Clinical trials: Ischemia Vascular
Stable Angina, Non ST Segment Elevation Myocardial Infarction
INsTantenous wavE-Free Ratio-guided PCI Versus Fractional Flow REserve-Guided PCI in rouTine Clinical Practice, Prospective, Multicenter Registry
The current study sought to evaluate the clinical relevance of iFR-guided strategy in real world clinical practice using unrestricted study population from stable angina to acute coronary syndrome including acute ST-segment…
- Conditions
- Stable Angina, Non ST Segment Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction, Silent Myocardial Ischemia
- Trial name
- INTERPRET (NCT03338309)
- Testing
- Instantaneous wave-free ratio measurement
- Where
- 4 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Acute Ischemic Stroke, Endovascular Treatment
Early vs Delayed Extubation After Endovascular Treatment for Acute Ischemic Stroke
Although older studies, most of them retrospective in design, advocated sedation over general anesthesia during endovascular treatment for acute ischemic stroke, a recent meta-analysis and randomized studies have shown that…
- Trial name
- EDESTROKE (NCT05847309)
- Testing
- Delayed extubation, Early extubation
- Where
- Spain
- Volunteers
- 174 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Ischemic Stroke
Study of Efficacy and Safety of MEXIDOL® in Ischemic Stroke Therapy
The purpose of this study is to evaluate the efficacy and safety of long-term sequential therapy with Mexidol® in long-term sequential treatment of patients in the acute and early recovery periods of hemispheric ischemic stroke…
- Trial name
- EPICA (NCT02793687)
- Testing
- Mexidol
- Where
- 11 sites in Russia
- Volunteers
- 150 people
- Sponsor
- Pharmasoft
Chronic Coronary Syndrome, Hypertension
Benidipine in Hypertensive and/or Chronic Coronary Syndrome Patients
Evaluation of the clinical outcomes of Benidipine initiated by physician's preference in patients with hypertension and/or angina pectoris (chronic coronary syndrome) presenting to cardiology outpatient clinics in Türkiye.
- Conditions
- Chronic Coronary Syndrome, Hypertension, Angina Pectoris
- Trial name
- BenidipineTR (NCT06808321)
- Testing
- Benidipine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 1,659 people
- Sponsor
- The Society of Prevention and Awareness of Cardiovascular Diseases
Immunosuppression
Safety Outcomes of Lower Immunosuppression Versus Traditional Immunosuppression in Heart Transplant Recipients
This was a study to compare less intense immunosuppression with a more traditional approach. The hypothesis was that less immunosuppression will provide similar protection against rejection than typical 2-3 drug therapy.
- Trial name
- TICTAC (NCT00299221)
- Testing
- Tacrolimus, combination therapy
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Newark Beth Israel Medical Center
Obstructive Coronary Artery Disease, Obstructive Peripheral Artery Disease
Catheter-Based Treatment of Cardiovascular Disease
This study offers catheter-based treatment of heart or artery disease. This protocol permits treatment of patients with cardiovascular diseases who may not be eligible to participate in current research protocols.
- Conditions
- Obstructive Coronary Artery Disease, Obstructive Peripheral Artery Disease, Structural Heart Disease
- Trial name
- NCT00380016
- Testing
- Percutaneous Transluminal Angioplasty
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Cardiovascular Diseases
Functional Diagnostic Accuracy of Quantitative Flow Ratio in Tandem Lesions and Virtual Stenting
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. Virtual stent implantation technique combined with QFR was recently developed to predict the functional significance…
- Conditions
- Coronary Artery Disease, Cardiovascular Diseases, Myocardial Ischemia, Arterial Occlusive Diseases
- Trial name
- FORTRESS (NCT03405506)
- Testing
- Quantitative Flow Ratio (QFR)
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Pulse Medical Imaging Technology (Shanghai) Co., Ltd
Coronary Occlusion
Decision Aid in Chronic Total Occlusion (CTO) Patients
The aim of this study is to assess the feasibility and validity of patient-level randomization (vs. cluster randomization) in pilot trials of decision aid efficacy.
- Trial name
- NCT02963584
- Testing
- decision aid
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Cardiovascular Diseases, Coronary Disease
Framingham Cycle V Offspring-Spouse Nutrition Studies
To examine the associations between diet, nutrition and coronary heart disease (CHD) incidence over seven years using the Cycle V Framingham Offspring/Spouse examination ; to examine the cross-sectional associations between…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension
- Trial name
- NCT00005347
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Stress Echocardiography Versus Exercise ECG (ExECG) in Women With Chest Pain
The overall question the investigators would like to help answer is whether SE with or without MCE data can be widely used as a first line investigation in women with no previous history of Coronary Artery Disease (CAD) who…
- Trial name
- NCT02346565
- Testing
- Exercise ECG, Stress Echocardiography
- Where
- United Kingdom
- Volunteers
- 416 people
- Sponsor
- London North West Healthcare NHS Trust
Brain Ischemia
Brain and Cognitive Reserve
Ischemic strokes are one of the leading causes of handicap and death in elderly people in France. Cognitive reserve (CR) is an active model, defined as a function of lifetime intellectual activities and other environmental…
- Trial name
- BCN (NCT02819167)
- Testing
- neurologic and neuropsychological evaluation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Atrial Fibrillation (AF), Coronary Artery Disease
Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation
The goal of this clinical trial is to learn whether the antiarrhythmic drug flecainide can be used as safely as standard rhythm-control drugs in people with atrial fibrillation (AF) and stable coronary artery disease (CAD).
- Trial name
- ReCAST AF (NCT07405671)
- Testing
- flecainide, Sotalol or Amiodarone
- Where
- 14 sites in Belgium
- Volunteers
- 988 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Coronary Syndrome, Myocardial Infarction
Stent For Life Observatory
Observatory multicenter, prospective, to support the acute phase of acute coronary syndromes with ST segment elevation ST (myocardial infarction).
- Trial name
- SFL (NCT01251198)
- Where
- France
- Volunteers
- 460 people
- Sponsor
- French Cardiology Society
Cardiovascular Diseases, Coronary Disease
Post Coronary Artery Bypass Graft (CABG) Study
To determine the relative effectiveness of moderate versus more aggressive lipid lowering, and of low dose anticoagulation versus placebo, in delaying saphenous vein coronary bypass graft atherosclerosis and preventing occlusion…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- NCT00000463
- Testing
- lovastatin, cholestyramine, warfarin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction, Ischemic Stroke
Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease
Autoimmune diseases are diseases in which inappropriate immune responses that have the capability of harming host cells play an important role.
- Conditions
- Myocardial Infarction, Ischemic Stroke, Stroke, Subarachnoid Haemorrhage
- Trial name
- NCT02062021
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Heart Failure With Reduced Ejection Fraction, Cardiogenic Shock
Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF
This study aims to compare the impact of hemodynamic monitoring using pulmonary artery catheter (PAC) on survival and inotropic agent reduction in patients with cardiogenic shock caused by heart failure with reduced ejection…
- Trial name
- PACE-SHOCK (NCT06078436)
- Testing
- Pulmonary artery catheter
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Min-Seok Kim
Stroke
General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke
In France, the annual incidence rate of acute ischaemic stroke is around 150 000 patients, 65 % of whom keep long-term disability.
- Trial name
- GASS (NCT02822144)
- Testing
- Etomidate, Succinylcholine, Propofol
- Where
- 4 sites in France
- Volunteers
- 351 people
- Sponsor
- Rennes University Hospital
Coronary Artery Disease
RADIQAL Study (Radiation Dose and Image Quality Trial)
The Azurion R4.0 is developed by Philips Medical Systems Nederland B.V., a Philips Healthcare company. The Azurion is an interventional X-ray system which is used for live X-ray imaging during invasive cardiac procedures.
- Trial name
- RADIQAL (NCT06944509)
- Testing
- treatment with the Azurion system with Xres5, Azurion with Clairy IQ
- Where
- 6 sites in United States, Czechia and 2 more
- Volunteers
- 824 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication
Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
Acute compartment syndrome (ACS) is a surgical emergency that can develop in patients on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
- Trial name
- VA-ECMO (NCT05830721)
- Testing
- MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Cerebral Ischemia
Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation
During clamping of one internal carotid artery for endarterectomy, blood flow through this vessel has to be compensated by collateral arteries including the contralateral internal artery and vertebral arteries.
- Trial name
- NIRSMED (NCT01311414)
- Testing
- cafedrine/theodrenaline, urapidil
- Where
- Germany
- Sponsor
- University Hospital Schleswig-Holstein
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