Clinical trials: Iris Disease
Rare Diseases, Aniridia
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with…
- Conditions
- Rare Diseases, Aniridia, Neurotrophic Keratopathy, Limbal Stem Cell Deficiency
- Trial name
- NCT06412718
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Aniridia
Positive Angle Kappa
Patients with aniridia have positive angle kappas.
- Trial name
- NCT01644552
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Mucopolysaccharidoses
Validation and Reliability of Iris Cameras in Mucopolysaccharidoses
To assess the reliablity and validity of 2 new iris cameras in the assement of corneal opacification in mucopolysaccharidoses
- Trial name
- NCT05354219
- Testing
- Imaging
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Exfoliation Syndrome, Glaucoma
The International Collaborative Exfoliation Syndrome Treatment Study
Purpose: To determine the efficacy of treatment with latanoprost in combination with pilocarpine versus timolol or timolol/dorzolamide fixed combination (Timoptic or Cosopt) in eyes with XFS and elevated intraocular pressure…
- Conditions
- Exfoliation Syndrome, Glaucoma, Ocular Hypertension
- Trial name
- NCT00804115
- Testing
- Latanoprost with Pilocarpine vs Timolol or Cosopt
- Where
- United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- The New York Eye & Ear Infirmary
Glaucoma Open-Angle, Glaucoma Eye
INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma: Long-term Results and Success Predictors Analysed From a Large-scale Retrospective and Prospective Glaucoma Register
The study is an observational analysis of patients' medical data recorded in a large-scale register, both retrospective (for patients operated and data recorded before 2018) and prospective (for data collected after 2018) in…
- Conditions
- Glaucoma Open-Angle, Glaucoma Eye, Glaucoma; Drugs, Glaucoma, Angle-Closure
- Trial name
- NCT04381611
- Where
- Switzerland
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Dr. Kaweh Mansouri
Presbyopia, Ametropia
Clinical Trial With Artiflex Presbyopic (Artiplus)
The purpose of this clinical trial is to evaluate the effectiveness and safety of the multifocal Artiflex Presbyopic (Artiplus) intraocular lens.
- Conditions
- Presbyopia, Ametropia, Refractive Errors, Myopia
- Trial name
- NCT04632784
- Testing
- Artiflex Presbyopic (Artiplus) implantation
- Where
- 7 sites in South Korea, Spain
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ophtec BV
Exfoliation Syndrome
Early Diagnosis in Glaucoma With GDxVcc
To compare the Retina Nerve Fiber Layer thickness, measured with Scanning Laser Polarimetry in subjects with exfoliation syndrome and normal controls and to evaluate the value of scanning laser polarimetry in the early diagnosis…
- Trial name
- NCT01022281
- Where
- Greece
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Pseudoexfoliation Syndrome, Biomechanical Parameters
Corneal Biomechanics, Optical Properties and Anterior Segment Structural Features in Patients With Pseudoexfoliation
The purpose of this study is to assess the effect of pseudoexfoliation syndrome on corneal biomechanics, optical clarity of the cornea, and anterior segment structural features.
- Conditions
- Pseudoexfoliation Syndrome, Biomechanical Parameters, Corneal Densitometry
- Trial name
- CorPEX (NCT06731530)
- Testing
- Pentacam-AXL, HD Analyzer, Corvis ST
- Where
- Greece
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
HIV Infections, Cytomegalovirus
CMV Disease and IRIS in HIV-1 Infected Persons
Various diagnostic methods are available for CMV infection. But none of them could be a standard and highly valuable. Our first goal is to setup a series of molecular diagnostic tools for HIV-1 infected person.
- Trial name
- NCT00456664
- Testing
- IE gene
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Aniridia
Comparison of the Healing Properties on Corneal Cells of Groth Factor-enriched Plasma and Autologous Serum From Aniridia Patients
Keratopathy of patients with aniridia leads to epithelial scarring disorders and a progressive clouding of the cornea linked to this abnormal healing (fibrosis).
- Trial name
- CICASAND (NCT05400590)
- Testing
- Peripheral venous blood sample, Conjunctival impression
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Exfoliation Syndrome
Central Corneal Thickness in Glaucoma
The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate…
- Trial name
- NCT01023997
- Where
- Greece
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Primary Open Angle Glaucoma, Primary Open-Angle Glaucoma, Unspecified Eye
Glaucoma Screening Using Dynamic Analysis of Computerized Pupillary Light Reflex Assessment Device
To explore an effective diagnostic tool of glaucoma through the dynamic analysis of computerized pupillary light reflex assessment device (CPLRAD) pupillography based on iris recognition techniques and investigate its feasibility…
- Conditions
- Primary Open Angle Glaucoma, Primary Open-Angle Glaucoma, Unspecified Eye, Primary Open Angle Glaucoma of Both Eyes, Suspect Glaucoma
- Trial name
- NCT04595227
- Testing
- Computerized pupillary light reflex assessment device
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University
Pseudoexfoliation Syndrome
The Endothelial Count in Pxf
Pseudoexfoliation Syndrome Is a common disorder in Egypt. IT is one of the common causes of coexisting cataract and glaucoma. It may be associated with a less than normal endothelial count.
- Trial name
- NCT03265457
- Testing
- Specular microscopy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Autonomic Nervous System Diseases
Sympathetic-parasympathetic Ratio of Our Gaze
ABSTRACT BACKGROUND The existence of the retinohypothalamic pathway suggests that light may influence autonomic outflow activity.
- Trial name
- NCT03322904
- Testing
- iris photography
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kecioren Education and Training Hospital
Iritis
Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology
The investigators plan to use an herbal eye drop, Euphrasia, aka Eyebright, for post-operative inflammation for Peripheral Laser Iridotomy for the treatment of narrow angle glaucoma.
- Trial name
- NCT02416128
- Testing
- Euphrasia, Prednisolone acetate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Larkin Community Hospital
Iris Tumor
Observational Study of Iris Tumors
This is an observational study using OCT angiography to assist with tumor characterization in melanotic and amelanotic iris lesions.
- Trial name
- NCT03809585
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Open Angle Glaucoma, Ocular Hypertension
Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan
The purpose of this study is to compare the additive effect on eye pressure of Azopt and Alphagan P to Travatan.
- Conditions
- Open Angle Glaucoma, Ocular Hypertension, Pseudoexfoliation Syndrome
- Trial name
- NCT00121147
- Testing
- Travatan, Azopt, Alphagan P
- Where
- 21 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hermann Eye Center
HIV Infection, Tuberculosis Infection
Micro RNA as Prediction and/or Prognostic Markers of IRIS in TB-HIV Co-infected Patients
The role of miRNAs in HIV disease is yet to be completely defined. Host miRNAs target certain HIV genes, thus can affect HIV replication and participate in viral control.
- Trial name
- miRNA (NCT03941210)
- Testing
- Detection of molecular Biomarkers
- Where
- Cambodia
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Glaucoma
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and primary open-angle glaucoma…
- Trial name
- NCT03423758
- Testing
- Blood sample
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna