Clinical trials: Intravitreal Bevacizumab Injection
Macular Edema
Avastin for Post-photocoagulation Macular Edema
to evaluate the efficacy of a single intravitreal bevacizumab (IVB) injection, 0.1mL (2.5mg), against panretinal photocoagulation (PRP)-induced macular thickening and visual disturbance in patients with severe nonproliferative…
- Trial name
- NCT00801866
- Testing
- Bevacizumab, Panretinal Photocoagulation
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Proliferative Diabetic Retinopathy
Intravitreal Bevacizumab Pretreatment for Reducing Preretinal Hemorrhage in Diabetic Vitrectomy
Treatment of severe proliferative diabetic retinopathy (PDR) may require the use of silicone oil for long-term retinal tamponade to prevent recurrent retinal detachment.
- Trial name
- NCT00596505
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- National Taiwan University Hospital
Angioid Streaks, Choroidal Neovascularization
Intravitreal Bevacizumab in Agioid Streaks
The purpose of this study is to investigate the safety and efficacy of intravitreal bevacizumab in patients with choroidal neovascularization associated with angioid streaks.
- Trial name
- NCT00406250
- Testing
- intravitreal injection
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- University of Campania Luigi Vanvitelli
Recurrent, Hemorrhage
Adjuvant Intravitreal Bevacizumab in Pars Plana Vitrectomy for Diabetic Vitreous Hemorrhage
Postoperative vitreous hemorrhage is a common complication after vitrectomy for proliferative diabetic retinopathy. There have been efforts to lower the incidence of postoperative vitreous hemorrhage such as preoperative…
- Trial name
- ABeVi (NCT01151722)
- Testing
- bevacizumab injection
- Where
- Brazil
- Volunteers
- 2 people
- Sponsor
- University of Sao Paulo
Age Related Macular Degeneration
Comparison of Treatment Response to Intravitreal Injection of Combined Propranolol and Bevacizumab Versus Bevacizumab Monotherapy in Patients With Wet Age Related Macular Degeneration :A Clinical Trial
This study is designed to compare the effect of combined intravitreal Bevacizumab and Propranolol injection versus Bevacizumab monotherapy in patients with Age Related Macular Degeneration.
- Trial name
- NCT03609307
- Testing
- Combined Intravitreal bevacizumab and propranolol, Intravitreal bevacizumab
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Age-related Macular Degeneration, Diabetic Macular Edema
Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF
Comparable data for bevacizumab and aflibercept are lacking, as are studies comparing the systemic levels of ranibizumab, bevacizumab, and aflibercept and their relative effects on circulating vascular endothelial growth factor.
- Conditions
- Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT02118831
- Testing
- Blood Sample Collection, Aflibercept, Bevacizumab
- Volunteers
- 56 people
- Sponsor
- California Retina Consultants
Diabetic Macular Edema
Safety and Efficacy of Ranibizumab for Diabetic Macular Edema
The primary objective of the study is to assess the ocular and systemic adverse events of ranibizumab (Lucentis)for DME (diabetic macular edema) following previous treatment with intravitreal bevacizumab (Avastin).
- Trial name
- REACT (NCT01982435)
- Testing
- Ranibizumab
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Justis Ehlers
Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration
Changes in Intraocular Pressure After Intravitreal Injection
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections introduce additional fluid volume into the eye, which can cause an acute, transient elevation in intraocular pressure (IOP).
- Conditions
- Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration, Retinal Vein Occlusion, Ocular Hypertension
- Trial name
- NCT07826286
- Volunteers
- 50 people
- Sponsor
- Assiut University
Diabetic Macular Edema
Effect of Intravitreal Bevacizumab on Clinically Significant Macular Edema
to compare the effect of intravitreal bevacizumab alone or in combination with triamcinolone acetonide with laser photocoagulation on clinically significant macular edema (CSME)
- Trial name
- NCT00370669
- Testing
- bevacizumab, triamcinolone acetonide
- Where
- Iran
- Volunteers
- 150 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Macular Edema, Diabetic Retinopathy
Intravitreal Bevacizumab for Diabetic Macular Edema
Diabetic macular edema is a common cause of visual loss among diabetic patients. Studies have demonstrated the role of vascular endothelial growth factor (VEGF) in the pathogenesis of edema.
- Trial name
- NCT00703235
- Testing
- Bevacizumab
- Sponsor
- Isfahan Ophthalmology Research Center
Diabetic Macular Edema
Intravitreal Bevacizumab and Triamcinolone in Diabetic Macular Edema
One of the most frequent complications of diabetic retinopathy is diabetic macular edema. Recently, intravitreal bevacizumab and intravitreal triamcinolone were the most popular therapeutic modalities.
- Trial name
- NCT01342159
- Testing
- Intravitreal injection
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Hallym University Medical Center
Severe Nonproliferative, Proliferative Diabetic Retinopathy
Intravitreal Bevacizumab for Diabetic Retinopathy
Background: to evaluate the 3-month efficacy of a single dose of intravitreal bevacizumab on the progression of severe non proliferative diabetic retinopathy, proliferative diabetic retinopathy and active photocoagulated diabetic…
- Conditions
- Severe Nonproliferative, Proliferative Diabetic Retinopathy, Active Photocoagulated Diabetic Retinopathy
- Trial name
- NCT00600262
- Testing
- intravitreal bevacizumab
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Retinopathy of Prematurity
Refractive Error and Biometry in Retinopathy of Prematurity
The investigators compared long-term refractive and biometric outcomes in children with retinopathy of prematurity who received two different anti-vascular endothelial growth factor agents.
- Trial name
- NCT03334513
- Testing
- Bevacizumab, Ranibizumab
- Volunteers
- 35 people
- Sponsor
- San Ni Chen
Myopia, Choroidal Neovascularization
Efficacy and Safety of Intravitreal Bevacizumab in the Treatment of Choroidal Neovascular Membranes Associated to High Myopia
The purpose of this study is to determine the efficacy and safety of intravitreal injections of bevacizumab in High Myopia´s choroidal neovascularization versus the standard treatment of Photodynamic therapy.
- Trial name
- NCT00967850
- Testing
- Intravitreal Injection, Photodynamic Therapy (Visudyne)
- Where
- 7 sites in Spain
- Volunteers
- 56 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Neovascular Age-Related Macular Degeneration
Intravitreal Bevacizumab vs. Bevacizumab Combined With Triamcinolone for Neovascular AMD
To compare the efficacy and safety results of intravitreal bevacizumab alone with bevacizumab + triamcinolone acetonide in neovascular AMD.
- Trial name
- NCT00370370
- Testing
- bevacizumab, bevacizumab + triamcinolone acetonide
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Age-related Macular Degeneration
Photodynamic Therapy Alone Versus Combined With Intravitreal Bevacizumab for Age-related Macular Degeneration
The purpose of this study is to compare 12-month results of two single initial treatments-photodynamic therapy with verteporfin alone and this therapy combined with intravitreal bevacizumab-for neovascular age-related macular…
- Trial name
- NCT01032109
- Testing
- Bevacizumab
- Where
- Japan
- Volunteers
- 45 people
- Sponsor
- Kumamoto University
Diabetic Retinopathy
Intravitreal Bevacizumab vs Photocoagulation for Proliferative Diabetic Retinopathy
The purpose of the study is to evaluate the safety and efficacy of 2.5 mg of intravitreal bevacizumab in one eye, versus panretinal photocoagulation in the contralateral eye, for the treatment of patients with untreated symmetric…
- Trial name
- NCT00347698
- Testing
- intravitreal injection of bevacizumab, panretinal photocoagulation
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Non-arteritic Anterior Ischemic Optic Neuropathy
Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy
Non-Arteritic Ischemic Optic Neuropathy (NAION) is a disease producing swelling of the optic nerve (the "cable" going from the eye to the brain) resulting in decreased vision.
- Trial name
- NCT00813059
- Testing
- Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Mount Sinai Hospital, Canada
Retinal Neovascularization, Macular Edema
Longterm Efficiency and Safety of Intravitreal Injections With Bevacizumab in Patients With Neovascularisation or Macular Edema
Although the safety and efficacy of bevacizumab has been established in several phase 3 trials, there is only little documented about the long-term safety and efficacy in the 'real-world practice' in large populations from…
- Trial name
- 2013-005056-15 (NCT03211741)
- Testing
- Bevacizumab Injection [Avastin]
- Where
- Belgium
- Volunteers
- 583 people
- Sponsor
- University Hospital, Ghent
Diabetic Macular Edema (DME)
Suprachoroidal Bevacizumab Versus Intravitreal Bevacizumab in Diabetic Macular Edema
Diabetic macular edema is an eye condition caused by diabetes in which fluid accumulates in the central part of the retina, leading to blurred vision and potentially permanent vision loss.
- Trial name
- Macular Edema (NCT07897630)
- Testing
- Bevacizumab
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Teaching Hospital