT01268319)
- Testing
- Embolic Protection Device (EPD), Intracoronary Spectroscopy and Ultrasonic Evaluation, Angioplasty and Stent Implant
- Where
- 9 sites in United States
- Volunteers
- 85 people
- Sponsor
- Infraredx