Clinical trials: Ischemic Conditioning
Enterocolitis, Necrotizing
Remote Ischemic Conditioning in Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) affects up to 10% of very preterm infants. NEC mortality is high (30-50 %) and has remained unchanged over the last decades. New treatments are urgently needed.
- Trial name
- NCT03860701
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- The Hospital for Sick Children
Acute Stroke
Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic Stroke (REVISE-1)
Currently, early reperfusion is considered as the most effective therapy for the treatment of acute ischemic stroke (AIS). Over the past 20 years, intravenous tissue plasminogen activator (IV tPA) has been demonstrated to be the…
- Trial name
- NCT03210051
- Testing
- Remote ischemic conditioning, Endovascular treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke Due to Large Artery Atherosclerosis
Large Artery Atherosclerosis is one of the most prevalent causes of stroke worldwide and is associated with a high risk of disability and recurrent strokes.
- Trial name
- RIC-LAA (NCT06775782)
- Testing
- Remote Ischemic Conditioning (RIC) treatment, Medical Management
- Where
- China
- Volunteers
- 1,150 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Refractory Angina Pectoris
Effect of Daily Remote Ischemic Conditioning on the Life Quality of Refractory Angina Pectoris Patients
The purpose is to test whether daily ischemic conditioning of the arms over 30 days could reduce the frequency and severity of angina pectoris and improve the life quality of refractory angina pectoris patients.
- Trial name
- D-RIC-RAP (NCT02499250)
- Testing
- remote ischemic conditioning (TDFT-12-A2), Optimal medical treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Navy General Hospital, Beijing
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Diabetic Foot Ulcer, Diabetic Angiopathies
Remote Ischemic Conditioning and Diabetic Foot Ulcers
Study type: Randomized, double blinded, interventional, single-site study. Two groups: Active receiving RIC therapy from the LifeCuff device and standard of care treatment without RIC.
- Trial name
- NCT04567563
- Testing
- Remote Ischemic conditioning (RIC)
- Volunteers
- 50 people
- Sponsor
- Des Moines University
Chronic Kidney Diseases
The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease
The incidence of Chronic kidney disease (CKD) is showing an upward trend, but the therapeutic effect of treatment is limited. Remote ischemic conditioning (RIC) has the potential to safeguard remote organs via the repeated…
- Trial name
- NCT06501222
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Yuanjun Yang
Unruptured Intracranial Aneurysm, Infarction Cerebral
Chronic Remote Ischemic Conditioning in Small Infarctions Associated with Stent-assisted Coiling of Unruptured Intracranial Aneurysms
1. Disease Description Stent-assisted coiling has become an effective treatment modality for intracranial aneurysms. With continuous advancements in periprocedural antiplatelet regimens, the incidence of symptomatic…
- Trial name
- CRISIS (NCT06826144)
- Testing
- remote ischemic conditioning
- Volunteers
- 84 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Aortic Aneurysm, Surgery
Evaluation of the Effectiveness of Ischemic Pre-conditioning on the Morbidity and Mortality of Open Surgery of Thoracoabdominal Aortic Aneurysms.
Patients having a planned open surgery of thoracoabdominal aortic aneurysms and enrolled in the study will be randomized the day of the surgery in 2 groups: Arm 1 : Patients with aortic clamping with pre-conditioning Arm 2 …
- Trial name
- EPICATA (NCT03718312)
- Testing
- clamping with pre-conditioning (PCl)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Rouen
Central Sympathetic Nervous System Diseases
Role of Sympathetic Activation in Ischemia Reperfusion Injury
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote…
- Trial name
- NCT04479813
- Testing
- Moxonidine 0.2 MG
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Royal Perth Hospital
Myocardial Infarction, Anterior Wall
COmprehensive Remote Ischemic Conditioning in Myocardial Infarction
The primary objective of the CORIC-MI trial is to evaluate whether comprehensive (per, post plus delayed) remote ischemic conditioning (CORIC) as an adjunctive therapy in patients with ST-elevation myocardial infarction (STEMI)…
- Trial name
- CORIC-MI (NCT03233919)
- Testing
- comprehensive remote ischaemic conditioning
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Ischemic Cerebrovascular Disease
Limb Remote Ischemic Conditioning and Cerebrovascular Reserve
Cerebrovascular reserve (CVR), defined as the increase in cerebral blood flow (CBF)in response to a vasodilatory stimulus, is known to reflect the compensative capacity of the brain to maintain adequate blood flow in the face of…
- Trial name
- NCT03589053
- Testing
- Limb remote ischemic conditioning, Control group
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Brain Aneurysms
Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage
The purpose of the study is to investigate if briefly stopping blood flow to the patient's leg will lead to the patient's body being better able to tolerate possible decreased blood flow to regions of the brain which otherwise…
- Trial name
- RIPC-SAH (NCT02381522)
- Testing
- Remote Ischemic Pre-conditioning
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Loma Linda University
Stroke, Acute
r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery
to detect the efficiency and safety of intravenous rtPA combined with RIPC in acute ischemic stroke patients
- Trial name
- rtPA-RIC (NCT02886390)
- Testing
- ischemic conditioning
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Intracranial Atherosclerosis
Remote Ischemic Conditioning for Avoiding Recurrence of Symptomatic Intracranial Atherosclerotic Stenosis (sICAS)
The primary objective of the study will be to determine whether remote limb ischemic conditioning (RLIC) compared with sham RLIC (placebo) treatment reduces the 12-month risk of recurrent IS in patients with a recent TIA or IS…
- Trial name
- NCT02534545
- Testing
- Doctormate® (200mmHg), Doctormate® (60mmHg)
- Where
- 50 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Ji Xunming,MD,PhD
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Post-stroke Depression, Remote Ischemic Conditioning
Efficacy of Remote Ischemic Conditioning in Preventing Post-Stroke Depression
Post-stroke depression (PSD) is characterized primarily by low mood and loss of interest following a stroke. It is one of the most common and serious complications of stroke, with an incidence of 11% to 41% within two years…
- Trial name
- NCT06920706
- Testing
- RIC
- Where
- 5 sites in China
- Volunteers
- 240 people
- Sponsor
- Xuanwu Hospital, Beijing
Vertebrobasilar Ischemia
Remote Ischemic Conditioning for Reducing Stroke Risk of Symptomatic Vertebrobasilar Lesion of Atherosclerosis
The purpose of this study is to investigate whether remote ischemic conditioning(RIC) would reduce the stroke risk of patients with symptomatic vertebrobasilar lesion of atherosclerosis,then we would observe the haemodynamics and…
- Trial name
- NCT02971462
- Testing
- ischemic conditioning
- Volunteers
- 80 people
- Sponsor
- Ji Xunming
Participants Undergoing Anthracycline Chemotherapy
Remote Ischemic Conditioning in Oncology
This is a feasibility study at a single site, Cincinnati Children's Hospital Medical Center. Patients undergoing anthracycline chemotherapy for Hodgkin disease and soft-tissue and bone sarcoma who meet eligibility requirements…
- Trial name
- RICO (NCT04805346)
- Testing
- autoRIC®
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cerebral Autoregulation, Blood Pressure
Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically.
- Conditions
- Cerebral Autoregulation, Blood Pressure, Dynamic Cerebral Autoregulation
- Trial name
- RICE-DCA (NCT07179887)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham