Clinical trials: Kidney Transplant; Complications
Arteriovenous Fistula, Arteriovenous Graft
A Randomised Trial Comparing Supraclavicular Block vs Supraclavicular and Pecs II Block in Arteriovenous Grafting
This study evaluates the addition of Pecs II block to ultrasound-guided supraclavicular brachial plexus block in patients undergoing arteriovenous graft creation surgery.
- Conditions
- Arteriovenous Fistula, Arteriovenous Graft, Kidney Failure, Chronic, Renal Failure, End-stage
- Trial name
- NCT02331030
- Testing
- Supraclavicular, Pecs II block, Ropivacaine 0.5% 20ml
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Changi General Hospital
Chronic Kidney Disease, Cardiovascular Disease
Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT)
The purpose of this randomized clinical trial is to determine if lowering homocysteine levels in renal transplant recipients with a multivitamin will reduce the occurrence of cardiovascular disease outcomes.
- Conditions
- Chronic Kidney Disease, Cardiovascular Disease, Death
- Trial name
- FAVORIT (NCT00064753)
- Testing
- High Dose Multivitamin, Low Dose Multivitamin
- Where
- 30 sites in United States, Brazil and 1 more
- Volunteers
- 4,110 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Chronic Kidney Diseases, Apolipoprotein L1
APOL1 Genetic Testing Program for Living Donors
Living donor (LD) kidney transplantation is the optimal treatment for patients with end-stage kidney disease (ESKD). However, LDs take on a higher risk of future ESKD themselves.
- Conditions
- Chronic Kidney Diseases, Apolipoprotein L1, Kidney Transplantation
- Trial name
- NCT04910867
- Testing
- Components of Genetic Counseling, APOL1 genetic testing, EHR integration
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- Northwestern University
Latent Tuberculosis, End Stage Renal Disease
One-month Latent Tuberculosis Treatment for Renal Transplant Candidates
This is a prospective, single-center, single-arm, open-label study investigating the safety, compliance and pharmacokinetics of 1-month treatment of Isoniazid, Rifapentine and Vitamin B6 in renal transplant candidates.
- Conditions
- Latent Tuberculosis, End Stage Renal Disease, Renal Transplant Candidate for Right Kidney, Renal Transplant Candidate for Left Kidney
- Trial name
- NCT05411744
- Testing
- 1 month Rifapentine, Isoniazid and Vitamin B6
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Asymptomatic Bacteriuria, Pyelonephritis
Antibiotic Treatment Versus no Therapy in Kidney Transplant Recipients With Asymptomatic Bacteriuria
Objective: To determine whether antibiotic treatment of asymptomatic bacteriuria in kidney transplant recipients could be useful to prevent pyelonephritis in these patients.
- Trial name
- BAC01 (NCT01771432)
- Testing
- Antibiotic treatment, No treatment
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Núria Sabé Fernàndez
Acute Kidney Injury, Kidney Transplant
MEMRI and Kidney Disease
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD).
- Conditions
- Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
- Trial name
- NCT06698614
- Testing
- MRI, Blood tests, Urine tests
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh
Renal Insufficiency
Anti-inflammatory Effect of Atorvastatin on Graft Donor Kidney
Renal Insufficiency is a priority disease in health system, which may require renal replacement therapy based on renal transplantation, which is considered as therapy of choice.
- Trial name
- NCT02355704
- Testing
- Atorvastatin
- Where
- Mexico
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
End-stage Renal Disease
Reducing Disparities in Access to Kidney Transplantation (RaDIANT) Regional Study
The purpose of this study is to facilitate coordination of transplant centers in North Carolina, South Carolina, and Georgia to share kidney transplant referral data in patients with End-Stage Renal Disease (ESRD) who are…
- Trial name
- NCT02389387
- Testing
- Intensive Intervention
- Volunteers
- 440 people
- Sponsor
- Emory University
Liver Transplant; Complications, Renal Injury
Association of Intraoperative Renal Regional Oxygen Saturation and Acute Kidney Injury
This study is a prospective observational study of a single cohort of the patients who will undergo a scheduled living donor liver transplantation.
- Trial name
- NCT03877133
- Testing
- Near-infrared spectroscopy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
End Stage Renal Disease
Study of ChoironeX GalKO Porcine Thymokidney Xenotransplantation in End-Stage Renal Disease
The goal of this clinical trial is to learn if a GalKO Porcine Thymokidney can maintain renal function, without the need for dialysis, after transplantation into adult subjects with End Stage Renal Disease.
- Trial name
- NCT07696962
- Testing
- ChoironeX GalKO Porcine Thymokidney
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Xeno Holdings (US), LLC dba ChoironeX
Ischemia-reperfusion Injury, Kidney Transplant; Complications
FIH Phase I/IIa Trial Evaluating Safety of TUM012 to Minimize Ischemic Reperfusion Injury in Kidney Transplantation
A first-in-human single center, randomized, double-blind, placebo-controlled trial, with primary objective to evaluate safety and tolerability of ex-vivo kidney allograft treatment with TUM012 to reduce ischemia-reperfusion…
- Trial name
- NCT05246618
- Testing
- TUM012
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- iCoat Medical AB
Kidney Disease, Chronic, Transplant Recipient (Kidney)
Effectiveness and Cost-effectiveness of a Pre-emptive Genotyping Strategy in Patients Receiving Tacrolimus
This is a phase IV multicentre adaptive single-blinded randomized clinical trial to evaluate if preemptively genotyping populations at pretransplant chronic kidney disease susceptible of receiving tacrolimus therapy is effective…
- Conditions
- Kidney Disease, Chronic, Transplant Recipient (Kidney), Immunosuppression
- Trial name
- TRANSPGx (NCT06701825)
- Testing
- Tacrolimus
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Kidney Transplant, Renal Transplant Failure
Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage.
- Conditions
- Kidney Transplant, Renal Transplant Failure, Kidney Transplant Rejection, Frailty
- Trial name
- HLA-AB (NCT06025240)
- Testing
- cf-DNA, Immunological Events following renal transplant in older age, Determining Predictive Models for Post-transplant HLA-specific Antibody Formation
- Where
- United Kingdom
- Volunteers
- 282 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Liver Transplant; Complications, Renal Complication of Procedure
Renal Outcomes Among Post Liver Transplantation Patients
To evaluate Renal outcomes among patients, post liver transplantation at Assiut university.
- Trial name
- NCT06123260
- Testing
- renal function tests
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Opioid Use, Kidney Diseases
Enhanced Recovery After Surgery in Kidney Transplant Donors
Enhanced recovery after surgery (ERAS) pathways are designed to optimize perioperative management, improving patient outcomes and satisfaction through multimodal techniques.
- Conditions
- Opioid Use, Kidney Diseases, Pain, Postoperative, Postoperative Complications
- Trial name
- NCT04110080
- Testing
- multimodal pain management, goal directed fluid management, preoperative carbohydrate loading
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Gout, Chronic Kidney Disease
Anakinra vs Prednisone to Treat Gout Flare in Patients With Chronic Kidney Disease Stage 4/5 or Renal Transplantation
Gout is secondary to urate crystal deposition after chronic elevation of serum urate level. Urate crystal deposition is responsible for acute and recurrent inflammatory flares which can be treated with colchicine, non-steroid…
- Conditions
- Gout, Chronic Kidney Disease, Renal Transplantation
- Trial name
- Ana4CKD (NCT04844814)
- Testing
- Anakinra 100Mg/0.67Ml Inj Syringe, Prednisone
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Failure, Kidney Transplant
Infusion of T-Regulatory Cells in Kidney Transplant Recipients (The ONE Study)
This research study is for patients who are going to receive a kidney transplant from a living donor. After kidney transplantation, it is necessary for transplant recipients to take "immunosuppressive drugs".
- Trial name
- NCT02091232
- Testing
- T Regulatory Cell Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Massachusetts General Hospital
Kidney Disease
Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants
Diabetes and end-stage kidney, liver and heart disease are prominent health issues among veteran patients. Successful solid organ transplantation in the absence of chronic immunosuppressive therapy (specific acquired…
- Trial name
- NCT00018785
- Testing
- donor bone marrow infusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Polycystic Liver Disease
Polycystic Liver Disease in Kidney Transplant
The purpose of this study is to see if one kind of immunosuppressive drug has better effects for the patient's polycystic liver disease than another type.
- Trial name
- NCT00934791
- Testing
- Tacrolimus, Sirolimus, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
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