Clinical trials: Ischemia Reperfusion Injury
Ischemia Reperfusion Injury, Peripheral Artery Disease
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury.
- Trial name
- NCT06369350
- Testing
- Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Acute Myocardial Infarction, Ischemia-reperfusion Injury
Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study.
Background: Acute myocardial infarction (AMI) has remained a leading cause of mortality and disability worldwide. Although percutaneous coronary angioplasty (PCA) is the best treatment for these patients, paradoxically this…
- Conditions
- Acute Myocardial Infarction, Ischemia-reperfusion Injury, Reperfusion Injury, Myocardial, Reperfusion Arrhythmias
- Trial name
- NCT05215743
- Testing
- Antioxidant therapy, NaCl 0.9%
- Where
- Chile
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Chile
Ischemia-reperfusion Injury
Heme Arginate in Functional Magnetic Resonance Imaging (fMRI)
Ischemia reperfusion injury may be attenuated by HO-1 induction. Heme arginate showed protective effects during prolonged ischemia in animal studies.
- Trial name
- NCT01461512
- Testing
- heme arginate administration
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- MWolzt
Ischemia Reperfusion Injury, Endothelial Function
The Metformin-FMD Trial
In acute myocardial infarction early restoration of coronary blood flow is the most effective strategy to limit infarct-size. Paradoxically, reperfusion itself also aggravates myocardial injury and contributes to final infarct…
- Trial name
- MetFMD (NCT01610401)
- Testing
- Metformin, Pretreatment with metformin in combination of infusion of caffeine., No pretreatment with metformin in combination with infusion of caffeine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease, Ischemia-reperfusion Injury
Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
To adjust our forearm model for ischemia reperfusion injury, in order to used it for assessment of ischemia reperfusion damage in elderly and patients.
- Conditions
- Cardiovascular Disease, Ischemia-reperfusion Injury, Postconditioning
- Trial name
- NCT00441714
- Testing
- repetitive short ischemia and reperfusion of non dominant fore arm after 10 minute ischemic exercise
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Primary Graft Dysfunction, Lung Transplant; Complications
Perioperative Vitamin C Lung Transplant
This study is being done to determine if parenterally administered ascorbic acid (Vitamin C) given at the time of lung transplant is safe. Vitamin C may be an effective intervention towards primary graft dysfunction (PGD).
- Trial name
- NCT04505878
- Testing
- Vitamin C
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Myocardial Infarction
Intravenous MSC Therapy on Ischemia-Reperfusion Injury in Patients With Myocardial Infarction
The investigators scheduled to assess the value of intravenous injection of WJ-MSC in patients with ST-segment elevation myocardial infarction (STEMI).
- Trial name
- NCT03533153
- Testing
- WJ-MSC cells implantation, CTSTMD PBS without WJ-MSC, Conventional drug therapy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cardiovascular Disease
Exercise Test and Cardiac Injury
Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply…
- Trial name
- NCT01660828
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia Reperfusion Injury
The Effect of Pregabalin Given Preoperatively on the Tourniquet Induced Ischemia-reperfusion
The application of tourniquet is indispensable for a bloodless surgical area in total knee arthroplasty surgery. The release of tourniquet produces reactive oxygen species which can cause injury and then ischemia-reperfusion…
- Trial name
- NCT03482544
- Testing
- Pragabalin
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Baskent University
Caffeine, Ischemic Preconditioning
The Effect of Caffeine on Ischemic Preconditioning
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion.
- Conditions
- Caffeine, Ischemic Preconditioning, Ischemia-Reperfusion Injury
- Trial name
- NCT00184912
- Testing
- caffeine, Technetium-TC99m-labeled Annexin A5, ten minutes forearm ischemia
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Central Sympathetic Nervous System Diseases
Role of Sympathetic Activation in Ischemia Reperfusion Injury
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote…
- Trial name
- NCT04479813
- Testing
- Moxonidine 0.2 MG
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Royal Perth Hospital
Cardiovascular Disease
The Impact of Age and Fitness on Reperfusion Injury and Ischemic Preconditioning to Prevent This Injury
Rationale: Ischaemic preconditioning (IP) refers to the reduction of ischemia-reperfusion injury induced by a brief preceding period of ischemia. Also the arterial endothelium can be protected by IP.
- Trial name
- NCT01606410
- Testing
- IPC
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Oophorectomy, Oxidative Stress
Role of Oxidative Stress in Ovarian Tissue After CO2-pneumoperitoneum Application-induced I/R
Because of cellular changes in response to ischemia and a following period of reperfusion, damages to organs and different tissues occur.
- Conditions
- Oophorectomy, Oxidative Stress, Ischemia Reperfusion Injury
- Trial name
- NCT04493983
- Testing
- laparoscopic salpingo-oophorectomy, Laparoscopic bilateral salpingo-oophorectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ismet Hortu
Reperfusion Injury
Diagnostics for the Reperfusion Injury Following MI
The primary purpose of this study is to correlate new cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI) to biochemical parameters as the L-arginine-nitric oxide…
- Trial name
- NCT00529607
- Testing
- contrast echocardiography, 2D and 3D echocardiography, cardiac MRI
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Ischemia
Rosuvastatin and Ischemia Reperfusion
Statins, including rosuvastatin, are drugs that lower plasma cholesterol and prevent atherosclerotic disease. Recent preclinical evidence suggests that statins also increase tissue tolerance to ischemia-reperfusion injury.
- Trial name
- NCT00315510
- Testing
- Rosuvastatin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Reperfusion Injury
Pulmonary Protection of Transcutaneous Electrical Acupoint Stimulation in Gynecologic Laparoscopic Surgery
TEAS might protect against postoperative pulmonary such as ischemia-reperfusion injury (IRI) and atelectasis. We tested the hypothesis that transcutaneous electrical acupoint stimulation protects against postoperative pulmonary…
- Trial name
- NCT02850471
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Reperfusion Injury
Role of Volatile Anesthetics for Hepatic Protection
This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of…
- Trial name
- NCT00516711
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Primary Graft Dysfunction, Lung Transplantation
This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft Dysfunction
Lung transplant recipient survival lags other solid organ recipients, with the main early cause of death being primary graft dysfunction (PGD).
- Conditions
- Primary Graft Dysfunction, Lung Transplantation, Acute Lung Injury(ALI), Natural Killer Cell Mediated Immunity
- Trial name
- MARAVIROC (NCT06853223)
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Effect of Acupuncture to Endothelial Dysfunction Induced by Ischemia-reperfusion Injury
Some studies suggest that acupuncture improve flow mediated dilation (FMD) that represents endothelial function, but no study has investigated whether acupuncture protects against ischemia and reperfusion (IR)-induced endothelial…
- Trial name
- AURORAS (NCT02255006)
- Testing
- Active acupuncture, Euglucon 5mg, Celebrex 200mg
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center