Clinical trials: Intravenous Sedation
Nociception
Quantitative Consciousness Index Monitoring (qNOX) of Sedation During Endoscopy
Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious…
- Trial name
- NCT06777589
- Testing
- Monitoring of anesthesia depth
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Min Su
Otosclerosis
Dexmedetomidine vs. Remifentanil Conscious Sedation for Stapedotomy/Stapedectomy
Dexmedetomidine continuous intravenous infusion vs. remifentanil target-controlled infusion conscious sedation for stapedotomy/stapedectomy- a prospective, single-center, double-masked randomized trial The goal of this clinical…
- Trial name
- NCT06283836
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Romania
- Volunteers
- 74 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Postoperative Pain
Effect of Intravenous Dexmedetomidine on Analgesic Duration of Infraclavicular Block
The study will evaluate the effect of Dexmedetomidine sedation on the duration of infraclavicular block in patients scheduled for surgery of elbow, forearm and/or hand.
- Trial name
- NCT01981369
- Testing
- Dexmedetomidine, Propofol, Infraclavicular block
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Shivering, Post-Spinal Shivering
Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean Section
Spinal anesthesia is the preferred anesthetic method for elective cesarean deliveries, but it frequently causes post-spinal shivering.
- Conditions
- Shivering, Post-Spinal Shivering, Hypothermia, Cesarean Section
- Trial name
- NCT07855523
- Testing
- Midazolam and Ketamine, 0.9% Sodium Chloride
- Volunteers
- 120 people
- Sponsor
- Assiut University
Bone Fractures, Dislocations
Intranasal Ketamine for Procedural Sedation
This study will examine the effectiveness of intranasal (IN) ketamine compared to standard intravenous (IV) ketamine administration for simple reductions of orthopaedic injuries in the paediatric population.
- Trial name
- INK (NCT02828566)
- Testing
- IN ketamine, IV ketamine, IN saline 0.9%
- Volunteers
- 470 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sedation in Intensive Care
A Study Evaluating Sedation of Intravenous Administration of HSK3486 Injectable Emulsion in ICU Patients Undergoing Mechanical Ventilation
This is a multi-center, randomized, single-blind, propofol-controlled phase III clinical study. In this study, ICU patients undergoing mechanical ventilation are expected to be enrolled and will be randomly assigned to the…
- Trial name
- NCT04620031
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Recovery Period, Hypoxemia
Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is becoming increasingly important in the diagnosis and follow-up of pediatric diseases. However, successful MRI requires complete and prolonged immobility, which can be challenging for young…
- Conditions
- Recovery Period, Hypoxemia, Patient Safety
- Trial name
- NCT06832683
- Testing
- Sevoflurane, Propofol, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Kocaeli City Hospital
Cholangitis, Pancreatic Cancer
Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography.
Does Ketamine-Midazolam have a better efficacy and safety profile compared to Midazolam - Pethidine in Endoscopic Retrograde Cholangiopancreatography (ERCP)?
- Conditions
- Cholangitis, Pancreatic Cancer, Choledocholithiasis, Choledochal Cyst
- Trial name
- NCT06111872
- Testing
- Ketamine, Midazolam, Pethidin
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- National University of Malaysia
Anxiety, Preoperative Care
A Study of Dexmedetomidine Pharmacokinetics for Preoperative Sedation
Proper preoperative sedation can reduce patients' anxiety, enhance patients' cooperation and reduce perioperative complications.
- Conditions
- Anxiety, Preoperative Care, Pharmacokinetics, Emergence Delirium
- Trial name
- NCT03800641
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Critical Illness, Mechanical Ventilation Complication
Enteral Versus Intravenous Sedation in Critically Ill High-risk ICU Patients
Recent studies suggest the employment of 'conscious' sedation (1) for critically high - risk patients (2), showing more efficacy then deep sedation (3).
- Trial name
- NCT01360346
- Testing
- Enteral Sedation (EN), Control group: Intravenous Sedation (IV)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Milan
Duodenal Spasm, ERCP
Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP
This study aims to evaluate the efficacy of intravenous lidocaine infusion on duodenal peristalsis during Endoscopic Retrograde Cholangiopancreatography (ERCP).
- Conditions
- Duodenal Spasm, ERCP, Sedation
- Trial name
- LIDO ERCP (NCT07333859)
- Testing
- Lidocaine Hydrochloride 2%, 0.9 % Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Anesthesia
A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation
Hypothesis: A combination of midazolam with dexmedetomidine for sedation during third molar surgery will provide 1) superior patient satisfaction, 2) superior operator satisfaction and 3) no significant hemodynamic or respiratory…
- Trial name
- NCT03255824
- Testing
- Dexmedetomidine and Midazolam, Propofol, Midazolam, and Fentanyl
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Sedation Complication
Comparison Between Sevoflurane and Propofol for Maintenance of Sedation During ERCP
After approval of ethical committee of Sindh Institute of Urology \& Transplantation (SIUT), 86 patients were enrolled for the elective endoscopic retrograde cholangiopancreatography (ERCP).
- Trial name
- NCT05996588
- Testing
- Propofol 1 % Injectable Suspension, Sevoflurane
- Where
- Pakistan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Surgery, Anesthesia
Intravenous Sedation Versus General Anesthesia in Patients Undergoing Minor Gynecologic Surgery
The use of deep sedation may improve the quality of recovery of patients undergoing minor gynecologic procedures. These patients may also have shorter hospital stays and potentially lower healthcare costs.
- Conditions
- Surgery, Anesthesia, Pain
- Trial name
- NCT01890707
- Testing
- General Anesthesia, Deep Sedation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Analgesia
Methoxyflurane for Analgesia During Hysteroscopy
This study is to assess the non-inferiority of using inhaled methoxyflurane (MOF) versus intravenous conscious sedation with fentanyl and midazolam on women's perception of pain, during hysteroscopy and/or polypectomy in an…
- Trial name
- NCT06899724
- Testing
- Anesthetics, Inhalation, Intravenous Sedatives with or Without Analgesia
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Dr. John A. Thiel Medical Professional Corporation
Sedation
Intravenous Infusion of Lidocaine in Gastroscopy
Intravenous infusion of lidocaine significantly reduces incidence of bucking when perfomed gastroscopy.
- Trial name
- NCT04439773
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Shandong University
Sedation
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
This is a study to compare safety and efficacy of inhaled isoflurane administered via the Sedaconda ACD-S device system versus intravenous propofol for sedation of mechanically ventilated patients in the Intensive Care Unit (ICU)…
- Trial name
- INSPiRE-ICU2 (NCT05327296)
- Testing
- Isoflurane, Propofol
- Where
- 16 sites in United States
- Volunteers
- 282 people
- Sponsor
- Sedana Medical
Procedural Sedation
Low-Dose Intravenous Ketamine Bolus Versus Conventional Technique
Abstract Background: Ketamine has been introduced as one of the most common drugs, administered to sedate children for different painful procedures in the emergency department (ED) but administration in higher dosage causes some…
- Trial name
- NCT03499886
- Testing
- Ketamine Hydrochloride 50Mg/1mL Solution for Injection, Ketamine Hcl 50Mg/Ml Inj
- Where
- 2 sites in Iran
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Septic Shock
Comparison of Extubation Delay After Prolonged Sedation
This monocentric, prospective, controlled, randomized, single-blind study will be conducted in surgical resuscitation at the Rouen University Hospital.
- Trial name
- ISOREA (NCT04710914)
- Testing
- Prolonged sedation with isoflurane, Prolonged sedation with midazolam
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Rouen
Conscious Sedation, Remifentanil
Local Anaesthesia and Remifentanil Sedation Versus Total Intravenous Anaesthesia for Hysteroscopic Surgery in an Ambulatory Surgery Department.
The purpose of this study is to compare a new method: the combination of conscious sedation with remifentanil (a shortlasting opioid drug) and local anaesthesia, with the traditional general anaesthesia for hysteroscopic surgery.
- Conditions
- Conscious Sedation, Remifentanil, Hysteroscopic Surgery, Anesthesia Recovery Period
- Trial name
- NCT00763789
- Testing
- local anaesthesia and remifentanil sedation, total intravenous anaesthesia
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Copenhagen University Hospital at Herlev