Clinical trials: Ischemia, Cerebral
Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease
Cambridge 7 Tesla Cerebral Small Vessel Disease Study
CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using…
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease, Lacunar Stroke
- Trial name
- CamSVD (NCT04330222)
- Testing
- 7 Tesla Magnetic Resonance Imaging, Brief Memory and Executive Test
- Where
- United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Stroke, Acute, Ischemic Stroke, Acute
MyStroke for Stroke Survivors and Caregivers
The goal of this multicenter randomized trial is to evaluate the impact of a personalized video-based stroke education platform on patient-centered and health system-centered outcomes.
- Trial name
- NCT06442631
- Testing
- MyStroke
- Where
- 5 sites in United States
- Volunteers
- 690 people
- Sponsor
- University of Pennsylvania
Ischemic Stroke
Endothelial Function and Progenitor Cells in Acute Ischemic Stroke
The purpose of this study is to determine whether levels of circulating endothelial progenitor cells (cEPC) are increased in the acute phase of ischemic stroke.
- Trial name
- EPCAS (NCT01289795)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Ischemic Stroke
POSITIVE Stroke Clinical Trial
Primary Endpoint: The primary objective is to show that AIS patients, ineligible for or refractory to treatment with IV-tPA, with appropriate image selection, treated with mechanical thrombectomy within 6-12 hours of symptom…
- Trial name
- NCT01852201
- Testing
- Endovascular Mechanical Thrombectomy
- Where
- 20 sites in United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Cardiovascular Diseases, Heart Diseases
Pawtucket Heart Health Program
To conduct a community-based research and demonstration project in cardiovascular disease prevention in the town of Pawtucket, Rhode Island.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypercholesterolemia, Hypertension
- Trial name
- NCT00005151
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Stroke
Predictive Factors Of Acute Ischemic Stroke Outcome in Adult
Stroke is a devastating disease that affects 15 million patients worldwide each year, resulting in death in about one-third of patients and severe disability in two-thirds of the survivors.
- Trial name
- NCT03700879
- Testing
- MRI,MRA,Carotid ,vertebrobasilar and Transcranial Doppler
- Volunteers
- 50 people
- Sponsor
- Assiut University
Hypoxic Ischemic Encephalopathy, Cerebral Infarction
Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encephalopathy
This study examines the effect of cord blood in the treatment of newborn infants with neonatal encephalopathy in combination with hypothermia, which is the standard treatment for this condition.
- Trial name
- NCT02551003
- Testing
- Autologous cord blood, Hypothermia
- Where
- China
- Sponsor
- Children's Hospital of Fudan University
Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy
Neonatal Neurological Observation With Video AI
NeoNOVA is a multi-site, prospective, single-arm, silent observational study to determine: among (Population) infants admitted to newborn services during their inpatient hospital stay, whether (Intervention) continuous bedside…
- Conditions
- Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Sedation, Sleep
- Trial name
- NeoNOVA (NCT07628829)
- Testing
- Continuous bedside video monitoring with AI anatomic landmark tracking for neurologic monitoring
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Artemis AI Labs
Cerebral Ischemia
Autologous Mitochondrial Transplant for Cerebral Ischemia
The investigators propose to infuse healthy autologous mitochondria into cerebral vessels supplying brain tissue experiencing ischemia in patients who undergo standard-of- care endovascular reperfusion therapy.
- Trial name
- NCT04998357
- Testing
- Endovascular autologous mitochondrial transplantation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Ischemic Stroke
The Effect of Low Intensity With BFR on Stroke Patients
To compare the effects of low-intensity resistance training with blood flow restriction (BFR) versus traditional resistance training on lower limb isokinetic torque and dynamic balance in ischemic stroke survivors.
- Trial name
- NCT07292675
- Testing
- low-intensity resistance training with blood flow restriction, High intensity resistance training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Delta University for Science and Technology
Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation
Sodium Sivelestat With Mechanical Thrombectomy for Acute Stroke: A Pilot Study
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as the standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation, Large Vessel Occlusion, Thrombectomy
- Trial name
- NCT07196605
- Testing
- Sodium Sivelestat
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Transient Ischemic Attack
Chinese Atherosclerosis Risk Evaluation- Phase II
Stroke is the first and the fourth leading cause of death in the United States and China, respectively. Disruption of cerebrovascular vulnerable atherosclerotic plaque is the major etiology of ischemic stroke.
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Carotid Atherosclerotic Disease
- Trial name
- CARE-II (NCT02017756)
- Where
- 14 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tsinghua University
Ischemic Stroke, Acute
Shuxuening Injection in the Treatment With Intravenous Thrombolysis in Patients With Ischemic Stroke (SHINY)
Shuxuening injection is a multi-target neuroprotective agent, it is expected to play a neuroprotective role on the basis of intravenous thrombolysis therapy.
- Trial name
- NCT06157502
- Testing
- Shuxuening Injection
- Where
- 82 sites in China
- Volunteers
- 1,380 people
- Sponsor
- Beijing Tiantan Hospital
Cardiovascular Disease
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064 patients with myocardial infarction (MI) prior to study entry which aims to demonstrate whether a more intensive cholesterol lowering regimen…
- Trial name
- SEARCH (NCT00124072)
- Testing
- Simvastatin 20 mg daily, Folic acid 2 mg + vitamin B12 1 mg daily, Simvastatin 80 mg daily
- Where
- United Kingdom
- Volunteers
- 12,064 people
- Sponsor
- University of Oxford
Chronic Subdural Hematoma, Anticoagulant-induced Bleeding
Management of Anticoagulants and Antithrombotics in Patients With CSDH
Primary objective of the study will be to compare, up to 6 months after surgery, number of relapses (post operative re-bleeding) or intracerebral hemorrhage (others than subdural hematomas) and thromboembolic or cardiovascular…
- Conditions
- Chronic Subdural Hematoma, Anticoagulant-induced Bleeding, Thromboembolic Stroke, Cardiovascular Stroke
- Trial name
- THERCA (NCT05079295)
- Testing
- CSDH evacuation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital of Ferrara
Stroke
Factor XI Levels in Acute Ischemic Stroke
The purpose of this study is to evaluate the utility of measuring coagulation factor activities in the setting of acute ischemic stroke, as potential markers of inherited thrombotic risk.
- Trial name
- NCT00890812
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Utah
Cardiovascular Diseases, Heart Diseases
Lifestyle and Chronic Disease in College Alumni (Harvard Alumni Health Study)
To monitor the relationship of lifestyle variables, particularly exercise, to cardiovascular mortality, all-cause mortality, projected longevity and aging, and cardiovascular morbidity in a large cohort of college graduates.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005169
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Strokes, Traditional Chinese Medicine (TCM)
Spatiotemporal Evolution of Traditional Chinese Medicine Mechanisms in Acute Ischemic Stroke Treated With Dengzhan Xixin and Dengzhan Shengmai
To integrate large-scale RCT data on clinical symptoms, TCM syndromes, prognosis, and multi-omics profiles, construct a spatiotemporal dynamic network for disease-syndrome evolution of acute ischemic stroke (AIS) in the acute and…
- Conditions
- Ischemic Strokes, Traditional Chinese Medicine (TCM), Prognosis
- Trial name
- STEM-DZ (NCT07591883)
- Testing
- Dengzhan Shengmai - Erigeron breviscapus sequential intervention, corresponding control group sequential intervention
- Volunteers
- 358 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Head Injury, Intracerebral Hemorrhage
The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients
The purpose of this study is to use transcranial Doppler (TCD) to predict intracranial pressure (ICP) and clinical outcome of neurocritical patients.
- Conditions
- Head Injury, Intracerebral Hemorrhage, Ischemic Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT00886054
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Stroke, Ischemic Stroke
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Cognitive problems are common after a stroke and must be identified early so that rehabilitation can be initiated to improve outcome.
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral, Cognitive Dysfunction
- Trial name
- OCS-PRECISE (NCT07897916)
- Where
- 2 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen
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