Clinical trials: Kratom
Kratom Pharmacokinetics, Kratom Pharmacodynamics
Direct Observation Study of Kratom Product Effects Among Regular Consumers
The goal of this observational clinical study is to is to learn more about how commercial kratom products affect healthy adults who consume them regularly. The main questions it aims to answer are: 1.
- Conditions
- Kratom Pharmacokinetics, Kratom Pharmacodynamics, Kratom
- Trial name
- NCT06089980
- Testing
- Effects from acute kratom exposure
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Withdrawal Syndrome
Kratom Use Disorder Management Using Clonidine and/or Buprenorphine
Kratom is used for stimulant, analgesic, anxiolytic, and sedative effects. There is inadequate knowledge about Kratom addiction. Kratom withdrawal may be treated like opioid withdrawal.
- Trial name
- NCT05883358
- Testing
- Clonidine, Buprenorphine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Safety and Tolerability in Healthy Subjects
Phase 1 Study of Oral MG001
This research study is the first time the new medication MG001 is being tested in people. MG001 is a formulation of mitragynine, a compound that comes from a plant called Mitragyna speciosa (sometimes known as kratom), which some…
- Trial name
- NCT07204171
- Testing
- mitragynine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Safety, Pharmacokinetics
Single Ascending Doses of Kratom in Healthy Nondependent Adults With Opioid Experience
Kratom (Mitragyna speciosa) is a plant often used to self-treat conditions such as pain, coughing, diarrhea, anxiety and depression, opioid use disorder, and opioid withdrawal.
- Conditions
- Safety, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT06072170
- Testing
- Kratom
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Altasciences Company Inc.
Kratom Pharmacodynamics, Kratom Pharmacokinetics
Preliminary Characterization of Commercial Kratom Extract Products
To understand the acute subjective, physiological, and cognitive effects of commercial kratom extract products among US adults who consume these products regularly, and to understand how these products are metabolized by the…
- Trial name
- NCT06640569
- Where
- 2 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Herb-Herb Interaction, Pharmacokinetics
Pharmacokinetics of Kava and Kratom Alone and in Combination
This study is being conducted to evaluate how different formulations of the Feel Free® Tonic containing Kava, Kratom, or a combination of both are processed in the body in healthy adults.
- Trial name
- NCT07583407
- Testing
- Kava and Kratom Herbal Supplement, Kava Herbal Supplement, Kratom Herbal Supplement
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Botanic Tonics, LLC
Herbal Interaction
Evaluating a Potential Pharmacokinetic Kratom-oxycodone Interaction Concurrent With Clinical Endpoints
The goal of this study is to investigate whether the botanical product kratom affects how the body processes the opioid drug oxycodone. The main research questions to be answered are two-fold: 1.
- Trial name
- NCT05846451
- Testing
- Kratom, Oxycodone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Washington State University
Interaction Drug Food
Assessing the Pharmacokinetics and Drug Interaction Liability of Kratom, an Opioid-like Natural Product
Kratom is a botanical natural product that has opioid-like effects. Kratom is commonly used to self-treat withdrawal symptoms associated with opioid addiction, as well as pain.
- Trial name
- NCT04392011
- Testing
- Midazolam HCl, Dextromethorphan HBr, Kratom
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington State University
Topical Analgesia, Myofascial Pain Syndrome - Neck
Effectiveness of Mitragynine Topical Patch for Pain Reduction in Myofascial Pain Syndrome
Myofascial Pain Syndrome (MPS) is one of the leading causes of both acute and chronic musculoskeletal pain encountered in clinical practice.¹ The most common presentation is low back pain, followed by pain in the neck and…
- Trial name
- mirtapatch (NCT07713771)
- Testing
- mitragynine topical patch from kratom
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Prince of Songkla University
Chronic Pain, Fatigue
Real-world Momentary Assessment of Kratom Use Accompanied by Product Assays: A Natural-history Study for Interdisciplinary Characterization of Kratom Use and Pharmacology
Background: Mitragyna speciosa, also called kratom, is a plant used in Southeast Asia for its psychoactive effects. Its use has increased in the US, and an estimated 10 million adults may take it at least semiregularly.
- Conditions
- Chronic Pain, Fatigue, Substance Use Disorders
- Trial name
- NCT05457803
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pain
Ketum and Pain Tolerence
The study aim is to evaluate potential analgesic properties of ketum using the cold pressor task.
- Trial name
- NCT03414099
- Testing
- Ketum
- Where
- Malaysia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia