Clinical trials: Knee Infection
Infection
Bacterial Contamination of Operative Splash Basins
The primary objective of this study is to compare the efficacy of adding 0.05% chlorhexidine gluconate to the splash basin in reducing bacterial growth from splash basins at the end of a total joint replacement procedure.
- Trial name
- NCT02434510
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Utah
Ultrasound Therapy; Complications, Septic Arthritis
Exploratory Study of Ultrasound Signs of Native Septic Arthritis of the Knee
Primary objective: Description of ultrasound abnormalities seen in native septic arthritis of the knee during each visit. Primary endpoint: Describe the ultrasound abnormalities observed on Day 0, Day 10, 6 weeks, 3 months, 6…
- Conditions
- Ultrasound Therapy; Complications, Septic Arthritis, Knee Arthritis
- Trial name
- USAK (NCT04952220)
- Testing
- ultrasound
- Where
- 7 sites in France
- Volunteers
- 30 people
- Sponsor
- Poitiers University Hospital
Tendinopathy, Epicondylitis
TENDOSHOCK-2010 Combination Therapy for Athletic Tendinopathies
Athletic tendinopathies of the upper and lower extremity are often therapeutically challenging. Colour and Power-Doppler-ultrasound visualizes pathological neovessels in painful tendons, which are associated with pain-mediating…
- Trial name
- TENDOSHOCK (NCT01185951)
- Testing
- Polidocanol, Focused extracorporeal shock wave therapy, Topical NO
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Hannover Medical School
Surgical Wound, Revision Total Knee Arthroplasty
Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty
This study evaluates surgical site complications in subjects undergoing revision of a total knee arthroplasty when closed incision negative pressure therapy is used to manage the closed incision, as compared to a standard of care…
- Conditions
- Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease
- Trial name
- PROMISES (NCT03274466)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing
- Where
- 17 sites in United States
- Volunteers
- 294 people
- Sponsor
- KCI USA, Inc
Total Knee Replacement
Comparison of Surgical Site Infection After Skin Closure by Prolene or Staples in Bilateral Knee Arthroplasty Patients
Knee arthroplasty also known as the total knee replacement is an orthopedic surgical procedure done to resurface the knee that has been severely damaged by arthritis.
- Trial name
- NCT04492852
- Testing
- Polypropylene (PROLENE) sutures, Staple Sutures
- Volunteers
- 82 people
- Sponsor
- Indus Hospital and Health Network
Prosthetic Joint Infection (PJI)
A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants
This is a Phase 2b, randomized, controlled, open-label clinical study evaluating the efficacy, safety, and local PK profiles of TNP-2092 administered via IA injection on a background of antibiotic treatment in participants with…
- Trial name
- NCT07858916
- Testing
- TNP-2092 for injection, Vancomycin Hydrochloride for Injection, Oral antibiotics
- Where
- China
- Volunteers
- 40 people
- Sponsor
- TenNor Therapeutics (Zhongshan) Limited
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Patient Oriented Discharge Summary Impact Study
Improving the patient experience has become a major focus of quality improvement efforts in Ontario and in health systems worldwide.
- Conditions
- Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Pneumonia, Hip Fracture
- Trial name
- PODS (NCT02673892)
- Testing
- Patient Oriented Discharge Summary
- Where
- Canada
- Volunteers
- 581 people
- Sponsor
- University Health Network, Toronto
Chronically Infected Total Hip of Knee Prosthesis
Cost-effectiveness Evaluation of One Stage Versus Two Stage Exchange for Chronically Infected Total Hip and Total Knee Prostheses
Chronic infection after total joint arthroplasty generally requires implant exchange. Two stage exchange is considered as the gold standard procedure. However, some authors suggest that one stage exchange may be as effective.
- Trial name
- IPRO (NCT02651961)
- Testing
- Exchange of total hip or knee arthroplasty on same time, Exchange of total hip or knee arthroplasty in two time
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Prosthesis-Related Infections
Prospectively Observational Evaluation of Clinical Outcomes in Two-stage Revision for Periprosthetic Knee Infection
Total knee arthroplasty (TKA) infection is a complication requiring multiple hospitalizations, operations, and outpatient visits placing a significant burden on both patient and treating surgeons.
- Trial name
- NCT04622280
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
Prosthetic-joint Infection
A Second Trial of the Abbreviated Protocol Two-Stage Exchange
Apex-2 is a multi-site, parallel group, randomized trial. Patients will be randomly assigned in a 1:1 ratio to the Experimental Arm or the Control Arm.
- Trial name
- Apex-2 (NCT05607030)
- Testing
- VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics
- Where
- 19 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Infection, Surgical Site Infection
Changing of Dressing for Periprosthetic Joint Infection in Total Knee Arthroplasty
The primary aim of the study is to compare two methods for a relationship with total knee infection: regular changing of dressings and not changing dressings.
- Conditions
- Infection, Surgical Site Infection, Prosthetic Infection, Wound Infection
- Trial name
- NCT04346875
- Testing
- Regularly changing of dressing, No application
- Volunteers
- 842 people
- Sponsor
- Bezmialem Vakif University
Prosthetic Joint Infection
Cost Of Failure Following Reimplantation After a 2-Stage Exchange Strategy For Hip Or Knee Prosthetic Joint Infection
This study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done.
- Trial name
- NCT03612076
- Testing
- Global cost of management of PJI
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Hospices Civils de Lyon
Joint Infection
Study in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Occurring After Total Knee Arthroplasty (TKA)
The purpose of this study is to learn about the safety and effects of PLG0206 for treating periprosthetic joint infections (PJI) in conjunction with the DAIR (debridement, antibiotics and implant retention) surgical procedure for…
- Trial name
- NCT05137314
- Testing
- PLG0206
- Where
- 12 sites in United States
- Volunteers
- 14 people
- Sponsor
- Peptilogics
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI)
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- ACTIVE2 (NCT05269134)
- Testing
- Bacteriophage
- Where
- 10 sites in United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Infection of Total Knee Joint Prosthesis
Safety Study of High-dose Methylprednisolone in Fast-track Total Knee Arthroplasty
It has been shown that a single high dose of steroid before surgery may reduce pain the first 48 hours after insertion of a new joint in the knee, a so called "total knee arthroplasty" (TKA).
- Trial name
- NCT02019511
- Where
- 7 sites in Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Arthroplasty Complications, Knee Osteoarthritis
Large Doses of Methylprednisolone Combined With Gabapentin in Total Knee Arthroplasty
The aim of the study was to assess whether administration of gabapentin and methylprednisolone as "pre-emptive analgesia" in a group of patients above 65 years of age would be effective in complex pain management therapy…
- Conditions
- Arthroplasty Complications, Knee Osteoarthritis, Pain, Postoperative, Perioperative Complication
- Trial name
- NCT04653415
- Testing
- Gabapentin 300mg, Methylprednisolone 125 mg, Tablet
- Where
- Poland
- Volunteers
- 160 people
- Sponsor
- Jagiellonian University
Covid19, Hip Arthropathy
The Impact of COVID-19 Pandemic on Hip and Knee Replacement
During the COVID-19 pandemic, the care of patients undergoing hip or knee replacement for osteoarthritis remains a clinical priority.
- Conditions
- Covid19, Hip Arthropathy, Knee Arthropathy
- Trial name
- PTA/PTGCovid (NCT04883788)
- Testing
- Pandemic period
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Istituto Ortopedico Rizzoli
Infections Joint Prosthetic
Ancef Dosage in Knee Arthroplasty : Tourniquet Clinical Trial
Tourniquet inflation during total knee arthroplasty (TKA) is commonly used to reduce bleeding in the surgical field; thereby facilitating exposure and cementation.
- Trial name
- NCT05604157
- Testing
- Use of Tourniquet
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Arthropathy of Hip, Arthropathy of Knee
Diagnosis of Periprosthetic Joint Infection and the Common Pathogens, Durg-resistance in Periprosthetic Joint Infection
This retrospective study aims to improve the diagnosis of PJI as well as to identify microorganisms causing periprosthetic joint infection (PJI) and the drug-resistant spectrum
- Trial name
- NCT03365323
- Testing
- Periprosthetic Joint Infection, Non-Periprosthetic Joint Infection
- Volunteers
- 160 people
- Sponsor
- Peking University People's Hospital