Clinical trials: Ischemia Reperfusion Injury, active
Myocardial Ischemia, Heart Defects, Congenital
Spectroscopic Assessment of Myocardial Oxygenation Changes in Pediatric Heart Surgery
The goal of this observational study is to investigate the ability of the SpectroCor Tissue Oxygenation Monitor and its accessory SpectroCor Sensor to observe and monitor changes in cardiac oxygen availability in pediatric…
- Conditions
- Myocardial Ischemia, Heart Defects, Congenital, Reperfusion Injury, Myocardial
- Trial name
- NCT07785141
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Spectrocor
Liver Transplantation (LT), Ischemia-Reperfusion Injury
Avoiding Recooling After Normothermic Machine Perfusion in Liver Transplantation
The ARANMP-LT study is a multicenter, open-label, randomized, parallel-group, non-inferiority clinical trial designed to evaluate whether avoiding graft recooling after normothermic machine perfusion (NMP) improves early outcomes…
- Conditions
- Liver Transplantation (LT), Ischemia-Reperfusion Injury, Early Allograft Dysfunction
- Trial name
- ARANMP-LT (NCT07692490)
- Testing
- No Recooling Before Liver Implantation, Traditional Recooling Before Liver Implantation
- Where
- 14 sites in Italy
- Volunteers
- 170 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Ischemia Reperfusion Injury, Cardiac Surgery Associated - Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)
This is a Randomized, Single-blind, Multi-center, Placebo-controlled, Phase 2a clinical trial of BX-001N to prevent patients from Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and subsequent Major Adverse Kidney Events…
- Trial name
- NCT07164833
- Testing
- BX-001N Experimental group 1, BX-001N Experimental group 2
- Where
- 8 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Bilix Co.,Ltd.
Liver Transplantation (LT), Early Allograft Dysfunction
New Biomarkers for Organ Viability Assessment During Hypothermic Machine Perfusion in Liver Transplantation: the Role of Extemporaneous Histological Examination.
Liver transplantation is a life-saving treatment for patients with severe liver disease. Because of the shortage of donor organs, transplant centers increasingly use donor livers that may be more vulnerable to injury and…
- Conditions
- Liver Transplantation (LT), Early Allograft Dysfunction, Primary Non-function, Ischemia-Reperfusion Injury
- Trial name
- LOVE (NCT07674394)
- Testing
- Hypothermic Oxygenated Machine Perfusion (HOPE/D-HOPE)
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Obstructive Sleep Apnea, Vascular Aneurysm
OSA as a Remote Ischemic Preconditioning in Vascular Surgery
Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure.
- Conditions
- Obstructive Sleep Apnea, Vascular Aneurysm, Ischemia Reperfusion Injury
- Trial name
- NCT04630535
- Testing
- aorto-bifemoral bypass surgery
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Ischemia Reperfusion Injury, Delayed Graft Function
Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation
The objectives of this study are to test the preliminary safety and efficacy of a two-day peri-operative course of treprostinil in reducing ischemia-reperfusion injury in adult patients receiving a deceased donor kidney…
- Trial name
- NCT04005469
- Testing
- Treprostinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rhode Island Hospital
Ischemia Reperfusion Injury
Intravenous Estrogen in Kidney Transplant Study
Ischemia perfusion injury (IRI) is a major cause of organ injury during kidney transplantation. Currently there are no treatments for IRI other than dialysis.
- Trial name
- PERT (NCT03663543)
- Testing
- Conjugated Estrogen, Normal saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Stroke, Acute Ischemic Stroke
Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b)
COOLHEAD-2b is a multicentre, phase 2, prospective, randomised, controlled, open-label, blinded-endpoint trial evaluating the safety and efficacy of non-invasive convective head cooling as an adjunct to endovascular thrombectomy…
- Conditions
- Stroke, Acute Ischemic Stroke, Brain Ischemia, Ischaemic Stroke
- Trial name
- COOLHEAD-2B (NCT07526649)
- Testing
- Non-invasive convective head cooling, Standard of Care (SOC)
- Where
- New Zealand
- Volunteers
- 182 people
- Sponsor
- Auckland City Hospital
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Ischemia Reperfusion Injury, Peripheral Artery Disease
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury.
- Trial name
- NCT06369350
- Testing
- Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Myocardial Ischemia-Reperfusion Injury
OR6A2 on Monocytes and Cardiovascular Outcomes in Myocardial Ischemia-Reperfusion Injury
This study examines how the interaction between octanal (an OR6A2 receptor activator) and OR6A2 expression influences inflammation and clinical outcomes in Myocardial Ischemia-Reperfusion Injury patients.
- Trial name
- NCT07100457
- Testing
- Blood Biomarker Profiling and Prognostic Follow-up
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southeast University, China
Hepatic Ischemia-reperfusion Injury, Non-alcoholic Fatty Liver Disease
Mechanisms of Macrophage Polarization in HIRI in Patients With NAFLD
To better understand the occurrence of hepatic ischemia-reperfusion injury (IRI) in patients with non-alcoholic fatty liver disease (NAFLD) and the role of macrophage polarization in this process, this study will retrospectively…
- Trial name
- NCT06950710
- Testing
- NAFLD
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhifeng Gao
Ischemia-reperfusion Injury, Kidney Transplant; Complications
A Trial to Assess Efficacy and Safety of ex Vivo Allograft Admin of iCM012 Solution 2 mg/ml to Improve Its Function in Recipients of DCD Kidneys
Randomized (1:1), placebo controlled, double blind efficacy trial. 200 patients will be followed up for 12 months post transplantation.
- Trial name
- NCT06582485
- Testing
- iCM012 solution 2 mg/mL
- Volunteers
- 200 people
- Sponsor
- iCoat Medical AB
Cardiac Arrest, Ischemia Reperfusion Injury
Hypertonic Lactate After Cardiac Arrest
The study is intended to test the hypothesis that sodium lactate infusion after resuscitation from a cardiac arrest will decrease the magnitude of brain damage, as measured by the serum biomarker concentration of NSE.
- Conditions
- Cardiac Arrest, Ischemia Reperfusion Injury, Anoxic Brain Injury
- Trial name
- LATTE (NCT05004610)
- Testing
- Sodium Lactate Solution
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- Erasme University Hospital
Coronary Artery Bypass Grafting, Remote Ischemic Conditioning
Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafting
Remote ischemic conditioning (RIC) is the process of repeated ischemia and reperfusion in the peripheral vessels, which is proved in reducing IRI in vital organs.
- Conditions
- Coronary Artery Bypass Grafting, Remote Ischemic Conditioning, Ischemia-Reperfusion Injury
- Trial name
- IMPROVE (NCT06141525)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 648 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University