Clinical trials: Knee Cartilage Lesions
Defect of Articular Cartilage
HyaloFAST Trial for Repair of Articular Cartilage in the Knee
The purpose of this study is to evaluate the safety and efficacy of Hyalofast® scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- FastTRACK (NCT02659215)
- Testing
- Hyalofast, Microfracture
- Where
- 48 sites in United States, Austria and 7 more
- Volunteers
- 200 people
- Sponsor
- Anika Therapeutics, Inc.
Bone Lesion, Cartilage Degeneration
Efficacy of Bioceramic Materials for Bone Defects Repair
The purpose of this study is to demonstrate the effect of bioceramic implants on the repair of human bone defects, and to explore the application of bioceramic materials in bone defects, bone implantation, and bone fusion.
- Conditions
- Bone Lesion, Cartilage Degeneration, Osteo Arthritis Knee, Bone Fracture
- Trial name
- NCT06249906
- Testing
- Commercial bone implant product Group, Mirco-structured Bioceramic Group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Lipedema, Knee Osteoarthritis
The Effect of Lipedema on Knee Osteoarthritis
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context.
- Conditions
- Lipedema, Knee Osteoarthritis, Knee Acute and Chronic Pain, Knee
- Trial name
- NCT07575555
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Izmir Democracy University
Knee Injuries, Joint Surface Knee Lesions
Knee Cartilage Repair Registry
This registry is designed to collect information on how different surgical procedures are used and how well they work in treating knee cartilage damage.
- Trial name
- C-SHORE (NCT07786207)
- Testing
- Marketed Product - MP01, Other Surgical Treatments
- Where
- 6 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Smith & Nephew, Inc.
Knee Injury
Evaluation of the CR Plug (Allograft) for the Treatment of a Cartilage Injury in the Knee.
Determine the ability of the allograft plug for the treatment of a cartilage injury in the knee
- Trial name
- NCT00793104
- Testing
- Placement of allograft CR Plug in primary injury site
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- RTI Surgical
Knee Injuries, Cartilage Injury
Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee
Multi-center, prospective, concurrently controlled, non-randomized, double-blind (patient and assessor). Treatment of large chondral lesions in the knee with microfracture plus the Chondro-Gide® ACC is non-inferior to treatment…
- Conditions
- Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
- Trial name
- SECURE (NCT04537013)
- Testing
- Microfracture, Microfracture plus placement of Chondro-Gide® ACC
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 82 people
- Sponsor
- Geistlich Pharma AG
Knee Injuries, Cartilage Injury
Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions
The goal of this observational study is to evaluate the combined single-step approach with biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions.
- Conditions
- Knee Injuries, Cartilage Injury, Osteochondral Defect
- Trial name
- NCT06078072
- Testing
- Biomaterials augmented with mesenchymal stem/stromal cells
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana
Large Articular Cartilage Lesions of the Femoral, Condyle, Trochlea, Tibia or Retropatellar
Assessment of Efficacy and Safety of 3 Different Doses of co.Don Chondrosphere to Treat Large Cartilage Defects
This is a prospective, randomised, open label, multicentre Phase II clinical trial to investigate the efficacy and safety of the treatment of large defects with 3 different doses of the autologous chondrocyte transplantation…
- Trial name
- NCT01225575
- Testing
- co.don chondrosphere®
- Where
- 10 sites in Germany
- Volunteers
- 75 people
- Sponsor
- co.don AG
Knee Chondral Lesion
PRP vs AD-SVF in Addition to Marrow Stimulation for Knee Chondral Lesion
The goal of this clinical trial is to learn if PRP and adipose-derived stem cells (AD-SVF) enhance healing after knee microfracture for chondral lesions. It will also learn about the safety of the procedure.
- Trial name
- NCT07255547
- Testing
- Bone Marrow Stimulation, stromal vascular fraction (SVF), PRP injection
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Università degli Studi dell'Aquila
Cartilage Injury
The Hyalex First-in-Human Study
The Hyalex First-in-Human Study is a prospective, multicenter, open-label, single-arm, 2-phase, first-in-human study to evaluate the safety and technical performance of the HYALEX Knee Cartilage System for replacement of loss of…
- Trial name
- NCT06344481
- Testing
- Surgical (Hyalex Cartilage Knee Implant)
- Where
- 2 sites in Poland
- Volunteers
- 15 people
- Sponsor
- Hyalex Orthopaedics, Inc.
Focal Cartilage Lesions
Prospective Interventional Clinical Trial of an MRI Based Patient Specific Focal Knee Resurfacing Implant
Lesions in the cartilage are common disorders. Arthroscopy lavage and debridement micro fracturing, mosaic plasticity as well as osteochondral autograft transplantation (OATS) are methods used for treatment of the lesions.
- Trial name
- Episealer (NCT04808700)
- Testing
- Follow-up of Episealer implant
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cartilage Injury, Defect of Articular Cartilage
BioPoly RS Knee Registry Study for Cartilage Defect Replacement
Information will be collected on the pre-op and post-op clinical status of patients with focal cartilage defects of the femoral condyles treated with the BioPoly RS Partial Resurfacing Knee Implant, a permanent orthopaedic…
- Conditions
- Cartilage Injury, Defect of Articular Cartilage, Cartilage Damage
- Trial name
- NCT01473199
- Testing
- BioPoly RS Partial Resurfacing Knee Implant
- Where
- 5 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- BioPoly LLC
Degenerative Lesion of Articular Cartilage of Knee
Observational Study on the Treatment of Knee Osteochondral Lesions of Grade III-IV
The purpose of the study is to evaluate prospectively the outcome of treatment interventions of knee osteochondral lesions Outerbridge grade III and IV.
- Trial name
- LOGIC (NCT01554878)
- Testing
- knee surgery
- Where
- 4 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Knee Osteoarthritis
Multimodal Evaluation of Cartilage Lesions of Patellofemoral Joint
Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.
- Trial name
- MULTICART (NCT03210584)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Grenoble
Knee Cartilage Lesions
Nanochon Chondrograft First in Human (FIH) Early Feasibility Study (EFS) - Panama
The goal of this First in Human study is to learn if the Nanochon Chondrograft Implant is a safe primary surgical treatment for participants with cartilage lesions in the knee.
- Trial name
- NCT07542184
- Testing
- Nanochon Chondrograft
- Where
- Panama
- Volunteers
- 5 people
- Sponsor
- Nanochon, Inc.
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Neocartilage Implant to Treat Cartilage Lesions of the Knee
ISTO Technologies, Inc. is proposing a clinical study with 225 subjects, to establish the safety and efficacy of the Neocartilage Implant for the treatment of ICRS Grade 3 and 4 articular cartilage lesions of the knee compared to…
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01400607
- Testing
- Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
- Where
- 9 sites in United States
- Volunteers
- 14 people
- Sponsor
- ISTO Technologies, Inc.
Acute Knee Cartilage Injury, Tear of Articular Cartilage of Knee, Current
EAGLE European Post Market Study
Prospective, multi-center, non-randomized, historical controlled, post-market study of patients requiring surgical repair of a focal articular cartilage lesion or osteochondral defect in the knee.
- Trial name
- EAGLE (NCT02309957)
- Testing
- BioMatrix CRD
- Where
- 6 sites in Germany, Italy and 2 more
- Volunteers
- 33 people
- Sponsor
- Kensey Nash Corporation
Traumatic; Lesion, Degenerative Lesion of Articular Cartilage of Knee
Randomized Evaluation of BST-CarGel Versus Microfracture Alone On Recovery From Distal Femoral Cartilage Lesions
This multi-centre randomized, controlled trial will assess the impact of BST-CarGel scaffold with microfracture versus microfracture alone on short and long term clinical benefit in patients with cartilage lesions of the femoral…
- Trial name
- RECORD (NCT02981355)
- Testing
- Microfracture treatment, BST-CarGel
- Where
- 15 sites in Australia, Canada and 5 more
- Volunteers
- 5 people
- Sponsor
- Piramal Healthcare Canada Ltd
Tendonitis, Bursitis
Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis
The purpose of this study is to evaluate the effect of a ketoprofen topical patch on the pain associated with tendonitis or bursitis of the shoulder, elbow or knee.
- Trial name
- NCT00352625
- Testing
- Ketoprofen Topical Patch 20%
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Alkemira SA
Tear; Knee, Cartilage, Articular
Autologous Chondrocyte Transplantation For Articular Cartilage Regeneration
The purpose of this study is to assess safety and efficacy of autologous chondrocyte implantation delivered arthroscopically into chondral lesions of the knee using clinical, biochemical, and MRI outcomes.
- Trial name
- NCT01503970
- Testing
- Arthroscopic matrix encapsulated chondrocyte implantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto Nacional de Rehabilitacion