Clinical trials: Keratoconus, active
Keratoconus, Presbyopia
Proof-of-Concept for a Novel Optical Aperture Contact Lens in Presbyopia and Keratoconus
The purpose of this clinical study is to evaluate the effectiveness of the NOA lens, a custom-made scleral contact lens developed by Azalea Vision BV, in improving visual quality for individuals with keratoconus and presbyopia.
- Conditions
- Keratoconus, Presbyopia, Scleral Contact Lenses, Pinhole
- Trial name
- NOA (NCT07559188)
- Testing
- NOA lens type 1, NOA lens type 2
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 16 people
- Sponsor
- Azalea Vision
Keratoconus, Ectasia
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties…
- Conditions
- Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
- Trial name
- NCT02118922
- Testing
- Brillouin imaging
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Keratoconus, Keratoconus, Unstable
Corneal Biomechanical Analysis Using Brillouin Microscopy
The objective of this study is to measure the Brillouin biomechanical properties in keratoconic corneas and characterize biomechanical alterations that occur after corneal procedures that inherently strengthen or weaken the…
- Conditions
- Keratoconus, Keratoconus, Unstable, Keratoconus, Stable
- Trial name
- NCT04598932
- Testing
- Brillouin microscopy
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- The Cleveland Clinic
Tomography
UNITY DX Cornea Study
The purpose of this study is to validate the clinical measurement performance of an investigational biometer. Subjects will undergo multiple measurements of the eye, and the agreement, repeatability, and reproducibility of…
- Trial name
- NCT07768735
- Testing
- UNITY DX, ANTERION
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Keratoconus, Corneal Ectasia
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
- Trial name
- NCT07841470
- Testing
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Price Vision Group
Keratoconus
Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking
This study aims to compare the use of Dextenza, an FDA-approved intracanilular drug-eluting insert that is designed to deliver a tapered dose of dexamethasone to the ocular surface for 30 days, to the standard of care, or the use…
- Trial name
- NCT06235567
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, topical prednisolone acetate 1% (PredForte) eye drops
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Maanasa Indaram, MD
Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG)
A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases
The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.
- Conditions
- Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG), Dry Eye Disease (DED), Keratoconus
- Trial name
- NCT07780890
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Keratoconus
Corneal Lenticule Implantation in Keratoconus Disease With Relex Smile Surgery
CORNEAL LENTICULE IMPLANTATION IN KERATOCONUS DISEASE WITH RELEX SMILE SURGERY
- Trial name
- NCT04591587
- Testing
- Lenticule Implantation in Keratoconus Disease with RELEX Smile Surgery
- Where
- Kosovo
- Volunteers
- 40 people
- Sponsor
- Dr. Faruk Semiz
Keratoconus, Keratoconus of Right Eye
Fresh Corneal Lenticule Implantation and Autologous Serum - Case Report
The aim of our study is to investigate the feasibility and the effect of fresh lenticule implantation as allogenic graft that will be taken from myopic patients to implant in patients with keratoconus disease using VisuMax…
- Conditions
- Keratoconus, Keratoconus of Right Eye, Keratoconus, Unstable, Right Eye
- Trial name
- NCT04594512
- Testing
- Fresh corneal lenticule and autologous serum in advanced keratoconus using ReLex Smile surgery
- Where
- Kosovo
- Volunteers
- 1 people
- Sponsor
- Eye Hospital Pristina Kosovo
Keratoconus
German Corneal Cross Linking Register
Corneal Cross Linking is new treatment modality for patients with keratoconus. A keratoconus is characterized by progressive bulging and thinning of the eye's cornea.
- Trial name
- NCT00560651
- Testing
- CCL (Corneal Cross Linking)
- Where
- 2 sites in Germany
- Volunteers
- 356 people
- Sponsor
- Suphi Taneri
Keratoconus
Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus
Clinical trial to evaluate the safety and feasibility of corneal cross-linking in both eyes on the same day in subjects with keratoconus.
- Trial name
- NCT07629557
- Testing
- Riboflavin Ophthalmic Solutions, UV-A Irradiation System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Glaukos Corporation
Cornea; Ectasia, Refractive Errors
Corneal Elastography and Patient Specific Modeling
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors.
- Conditions
- Cornea; Ectasia, Refractive Errors, Keratoconus
- Trial name
- NCT03030755
- Testing
- Optical coherence tomography
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Keratoconus, Intraocular Pressure
Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT
To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT.
- Trial name
- NCT07599020
- Testing
- Corvis Machine
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Tanta University
Keratoconus
Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
The purpose of this study is to determine whether corneal collagen crosslinking is effective in the treatment of progressive keratoconus.
- Trial name
- CXL-RCT (NCT01604135)
- Testing
- Corneal Collagen Crosslinking
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Sahlgrenska University Hospital
Keratoconus
Clinical and Subclinical Keratoconus Cohort Study
The pathogenesis of keratoconus remains unclear, and its natural course has yet to be fully understood. For non-progressive patients and post-surgical cases, clinical management primarily involves follow-up observation, with…
- Trial name
- NCT07553832
- Where
- China
- Volunteers
- 421 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Keratoconus, Corneal Ectasia
Outcomes of CTAK Surgery
Measuring quality of vision and quality of life outcomes using a validated questionnaire in participants undergoing CTAK surgery for corneal ectasia
- Trial name
- CTAK (NCT07474870)
- Testing
- Questionnaire and Physical Exam
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Keratoconus
Intacs Prescription Inserts for Keratoconus Patients
The US food and Drug Administration (FDA) originally approved INTACS prescription inserts in April 1999 for the correction of low levels of nearsightedness (-1.00 to -3.00 diopters).
- Trial name
- NCT02138669
- Testing
- Intacs
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
Keratoconus
A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients
This randomized clinical trial will assess corneal astigmatism and visual outcomes in participants who have undergone corneal transplantation for keratoconus with ex vivo cross-linked donor corneal tissue versus participants who…
- Trial name
- EVOKE (NCT04584125)
- Testing
- Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light, Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Joseph B. Ciolino, MD
Macular Degeneration, Diabetic Retinopathy (DR)
Artificial Intelligence-assisted Diagnosis in Ophthalmology
This is a retrospective, multicenter, observational study designed to develop and validate an artificial intelligence (AI) system capable of detecting and classifying major ophthalmic diseases (glaucoma, cataract, diabetic…
- Conditions
- Macular Degeneration, Diabetic Retinopathy (DR), Glaucoma, Keratoconus
- Trial name
- AI-OPHTH-CR (NCT07497815)
- Testing
- No interventions
- Where
- 2 sites in Costa Rica
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Marisse Masis-Solano