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Developmental Language DisorderNCT06995014

Retrieval-based Word Learning in Developmental Language Disorder: Adaptive Retrieval Schedule

A study testing Retrieval-based word learning: Standard retrieval practice schedule and Retrieval-based word learning: Adaptive retrieval practice schedule in people with Developmental Language Disorder and Specific Language Impairment, run by Purdue University at 1 site in United States.

Terminated

Stopped early. The study ended before it was planned to and will not resume.

Official record
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Trial summary

Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and eventual economic wellbeing. Read more about this study

Who is it for?
Ages 48 to 71 monthsHealthy volunteers can take part
What is being tested?
Retrieval-based word learning: Standard retrieval practice schedule and Retrieval-based word learning: Adaptive retrieval practice schedule
Could I receive a placebo?
No, everyone receives an active treatment
How many people
7 participants
Where
1 siteUnited States
Study dates
15 Aug 2024to 31 Dec 2025
Phase
Interventional
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 48 to 71 months
  • All sexes
  • Healthy volunteers accepted
  • Child

Who may be able to join

  • a significant deficit in language ability (language test score below cutoff for best sensitivity/specificity) or documented age-appropriate language ability.
  • normal hearing.
  • no evidence of neurological damage or disease.
  • scores on tests of nonverbal intelligence above the intellectual disability range
  • not within Autistic range on Autism screening test
  • native English speaker (can be bilingual)

Who cannot join

  • failed hearing screening
  • known neurological damage or disease
  • scores on tests of nonverbal intelligence below the intellectual disability range (standard score less than 75)
  • autism spectrum disorder
  • non-native English speaker

Trial locations and contacts

1 site in 1 country.

United States1 site
  • Purdue University

    West Lafayette, Indiana, 47907

Other trials in United States

About this study

Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and eventual economic wellbeing. Word learning is one of the principal weaknesses in these children. This project focuses on the word learning abilities of four- and five-year-old children with DLD. The goal of the project is to determine whether special benefits accrue when these children must frequently recall newly introduced words during the course of learning. In the current study, the investigators compare a "standard" repeated spaced retrieval schedule, with fixed spacing between hearing a word and attempting to retrieve it, to an "adaptive" repeated spaced retrieval schedule in which opportunities to retrieve a given word are tailored to the individual child's current knowledge state. The goal of the study is to determine whether the adaptive schedule can increase children's absolute levels of learning while maintaining the advantages of repeated spaced retrieval.

Read the detailed description

Developmental Language Disorder (DLD) affects language learning in an estimated 7% of children. Although much of the research literature has emphasized difficulties learning grammar, children with DLD also have major deficits in vocabulary. In recent work, the investigators have been examining the benefit of retrieval practice to enhance word learning and retention in preschoolers with DLD. The rationale behind this work is grounded in the growing literature in the field of cognitive psychology which shows that repeated practice in retrieving information results in greater long-term retention than continuous study of that information without opportunities for retrieval. In addition, retrieval practice that occurs after a delay-or "spacing" between study of a word and subsequent recall attempts-can lead to stronger effects.

Despite the growing evidence that repeated spaced retrieval (RSR) results in greater word learning for preschoolers with DLD, much remains to be learned. One important question concerns the absolute level of learning achieved through RSR. These investigators have found that, in the more optimal condition of RSR, these children's ability to recall new word forms (i.e., recall the phonetic form of the word such as /pobɪk/) is still low, despite being higher than recall in the comparison conditions. The main obstacle appeared to be initial word form encoding during the learning period. Longer-term retention was less of a problem, i.e., those words children could recall immediately after the learning period were also recalled one week later. In the current study, the investigators seek to improve word form recall through modifications that may improve this initial encoding. The principal means by which this study will attempt to improve encoding and, as a result, subsequent recall, is through an adaptive retrieval schedule, described below.

Sixteen children with DLD will be recruited for this study along with 16 children with typical language development (TD) matched on chronological age. Using a within-subjects design, children will learn eight novel verbs, four at a time. Each set of four will be learned over two consecutive days, with one block of four in the standard RSR condition and the other block in the adaptive RSR condition. The referents for these novel words will be photos of unfamiliar plants and animals, presented on a laptop screen. Recall of word forms and meanings will be tested 5 minutes after the learning session on the second day, and again one week later. After the one-week recall testing, a picture-pointing recognition task will also be completed.

In both conditions, children will initially hear the word paired with a photo (Study trial: This is a nepp. It's a nepp. A nepp likes rain.), immediately be asked to recall the word (Retrieval trial: What's this called?), and then see/hear it again (Study trial: This is a nepp. It's a nepp. A nepp likes rain.). After three other words are presented, the children will be asked to recall the original word (nepp) again (What's this called? What does it like?); this retrieval trial is followed by a study or "feedback" trial (This is a nepp. It's a nepp. A nepp likes rain.). The "3" spaced retrieval schedule will continue for the rest of the learning session. The difference between conditions is this: in the adaptive condition, if the child is unsuccessful in retrieving the word form, whether on the initial trial or on one of the "3" spaced trials, the subsequent study/feedback trial will be followed by an additional immediate retrieval trial for that word. If, on the other hand the child retrieves the word form successfully, the next retrieval - study sequence will appear after three intervening words. In the standard condition, an unsuccessful recall attempt will be followed by a study trial but there will be no additional immediate retrieval opportunity. Note that while children will also be asked to retrieve the word meaning (what it likes), unsuccessful recall of this information will not trigger an additional immediate retrieval opportunity. This is based on previous findings showing that the real difficulty for children with DLD is recalling the phonetic form of words, rather than meaning information.

The investigators predict that the strategic placement of additional immediate retrieval trials after incorrect spaced retrieval trials in the adaptive condition will increase the likelihood of the child's success on the next spaced retrieval trial. Findings show that spaced retrieval needs to be successful in order to build strength and promote long-term retention. With the boost to encoding provided by the immediate retrieval trial for words the child is having difficulty remembering, the word form may be more firmly encoded and more likely to be recalled on the spaced retrieval trials. This should lead to higher absolute levels of word learning in the adaptive condition compared to the standard condition.

Being tested
Retrieval-based word learning: Standard retrieval practice schedule, Retrieval-based word learning: Adaptive retrieval practice schedule
Keywords
Word learning, Word retrieval, Preschool-aged children
Medical subject headings
Language Development Disorders, Specific Language Disorder

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Retrieval-based word learning: Standard retrieval practice scheduleBehavioural

    Novel nouns and their meanings are practiced on 2 consecutive days. At the beginning of each learning session, a retrieval trial will immediately follow hearing the word and what it likes (a study trial). In the standard condition, the remaining retrieval trials for each word will be spaced - occurring only after 3 other words have intervened. This practice schedule is repeated the next day (Day 2).

  • Retrieval-based word learning: Adaptive retrieval practice scheduleBehavioural

    Novel nouns and their meanings are practiced on 2 consecutive days. At the beginning of each learning session, a retrieval trial will immediately follow hearing the word and what it likes (a study trial). For the remainder of the session, there will be spaced retrieval trials for each word - occurring after 3 words have intervened. In the Adaptive condition, children will have additional retrieval opportunities throughout. These will be provided whenever the child does not remember the word form, whether it is an immediate (initial) or space retrieval trial. This practice schedule is repeated the next day (Day 2).

Study groups in NCT06995014
Study groupRoleWhat they receive
Children with Developmental Language DisorderExperimentalThese children have a significant delay in language development in the absence of hearing impairment, cognitive delay, autism, or neurological injury/disease.
Receives: Behavioral: Retrieval-based word learning: Standard retrieval practice schedule; Behavioral: Retrieval-based word learning: Adaptive retrieval practice schedule
Children With Typical Language DevelopmentExperimentalChildren whose language development is as expected for their age.
Receives: Behavioral: Retrieval-based word learning: Standard retrieval practice schedule; Behavioral: Retrieval-based word learning: Adaptive retrieval practice schedule

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Word Form Recall Accuracy (Number of Words Correctly Recalled) on Adaptive and Standard Retrieval Schedules at 5 Mins

    5 minutes after second learning session, child is asked to recall and say the word associated with each novel referent learned under one of two conditions: one in which retrieval trials occurred on an adaptive schedule and one in which retrieval trials occurred on the standard schedule.

    Measured: 5 minutes after end of learning period

  2. Word Form Recall Accuracy (Number of Words Correctly Recalled) on Adaptive and Standard Retrieval Schedules at 1 Week

    1 week after second learning session, child is asked to recall and say the word associated with each novel referent learned under one of two conditions: one in which retrieval trials occurred on adaptive schedule and one in which retrieval trials occurred on the standard schedule.

    Measured: 1 week after end of learning period

  3. Word Meaning Recall Accuracy (Number of Semantic Associations Correctly Recalled) on Adaptive and Standard Retrieval Schedules at 5 Mins

    5 minutes after second learning session, child is asked to recall and say the semantic information associated with each novel referent learned under one of two conditions: one in which retrieval trials occurred on an adaptive schedule and one in which retrieval trials occurred on the standard schedule.

    Measured: 5 minutes after end of learning period

  4. Word Meaning Recall Accuracy (Number of Semantic Associations Correctly Recalled) on Adaptive and Standard Retrieval Schedules at 1 Week

    1 week after second learning session, child is asked to recall and say the semantic information associated with each novel referent learned under one of two conditions: one in which retrieval trials occurred on an adaptive schedule and one in which retrieval trials occurred on the standard schedule.

    Measured: 1 week after end of learning period

  5. Word Recognition (Number of Words Accurately Identified) on on Adaptive and Standard Retrieval Schedules

    Upon hearing a novel word, the child is asked to indicate (by pointing) which picture among 4 options is referred to; for words learned on the adaptive condition and for words learned on the standard condition.

    Measured: 1 week after end of learning period

Secondary outcomes (2)
  1. Peabody Picture Vocabulary Test, Fifth Edition

    The Peabody Picture Vocabulary is an individually administered, norm-reference test that assesses receptive vocabulary for children and adults ages 2 years 6 months to 90 years and older. Standard scores are derived from number correct. Standard scores can range from a minimum of 40 and 160. Standard scores between 85 and 115 (1 standard deviation above and below the mean of 100) are interpreted as reflecting receptive vocabulary levels expected for age. Scores below 85 are interpreted as reflecting receptive vocabulary levels below what is expected for age.Scores above 115 are interpreted as reflecting receptive vocabulary levels above what is expected for age.

    Measured: at enrollment

  2. Years of Maternal Education

    Primary care-giver provides information regarding highest academic degree attained, converted to years of education

    Measured: at enrollment

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted29 May 2025
  2. Study start15 Aug 2024
  3. Primary completion31 Dec 2025
  4. Study completion31 Dec 2025

Why it stopped: Trial terminated due to a change in study priorities. A related study took precedence and was prioritized for completion, making continuation of this study unfeasible.

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Non-randomised
Intervention model
Factorial
Model description
Within-participant design in which each child learns words under two conditions. The clinical group (children with DLD) is compared to the control group (children with Typical development) on these two word learning conditions.
Masking
None (open label)
Enrolment
7 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06995014
Sponsor's protocol ID
1603017480D
Other IDs
R01DC014708
Status last verified
Aug 2026
First submitted
20 May 2025
Last updated
2 Sep 2026
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A study testing Retrieval-based word learning: Standard retrieval practice schedule and Retrieval-based word learning: Adaptive retrieval practice schedule in people with Developmental Language Disorder and Specific Language Impairment, run by Purdue University at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: stopped early, as of the sponsor's last update on 2 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 2 Sep 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Word Form Recall Accuracy (Number of Words Correctly Recalled) on Adaptive and Standard Retrieval Schedules at 5 Mins (time frame: 5 minutes after end of learning period). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Sep 2026.

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