Clinical trials: Ischemic Conditioning
Acute Ischemic Stroke
Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2)
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke.
- Trial name
- NCT05789823
- Testing
- Mechanical thrombectomy combined with ischemic post-conditioning, Mechanical thrombectomy alone
- Where
- 6 sites in China
- Volunteers
- 160 people
- Sponsor
- Capital Medical University
Platelet Function
Remote Ischemic Conditioning and Platelet Dysfunction
The purpose of this study is to evaluate the effects of remote ischemic conditioning on platelet function during off-pump coronary artery bypass surgery.
- Trial name
- NCT03125681
- Testing
- Remote ischemic conditioning, Control
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Cardiac Arrest
Ischemic Conditioning in STEMI Patients
The purposes of the study are to 1) study alterations in the metabolomic profile of patients exposed to post-ischemic conditions and 2) study alterations in myocardial infarction size of patients exposed to post-ischemic…
- Trial name
- EDICT (NCT03097419)
- Testing
- Remote post-ischemic conditioning
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Beth Israel Deaconess Medical Center
Esophageal Cancer
Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning
This retrospective monocentric comparative study aims to assess the efficacy of preoperative ischemic conditioning, in preventing anastomotic leakage in esophageal cancer surgery.
- Trial name
- NCT06312839
- Testing
- Collecting data from the medical record
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Moyamoya Disease, TIA
The Effect of RIC on TIA/Stroke in Children With Moyamoya Disease
Moyamoya disease is a common reason of transient ischemic attack (TIA) and stroke in children. Remote ischemic conditioning (RIC) has been shown to prevent recurrent stroke in intracranial arterial stenosis, but it is unclear…
- Conditions
- Moyamoya Disease, TIA, Children, Stroke
- Trial name
- RIC-PMD-1 (NCT03821181)
- Testing
- RIC group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke.
- Trial name
- PROTECT (NCT05153655)
- Testing
- Local ischemic post-conditioning
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Capital Medical University
Ischemic Heart Disease
Effects of Remote Ischemic Conditioning on Myocardial Perfusion in Humans
Cardiovascular disease is the second leading cause of death in Denmark, and ischemic heart disease accounts for the bulk of it. The purpose of this study is to clarify whether a mechanical method of remote ischemic conditioning…
- Trial name
- CONDI-PET (NCT02230098)
- Testing
- Remote Ischemic Conditioning
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Coronary Artery Disease (CAD)
Hypoxia Pre-conditioning and Mountain Sport
Mountain sport activities as for example hiking or skiing may involve the risk of adverse health events especially in older people not accustomed to the specific mountain sport at altitude or people with pre-existing health…
- Trial name
- Hyx-PRE-Spo (NCT04725539)
- Testing
- hypoxic exposure
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Institute of Mountain Emergency Medicine
Diabetes Mellitus, Coronary Artery Bypass
Remote Ischemic Preconditioning in Type 2 Diabetic Patients Undergoing CABG
This randomized, double-blind, prospective clinical trial aims to investigate the effect of remote ischemic preconditioning (RIPC) on myocardial protection in patients with type 2 diabetes mellitus undergoing elective coronary…
- Conditions
- Diabetes Mellitus, Coronary Artery Bypass, Remote Ischaemic Conditioning
- Trial name
- NCT06977230
- Testing
- Remote Ischemic Preconditioning
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Muğla Sıtkı Koçman University
Remote, Ischemic Conditioning
Remote Ischemic Conditioning in Patients Undergoing Primary Percutaneous Coronary Intervention
This study aimed to detect the effects of remote ischemic conditioning on infarct size, global contractility, morbidity, mortality, and renal function in patients undergoing primary percutaneous coronary intervention.
- Conditions
- Remote, Ischemic Conditioning, Primary Percutaneous Coronary Intervention
- Trial name
- NCT07272408
- Testing
- Remote ischemic conditioning, Normal primary percutaneous coronary intervention
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- Helwan University
Cerebral Small Vessel Diseases
Remote Ischemic Conditioning on Cerebral Small Vessel Disease
This trial is a randomized, controlled, single-center, double-blind trial. Cerebral small vessel disease (CSVD) patients will be recruited and randomized into RIC or control group.The protective effect of remote ischemic…
- Trial name
- RIC-SVD (NCT04816500)
- Testing
- Automatic ischemic conditioning treatment instrument, Regular treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Ischemic Stroke
Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Acute Stroke Infarct
The purpose of this study was to determine the effectiveness of a combination of intranasal conditioned medium (CM) with intraparenchymal umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in acute stroke patients to…
- Trial name
- NCT05008588
- Testing
- Conditioned Medium, Umbilical Cord Mesenchymal Stem Cells, Neurologic and Neutrophic Drugs
- Where
- 2 sites in Indonesia
- Volunteers
- 15 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Retinal Ischemia, Diabetes Complications
Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning in Patients With Type 1 Diabetes
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Conditions
- Retinal Ischemia, Diabetes Complications, Ischemia, Diabetes Mellitus, Type 1
- Trial name
- NCT03906383
- Testing
- Remote Ischemic Conditioning
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- University of Aarhus
Stroke
Augmenting Cerebral Blood Flow in Acute Ischemic Stroke
The most common type of stroke is ischemic (lack of blood flow to the brain due to a clot blocking a blood vessel). Time is brain and an average of 1.9 million brain nerve cells per minute are destroyed in patients experiencing a…
- Trial name
- NCT06911385
- Testing
- Arm Remote Ischemic Conditioning plus Pneumatic Compression lower limb
- Volunteers
- 150 people
- Sponsor
- University of Alberta
ST-elevation Myocardial Infarction
Effect of Conditioning on Myocardial Damage in STEMI
The LIPSIA-Conditioning trial is an investigater initiated, randomized, single-center study that will assess the effect of different intrahospital conditioning protocols on myocardial damage assessed by MRI in patients with acute…
- Trial name
- LIPSIA-COND (NCT02158468)
- Testing
- Combined intrahospital pre- and postconditioning, Postconditioning
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University of Leipzig
Stroke, Acute
Exercise and RIC and TCD
The first week after a stroke is a particularly important time, as improving blood flow may limit secondary ischaemic damage to the brain and help reduce the overall burden neurological injury and future disability.
- Trial name
- NCT03968068
- Testing
- Exercise Procedure, Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Moyamoya Disease, Moyamoya Syndrome
Evaluating Antiplatelet and Physical Therapy for Slowing Progression in Mild Moyamoya Disease.
Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease characterized by progressive stenosis or occlusion at the terminal portion of the internal carotid artery, with formation of an abnormal vascular network at…
- Conditions
- Moyamoya Disease, Moyamoya Syndrome, Aspirin, Remote Ischemic Conditioning
- Trial name
- MOUNT-EASE (NCT07762547)
- Testing
- aspirin treatment, Remote Ischemic Conditioning
- Where
- China
- Volunteers
- 724 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Palsy
Ischemic Conditioning to Enhance Function (I-C-FUN) in Children With Cerebral Palsy
The purpose of this research study is to determine if remote limb ischemic conditioning (RLIC) can increase skeletal muscle power, enhance learning of motor (dynamic balance) task, and improve walking performance in children with…
- Trial name
- I-C-FUN (NCT04598711)
- Testing
- RLIC, Muscle Power training, Balance training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- East Carolina University
ST-elevation Myocardial Infarction (STEMI)
Long-term Clinical Outcome in Patients Undergoing Remote Ischemic Conditioning Before Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction: a Follow-up Study
The aim of this prospective follow-up study is to investigate 5-year clinical outcome in patients with ST-elevation myocardial infarction undergoing remote ischemic conditioning before primary percutaneous coronary intervention.
- Trial name
- NCT01665365
- Testing
- Remote ischemic perconditioning
- Where
- Denmark
- Volunteers
- 251 people
- Sponsor
- University of Aarhus
Acute Myocardial Infarction
Phase II Clinical Trial to Evaluate the Benefits of Postconditioning in ST-Elevation Myocardial Infarction (STEMI)
This study will evaluate change in heart muscle function from baseline to three months and twelve months in participants who present with a heart attack and a completely occluded coronary artery.
- Trial name
- NCT01324453
- Testing
- Post Conditioning + Primary PCI, Standard Primary PCI
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Minneapolis Heart Institute Foundation