Clinical trials: Ischemic Heart Disease, active
Coronary Artery Disease, Atherosclerosis of Coronary Artery
Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold System in the Treatment of Subjects With Long de Novo Lesions
The study objective is the assessment of safety and clinical performance of Freesolve 35- and 40-mm in de novo coronary artery lesions up to 38 mm length.
- Conditions
- Coronary Artery Disease, Atherosclerosis of Coronary Artery, Myocardial Ischemia, Ischemic Heart Disease
- Trial name
- BIOMAG-LL (NCT07091682)
- Testing
- Implantation of a Sirolimus-Eluting Resorbable Coronary Magnesium Scaffold
- Where
- 14 sites in Germany, Hungary and 5 more
- Volunteers
- 100 people
- Sponsor
- Biotronik AG
Coronary Artery Disease, Coronary Disease
Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria at OCT in Patients With ACS
The INTERCLIMA (Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria Identified by Optical Coherence Tomography in Patients With Acute Coronary Syndrome) is a multi-center, prospective, randomized…
- Conditions
- Coronary Artery Disease, Coronary Disease, Ischemic Heart Disease
- Trial name
- INTERCLIMA (NCT05027984)
- Testing
- Optical coherence tomography, iFR/FFR/RFR
- Where
- 34 sites in Greece, Italy and 2 more
- Volunteers
- 1,425 people
- Sponsor
- Centro per la Lotta Contro l'Infarto - Fondazione Onlus
Heart Failure, Ischemic Heart Failure
Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study)
The purpose of this clinical study is to evaluate the safety and efficacy of endocardial delivery of HS-001 CS into severe heart failure patients with reduced ejection fraction for 26 weeks after transplantation.
- Conditions
- Heart Failure, Ischemic Heart Failure, Ischemic Heart Disease, Dilated Cardiomyopathy (DCM)
- Trial name
- EMERALD (NCT07347197)
- Testing
- HS-005
- Where
- 5 sites in Japan
- Volunteers
- 14 people
- Sponsor
- Heartseed Inc.
Coronary Artery Disease (CAD), Ischemic Heart Disease
Coroflex® ISAR NEO PMCF Study
International, Multicenter, prospective, non-randomized, post-market clinical follow-up (PMCF) study to confirm and support the clinical safety and performance of Coroflex® ISAR NEO coronary stent system to meet EU Medical Device…
- Trial name
- rEPIC07 (NCT05698732)
- Testing
- Coroflex® ISAR NEO coronary stent system
- Where
- 26 sites in France, Spain and 1 more
- Volunteers
- 3,000 people
- Sponsor
- Fundación EPIC
Ulcerative Colitis, Myocardial Infarction
Estimation of Cardiovascular Risk in Patients With Crohn's Disease and Ulcerative Colitis (PROVACI)
Inflammatory bowel diseases (IBD) are progressively increasing their prevalence worldwide. Up to half of patients may also have extraintestinal manifestation and cardiovascular diseases (CVDs) is one of the most relevant, being…
- Conditions
- Ulcerative Colitis, Myocardial Infarction, Stroke, Ischemic Heart Disease
- Trial name
- PROVACI (NCT07095634)
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Ischemic Heart Disease (IHD)
A Clinical Evaluation of AMJ-401
A Clinical Evaluation of AMJ-401 in the Treatment of Subjects with Ischemic Heart Disease in Japan
- Trial name
- NCT07373353
- Testing
- AMJ-401
- Where
- 10 sites in Japan
- Volunteers
- 50 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Gangwon PCI Prospective Registry
This prospective, multicenter registry will consecutively enroll patients of all ages undergoing percutaneous coronary intervention (PCI) at four university hospitals in Gangwon Province, Republic of Korea.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Unstable Angina (UA), Non-ST Elevated Myocardial Infarction
- Trial name
- GWPCI (NCT02038127)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 4 sites in South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Ischemic Heart Disease, Ischemic Heart Disease Chronic
DAN-RELEASE - Reconsidering Long-Term Aspirin in the Elderly Patients With Stable Ischemic Heart Disease
DAN-RELEASE is a national, randomized, registry-based trial including 7,000 participants in Denmark. The trial aims to determine whether discontinuation of long-term aspirin therapy is non-inferior to continued aspirin therapy in…
- Conditions
- Ischemic Heart Disease, Ischemic Heart Disease Chronic, Chronic Coronary Syndrome, Myocardial Infarction
- Trial name
- DAN-RELEASE (NCT07795398)
- Testing
- Continuation of daily low-dose Aspirin, Discontinuation of daily low-dose Aspirin
- Where
- 2 sites in Denmark
- Volunteers
- 7,000 people
- Sponsor
- Odense University Hospital
Delirium, Ischemic Stroke
CTSN Embolic Protection Trial
This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.
- Conditions
- Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease
- Trial name
- EMPRO (NCT06027788)
- Testing
- CardioGard Embolic Protection Cannula, Standard Aortic Cannula
- Where
- 24 sites in United States, Canada
- Volunteers
- 842 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ischemic Heart Disease, Ischemic Coronary Artery Disease
Optical Coherence Tomography in Acute Vessel Evaluation
The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACS
- Conditions
- Ischemic Heart Disease, Ischemic Coronary Artery Disease, ACS (Acute Coronary Syndrome)
- Trial name
- OCTAVE (NCT07422688)
- Testing
- Angiographic Guided PCI, OCT Guided PCI
- Where
- 26 sites in Belgium, Denmark and 10 more
- Volunteers
- 3,000 people
- Sponsor
- Aarhus University Hospital Skejby
Hypertension, Stroke
A Cluster-Randomized Controlled Trial
The goal of this study is to learn if an AI-generated personalized health report combined with face-to-face guidance from cardiologists can help rural adults with high blood pressure control their blood pressure better and reduce…
- Conditions
- Hypertension, Stroke, Cardiovascular, Coronary Heart Disease
- Trial name
- NCT07845448
- Testing
- AI-powered personalized health report with cardiologist consultation and prescription optimization, Integrated management (follow-up, education, quality control) without AI report and cardiologist consultation
- Volunteers
- 14,400 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Ischemic Heart Diseases
AI-enhanced Heart MRI for Evaluating Blood Flow
This study will compare the standard MRI protocol with an advanced MRI protocol for the assessment of ischemic heart disease. The goal is to evaluate whether the advanced protocol provides comparable or improved diagnostic…
- Trial name
- NCT07833774
- Testing
- Accelerated advanced MRI sequences protocol
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Myocardial Viability
- Trial name
- NCT06047028
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Coronary Artery Disease, Ischemic Heart Disease
LONG NAGOMI™ PMCF STUDY
The study is designed as a prospective, multi-center, observational PMCF (post-market clinical follow-up) study of the Ultimaster Nagomi™ _stent (lengths of 38, 44 and 50 mm) in the treatment of coronary artery disease according…
- Trial name
- LONG NAGOMI (NCT07399002)
- Testing
- LONG NAGOMI
- Where
- 10 sites in Spain
- Volunteers
- 1,039 people
- Sponsor
- Fundación EPIC
Ischemic Heart Disease, Coronary Artery Disease
Controlled Trial of High-risk Coronary Intervention With Percutaneous Left Ventricular Unloading
Over 100,000 coronary stent procedures, where small balloons are used to stretch open a narrowed blood vessel, are performed every year in the United Kingdom to treat people who have conditions such as angina or have suffered a…
- Trial name
- CHIP-BCIS3 (NCT05003817)
- Testing
- Percutaneous left ventricular unloading
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Ischemic Heart Disease, Coronary Artery Disease
Electronic Letters to Improve Patient Activation in IHD: The NUDGE-IHD Trial
The goal of this clinical trial is to learn whether simple electronic information letters can increase patient activation and improve risk-factor monitoring in adults in Denmark with ischemic heart disease (IHD) who have LDL…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Hypercholesterolemia, Lipoprotein(a)
- Trial name
- NUDGE-IHD (NCT07382414)
- Testing
- LDL-C information letter, Lp(a) information letter
- Where
- Denmark
- Volunteers
- 123,000 people
- Sponsor
- Tor Biering-Sørensen
Ventricular Tachycardia, Ischemic Heart Disease
Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia
ASCEND is a randomized controlled open-label pilot study evaluating the safety and effectiveness of pulsed field ablation (PFA) with the novel FARAPOINT catheter compared to the standard radiofrequency (RFA) ablation with…
- Conditions
- Ventricular Tachycardia, Ischemic Heart Disease, Sustained VT
- Trial name
- ASCEND-VT (NCT06891456)
- Testing
- RFA Ablation, PFA Ablation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pasquale Santangeli
Ischemic Heart Disease (IHD), Cardiac Magnetic Resonance Imaging
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in…
- Conditions
- Ischemic Heart Disease (IHD), Cardiac Magnetic Resonance Imaging, Myocardial Blood Flow
- Trial name
- SPINS2 (NCT06854458)
- Testing
- Quantitative Myocardial Blood Flow Evaluation, Qualitative Myocardial Blood Flow Evaluation, Gadavist
- Where
- 13 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Brigham and Women's Hospital
Heart Surgery, Ischemic Heart Disease
Efficacy of Carbohydrate Loading in Diabetic Type 2 Patients Undergoing CABG Surgery on CPB
Enhanced recovery after surgery protocols aim to optimize perioperative care and improve surgical outcomes. Preoperative carbohydrate loading has demonstrated benefits in reducing insulin resistance and improving patient…
- Trial name
- CLDM-CABG (NCT06951308)
- Testing
- Carbohydrate loading before surgery
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Ischemic Heart Disease (IHD), Off-pump Coronary Artery Bypass
Efficacy of Multiple Nerve Blocks on the Recovery of Patients Undergoing Off Pump CABG Surgeries
In cardiac surgery patients , effective pain control is crucial to support early extubation, mobilization, and cognitive recovery, yet systemic opioids carry substantial risks such as respiratory depression, delirium, and delayed…
- Conditions
- Ischemic Heart Disease (IHD), Off-pump Coronary Artery Bypass, Regional Block for Pain Control
- Trial name
- NCT07794527
- Testing
- regional nerve block with local anesthesia
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University