Clinical trials: Keloid, active
Keloid
Transdermal Versus Intralesional Betamethasone for Keloids
This study aims to evaluate the efficacy and safety of transdermal delivery of compound betamethasone using a medium-frequency device compared with intralesional injection in the treatment of keloids.
- Trial name
- KBT (NCT07835438)
- Testing
- Compound betamethasone, Medium-frequency Therapeutic Device
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Hospital of China Medical University
Keloid
Ritlecitinib in Patients With Keloids or Those Undergoing Keloidectomy
Keloids are common, benign cutaneous overgrowths that manifest clinically as raised, hypertrophic, often hyperpigmented lesions which are formed in response to dermal injury or idiopathic stimuli.
- Trial name
- NCT06373458
- Testing
- Ritlecitinib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Keloid
Radiotherapy for Keloids
The purpose of this pilot study is to evaluate the safety and efficacy of radiation therapy (RT) in the treatment of unresected keloids.
- Trial name
- NCT04722263
- Testing
- Radiotherapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Montefiore Medical Center
Keloid of Ear Lobe
siRNA Microneedle Patches for Ear Keloid Post-Surgical Scars
The goal of this clinical trial is to evaluate whether small interfering RNA (siRNA) microneedle patches can improve the scar appearances of ear keloids treated with surgery.
- Trial name
- SILK (NCT07596628)
- Testing
- Small interfering RNA (siRNA) Microneedle Patches, Carbon Dioxide (CO2) Laser Surgery, Intralesional Triamcinolone 40 mg/mL
- Where
- Singapore
- Volunteers
- 158 people
- Sponsor
- Ong Kim Yao
Keloids, Fibroblast
Keloid Pathogenesis And Fibroblast Activation Study
Keloids are benign fibroproliferative skin disorders characterized by excessive fibroblast activation and extracellular matrix deposition. The molecular mechanisms underlying keloid formation remain incompletely understood.
- Trial name
- KPS (NCT07682636)
- Testing
- Tissue Collection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Hypertrophic Scars, Keloids
Scar Gel Product Family Clinical Investigation
The purpose of this PMCF investigation is to determine whether there are differences between the two formulations (Dermatix and Dermatix Ultra) in improving keloid and hypertrophic scars clinical symptoms and in the overall scar…
- Trial name
- NCT07684573
- Testing
- Dermatix, Dermatix Ultra
- Volunteers
- 150 people
- Sponsor
- Hanson Medical, Inc.
Keloid
A Clinical Study on the Safety and Efficacy of Wide-Band Ultrasound Combined With Traditional Chinese Medicine Preparations in the Prevention and Treatment of Keloids
The prevention and treatment of patients with multiple keloids throughout the body are extremely challenging. Keloids are highly resistant, refractory, and prone to recurrence, and are thus known as the "cancer that does not…
- Trial name
- WBUS +TCM (NCT07679243)
- Testing
- Wide-Band Ultrasound, traditional Chinese medicine
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University Union Hospital
Keloid
Analyse of Diagnosis Value of Keloid on 68Ga-RGD PET-CT
Keloids are often described as benign dermal fibroproliferative lesions characterized by increased growth beyond the boundaries of the original wound margin.Fibroblasts are considered to be the key cellular mediators of…
- Trial name
- NCT07660406
- Testing
- 68Ga-RGD
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Keloid Scars, Hypertrophic Scars
Topical Cryotherapy and Keloid/Hypertrophic Scars
The goal of this clinical trial is to determine whether the application of brief topical cryotherapy immediately before intralesional corticosteroid injections can reduce pain and injection resistance during routine treatment of…
- Trial name
- NCT07336368
- Testing
- Cryotherapy with liquid nitrogen, Intralesional Triamcinolone 10 mg/ml
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sonal Choudhary
Keloid and Hypertrophic Scars
Polidocanol 1% and Steroid in Keloids and Hypertrophic Scars
we will inject intralesional polidocanol 1% in keloids and hypertrophic scars to decrease vascularity and decrease size of lesion compared to intralesional steroid as standard treatment line
- Trial name
- NCT07606391
- Testing
- Group 1 (polidocanol 1% group):, Group 2 (Triamcinolone acetonide group):, Group 3 (combined Triamcinolone acetonide and polidocanol 1% group):
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Sohag University
Wound Heal, Scar
Preoperative Silicone Ointment and Wound Healing
Optimal scar healing is of great importance to patients, especially following surgery of the head and neck. This study evaluates the effectiveness of preoperative silicone ointment in wound healing in head and neck surgeries.
- Conditions
- Wound Heal, Scar, Scar, Hypertrophic, Keloid
- Trial name
- NCT05461157
- Testing
- Preoperative silicone ointment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Keloids
Comparison Of Effectiveness Of Intralesional Injectioms Of 5 Flourouracil Alone Verses Its Cpmbination With Cryotherapy In The Treatment Of Keloids
The goal of this clinical trial is to learn how well intralesional 5 fluorouracil with cryotherapy works to treat keloids as compared to intralesional 5 fluorouracil alone on keloids.
- Trial name
- NCT07531056
- Testing
- Cryotherapy will be done followed by intralesional injection of 5-fluorouracil, Intralesional 5-fluorouracil
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan
Keloid
Genetic Analysis of Keloids
Keloids have a strong genetic component. The goal of this study is to identify genes and regulatory elements on chromosomes that are the cause for keloids or contribute to keloid scarring.
- Trial name
- NCT01619553
- Where
- United States
- Volunteers
- 7,000 people
- Sponsor
- UConn Health
Keloid
Intralesional Cryosurgery Alone Versus Combined With 5-FU and Triamcinolone for Keloids
evaluate the efficacy and safety of intralesional cryosurgery alone compared with intralesional cryosurgery combined with intralesional 5-fluorouracil and triamcinolone acetonide in the treatment of keloids.
- Trial name
- NCT07526168
- Testing
- Intralesional Cryotherapy + Saline Injection, Intralesional Cryotherapy + TAC/5-FU Injection
- Volunteers
- 32 people
- Sponsor
- Assiut University
Keloids, Keloids Scars
A Prospective Observational Clinical Study on Exploring the Value of Surgical Excision Combined With 32P Application in the Treatment of Keloids and the Factors Affecting the Prognosis of Combined Therapy
Keloids are non-cancerous (benign) growths on the skin. They form after an injury, when the skin makes too much connective tissue that thickens and hardens. These keloids cause big problems for people.
- Trial name
- NCT07413497
- Volunteers
- 401 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Keloids Scars
The Efficacy of Intralesional Bleomycin as Compared to 5-Flourouracil (5-FU) and Triamcinolone Acetonide (TAC) for the Treatment of Keloids: A Randomized Control Trial.
The goal of this clinical trial is to learn if drug bleomycin intralesionally is beneficial than intralesional 5FU and Triamcinolone Acetonide in treating Keloids.
- Trial name
- NCT07201766
- Testing
- intralesional bleomycin, 5-flourouracil and triamcinolone acetonide
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- King Edward Medical University
Acceptability Study, Real-use Conditions
Evaluation of Clinical, Perceived and Instrumental Efficacy of a Scar Gel in Preventing Hypertrophic Scars
Evaluation of the safety and topical efficacy of a scar gel after 90 days of continuous use, comparing it to a benchmark for preventing hypertrophic scars and improving appearance, hydration and pigmentation.
- Conditions
- Acceptability Study, Real-use Conditions, Safety and Efficacy, Topical Administration
- Trial name
- NCT06751433
- Testing
- Scar gel, Scar gel comparator
- Where
- 2 sites in Brazil
- Volunteers
- 80 people
- Sponsor
- Herbarium Laboratorio Botanico Ltda
Sternotomy Closure,Open Heart Surgery
Botulinum Toxin Injection After Sternotomies to Improve Scar Aspect and Impact
Sternotomy scars, which are localized in a high-tension area are often dystrophic, hypertrophic or keloidal, and can be difficult to accept to patients who already endured a heavy intervention with high psychologic impact.
- Trial name
- BotuCiSter (NCT07013240)
- Testing
- Botulinum toxin injection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Keloids
Bevacizumab Versus Triamcinolone Acetonide for the Treatment of Keloids.
The study compares the efficacy and safety of intralesional bevacizumab versus corticosteroids for the treatment of keloids. Assessment will be done clinically by the use of Modified Vancouver Scar Scale.
- Trial name
- NCT07014280
- Testing
- Bevacizumab, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Kasr El Aini Hospital
Patients With Keloid Scar
Comparison of Recurrence Rate of Keloid After Excision Between Intra-operative Steroid Injection and Steroid With Platelet-rich Plasma Injection Combination Therapy
Keloid scars are benign skin lesions characterized by excessive collagen deposition, and their treatment remains challenging due to a high recurrence rate even after surgical excision.
- Trial name
- NCT06965088
- Testing
- Combined Intra-operative platelet-rich plasma with corticosteroid injection, Intra-operative corticosteroid injection
- Where
- Thailand
- Volunteers
- 212 people
- Sponsor
- Ramathibodi Hospital