Clinical trials: Language
Developmental Language Disorder, Explicit Intervention
Evaluation of an Explicit Approach
This study is a randomized clinical trial that uses a Sequential Multiple Assignment Randomized Trial (SMART) study design. The study will directly compare the efficacy of an innovative intervention that combines explicit and…
- Conditions
- Developmental Language Disorder, Explicit Intervention, Grammatical Language
- Trial name
- NCT04902508
- Testing
- Implicit-only, Explicit-added
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Minnesota
Developmental Language Disorder, Specific Language Impairment
Retrieval-based Word Learning in Developmental Language Disorder: Adaptive Retrieval Schedule
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder, Specific Language Impairment, Language Development
- Trial name
- NCT06995014
- Testing
- Retrieval-based word learning: Standard retrieval practice schedule, Retrieval-based word learning: Adaptive retrieval practice schedule
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Purdue University
Sign Language Skills, Teacher Practice
Strategic and Interactive Signing Instruction Experiment
This RCT study involves teachers divided into an experimental group and a control group. Teachers in the experimental group will receive SISI training to support the sign language development of deaf children, while those in the…
- Trial name
- NCT06729164
- Testing
- Strategic and Interactive Signing Instruction, Business-As-Usual Instruction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Tennessee, Knoxville
Aphasia, Development, Human
Cognitive Functioning in Adults With Somatic Diseases and General Population From a Biopsychosocial Perspective
The goal of this observational study is to investigate cognitive functioning profiles in adults with neurologically recognized aphasic syndromes and general population.
- Conditions
- Aphasia, Development, Human, Neuropathology
- Trial name
- NCT06365658
- Testing
- Psychological assessment
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Bartosz M. Radtke
Language Impairment, Autism
Pilot Evaluation of the Developed Syntactic-Semantic Visual Configuration Intervention for Children With Language Impairment
This study will pilot a newly developed Syntactic-Semantic Visual Configuration Intervention (SSVCI) designed to help Urdu-speaking children with language impairment improve their ability to understand and produce phrases and…
- Conditions
- Language Impairment, Autism, Hearing Impaired Children, Down Syndrome
- Trial name
- SSVC-PILOT (NCT07786545)
- Testing
- Syntactic-Semantic Visual Configuration Intervention (SSVCI)
- Where
- Pakistan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Developmental Language Disorder
Maximizing Outcomes for Preschoolers With Developmental Language Disorders
The objective of the proposed study is to evaluate the efficacy of the Enhanced Milieu Teaching-Sentence Focus (EMT-SF) intervention, implemented by caregivers and interventionists, relative to a control condition enrolling 108…
- Trial name
- NCT03782493
- Testing
- the Enhanced Milieu Teaching-Sentence Focus
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Northwestern University
AI (Artificial Intelligence), Large Language Model
OpenEvidence Safety and Comparative Efficacy of Four LLM's in Clinical Practice
OpenEvidence is an online tool that aggregates and synthesizes data from peer-reviewed medical studies, then producing a response to a user's questions using generative AI.
- Conditions
- AI (Artificial Intelligence), Large Language Model, Generative Artificial Intelligence
- Trial name
- NCT07199231
- Testing
- AI clinical reference tool
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Literacy, Literacy-language Intervention
Haptics in Virtual Reality
The purpose of this study is to investigate the role of non-invasive wearable haptic feedback, in supporting literacy-focused Virtual Reality (VR) learning environments.
- Conditions
- Literacy, Literacy-language Intervention, Haptics
- Trial name
- NCT07209228
- Testing
- Haptic-Integrated Interactive Virtual Reality Experience, Traditional Virtual Reality Experience (Hand Controllers)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Miami
Language Development, Learning
Brain Stimulation Paired With Structured Language Learning in Adults
This study investigates whether transcranial electrical stimulation (tES) delivered during structured language-learning sessions affects the rate and quality of second-language acquisition in adults.
- Trial name
- NCT07762118
- Testing
- Active transcranial electrical stimulation (tES)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- General Neuro Inc.
Large Language Models
Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinical Decision Support
Clinical decision support tools powered by artificial intelligence (AI) are being rapidly integrated into medical practice. Two leading systems currently available to clinicians are OpenEvidence, which uses retrieval-augmented…
- Trial name
- PRECISE (NCT07037940)
- Testing
- OpenEvidence, GPT-4
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Autism Spectrum Disorder, Autistic Disorder
Telehealth Parent-Implemented Intervention for Young Children With Autism Spectrum Disorder (ASD)
The primary objective of this research study is to improve outcomes involving core social-communication symptoms for young children with ASD or social communication delays by increasing access to clinically validated early…
- Conditions
- Autism Spectrum Disorder, Autistic Disorder, Active Autistic Disorder, Autism
- Trial name
- NCT05176808
- Testing
- Early Achievements- Parent Coaching Intervention
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Chatbot, Large Language Model
Effects of a Large Language Model-Driven Chatbot on Reproductive Concerns After Cancer
Reproductive health has emerged as a critical yet overlooked concern among Adolescent and Young Adult (AYA) cancer survivors, given their compromised potential for biological parenthood in prime childbearing years.
- Conditions
- Chatbot, Large Language Model, Adolescent and Young Adult Cancer Survivors, Reproductive Health
- Trial name
- NCT07741266
- Testing
- Chatbot, Electronic brochure
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Hearing Loss, Bilateral, Language Development
Technology-assisted Language Intervention (TALI)
This study is testing the effectiveness of augmentative and alternative communication technology among deaf or hard of hearing children for improving language development.
- Trial name
- TALI (NCT04857255)
- Testing
- Technology assisted language intervention, Treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism
Project VOICES: Vocal Optimization in Children Elevating the Spectrum
Thirty percent of children with autism barely talk or do not talk at all despite years of intervention. This study aims to address this important and long-standing challenge by developing a novel intervention to increase the…
- Trial name
- Project VOICES (NCT06875843)
- Testing
- Contingent responses, Contingent responses plus vocal elicitation strategies, Non-contingent control
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt University Medical Center
Large Language Models, Lung Cancer (NSCLC)
Preliminary Evaluation of a Large Language Model-Based Tool for Complex Surgical Decision Support in Lung Cancer
This study is an exploratory effect-size estimation study, with the following specific objectives: ① to estimate the point estimate and 95% confidence interval of the Win Ratio for the experimental group (GAPS-Agent) versus the…
- Trial name
- NCT07654036
- Testing
- GAPS-Agent, LLM
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking University People's Hospital
Aphasia, Stroke
Transcranial Alternating Current Stimulation (tACS) in Aphasia
This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.
- Trial name
- NCT04375722
- Testing
- tACS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Language Development, Screen Time
Screen Time and Language Development in Toddlers Assessed With the Bayley-4
This cross-sectional study investigated whether caregiver-reported daily screen time is associated with language development in toddlers aged 12 to 42 months, measured with the Bayley-4.
- Conditions
- Language Development, Screen Time, Child Development
- Trial name
- Leave blank (NCT07731386)
- Testing
- Daily Screen Media Exposure, Bayley Scales of Infant and Toddler Development, Fourth Edition (Bayley-4)
- Where
- Turkey (Türkiye)
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Peritoneal Dialysis (PD), Large Language Models
A Simulated Case Study of a Peritoneal Dialysis-Specialized Large Language Model Assisting Doctors in Improving Decision-Making in Peritoneal Dialysis Management
This study is a randomized controlled trial based on simulated clinical cases, aiming to establish a standardized evaluation system for PD physicians, to assess the differences in PD management quality between a workflow assisted…
- Trial name
- NCT07724327
- Testing
- Peritoneal dialysis-specialized large language model.
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Developmental Dysphasia, Epileptic Encephalopathy, Childhood-Onset
CNKSR2 Natural History Study
This prospective natural history study is being conducted to define the electroclinical, neurodevelopmental, and behavioral characteristics of CNKSR2 epilepsy aphasia syndrome (EAS) and intellectual disability (ID) in children…
- Conditions
- Developmental Dysphasia, Epileptic Encephalopathy, Childhood-Onset, X-Linked Intellectual Disability
- Trial name
- CNKSR2 (NCT06500260)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Young Adults
Effects of Tool Handling on Language Processing
This randomized controlled trial aims to investigate the effects of a context-specific tool-handling intervention on linguistic processing in healthy young adults.
- Trial name
- NCT07718698
- Testing
- Dexterous tool-use training, Dexterous manual training group without tools (Online), Control
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre