Clinical trials: Kava
Pharmacokinetics
A Phased Clinical Trial of Dietary Supplemental Kava: Kava Pharmacokinetics
Kava is a dietary supplement on the US market and is experiencing a resurgence of its use. Its pharmacokinetic information, however, is lacking which is important for its future effective usage as a dietary supplement or…
- Trial name
- KavaPK (NCT03843502)
- Testing
- Kava Dietary Supplement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Generalized Anxiety Disorder
Kava for the Treatment of Generalised Anxiety Disorder: A Double-Blind Randomised Placebo-Controlled Trial
The use of Kava in Generalised Anxiety Disorder: an 18-week double-blind, randomised, placebo-controlled study.
- Trial name
- KGAD (NCT02219880)
- Testing
- Kava (240mg of kavalactones per day)
- Where
- 2 sites in Australia
- Volunteers
- 178 people
- Sponsor
- University of Melbourne
Healthy
Effects of Kava on the Body's Elimination of Caffeine and Dextromethorphan
This study will examine how kava-a widely used herbal remedy-may affect the body's elimination of other medicines. Many people take kava to reduce anxiety or cause sedation.
- Trial name
- NCT00009542
- Testing
- kava (Piper methysticum)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pharmacokinetics
Biomarker Changes and Anxiolytic Effects-Phase 2
This study will examine the utility of plasma and urinary based biomarkers for the anxiolytic properties of kava. The investigators will conduct a one week, double blind, randomized placebo controlled trial of kava, dosed at…
- Trial name
- KavaPK (NCT04565145)
- Testing
- Kava Dietary Supplement
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Herb-Herb Interaction, Pharmacokinetics
Pharmacokinetics of Kava and Kratom Alone and in Combination
This study is being conducted to evaluate how different formulations of the Feel Free® Tonic containing Kava, Kratom, or a combination of both are processed in the body in healthy adults.
- Trial name
- NCT07583407
- Testing
- Kava and Kratom Herbal Supplement, Kava Herbal Supplement, Kratom Herbal Supplement
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Botanic Tonics, LLC
Smoking
The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence
This study will evaluate the compliance with a daily kava regimen among active smokers who have an intention to quit smoking. This study will also investigate whether kava use can facilitate tobacco cessation, reduce stress, and…
- Trial name
- NCT05814055
- Testing
- AB-free kava
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Florida
Sleep
Kavalactones on Sleep and Cortisol in Healthy Special Forces Trainees
This research study is being done to better understand the effects of kava supplementation on sleep quality and salivary cortisol in the context of the acute physical and psychological stress of military special forces…
- Trial name
- NCT05381025
- Testing
- Kava (Piper methysticum) extract
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Thorne HealthTech, Inc
Smoking
Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava
Tobacco use is the leading cause of many preventable diseases, particularly lung cancer. Based on the national cancer data in 2020, Florida has the highest lung cancer incidence (18,150 cases) with the most deaths (10,580 deaths)…
- Trial name
- NCT05081882
- Testing
- Kava
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Tobacco Smoking
Investigation of Kava Effects on NNK Metabolism
This is a non-therapeutic, single-arm pilot clinical trial in adult healthy smokers to assess whether kava can alter NNK metabolism in humans.
- Trial name
- NCT02500472
- Testing
- Kava
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Kava on the Metabolism of Nicotine and NNK
Exploring the Impact of Two-week Kava on the Metabolism of Nicotine and NNK
Tobacco smoking is the leading cause of head and neck cancer in the United States. Smoking cessation remains a challenge for many head/neck cancer survivors, indicating a need for development of more effective smoking cessation…
- Trial name
- NCT03606655
- Testing
- Kava
- Sponsor
- University of Florida
Kava, Anxiety
Effect of Kava on Anxiety and Stress in Cancer Survivors
This is a pilot, two-arm, randomized, blinded, placebo-controlled cross-over clinical trial to study the safety and effect of 14 days of kava on anxiety and physiologic stress in survivors of cancer and its treatment.
- Conditions
- Kava, Anxiety, Stress, Cancer
- Trial name
- NCT06213298
- Testing
- Kava
- Where
- United States
- Sponsor
- Masonic Cancer Center, University of Minnesota
Depressive Disorder, Major, Anxiety Disorders
St. John's Wort And Kava In The Treatment Of Major Depressive Disorder With Comorbid Anxiety
SJW has the greatest evidence of herbal medicine efficacy in treating MDD. In treating anxiety, kava has the greatest evidence of efficacy.
- Trial name
- NCT00451516
- Testing
- Herbal medicine (St. John's wort and Kava)
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- The University of Queensland
Old Adults, Sleep Quality
Kava Aging and Mobility Study
The goal of this clinical trial is to learn if AB-free kava works to improve mobility and physical function in older adults with sleep difficulties. It will also learn about the safety of AB-free kava.
- Conditions
- Old Adults, Sleep Quality, Kava, Mobility Impairment
- Trial name
- NCT07219186
- Testing
- AB-free kava
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Anxiety Disorders
Kava Kava for the Treatment of Generalized Anxiety Disorder (GAD)
The purpose of this study is to evaluate the safety and effectiveness of the herbal medicine kava kava for the treatment of generalized anxiety disorder (GAD).
- Trial name
- NCT00083980
- Testing
- Venlafaxine ER, Sugar pill, Kava
- Volunteers
- 16 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)