Acute Ischemic StrokeEDESTROKENCT05847309
Early vs Delayed Extubation After Endovascular Treatment for Acute Ischemic Stroke
A study testing Delayed extubation and Early extubation in people with Acute Ischemic Stroke and Endovascular Treatment, run by Hospital Clinico Universitario de Santiago at 1 site in Spain.
Trial summary
Although older studies, most of them retrospective in design, advocated sedation over general anesthesia during endovascular treatment for acute ischemic stroke, a recent meta-analysis and randomized studies have shown that general anesthesia is associated with better functional status at 3 months compared with local… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Ischemic Stroke, Endovascular Treatment
- What is being tested?
- Delayed extubation and Early extubation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 174 participants
- Where
- 1 siteSpain
- Study dates
- 18 Apr 2023to 30 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adult (age ≥ 18 years)
- Acute ischemic stroke due to large intracranial vessel occlusion demonstrated on CT-angiography in the following anterior circulation locations (occlusion of the internal carotid artery and/or middle cerebral artery in segments M1, M2, M3) within 24 hours of symptom onset.
- Patients admitted with a NIHSS neurological status ≥ 6.
- Patients who received endovascular treatment under general anesthesia (intubated in the interventional radiology room) with satisfactory reperfusion (TICI 2b-2c-3).
- Patients admitted in the intensive care unit (ICU) with mechanical ventilation.
- Written informed consent from the patient or proxy (if present) before inclusion or once possible when patient has been included in a context of emergency.
Who cannot join
- Patients who have not been intubated in the interventional radiology room.
- Pregnancy
- Patients who suffer bronchial aspiration prior to the endovascular procedure or during intubation.
- Patients who underwent the procedure under local anesthesia and sedation.
- Patients with functional neurological status, prior to the ischemic stroke, measured with the modified Rankin scale (mRS) of value: 3-6.
- Patients with vascular involvement of the posterior cerebral circulation, or intracranial haemorrhage associated with stroke.
- Patients who do not sign the informed consent by themselves or their relatives.
Trial locations and contacts
1 site in 1 country.
Spain1 site
University Clinical Hospital of Santiago de Compostela
Santiago de Compostela, A Coruña, 15866
About this study
Official title: Optimal Ventilation Time After Endovascular Treatment Under General Anesthesia for Acute Ischemic Stroke. A Prospective, Randomized Comparison Between Early vs Delayed Extubation
Although older studies, most of them retrospective in design, advocated sedation over general anesthesia during endovascular treatment for acute ischemic stroke, a recent meta-analysis and randomized studies have shown that general anesthesia is associated with better functional status at 3 months compared with local anesthesia and sedation. In our center, most procedures are performed under general anesthesia, and once the procedure is complete, the patient is transferred intubated and sedated to the ICU. If the patient is hemodynamically and respiratory stable, the patient will be extubated, and will be discharged to the Neurology hospitalization floor.
Several factors have been described that may influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment, such as the time between the onset of symptoms and admission to the ward for performing the procedure, the use of general anesthesia compared to sedation and local anesthesia, adequate control of blood pressure, the size of the cerebral infarct, or a worse neurological examination at the time of the procedure. In turn, several factors have been described that may influence the success of extubation in a patient who has suffered an acute ischemic stroke and who has required orotracheal intubation, such as the absence of dysarthria, the size of the infarct, the location of the infarction, the NIHSS (National Institutes of health Stroke Scale) or neurological status prior to orotracheal intubation. The investigators do not know, however, whether the time of mechanical ventilation can influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment under general anesthesia
Read the detailed description
The authors do not know whether the time of mechanical ventilation can influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment under general anesthesia. The purpose of this prospective randomized study is to compare the neurological functional status at 3 months according to the modified Rankin scale (mRS), of patients with stroke who underwent endovascular intervention with satisfactory results and who underwent early extubation (< 6 hours) compared to delayed extubation (6-12 hours).
- Conditions
- Acute Ischemic Stroke, Endovascular Treatment
- Being tested
- Delayed extubation, Early extubation
- Keywords
- Stroke, endovascular treatment, Extubation, mechanical ventilation, functional status
- Medical subject headings
- Ischemic Stroke, Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Delayed extubationOther
Patients randomized to delayed extubation, will be extubated 6-12 hours after endovascular treatment under general anesthesia.
Early extubationOther
Patients randomized to early extubation, will be extubated < 6 hours after endovascular treatment under general anesthesia.
| Study group | Role | What they receive |
|---|---|---|
| Early extubation | Active comparator | Patients randomized to early extubation, will be extubated < 6 hours after endovascular treatment under general anesthesia. Receives: Other: Early extubation |
| Delayed extubation | Experimental | Patients randomized to delayed extubation, will be extubated 6-12 hours after endovascular treatment under general anesthesia. Receives: Other: Delayed extubation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Modified Ranking Scale (mRS)
Comparison of independent functional outcome as measured by the percentage of patients with a 0 to 2 on the modified Rankin Scale (mRS) at 90 days assessed by study personal blinded to the treatment (early vs delayed extubation)
The scale of mRS is 0 to 6. The best neurological outcome is the mRS with 0, indicating no any symptom left, and a good neurological outcome is agreed with a mRS 0 to 2. mRS of 6 is the worst, indicating death. mRS will be evaluated by outcome assessor who is blinded to the group
Measured: 90 days
Secondary outcomes (8)
NIHSS (National Institutes of Health Stroke Scale)
Change in NIHSS score on day 1 and at the time of hospital discharge compared to admission to hospital.
The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment.The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42, with the minimum score being a 0. NIHSS score of 42 is the worst score (severe stroke), NIHSS score of 0 is "No stroke symptoms".
0 No stroke symptoms 1-4 Minor stroke 5-15 Moderate stroke 16-20 Moderate to severe stroke 21-42 Severe stroke
Measured: Approximately 1-15 days post procedure
Modified Ranking Scale (mRS)
Comparison of independent functional outcome as measured by the percentage of patients with a 0 to 2 on the modified Rankin Scale (mRS) at the time of hospital discharge assessed by study personal blinded to the treatment (early vs delayed extubation)
The scale of mRS is 0 to 6. The best neurological outcome is the mRS with 0, indicating no any symptom left, and a good neurological outcome is agreed with a mRS 0 to 2. mRS of 6 is the worst, indicating death. mRS will be evaluated by outcome assessor who is blinded to the group
Measured: Approximately 3-15 days post procedure
Hospital length of stay
Duration in days of hospital stay
Measured: Approximately 3-15 days post procedure
Intensive Care Unit length of stay
Duration in days of ICU stay
Measured: Approximately 1-15 days post procedure
Patients extubated in the assigned group
Percentage of patients who can be extubated in the assigned group
Measured: Post procedure within 24 hours
Number of patients with ICU complications
Complications: Pneumonia, sepsis, bacteraemia, tracheostomy, bronchial aspiration, others
Measured: Approximately 1-10 days post procedure
Number of patients with complications associated with mechanical ventilation
Complications: Pneumonia, pneumothorax, respiratory distress, others
Measured: Approximately 1-10 days post procedure
Number of patients with Hospital complications
Complications: Pneumonia, sepsis, others
Measured: Approximately 1-15 days post procedure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 May 2023
- Study start18 Apr 2023
- Primary completion30 Jun 2025
- Study completion30 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Acute Ischemic StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Intervention study, prospective, randomized, parallel and blind for the end point evaluators. (Prospective Randomized, Blinded End-point))
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 174 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospital Clinico Universitario de Santiago
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Manuel Taboada Muñiz, Hospital Clinico Universitario de Santiago
- Investigators
- Manuel Taboada, Ph.D., Principal investigator, Clinical University Hospital of Santiago de CompostelaManuel Rodríguez, M.D., Principal investigator, Clinical University Hospital of Santiago de Compostela
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05847309
- Sponsor's protocol ID
- EDESTROKE
- Acronym
- EDESTROKE
- Status last verified
- Mar 2026
- First submitted
- 14 Apr 2023
- Last updated
- 25 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Data types: Deidentified participant data How to access data: Requests must be sent to manutabo@yahoo.es When available: With publication Additional Information Who can access the data: Researchers whose proposed use of the data has been approved Types of analyses: For scientific purpose Mechanisms of data availability: With investigator support
Publications
Nikoubashman O, Schurmann K, Probst T, Muller M, Alt JP, Othman AE, Tauber S, Wiesmann M, Reich A. Clinical Impact of Ventilation Duration in Patients with Stroke Undergoing Interventional Treatment under General Anesthesia: The Shorter the Better? AJNR Am J Neuroradiol. 2016 Jun;37(6):1074-9. doi: 10.3174/ajnr.A4680. Epub 2016 Jan 28.
PubMed 26822729Coplin WM, Pierson DJ, Cooley KD, Newell DW, Rubenfeld GD. Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med. 2000 May;161(5):1530-6. doi: 10.1164/ajrccm.161.5.9905102.
PubMed 10806150Fandler-Hofler S, Heschl S, Kneihsl M, Arguelles-Delgado P, Niederkorn K, Pichler A, Deutschmann H, Fazekas F, Berghold A, Enzinger C, Gattringer T. Ventilation time and prognosis after stroke thrombectomy: the shorter, the better! Eur J Neurol. 2020 May;27(5):849-855. doi: 10.1111/ene.14178. Epub 2020 Mar 17.
PubMed 32065457Taboada M, Estany-Gestal A, Fernandez J, Dos Santos L, Barreiro L, Williams K, Cardalda-Serantes B, Lopez C, Mendez M, Rodriguez-Yanez M, Otero P, Naveira A, Caruezo V, Veiras S, San Luis E, Diaz-Vieito M, Arias-Rivas S, Santamaria-Cadavid M, Rodriguez-Castro E, Mosquera A, Castineiras JA, Vazquez F, Blanco M, Taboada JL, Muniategui I, Ferreiroa E, Carinena A, Tubio A, Campana O, Selas S, Aneiros F, Martinez A, Eiras M, Costa J, Prieto JM, Alvarez J, Seoane-Pillado T. Early vs Delayed Extubation After Thrombectomy for Acute Ischemic Stroke: The EDESTROKE Randomized Clinical Trial. JAMA Neurol. 2026 May 1;83(5):481-489. doi: 10.1001/jamaneurol.2026.0475.
PubMed 41910960Taboada M, Estany-Gestal A, Fernandez J, Barreiro L, Williams K, Rodriguez-Yanez M, Otero P, Naveira A, Caruezo V, Veiras S, San Luis E, Dos Santos L, Diaz-Vieito M, Arias-Rivas S, Santamaria-Cadavid M, Rodriguez-Castro E, Vazquez F, Blanco M, Mosquera A, Castineiras JA, Muniategui I, Ferreiroa E, Carinena A, Tubio A, Campana O, Selas S, Aneiros F, Martinez A, Eiras M, Costa J, Prieto JM, Alvarez J. Effect of early vs. delayed extubation on functional outcome among patients with acute ischemic stroke treated with endovascular thrombectomy under general anesthesia: the prospective, randomized controlled EDESTROKE trial study protocol. Trials. 2024 Jun 4;25(1):357. doi: 10.1186/s13063-024-08181-y.
PubMed 38835061
Study at a glance
From the registry record, last updated by the sponsor on 25 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Optimal Ventilation Time After Endovascular Treatment Under General Anesthesia for Acute Ischemic Stroke. A Prospective, Randomized Comparison Between Early vs Delayed Extubation
- ClinicalTrials.gov ID
- NCT05847309
- Acronym / sponsor ID
- EDESTROKE / EDESTROKE
- Conditions
- Acute Ischemic Stroke, Endovascular Treatment
- Keywords
- Stroke, endovascular treatment, Extubation, mechanical ventilation, functional status
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 174 participants (actual)
- Lead sponsor
- Hospital Clinico Universitario de SantiagoUniversity, hospital or other
- Study start
- 18 Apr 2023 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 30 Jun 2025 (actual)
- First posted
- 6 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Although older studies, most of them retrospective in design, advocated sedation over general anesthesia during endovascular treatment for acute ischemic stroke, a recent meta-analysis and randomized studies have shown that general anesthesia is associated with better functional status at 3 months compared with local anesthesia and sedation. In our center, most procedures are performed under general anesthesia, and once the procedure is complete, the patient is transferred intubated and sedated to the ICU. If the patient is hemodynamically and respiratory stable, the patient will be extubated, and will be discharged to the Neurology hospitalization floor.
Several factors have been described that may influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment, such as the time between the onset of symptoms and admission to the ward for performing the procedure, the use of general anesthesia compared to sedation and local anesthesia, adequate control of blood pressure, the size of the cerebral infarct, or a worse neurological examination at the time of the procedure. In turn, several factors have been described that may influence the success of extubation in a patient who has suffered an acute ischemic stroke and who has required orotracheal intubation, such as the absence of dysarthria, the size of the infarct, the location of the infarction, the NIHSS (National Institutes of health Stroke Scale) or neurological status prior to orotracheal intubation. The investigators do not know, however, whether the time of mechanical ventilation can influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment under general anesthesia
Detailed description
The authors do not know whether the time of mechanical ventilation can influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment under general anesthesia. The purpose of this prospective randomized study is to compare the neurological functional status at 3 months according to the modified Rankin scale (mRS), of patients with stroke who underwent endovascular intervention with satisfactory results and who underwent early extubation (< 6 hours) compared to delayed extubation (6-12 hours).
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- Intervention study, prospective, randomized, parallel and blind for the end point evaluators. (Prospective Randomized, Blinded End-point))
| Arm | Type | Receives |
|---|---|---|
| Early extubation | Active comparator | Other: Early extubationPatients randomized to early extubation, will be extubated < 6 hours after endovascular treatment under general anesthesia. |
| Delayed extubation | Experimental | Other: Delayed extubationPatients randomized to delayed extubation, will be extubated 6-12 hours after endovascular treatment under general anesthesia. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Adult (age ≥ 18 years)
- Acute ischemic stroke due to large intracranial vessel occlusion demonstrated on CT-angiography in the following anterior circulation locations (occlusion of the internal carotid artery and/or middle cerebral artery in segments M1, M2, M3) within 24 hours of symptom onset.
- Patients admitted with a NIHSS neurological status ≥ 6.
- Patients who received endovascular treatment under general anesthesia (intubated in the interventional radiology room) with satisfactory reperfusion (TICI 2b-2c-3).
- Patients admitted in the intensive care unit (ICU) with mechanical ventilation.
Key exclusion criteria (7 listed)
- Patients who have not been intubated in the interventional radiology room.
- Pregnancy
- Patients who suffer bronchial aspiration prior to the endovascular procedure or during intubation.
- Patients who underwent the procedure under local anesthesia and sedation.
- Patients with functional neurological status, prior to the ischemic stroke, measured with the modified Rankin scale (mRS) of value: 3-6.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Delayed extubationPatients randomized to delayed extubation, will be extubated 6-12 hours after endovascular treatment under general anesthesia. | Other | Delayed extubation |
| Early extubationPatients randomized to early extubation, will be extubated < 6 hours after endovascular treatment under general anesthesia. | Other | Early extubation |
Primary outcome
Modified Ranking Scale (mRS)
Time frame: 90 days
Comparison of independent functional outcome as measured by the percentage of patients with a 0 to 2 on the modified Rankin Scale (mRS) at 90 days assessed by study personal blinded to the treatment (early vs delayed extubation) The scale of mRS is 0 to 6. The best neurological outcome is the mRS with 0, indicating no any symptom left, and a good neurological outcome is agreed with a mRS 0 to 2. mRS of 6 is the worst, indicating death. mRS will be evaluated by outcome assessor who is blinded to the group
8 secondary outcomes
NIHSS (National Institutes of Health Stroke Scale)
Time frame: Approximately 1-15 days post procedure
Modified Ranking Scale (mRS)
Time frame: Approximately 3-15 days post procedure
Hospital length of stay
Time frame: Approximately 3-15 days post procedure
Intensive Care Unit length of stay
Time frame: Approximately 1-15 days post procedure
Patients extubated in the assigned group
Time frame: Post procedure within 24 hours
Number of patients with ICU complications
Time frame: Approximately 1-10 days post procedure
Number of patients with complications associated with mechanical ventilation
Time frame: Approximately 1-10 days post procedure
Number of patients with Hospital complications
Time frame: Approximately 1-15 days post procedure
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Mar 2026.
- Background: PubMed 26822729Nikoubashman O, Schurmann K, Probst T, Muller M, Alt JP, Othman AE, Tauber S, Wiesmann M, Reich A. Clinical Impact of Ventilation Duration in Patients with Stroke Undergoing Interventional Treatment under General Anesthesia: The Shorter the Better? AJNR Am J Neuroradiol. 2016 Jun;37(6):1074-9. doi: 10.3174/ajnr.A4680. Epub 2016 Jan 28.
- Background: PubMed 10806150Coplin WM, Pierson DJ, Cooley KD, Newell DW, Rubenfeld GD. Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med. 2000 May;161(5):1530-6. doi: 10.1164/ajrccm.161.5.9905102.
- Results publication: PubMed 32065457Fandler-Hofler S, Heschl S, Kneihsl M, Arguelles-Delgado P, Niederkorn K, Pichler A, Deutschmann H, Fazekas F, Berghold A, Enzinger C, Gattringer T. Ventilation time and prognosis after stroke thrombectomy: the shorter, the better! Eur J Neurol. 2020 May;27(5):849-855. doi: 10.1111/ene.14178. Epub 2020 Mar 17.
- Derived from this study: PubMed 41910960Taboada M, Estany-Gestal A, Fernandez J, Dos Santos L, Barreiro L, Williams K, Cardalda-Serantes B, Lopez C, Mendez M, Rodriguez-Yanez M, Otero P, Naveira A, Caruezo V, Veiras S, San Luis E, Diaz-Vieito M, Arias-Rivas S, Santamaria-Cadavid M, Rodriguez-Castro E, Mosquera A, Castineiras JA, Vazquez F, Blanco M, Taboada JL, Muniategui I, Ferreiroa E, Carinena A, Tubio A, Campana O, Selas S, Aneiros F, Martinez A, Eiras M, Costa J, Prieto JM, Alvarez J, Seoane-Pillado T. Early vs Delayed Extubation After Thrombectomy for Acute Ischemic Stroke: The EDESTROKE Randomized Clinical Trial. JAMA Neurol. 2026 May 1;83(5):481-489. doi: 10.1001/jamaneurol.2026.0475.
- Derived from this study: PubMed 38835061Taboada M, Estany-Gestal A, Fernandez J, Barreiro L, Williams K, Rodriguez-Yanez M, Otero P, Naveira A, Caruezo V, Veiras S, San Luis E, Dos Santos L, Diaz-Vieito M, Arias-Rivas S, Santamaria-Cadavid M, Rodriguez-Castro E, Vazquez F, Blanco M, Mosquera A, Castineiras JA, Muniategui I, Ferreiroa E, Carinena A, Tubio A, Campana O, Selas S, Aneiros F, Martinez A, Eiras M, Costa J, Prieto JM, Alvarez J. Effect of early vs. delayed extubation on functional outcome among patients with acute ischemic stroke treated with endovascular thrombectomy under general anesthesia: the prospective, randomized controlled EDESTROKE trial study protocol. Trials. 2024 Jun 4;25(1):357. doi: 10.1186/s13063-024-08181-y.
- Individual participant dataSharing planned: Yes. Data types: Deidentified participant data How to access data: Requests must be sent to manutabo@yahoo.es When available: With publication Additional Information Who can access the data: Researchers whose proposed use of the data has been approved Types of analyses: For scientific purpose Mechanisms of data availability: With investigator support
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Manuel Taboada, Ph.D. principal investigator
Clinical University Hospital of Santiago de Compostela
Manuel Rodríguez, M.D. principal investigator
Clinical University Hospital of Santiago de Compostela
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Delayed extubation and Early extubation in people with Acute Ischemic Stroke and Endovascular Treatment, run by Hospital Clinico Universitario de Santiago at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Modified Ranking Scale (mRS) (time frame: 90 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05847309, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Mar 2026; AzTrials last refreshed its copy on 7 Nov 2026.